Heterocyclic compounds, 3-acetyl-2-methylpyridines, chemical modifications, biological activity
15
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147
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8
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7
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Scopus Publications
Acute Toxicity Evaluation of Pyridine Derivatives of 3,4-Dihydroquinoxalin-2-one and 3,4-Dihydro-2H-1,4-benzoxazin-2-one S. A. Ternovskaya, V. S. Vlasenko, A. N. Novikov, N. A. Dengis, A. L. Stalinskaya, I. V. Kulakov Russian Journal of Bioorganic Chemistry, 2024 Abstract Objective: Compounds containing the quinoxaline and oxazine core have a diverse spectrum of biological activity, including antibacterial, antiviral, antitumor, antituberculosis, anti-inflammatory, and others. The introduction of a new pharmacophoric pyridine component into these derivatives can enhance the biochemical activity and metabolic stability of the resulting substance, increase cell permeability, and improve pharmacokinetic and pharmacodynamic properties. Previously, a number of pyridine derivatives of quinoxaline and oxazine were found to have pronounced and moderate antituberculosis, antibacterial, antifungal, and analgesic properties in vitro. In this regard, the aim of this study is to evaluate the acute toxicity of bis(3,4-dihydroquinoxalin-2-one) and bis(3,4-dihydro-2H-1,4-benzoxazin-2-one) derivatives upon intraperitoneal administration to guinea pigs. Methods: The acute toxicity of the bis-derivatives synthesized on the basis of 3,5-diacetyl-2,6-dimethylpyridine was studied after a single intraperitoneal administration to guinea pigs (6 groups of 6 individuals) at doses of 100, 200, and 400 mg/kg. The control group was group 7, which received 1.0 mL of physiological solution. Observation was carried out for 14 days. In the next stage, on the 15th day of the experiment, blood was collected for hematological and biochemical studies from the guinea pigs that were intraperitoneally administered with the test compounds, as well as from the guinea pigs of the control group. Results and Discussion: It was established that, according to K.K. Sidorov’s classification, pyridine derivative (3Z,3′Z)-3,3′-[(2,6-dimethylpyridin-3,5-diyl)bis(2-oxoethane-2-yl-1-ylidene)]bis(3,4-dihydroquinoxalin-2(1H)-one) had low toxicity, as evidenced by the absence of lethal outcomes from its administration to animals in the range of 100–400 μg/kg, which, however, was accompanied by signs of nervous disorder regardless of the dose of the compound, which disappeared within 24 h. When the guinea pigs were inoculated with another pyridine derivative, (3Z,3′Z)-3,3′-[(2,6-dimethylpyridin-3,5-diyl)bis(2-oxoethane-2-yl-1-ylidene)]bis(3,4-dihydro-2H-1,4-benzoxazin-2-one), more pronounced and prolonged signs of intoxication were observed as manifested by convulsive twitching of the hind limbs, decreased mobility, and a slow reaction to environmental stimuli, followed by the death of 33% of animals, when the compound was administered at a dose of 100 mg/kg, 66% at a dose of 200 mg/kg, and 100% at a dose of 400 mg/kg. The hematological and biochemical studies conducted on the 15th day after the administration of the test compounds showed the absence of significant deviations from normal physiological values, despite the presence of a reliable difference in individual indicators compared to the control group. Conclusions: Thus, the acute toxicity parameters of the test compounds were of different nature and were more pronounced in the pyridine derivative (3Z,3′Z)-3,3′-[(2,6-dimethylpyridin-3,5-diyl)bis(2-oxoethane-2-yl-1-ylidene)]bis(3,4-dihydro-2H-1,4-benzoxazin-2-one), however, both compounds can be recommended for subsequent study of the antibacterial and antiviral activity in guinea pigs.
Synthesis of New Structural Analogues of Natural Integrastatins with a Basic Epoxybenzo[7,8]oxocine Skeleton: Combined Experimental and Computational Study Ivan V. Kulakov, Alena L. Stalinskaya, Semyon Y. Chikunov, Irina A. Pustolaikina, Yuri V. Gatilov Synthesis Germany, 2024 In this work, the cyclization reactivity of various 3-acetyl-2-methylpyridines (including 3-acetyl-2-methylquinoline) containing both electron donor and acceptor substituents with salicylaldehyde into epoxybenzooxocino[4,3-b]pyridine derivatives was studied. The reactions were carried out in mild (under room temperature or reflux in 2-propanol) and harsh (in a sealed glass ampoule) conditions. It was shown that 3-acetyl-2-methylpyridines with an aryl substituent in the 4-position do not react with salicylaldehyde either under normal convection heating conditions or under more severe conditions. This effect was explained by the steric hindrance of the substituents using quantum chemical calculations. It was found that electron donor substituents in 3-acetyl-2-methylpyridines significantly facilitate cyclization in epoxybenzooxocino[4,3-b]pyridines. The presence of electron acceptor substituents (NO2 group for example) in the 5-position of pyridine prevents cyclization under normal conditions, but gives a rather high conversion to oxocinopyridines under more specific conditions. This effect is quantum-chemically explained by the decrease in the basicity of pyridine. Pyridines with two pairs of methyl groups in ortho-positions to the acetyl group are capable to form mixtures of regioisomeric epoxybenzooxocinopyridines. Further, epoxybenzooxocinopyridines with methyl and acetyl groups can form a mixture of diastereomeric bisoxocins under more specific conditions. All 17 initial pyridines were studied quantum-chemically in order to understand what features of their structure and properties affect the success of the cyclization reaction and the yield of the target product. The pyridine molecules were calculated by the DFT RB3LYP/6-311++G(d,p) method taking into account the alcohol solvent within the CPCM model using Gaussian-2016 program. It was shown that the absence of steric hindrances in the form of bulky substituents in 4-position of pyridines is the main factor affecting the success of the cyclization reaction. Also, the yield of the target product is affected by the CH-acidity of the methyl group in 2-position, which, in turn, is affected by electron-donating and electron-withdrawing substituents in the 5- and 6-positions.
A Series of Novel Integrastatins Analogues: In silico Study of Physicochemical and Bioactivity Parameters Aida S. Rakhimzhanova, Ruslan A. Muzaparov, Irina A. Pustolaikina, Alfiya F. Kurmanova, Sergey N. Nikolskiy, Darya D. Kapishnikova, Alena L. Stalinskaya, Ivan V. Kulakov Eurasian Journal of Chemistry, 2024 Integrastatins are naturally occurring heterotetracyclic compounds with a broad spectrum of biological activity. A number of new structural analogues of integrastatins 2a-u have been synthesized using a novel one-step method [1], but a systematic theoretical study of their structural features and biological activity has not been realized. This study aimed to in silico investigate physicochemical and bioactivity properties for a series of 21 new synthetic analogues of natural integrastatins. Global chemical reactivity descriptors was assessed using DFT B3LYP 6-311++G(d, p) CPCM (solvent — water) calculations. High ionization potential IP in the range from 5.9 to 7.1 eV and electron affinity EA at the level of 2.1 to 3.2 eV were shown, which together with a sufficiently large energy gap DEgap from 3.8 to 4.6 eV indicates the hard nature of the compounds 2a-u. Antiviral activity and inhibitory potential as CYP2C19 inducers were identified using the PASSOnline resource. According to the results of molecular docking studies Human immunodeficiency virus HIV-1 reverse transcriptase protein (PDB ID: 3V81) and protein of the RNA-dependent RNA polymerase of the SARS-CoV-2 (PDB ID: 7AAP) can serve as a likely biological target for the compounds 2a-u. Potentially high oral efficacy and a promising safety profile for the therapeutic use were showed using ADMETlab 3.0 online portal. Further experimental in vitro and in vivo studies of the pharmaceutical potential of compounds 2a-u is need for more accurate evaluation the assumptions made on the basis of in silico approach.
Synthesis, hemorheological and antifibrotic activity of newly synthesized 3-acetyl-2,4,6-trimethylpyridine derivatives Zarina Shulgau, Alena Stalinskaya, Shynggys Sergazy, Aigerim Zhulikeyeva, Yevgeniy Kamyshanskiy, Alexander Gulyayev, Yerlan Ramankulov, Ivan Kulakov Arabian Journal of Chemistry, 2023 Pyridine derivatives still attract the attention of many researchers for their comprehensive biological research, possible promotion to the pharmaceutical market in order to be used as effective drugs. In this article, based on the well-known and fairly accessible in terms of laboratory synthesis of the 3-acetyl derivative of collidine, we carried out several simple chemical modifications to obtain new collidine derivatives not previously described. The structure of the synthesized compounds was confirmed by 1H- and 13C NMR spectroscopy. A biological screening of the synthesized compounds for hemorheological activity was carried out on an in vitro blood hyperviscosity model. It was shown that pronounced hemorheological activity was established for compounds 3, 4 and 5. Compound 4 also showed a pronounced antifibrotic effect in an experimental model of pulmonary fibrosis induced by intratracheal administration of bleomycin to rats. In an experimental model of pulmonary fibrosis in rats, the formation of a hyperviscosity syndrome was also observed, and blood viscosity decreased when compound 4 was administered to animals.
Multicomponent Synthesis of Unsymmetrical Derivatives of 4-Methyl-Substituted 5-Nitropyridines Daria M. Turgunalieva, Alena L. Stalinskaya, Ilya I. Kulakov, Galina P. Sagitullina, Victor V. Atuchin, Andrey V. Elyshev, Ivan V. Kulakov Processes, 2023 The multicomponent reaction of 2-nitroacetophenone (or nitroacetone), acetaldehyde diethyl acetal, β-dicarbonyl compound, and ammonium acetate in an acetic acid solution allowed the acquisition of previously undescribed 4-methyl-substituted derivatives of 5-nitro-1,4-dihydropyridine in satisfactory yields. The oxidation of the obtained 5-nitro-1,4-dihydropyridine derivatives resulted in the corresponding 2,4-dimethyl-5-nitropyridines. In addition, for the first time in the synthesis of unsymmetrical 1,4-dihydropyridines by the Hantzsch reaction acetaldehyde, diethyl acetal was used as a source of acetaldehyde. The use of more volatile and sufficiently reactive acetaldehyde in this reaction did not lead to a controlled synthesis of unsymmetrical 5-nitro-1,4-dihydropyridines. The proposed multicomponent approach to the synthesis of 4-methyl-substituted 5-nitro-1,4-dihydropyridines and their subsequent aromatization into pyridines made it possible to obtain previously undescribed and hardly accessible substituted 5(3)-nitropyridines.
Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3-b]Pyridine Derivatives Alena L. Stalinskaya, Nadezhda V. Martynenko, Zarina T. Shulgau, Alexandr V. Shustov, Viktoriya V. Keyer, Ivan V. Kulakov Molecules, 2022 The COVID-19 pandemic is ongoing as of mid-2022 and requires the development of new therapeutic drugs, because the existing clinically approved drugs are limited. In this work, seven derivatives of epoxybenzooxocinopyridine were synthesized and tested for the ability to inhibit the replication of the SARS-CoV-2 virus in cell cultures. Among the described compounds, six were not able to suppress the SARS-CoV-2 virus’ replication. One compound, which is a derivative of epoxybenzooxocinopyridine with an attached side group of 3,4-dihydroquinoxalin-2-one, demonstrated antiviral activity comparable to that of one pharmaceutical drug. The described compound is a prospective lead substance, because the half-maximal effective concentration is 2.23 μg/μL, which is within a pharmacologically achievable range.
Cyclization Reaction of 3,5-Diacetyl-2,6-dimethylpyridine with Salicylic Aldehyde and Its Derivatives: Quantum-Chemical Study and Molecular Docking A. L. Stalinskaya, S. Y. Chikunov, I. A. Pustolaikina, I. V. Kulakov Russian Journal of General Chemistry, 2022 Computational study of some details of the cyclization reaction between 3,5-diacetyl-2,6-dimethylpyridine and salicylic aldehyde in an acidic medium was performed by the DFT RB3LYP/6-31G method using the Gaussian-2016 software package. It was shown that protonation of the pyridine nitrogen atom leads to a significant increase in the charge of the hydrogen atom of the 2-methyl group of pyridine and the methyl acetyl group. This leads to the growth of the methyl group CH-acidity and enolization of the acetyl group. It was also found that the protonated tautomeric enol form of 3,5-diacetyl-2,6-dimethylpyridine gives a stable pre-reaction complex with salicylic aldehyde due to the formation of three hydrogen bonds. The formation of this pre-reaction complex, apparently, leads to the implementation of the Knoevenagel reaction, instead of the alternative possible Claisen–Schmidt reaction of salicylic aldehyde at the acetyl group of pyridine. The possible biological activity of the previously obtained cyclization products was evaluated by molecular docking using the AutoDock Vina software. Some cyclization products showed higher values of the binding affinity with the selected target proteins in comparison with the known antiviral drugs Nevirapine and Favipiravir. The results obtained confirm the correctness of the proposed cyclization mechanism between 3,5-diacetyl-2,6-dimethylpyridine and salicylic aldehyde. This also makes it possible to assess the prospects of previously obtained derivatives of epoxybenzo[7,8]oxocino[4,3-b]pyridine as synthetic analogs of natural integrastatins A, B for further synthesis and study of their antiviral activity.
Synthesis, Structure, and Biological Activity of N-p-(Dimethylamino)-N′-(p-dimethylaminobenzylidene)-N,N′′-diphenylbenzohydrazonohydrazide A. L. Stalinskaya, Z. T. Shulgau, Sh. D. Sergazy, A. E. Gulyaev, D. M. Turdybekov, K. M. Turdybekov, I. V. Kulakov Russian Journal of General Chemistry, 2022 A three-component reaction of 3,5-diacetyl-2,6-dimethylpyridine, p-N-dimethylaminobenzaldehyde and phenylhydrazine in the presence of KOH in ethanol gave the condensation product of two p-N-dimethylaminobenzaldehyde and phenylhydrazine molecules, namely bis(biarylhydrazone). Structure of the obtained derivative was proved by the 1H and 13C NMR spectroscopy and X-ray diffraction analysis data. It was shown that the bis(biarylhydrazone) derivative has high antiradical and cytoprotective activity.
Synthesis, characterization, and computational study of s-methylthio-and n-methylamine substituted epoxybenzo [7, 8] oxocyno [4, 3-b] pyridine derivatives AL Stalinskaya, IA Pustolaikina, AF Kurmanova, AS Rakhimzhanova, ... Journal of Molecular Structure, 143346 , 2025 2025.0
Pyridine derivatives of 3, 4-dihydroquinoxalin-2-one and 3, 4-dihydro-2 H-1, 4-benzoxazin-2-one acute toxicity evaluation SA Ternovskaya, VS Vlasenko, AN Novikov, NA Dengis, AL Stalinskaya, ... Bioorganičeskaâ himiâ 50 (6), 856-861 , 2024 2024.0
A Series of Novel Integrastatins Analogues: In silico Study of Physicochemical and Bioactivity Parameters AS Rakhimzhanova, RA Muzaparov, IA Pustolaikina, AF Kurmanova, ... Eurasian Journal of Chemistry 29 (4 (116)), 44-60 , 2024 2024.0 Citations: 3
Acute Toxicity Evaluation of Pyridine Derivatives of 3,4-Dihydroquinoxalin-2-one and 3,4-Dihydro-2 H -1,4-benzoxazin-2-one SA Ternovskaya, VS Vlasenko, AN Novikov, NA Dengis, AL Stalinskaya, ... Russian Journal of Bioorganic Chemistry 50 (6), 2627-2633 , 2024 2024.0 Citations: 3
The synthesis and antitubercular activity of 4,5-dihydro-1 H -pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework AL Stalinskaya, NA Dengis, VS Vlasenko, IV Kulakov Chemistry of Heterocyclic Compounds 60 (1), 41-47 , 2024 2024.0
EURASIAN JOURNAL OF CHEMISTRY AS RAKHIMZHANOVA, RA MUZAPAROV, IA PUSTOLAIKINA, ... EURASIAN JOURNAL OF CHEMISTRY Учредители: Карагандинский университет им … , 2024 2024.0
Synthesis of new structural analogues of natural Integrastatins with a basic epoxybenzo [7, 8] oxocine skeleton: Combined experimental and computational study AL Stalinskaya, SY Chikunov, IA Pustolaikina, YV Gatilov, IV Kulakov Synthesis 56 (02), 329-345 , 2024 2024.0 Citations: 11
Synthesis, hemorheological and antifibrotic activity of newly synthesized 3-acetyl-2, 4, 6-trimethylpyridine derivatives Z Shulgau, A Stalinskaya, S Sergazy, A Zhulikeyeva, Y Kamyshanskiy, ... Arabian Journal of Chemistry 16 (7), 104821 , 2023 2023.0 Citations: 1
Synthesis and bacteriostatic properties of epoxybenzooxocino [4, 3-b] pyridine derivatives AL Stalinskaya, NV Martynenko, LE Alkhimova, DS Dilbaryan, ... Journal of Molecular Structure 1275, 134689 , 2023 2023.0 Citations: 13
Multicomponent synthesis of unsymmetrical derivatives of 4-Methyl-Substituted 5-Nitropyridines DM Turgunalieva, AL Stalinskaya, II Kulakov, GP Sagitullina, VV Atuchin, ... Processes 11 (2), 576 , 2023 2023.0 Citations: 12
Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3- b ]Pyridine Derivatives AL Stalinskaya, NV Martynenko, ZT Shulgau, AV Shustov, VV Keyer, ... Molecules 27 (12), 3701 , 2022 2022.0 Citations: 29
Cyclization Reaction of 3, 5-Diacetyl-2, 6-dimethylpyridine with Salicylic Aldehyde and Its Derivatives: Quantum-Chemical Study and Molecular Docking AL Stalinskaya, SY Chikunov, IA Pustolaikina, IV Kulakov Russian Journal of General Chemistry 92 (5), 914-924 , 2022 2022.0 Citations: 8
Synthesis, Structure, and Biological Activity of N - p -(Dimethylamino)- N ′-( p -dimethylaminobenzylidene)- N , N ′′-diphenylbenzohydrazonohydrazide AL Stalinskaya, ZT Shulgau, SD Sergazy, AE Gulyaev, DM Turdybekov, ... Russian Journal of General Chemistry 92 (2), 147-153 , 2022 2022.0 Citations: 1
Synthesis of 4,5-dihydro-1 H -pyrazole derivatives based on 3-acetyl-5-nitropyridines AL Stalinskaya, DF Weber, TM Seilkhanov, IV Kulakov Monatshefte für Chemie-Chemical Monthly 152 (3), 337-343 , 2021 2021.0 Citations: 5
Synthesis of new representatives of 11, 12-dihydro-5 H-5, 11-epoxybenzo [7, 8] oxocino [4, 3-b] pyridines–structural analogues of integrastatins A, B IV Kulakov, AL Stalinskaya, SY Chikunov, YV Gatilov New Journal of Chemistry 45 (7), 3559-3569 , 2021 2021.0 Citations: 22
Multicomponent synthesis of 4-unsubstituted 5-nitropyridine derivatives IV Kulakov, AL Oleshchuk, VA Koveza, IV Palamarchuk Synthetic Communications 50 (16), 2432-2439 , 2020 2020.0 Citations: 10
Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives AL Oleshchuk, ZT Shulgau, TM Seilkhanov, AS Vasilchenko, SA Talipov, ... Synlett 31 (02), 165-170 , 2020 2020.0 Citations: 8
Synthesis and biological activity of 3, 5-diacetyl-2, 6-dimethylpyridine derivatives AL Oleshchuk, AA Karbainova, TN Krivoruchko, ZT Shulgau, ... Chemistry of Heterocyclic Compounds 55 (1), 47-51 , 2019 2019.0 Citations: 21
ANTIVIRAL ACTIVITY OF SOME NEW OXOCIN DERIVATIVES: IN SILICO STUDY AND IN VITRO RESULTS IA PUSTOLAIKINA, S NORMATOV, RA MUZAPAROV, AF KURMANOVA, ... Scientific Research Institute of Biomedical Chemistry named after VN … , 0
MOST CITED SCHOLAR PUBLICATIONS
Synthesis and Antiviral Properties against SARS-CoV-2 of Epoxybenzooxocino[4,3- b ]Pyridine Derivatives AL Stalinskaya, NV Martynenko, ZT Shulgau, AV Shustov, VV Keyer, ... Molecules 27 (12), 3701 , 2022 2022.0 Citations: 29
Synthesis of new representatives of 11, 12-dihydro-5 H-5, 11-epoxybenzo [7, 8] oxocino [4, 3-b] pyridines–structural analogues of integrastatins A, B IV Kulakov, AL Stalinskaya, SY Chikunov, YV Gatilov New Journal of Chemistry 45 (7), 3559-3569 , 2021 2021.0 Citations: 22
Synthesis and biological activity of 3, 5-diacetyl-2, 6-dimethylpyridine derivatives AL Oleshchuk, AA Karbainova, TN Krivoruchko, ZT Shulgau, ... Chemistry of Heterocyclic Compounds 55 (1), 47-51 , 2019 2019.0 Citations: 21
Synthesis and bacteriostatic properties of epoxybenzooxocino [4, 3-b] pyridine derivatives AL Stalinskaya, NV Martynenko, LE Alkhimova, DS Dilbaryan, ... Journal of Molecular Structure 1275, 134689 , 2023 2023.0 Citations: 13
Multicomponent synthesis of unsymmetrical derivatives of 4-Methyl-Substituted 5-Nitropyridines DM Turgunalieva, AL Stalinskaya, II Kulakov, GP Sagitullina, VV Atuchin, ... Processes 11 (2), 576 , 2023 2023.0 Citations: 12
Synthesis of new structural analogues of natural Integrastatins with a basic epoxybenzo [7, 8] oxocine skeleton: Combined experimental and computational study AL Stalinskaya, SY Chikunov, IA Pustolaikina, YV Gatilov, IV Kulakov Synthesis 56 (02), 329-345 , 2024 2024.0 Citations: 11
Multicomponent synthesis of 4-unsubstituted 5-nitropyridine derivatives IV Kulakov, AL Oleshchuk, VA Koveza, IV Palamarchuk Synthetic Communications 50 (16), 2432-2439 , 2020 2020.0 Citations: 10
Cyclization Reaction of 3, 5-Diacetyl-2, 6-dimethylpyridine with Salicylic Aldehyde and Its Derivatives: Quantum-Chemical Study and Molecular Docking AL Stalinskaya, SY Chikunov, IA Pustolaikina, IV Kulakov Russian Journal of General Chemistry 92 (5), 914-924 , 2022 2022.0 Citations: 8
Synthesis and Biological Activity of 4-(Pyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic Acid Derivatives AL Oleshchuk, ZT Shulgau, TM Seilkhanov, AS Vasilchenko, SA Talipov, ... Synlett 31 (02), 165-170 , 2020 2020.0 Citations: 8
Synthesis of 4,5-dihydro-1 H -pyrazole derivatives based on 3-acetyl-5-nitropyridines AL Stalinskaya, DF Weber, TM Seilkhanov, IV Kulakov Monatshefte für Chemie-Chemical Monthly 152 (3), 337-343 , 2021 2021.0 Citations: 5
A Series of Novel Integrastatins Analogues: In silico Study of Physicochemical and Bioactivity Parameters AS Rakhimzhanova, RA Muzaparov, IA Pustolaikina, AF Kurmanova, ... Eurasian Journal of Chemistry 29 (4 (116)), 44-60 , 2024 2024.0 Citations: 3
Acute Toxicity Evaluation of Pyridine Derivatives of 3,4-Dihydroquinoxalin-2-one and 3,4-Dihydro-2 H -1,4-benzoxazin-2-one SA Ternovskaya, VS Vlasenko, AN Novikov, NA Dengis, AL Stalinskaya, ... Russian Journal of Bioorganic Chemistry 50 (6), 2627-2633 , 2024 2024.0 Citations: 3
Synthesis, hemorheological and antifibrotic activity of newly synthesized 3-acetyl-2, 4, 6-trimethylpyridine derivatives Z Shulgau, A Stalinskaya, S Sergazy, A Zhulikeyeva, Y Kamyshanskiy, ... Arabian Journal of Chemistry 16 (7), 104821 , 2023 2023.0 Citations: 1
Synthesis, Structure, and Biological Activity of N - p -(Dimethylamino)- N ′-( p -dimethylaminobenzylidene)- N , N ′′-diphenylbenzohydrazonohydrazide AL Stalinskaya, ZT Shulgau, SD Sergazy, AE Gulyaev, DM Turdybekov, ... Russian Journal of General Chemistry 92 (2), 147-153 , 2022 2022.0 Citations: 1
Synthesis, characterization, and computational study of s-methylthio-and n-methylamine substituted epoxybenzo [7, 8] oxocyno [4, 3-b] pyridine derivatives AL Stalinskaya, IA Pustolaikina, AF Kurmanova, AS Rakhimzhanova, ... Journal of Molecular Structure, 143346 , 2025 2025.0
Pyridine derivatives of 3, 4-dihydroquinoxalin-2-one and 3, 4-dihydro-2 H-1, 4-benzoxazin-2-one acute toxicity evaluation SA Ternovskaya, VS Vlasenko, AN Novikov, NA Dengis, AL Stalinskaya, ... Bioorganičeskaâ himiâ 50 (6), 856-861 , 2024 2024.0
The synthesis and antitubercular activity of 4,5-dihydro-1 H -pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework AL Stalinskaya, NA Dengis, VS Vlasenko, IV Kulakov Chemistry of Heterocyclic Compounds 60 (1), 41-47 , 2024 2024.0
EURASIAN JOURNAL OF CHEMISTRY AS RAKHIMZHANOVA, RA MUZAPAROV, IA PUSTOLAIKINA, ... EURASIAN JOURNAL OF CHEMISTRY Учредители: Карагандинский университет им … , 2024 2024.0
ANTIVIRAL ACTIVITY OF SOME NEW OXOCIN DERIVATIVES: IN SILICO STUDY AND IN VITRO RESULTS IA PUSTOLAIKINA, S NORMATOV, RA MUZAPAROV, AF KURMANOVA, ... Scientific Research Institute of Biomedical Chemistry named after VN … , 0
