Born in Varanasi (Uttar Pradesh) brought up and educated in different part of India like UP board Allahabad, Nagpur University, Rajiv Gandhi Univ of Health Sciences Karnataka, Bengaluru and Bundelkhand University. Started academic carrier as Lecturer at Division of Pharmaceutical Sciences, SGRRITS, Dehradun (1999-2001), followed by Institute of Pharmacy, Bundelkhand University, Jhansi (2001-05); and presently serving CSJM University, Kanpur since from 2005. Awarded with Fellow Membership of ISCA, ICCE, FBPS, FABRF; Life Member: PRAYATNA, IPA, APTI, IPGA. Associate Editor/Editorial Board Member of several international and national journals. Guided several PG (M.Pharm), UG (B.Pharm.) projects and still guiding PG, UG & PhD scholars. Received various International, National and local Awards. Several articles are published and patents are granted.
EDUCATION
M.Pharm. (Pharmacology), PhD (Pharmacy), PDCR
RESEARCH INTERESTS
Pharmacology, Ethnopharmacology, Pharmaceutical Sciences, Drug discovery and development
46
Scopus Publications
1902
Scholar Citations
15
Scholar h-index
19
Scholar i10-index
Scopus Publications
In Vitro Assessment of the Cytoprotective Activity of Syzygium cumini Seed Extract on RIN-5F Pancreatic β-Cell Lines and HUH-7 Hepatocellular Carcinoma Cell Lines Anshuman Prajapati, Priyanka Prajapati, Ajay Kumar Gupta International Journal of Drug Delivery Technology, 2026 Oxidative stress is a critical mediator of pancreatic β-cell dysfunction and hepatic cellular injury in diabetes and related metabolic disorders. Pancreatic β-cells are particularly susceptible to oxidative damage due to limited intrinsic antioxidant capacity, while hepatic cells are central to metabolic regulation and redox homeostasis. Natural phytochemicals rich in polyphenols have gained attention for their antioxidant and cytoprotective potential. Syzygium cumini seeds, traditionally used in glycemic management, contain bioactive compounds with established free radical scavenging properties. The present study evaluated the in vitro cytoprotective activity of Syzygium cumini seed extract (SCSE) in pancreatic and hepatic cell models subjected to oxidative stress. Methods Ethanolic extract of Syzygium cumini seeds was prepared and subjected to qualitative and quantitative phytochemical analysis. RIN-5F pancreatic β-cell lines and HUH-7 hepatocellular carcinoma cell lines were cultured under standard conditions. Oxidative stress was induced using hydrogen peroxide. Cytoprotective effects were assessed using MTT assay. Intracellular reactive oxygen species (ROS), lipid peroxidation (malondialdehyde levels), and antioxidant defense markers including superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) were evaluated. Statistical significance was determined using one-way ANOVA. Results Hydrogen peroxide exposure significantly reduced cell viability and increased oxidative stress markers in both cell lines. Pretreatment with SCSE produced a dose-dependent restoration of viability and significantly reduced ROS generation and lipid peroxidation. Antioxidant enzyme activities and GSH levels were markedly improved following extract treatment. The protective effect was more pronounced in RIN-5F β-cells compared to HUH-7 cells, indicating differential cellular responsiveness. Conclusion Syzygium cumini seed extract demonstrates significant cytoprotective and antioxidant activity in pancreatic and hepatic cellular models. These findings provide mechanistic support for its therapeutic potential in oxidative stressassociated metabolic disorders and warrant further in vivo and translational investigations.
Exploring Siderophore Diversity: Production, Extraction And Functional Applications Shreya Verma, Vaishnavi Srivastava, Prashant Kumar Singh, Ajay Kumar Gupta, Manishi Tripathi International Journal of Drug Delivery Technology, 2026 Siderophores are metal-binding compounds that are of low molecular weight, high affinity, produced by living organisms to obtain iron under limiting environmental conditions. Iron plays a critical role in respiration, enzymatic processes, synthesis of DNA and redox balance but the bioavailability of iron is severely limited in aerobic conditions because it forms insoluble ferric complex. To mitigate this drawback, microorganisms, plants and even mammals synthesize siderophores which bind to the ferric ions and deliver them to the cell via special receptor-mediated processes. In addition to the iron-acquiring properties, siderophores are also involved in heavy metal detoxification, interspecies competition, pathogenesis, and various industrial and biomedical uses. Their spectacular structural diversity mostly the catecholates, hydroxamates, and carboxylates control their metal specificity, stability constants and transport route. The review describes the variety of siderophores in terms of chemistry and biological synthesis, the key approaches to their production and extraction, and their growing role in agriculture, the environment, medicine and biotechnology.
NEUROPROTECTIVE ROLES OF BDNF AND NGF IN ARSENIC-INDUCED NEUROTOXICITY: MECHANISMS AND THERAPEUTIC IMPLICATIONS AYUSH CHAURASIA, ZEESHAN ANSARI, G. HEMA, ANJU SINGH, AJAY KUMAR GUPTA International Journal of Applied Pharmaceutics, 2025 Arsenic-induced neurotoxicity is increasingly recognized as a major global health issue, leading to both developmental and degenerative neurological impairments, therefore, arsenic is becoming one of the potent environmental neurotoxins that can lead to significant health risks, particularly through long-term exposure via water, food, and air. Arsenic exposure can initiate a range of pathological events such as-disruption of mitochondrial function, oxidative stress, apoptosis, and inflammatory processes, which result in neuronal damage and cognitive dysfunction. Conversely, neurotrophins growth factors that regulate neuronal survival, growth, and function, are emerging as promising neuroprotective agents against such neurotoxic effects. This article explores the neuroprotective roles of BDNF (Brain-derived neurotrophic factor) and NGF (Nerve growth factor) in counteracting arsenic-induced neurodegeneration, through the analysis of epidemiology and mechanism-based preclinical studies of last decade. Arsenic disrupts neurotrophin signaling by inhibiting Trk (Tropomyosin receptor kinase) receptor phosphorylation and downstream survival pathways PI3K-AKT (Phosphoinositide 3-kinase–Protein kinase B), ERK-CREB (Extracellular signal-regulated kinase-cAMP response element-binding protein), thus contributing to neurodegeneration. In animal models, BDNF supplementation exhibited reduction in oxidative stress by 45–60%, neuronal apoptosis declined by about 55%, and improvement in cognitive function up to 40%. Additionally, NGF supplementation shows a 40-55% reduction in apoptosis. By integrating toxicological mechanisms with therapeutic perspectives, this narrative review underscores the potential of neurotrophin-based strategies to mitigate arsenic-related neurodegeneration and highlights future research directions for translational applications.
Novel perspective of therapeutic modules to overcome motor and nonmotor symptoms in Parkinson’s disease Anmol Kumar, Ajay Kumar Gupta, Prashant Kumar Singh Aims Neuroscience, 2024 Parkinson's disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons, which leads to motor and non-motor symptoms that have a significant impact. The pathophysiology of PD is complex and involves environmental and genetic factors that contribute to alpha-synuclein aggregation, mitochondrial dysfunction, oxidative stress, and neuroinflammation. The current treatments of PD primarily focus on symptom management and have limitations in addressing disease progression and non-motor symptoms. Epidemiological data indicates a rise in PD cases worldwide, which highlights the need for effective treatments. Pathophysiological insights point out the involvement of various factors in PD progression, such as dopamine dysregulation, genetic mutations, oxidative stress, mitochondrial damage, alpha-synuclein aggregation, and neuroinflammation. Although current treatments, which include dopamine precursors, monoamine oxidase (MAO) inhibitors, and non-dopaminergic drugs, can alleviate motor symptoms, they are not effective in preventing disease progression or managing non-motor symptoms. Additionally, they can lead to adverse effects and become less effective over time. Novel therapeutic approaches, including cell-based therapies, gene therapies, targeted drug delivery therapies, and magnetic field therapies, are promising in improving symptom management and providing personalized treatment. Additionally, emerging therapies that target alpha-synuclein aggregation, mitochondrial dysfunction, and neuroinflammation may have potential disease-modifying effects. To sum up, for dealing with the multiple aspects of PD, there is a great need to come up with new and creative therapeutic approaches that not only relieve symptoms, but also prevent the progression of disease and non-motor symptoms. The progress made in comprehending the underlying mechanisms of PD provides optimism for developing successful treatments that can enhance the outcomes and quality of life.
Comparison of Radiological and Clinical Outcomes between Expandable and Non-expandable Cages Following Cervical Corpectomy: A Systematic Review and Meta-analysis Anand Kumar Das, Devendra Kumar Purohit, Ajay Gupta, Rashim Kataria Asian Spine Journal, 2023 Anterior cervical corpectomy and fusion is considered the mainstay of surgical treatment in cervical pathology. Expandable and nonexpandable cages are preferred over autogenous bone graft because of donor-related morbidity. However, the choice of the cage type remains a debatable topic as studies report conflicting results. Thus, we evaluated the outcomes of expandable and non-expandable cages following cervical corpectomy. Studies were searched in various electronic databases (MEDLINE, PubMed, EMBASE, CINAHL, Scopus, and Cochrane) between 2011 and 2021. Forest plot was made to compare the radiological and clinical outcomes between expandable and non-expandable cages following cervical corpectomy. Altogether, 26 studies (1,170 patients) were included in the metaanalysis. The mean change in segmental angle was significantly greater in the expandable cage group than in the non-expandable cage group (6.7° vs. 3.0°, p p p =0.06) and the mean displacement rate was significantly higher in the expandable cage group (29% vs. 5%, p p >0.05). The improvement in segmental angle is better with expandable cages. Higher subsidence is a major problem with non-expandable cages, but it seems to be beneficial as evidenced by the high fusion rate and minimal effect on clinical outcome in patients with this cage.
Prevalence, Patterns, and Predictors of Tobacco Consumption among Adolescents: An Observational Study from a Rural area of Rajasthan Ajay Gupta, Somya Grover, Komal Sakrawal, Abhishek Kumar, Sadhana Meena, et al. Indian Journal of Community Medicine, 2023 Background: The prevalence of smoking cigarettes among adolescents in India is nearly one in 10, and almost half of them initiate tobacco use before turning 10 years old. Our study objective was to assess the prevalence of tobacco consumption and the sociodemographic factors associated with tobacco consumption among adolescents in a rural area of Rajasthan. Materials and Methods: This community-based, cross-sectional study was conducted for a period of 1 year from April 2021 to March 2022 in village Naila, Jaipur. All 1083 adolescents of village Naila were contacted; however, 1049 were included in the study. Multivariate logistic regression (forward likelihood model) was used to assess the strength of the association of risk factors for the consumption of tobacco. Results: A considerable proportion, that is, 22.4% (235/1049), of adolescents were tobacco consumers. Out of 235 consumers, 104 were smokers, 65 were consuming smokeless tobacco, and 66 were consuming both forms of tobacco. In multivariate analysis, age, sex, grade of participants, pocket money, family history of tobacco and alcohol consumption, maternal education, and per capita income were found to be significant predictors of tobacco consumption ( P < 0.05). Conclusion: Tobacco consumption is highly common in Rajasthan’s rural adolescent population, and it begins at a very young age. Hence, corrective measures need to be initiated in an early stage of life. To reduce the impact of social norms, peer pressure, and family members who consume tobacco, the behavioral change communication activities must be strengthened.
Denosumab: A bone antiresorptive drug Navdeep Dahiya, Anjan Khadka, A.K. Sharma, A.K. Gupta, Nishith Singh, et al. Medical Journal Armed Forces India, 2015
Coordination of cobalt(II), nickel(II) and copper(II) with schiff bases derived from pyridine-2-carboxaldehyde and amino acids International Journal of Chemtech Research, 2014
'Human development': A threat to biodiversity and ethno-medicinal plants Research Journal of Chemistry and Environment, 2012
Synthesis of some quinolone derivatives with possible local anaesthetics activities Asian Journal of Chemistry, 2012
Harnessing the Wisdom of Traditional Millets and Walking Habits for Graceful Aging DSDN Dr. Ajay Kumar Gupta THE HARBINGER A Felicitation, 61-68 , 2025 2025
Abiochemical approach to cardiac risk: association of AST & ALT levels with myocardial infarction in Type 2 Diabetes Mellitus. A Mishra, AK Gupta, V Singh, R Srivastava, A Baboo, P Katiyar Revista Latinoamericana de Hipertension 20 (6) , 2025 2025 Citations: 2
Asymmetric Janus nanofibrous agar-based wound dressing infused with enhanced antioxidant and antibacterial properties K Rathore, D Upadhyay, N Verma, AK Gupta, S Matheshwaran, S Sharma, ... ACS Applied Bio Materials 7 (11), 7608-7623 , 2024 2024 Citations: 6
Novel perspective of therapeutic modules to overcome motor and nonmotor symptoms in Parkinson's disease A Kumar, AK Gupta, PK Singh AIMS neuroscience 11 (3), 312 , 2024 2024 Citations: 5
Evaluation of green inhibitors for corrosion control of bronze by using thin layer activation method J Biswal, HJ Pant, VK Sharma, SC Sharma, AK Gupta Nuclear Instruments and Methods in Physics Research Section B: Beam … , 2024 2024 Citations: 1
Small Fenestra Stapedotomy in Comparison to Large Fenestra Stapedectomy in Improving Hearing Loss Caused by Otosclerosis: A Retrospective Study P Kumar, B Chhabra, AK Gupta, A Tamrakar, P Kumar Indian Journal of Otology 30 (1), 18-21 , 2024 2024
ZYLLA D., PARSONS H., ZIEGENFUSS J., LINDGREN B., PARK S. P JEWETT, A GUPTA, A BLAES CANNABIS Учредители: Research Society on Marijuana , 2024 2024
Health Care Contact Days Among Older US Cancer Survivors A Gupta, E Chant, R Vogel, H Parsons, A Blaes, C Booth, S Mohile, ... Journal of Geriatric Oncology 14 (8), S9 , 2023 2023
Frequency of Conjugal Transfer of Genes Between Non-pathogenic and Pathogenic Agrobacteria: A. Sharma, AK Gupta A Sharma, AK Gupta National Academy Science Letters 46 (4), 351-354 , 2023 2023
Service quality in health care: a bibliometric analysis M Datt, A Gupta, SK Misra International Conference on Production and Industrial Engineering, 237-245 , 2023 2023 Citations: 1
Optimization of daily vibration dose during different ride parameters among tractor driving C Prakash, LP Singh, A Gupta SAE International Journal of Transportation Safety 11 (3), 321-330 , 2023 2023 Citations: 1
Drug utilization study of urinary tract infections in obstetrics and gynecology department A Gupta, C Agarwal, K Bhatti, A Agarwal, R Tayal 2023
Evaluation of antimicrobial activity of Calotropis gigantea extracts on two main skin infection causing bacteria-Escherichia Coli and Staphylococcus aureus S Patel, A Dubey, GA Kumar, N Sekhar Ghosh IJFANS International Journal of Food and Nutritional Sciences 12 (1), 145-156 , 2023 2023 Citations: 6
Investigation into the compressive stress on lumbar spine among tractor drivers during different ride conditions C Prakash, LP Singh, A Gupta IOP Conference Series: Earth and Environmental Science 1084 (1), 012064 , 2022 2022 Citations: 1
An update on Versatile role of Artificial Intelligence in the Health Sector AK Gupta, A Singh, R Tiwari NeuroQuantology 20 (10), 285-321 , 2022 2022
Formulation and evaluation of polyherbal anti-dandruff shampoo and its marketed comparison S Patel, A Gupta, M Gupta Journal for Research in Applied Sciences and Biotechnology 1, 1-9 , 2022 2022 Citations: 9
Application of Close-Range Photogrammetry for 3d Mapping of Parking Space D Deka, A Dashora, D Raj, A Gupta, A Chanda, AV Kulkarni The International Archives of the Photogrammetry, Remote Sensing and Spatial … , 2022 2022 Citations: 1
A Novel Method of Screening Helminthiasis AK Gupta, A Singh, G Singh, R Tiwari, Gaurav : A. Rajendiran and Tiwari AU Patent App. 2,021,104,894 , 2022 2022
Estimation of site response function using Nakamura technique: A case study from Kumaun Himalaya. P AK, S Joshi, R Upadhyay, CC Pant, AK Gupta 2022
Resident Doctors' Personality moderated the effect of Stress on Burnout and Professional fulfilment during COVID second wave VV Singh, AK Gupta, D Kattula, A Singh, T Agrawal Indian Journal of Psychiatry 64 (Suppl 3), S535-S536 , 2022 2022
MOST CITED SCHOLAR PUBLICATIONS
Effect of salt stress on proline metabolism in two high yielding genotypes of green gram N Misra, AK Gupta Plant science 169 (2), 331-339 , 2005 2005 Citations: 441
Effect of salinity and different nitrogen sources on the activity of antioxidant enzymes and indole alkaloid content in Catharanthus roseus seedlings N Misra, AK Gupta Journal of plant physiology 163 (1), 11-18 , 2006 2006 Citations: 306
Hepatoprotective activity of aqueous ethanolic extract of Chamomile Capitula in paracetamol intoxicated albino rats N Gupta, Ajay Kumar, Misra American Journal of Pharmacology and Toxicology 1 (1), 17-20 , 2006 2006 Citations: 218
Hepatoprotective activity of Rauwolfia serpentina rhizome in paracetamol intoxicated rats. AK Gupta, HC Havagiray Chitme, SK Dass, NM Neelam Misra 2006 Citations: 93
Molecular properties and bioactivity score of the Aloe vera antioxidant compounds - in order to lead finding. SS Sadhana Singh, AK Gupta, AV Amita Verma 2013 Citations: 86
Interactive effects of sodium and calcium on proline metabolism in salt tolerant green gram cultivar N Misra, AK Gupta Am. J. Plant Physiol 1 (1), 1-12 , 2006 2006 Citations: 60
Antioxidant activity of Chamomile recutita capitula methanolic extracts against CCl 4 -induced liver injury in rats. AK Gupta, HC Havagiray Chitme, SK Dass, NM Neelam Misra 2006 Citations: 50
Herbal medicine for health AK Gupta, HR Chitme The eastern pharmacist 23 (512), 41-44 , 2000 2000 Citations: 43
Wound-healing activity of Onosma hispidum (Ratanjot) in normal and diabetic rats N Kumar, AK Gupta Journal of herbs, spices & medicinal plants 15 (4), 342-351 , 2010 2010 Citations: 33
Changes in free amino acids and stress protein synthesis in two genotypes of green gram under salt stress N Misra, AK Gupta, UN Dwivedi Journal of Plant Sciences , 2006 2006 Citations: 29
Indian tribe’s and villager’s health and habits: Popularity of apocynaceae plants as medicine AKGSKP Nirmala Devi International Journal of Green Pharmacy (IJGP) 11 (02) , 2017 2017 Citations: 26
Aquasomes: a self-assembled nano-particulate carrier system AK Gupta, D Gupta, V Gupta Int J Cur Res Rev 13 (4), 44-52 , 2021 2021 Citations: 23
Cost efficiency of Green Buildings in India T Roy, AK Gupta Jones Lange Lasalle Meghrag: India , 2008 2008 Citations: 22
Differential response of scavenging of reactive oxygen species in green gram genotype grown under salinity stress N Misra, MS Ansari, AK Gupta Am. J. Plant Physiol 1, 41-53 , 2006 2006 Citations: 21
Hypoglycemic activity of Onosma hispidum (Ratanjot) N Kumar, AK Gupta, D Prakash, P Kumar International Journal of Diabetes in Developing Countries 30 (4), 213-216 , 2010 2010 Citations: 17
Kasni (Cichorium intybus L.) A propitious traditional medicinal herb P Katiyar, A Kumar, AK Mishra, RK Dixit, A Kumar, R Kumar, AK Gupta Int J Pharmacogn 8, 368-380 , 2015 2015 Citations: 15
Free radical scavenging activity of Rauwolfia serpentina rhizome against CCl4 induced liver injury AK Gupta, R Irchhaiya, C Misra Int J Pharm 2, 123-6 , 2015 2015 Citations: 11
Folklore medicines for cuts and wounds in Kalyanpur block of Kanpur District, Uttar Pradesh, India N Agnihotri, AK Gupta Ph Tech Med 2 (5), 381-386 , 2013 2013 Citations: 11
Facts on Generic drugs to meet out Worldwide challenges for implementing Generic medicine related policies of Health schemes GAK Katiyar P., Lakhani P., Tutu S., Sachan AK., Dixit RK. Int J Pharm Sci Res 8 (9), 3678-85 , 2017 2017 Citations: 10
Formulation and evaluation of polyherbal anti-dandruff shampoo and its marketed comparison S Patel, A Gupta, M Gupta Journal for Research in Applied Sciences and Biotechnology 1, 1-9 , 2022 2022 Citations: 9
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