Andre Gonzaga dos Santos

Scopus Publications

Cissus verticillata Leaf Extract Decreases the Production of AGEs and ROS In Vitro
Felipe Nunes Cardoso, Emanuel Victor dos Santos Nunes, Ingrid Delbone Figueiredo, Winner Duque Rodrigues, Renata Pires Assis, et al.
Molecules, 2026
Cissus verticillata (plant-insulin) is used in the Brazilian popular medicine to treat symptoms of diabetes. Studies about its ability to contrast glycoxidative stress is lacking, which may add mechanistic information about its effects on treat diabetic complications. This study investigated the ability of Cissus verticillata leaf hydroethanolic extract (CvExt) to scavenge reactive oxygen species (ROS) and to inhibit the formation of advanced glycation end products (AGEs). ROS scavenging assays were used to test CvExt antioxidant activity. Incubations of bovine serum albumin with glucose (0.5 M) or methylglyoxal (2 mM) and CvExt (250, 125, and 62.5 μg/mL) were used to test the antiglycation activity, by monitoring fluorescent AGEs, markers of amino acid oxidation, and protein carbonyl groups (PCO). The plant extract was submitted to liquid−liquid extractions, fractions were analyzed by liquid chromatography with tandem mass spectrometry, and the data obtained were subjected to partial least-squares discriminant analysis. CvExt scavenged ROS inhibited the formation of AGEs and amino acid oxidation products, and decreased PCO levels. The main metabolites found in CvExt were flavonoids, cinnamic acid derivatives, coumarins, free amino acids, and some lipophilic compounds. CvExt inhibited glycoxidative stress in vitro, which can be associated with its complex chemical composition.
Anti-Inflammatory, Antioxidant, and Reparative Effects of Casearia sylvestris Leaf Derivatives on Periodontium In Vitro
Angélica L. R. Pavanelli, Maria Eduarda S. Lopes, André T. Reis, Flávio A. Carvalho, Sven Zalewski, et al.
Antioxidants, 2025
Gingival inflammation compromises the integrity of the gingival epithelium and the underlying tissues, highlighting the need for adjuvant therapies with immunomodulatory and healing properties. Casearia sylvestris, a medicinal plant known as guaçatonga, is traditionally used to treat inflammatory lesions. This study aimed to investigate the effects of C. sylvestris on the synthesis of pro- and anti-inflammatory, proteolytic, and antioxidant molecules and on wound healing in epithelial cells. A human telomerase-immortalized gingival keratinocyte cell line (TIGKs) was used, and cells were exposed to Escherichia coli lipopolysaccharide (LPS) in the presence and absence of C. sylvestris extract, its diterpene-concentrated fraction, and its clerodane diterpene casearin J for 24 h and 48 h. Gene expression and protein synthesis were analyzed by RT-qPCR and ELISA, respectively. Nitric oxide (NO) and NF-κB activation were analyzed by Griess reaction and immunofluorescence, respectively. Additionally, cell viability was evaluated by alamarBlue® assay, and an automated scratch assay was used for wound healing. LPS significantly increased the expression of cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-10, IL-17), proteases (MMP-1 and MMP-13), iNOS as well as NO synthesis, and triggered NF-κB nuclear translocation. It also reduced IL-4 expression, cell viability, and cellular wound repopulation. Treatment with C. sylvestris derivatives significantly abrogated all aforementioned LPS-induced effects by 80–100%. Furthermore, even at higher concentrations, C. sylvestris did not affect cell viability, thus proving the safety of its derivatives. C. sylvestris exerts anti-inflammatory, antiproteolytic, and antioxidant effects on gingival keratinocytes, highlighting its potential as a valuable adjunct in the prevention and treatment of periodontal diseases.
Unconventional food plants from Brazil
Mateus Kawata Salgaço, Vanderson Gabriel Souza Torres, David de Paulo Farias, Flavio Alexandre Carvalho, Laira Lorraine Agostinho, et al.
Science and Culture of Latin American Foods Harnessing Ingredients for Health, 2025
Cordialin A isolated from Varronia curassavica Jacq. loaded in nanoemulsion as potential cytotoxic agent on human cervical tumor cells
Franciele Garcia Baveloni, Juhan Augusto Scardelato, Flávio Alexandre Carvalho, Ieda Maria Martinez Paino, Kaila Petrolina Medina-Alarcón, et al.
Chemical Papers, 2024
Promising Effects of Casearins in Tumor-Bearing Mice and Antinociceptive Action against Oncologic Pain: Molecular Docking and In Vivo Findings
Jurandy do Nascimento Silva, José Ivo Araújo Beserra Filho, Boris Timah Acha, Fernanda Regina de Castro Almeida, Emanuelle Karine Frota Batista, et al.
Pharmaceuticals, 2024
Safer analgesic drugs remain a hard challenge because of cardiovascular and/or gastrointestinal toxicity, mainly. So, this study evaluated in vivo the antiproliferative actions of a fraction with casearins (FC) from Casearia sylvestris leaves against human colorectal carcinomas and antihyperalgesic effects on inflammatory- or opiate-based pain relief and oncologic pain in Sarcoma 180 (S180)-bearing mice. Moreover, docking investigations evaluated the binding among Casearin X and NMDA(N-methyl-D-aspartate)-type glutamate receptors. HCT-116 colorectal carcinoma-xenografted mice were treated with FC for 15 days. Antinociceptive assays included chemically induced algesia and investigated mechanisms by pharmacological blockade. Intraplantar region S180-bearing animals received a single dose of FC and were examined for mechanical allodynia and behavior alterations. AutoDock Vina determined molecular interactions among Cas X and NMDA receptor subunits. FC reduced tumor growth at i.p. (5 and 10 mg/kg) and oral (25 mg/kg/day) doses (31.12–39.27%). FC reduced abdominal pain, as confirmed by formalin and glutamate protocols, whose antinociception activity was blocked by naloxone and L-NAME (neurogenic phase) and naloxone, atropine, and flumazenil (inflammatory phase). Meanwhile, glibenclamide potentiated the FC analgesic effects. FC increased the paw withdrawal threshold without producing changes in exploratory parameters or motor coordination. Cas X generated a more stable complex with active sites of the NMDA receptor GluN2B subunits. FC is a promising antitumor agent against colorectal carcinomas, has peripheral analgesic effects by desensitizing secondary afferent neurons, and inhibits glutamate release from presynaptic neurons and/or their action on cognate receptors. These findings emphasize the use of clerodane diterpenes against cancer-related pain conditions.
Machine Learning-Based Virtual Screening of Antibacterial Agents against Methicillin-Susceptible and Resistant Staphylococcus aureus
Philipe Oliveira Fernandes, Anna Letícia Teotonio Dias, Valtair Severino dos Santos Júnior, Mateus Sá Magalhães Serafim, Yamara Viana Sousa, et al.
Journal of Chemical Information and Modeling, 2024
The application of computer-aided drug discovery (CADD) approaches has enabled the discovery of new antimicrobial therapeutic agents in the past. The high prevalence of methicillin-resistantStaphylococcus aureus(MRSA) strains promoted this pathogen to a high-priority pathogen for drug development. In this sense, modern CADD techniques can be valuable tools for the search for new antimicrobial agents. We employed a combination of a series of machine learning (ML) techniques to select and evaluate potential compounds with antibacterial activity against methicillin-susceptible S. aureus (MSSA) and MRSA strains. In the present study, we describe the antibacterial activity of six compounds against MSSA and MRSA reference (American Type Culture Collection (ATCC)) strains as well as two clinical strains of MRSA. These compounds showed minimal inhibitory concentrations (MIC) in the range from 12.5 to 200 μM against the different bacterial strains evaluated. Our results constitute relevant proven ML-workflow models to distinctively screen for novel MRSA antibiotics.
Anti-Candida sp. activity of Astronium urundeuva derivatives free and loaded into a nanostructured lipid system
Bruna Vidal Bonifácio, Flávio Alexandre Carvalho, Luiza de Oliveira Mota, Patrícia Bento da Silva, Leonardo Perez de Souza, et al.
Chemical Papers, 2024
Casearia Essential Oil: An Updated Review on the Chemistry and Pharmacological Activities
Flavio Alexandre Carvalho, Natália Valadares de Moraes, Antônio Eduardo Miller Crotti, Eduardo José Crevelin, André Gonzaga dos Santos
Chemistry and Biodiversity, 2023
Casearia species are found in the America, Africa, Asia, and Australia and present pharmacological activities, besides their traditional uses. Here, we reviewed the chemical composition, content, pharmacological activities, and toxicity of the essential oils (EOs) from Casearia species. The EO physical parameters and leaf botanical characteristics were also described. The bioactivities of the EOs from the leaves and their components include cytotoxicity, anti‐inflammatory, antiulcer, antimicrobial, antidiabetic, antioxidant, antifungal, and antiviral activities. The main components associated with these activities are the α‐zingiberene, (E)‐caryophyllene, germacrene D, bicyclogermacrene, spathulenol, α‐humulene, β‐acoradiene, and δ‐cadinene. Data on the toxicity of these EOs are scarce in the literature. Casearia sylvestris Sw. is the most studied species, presenting more significant pharmacological potential. The chemical variability of EOs components was also investigated for this species. Caseria EOs have relevant pharmacological potential and must be further investigated and exploited.
Metabolism Characterization and Chemical and Plasma Stability of Casearin B and Caseargrewiin F
Fernando Bombarda Oda, Flávio Alexandre Carvalho, Priscila Akemi Yamamoto, Jonata Augusto de Oliveira, Rosângela Gonçalves Peccinini, et al.
Planta Medica, 2023
Oral preparations of Casearia sylvestris (guacatonga) are used as antacid, analgesic, anti-inflammatory, and antiulcerogenic medicines. The clerodane diterpenes casearin B and caseargrewiin F are major active compounds in vitro and in vivo. The oral bioavailability and metabolism of casearin B and caseargrewiin F were not previously investigated. We aimed to assess the stability of casearin B and caseargrewiin F in physiological conditions and their metabolism in human liver microsomes. The compounds were identified by UHPLC-QTOF-MS/MS and quantified by validated LC-MS methods. The stability of casearin B and caseargrewiin F in physiological conditions was assessed in vitro. Both diterpenes showed a fast degradation (p < 0.05) in simulated gastric fluid. Their metabolism was not mediated by cytochrome P-450 enzymes, but the depletion was inhibited by the esterase inhibitor NaF. Both diterpenes and their dialdehydes showed a octanol/water partition coefficient in the range of 3.6 to 4.0, suggesting high permeability. Metabolism kinetic data were fitted to the Michaelis-Menten profile with KM values of 61.4 and 66.4 µM and Vmax values of 327 and 648 nmol/min/mg of protein for casearin B and caseargrewiin F, respectively. Metabolism parameters in human liver microsomes were extrapolated to predict human hepatic clearance, and suggest that caseargrewiin F and casearin B have a high hepatic extraction ratio. In conclusion, our data suggest that caseargrewiin F and casearin B present low oral bioavailability due to extensive gastric degradation and high hepatic extraction.
Chemical variability and evaluation of physical parameters of the essential oil of the leaves of Casearia sylvestris varieties and morphoanatomical characterization of the leaves
Flávio A. Carvalho, Fernando B. Oda, Luis V. S. Sacramento, Fabíola M. V. Pereira, Eduardo J. Crevelin, et al.
Chemical Papers, 2023
Green Chromatographic Methods and in Vitro Pharmacological Analysis of Varronia curassavica Leaf Derivatives
Isabela Jacob Moro, Flávio Alexandre Carvalho, Juhan Augusto Scardelato Pereira, Gabriela Brasil Romão, André Faibicher, et al.
Chemistry and Biodiversity, 2023
Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis
Rondinelli Donizetti Herculano, Thainá Oliveira dos Santos, Natan Roberto de Barros, Giovana Sant'Ana Pegorin Brasil, Mateus Scontri, et al.
International Journal of Biological Macromolecules, 2023
Scavenging Activity on Reactive Oxygen Species with Biological Relevance by Varronia curassavica
Gabriela Brasil Romão Veloso, Flavio Alexandre Carvalho, Renata Pires Assis, Juhan Augusto Scardelato Pereira, Christiane Pienna Soares, et al.
Orbital, 2023
In Vitro Antiglycation Potential of Erva-Baleeira (Varronia curassavica Jacq.)
Winner Duque Rodrigues, Felipe Nunes Cardoso, Amanda Martins Baviera, André Gonzaga dos Santos
Antioxidants, 2023
Chemical variability of phenolic compounds in Phyllanthus niruri
Ingrid Albrecht, Natalia Coelho Da Silva, Flavio Alexandre Carvalho, Fernando Bombarda Oda, Andre Gonzaga Dos Santos
Ecletica Quimica, 2023
Cytotoxic Activity of Baccharis trimera (Less.) DC. Essential Oil in Tumor Cell Lines and its Role in Associated Death Mechanisms
Isabela Jacob Moro, Flavio Alexandre Carvalho, Thais Fernanda Moreira, Felipe de Oliveira Souza, Alexander Alves da Silva, et al.
Orbital, 2023
An improved folate stable isotope dilution assay of unexploited food sources from Brazil
Lisa Obermaier, Barbara Paes Miglioli da Mata, Caio Humberto Perego, Kátia Sivieri, Mateus Kawata Salgaço, et al.
Frontiers in Nutrition, 2023
A Sustainable Raw Material for Phytocosmetics: The Pulp Residue from the Caryocar brasiliense Oil Extraction
Giovana Sant’Ana Pegorin Brasil, Felipe Azevedo Borges, Amanda de Andrade Machado, Cassia Roberta Malacrida Mayer, Renata Giassi Udulutsch, et al.
Revista Brasileira De Farmacognosia, 2022
Identification of azaphilone derivatives of Monascus colorants from Talaromyces amestolkiae and their halochromic properties
Fernanda de Oliveira, Inês L.D. Rocha, Diana Cláudia Gouveia Alves Pinto, Sónia P.M. Ventura, André Gonzaga dos Santos, et al.
Food Chemistry, 2022
In Vitro Schistosomicidal Activities of the Leaf Extracts from Casearia sylvestris Varieties
Flávio A. Carvalho, Breno C. Silva, Fernando B. Oda, Júlio C. P. Junior, Eduardo J. Crevelin, et al.
Chemistry and Biodiversity, 2022
Baccharis trimera (Less.) DC leaf derivatives and eupatorin activities against Leishmania amazonensis
Esther Della Nina Sahid, Josiane Clarice Claudino, Fernando Bombarda Oda, Flávio Alexandre Carvalho, André Gonzaga dos Santos, et al.
Natural Product Research, 2022
Casearia sylvestris Essential Oil Degradation Products Generated by Leaf Processing
Flávio A. Carvalho, Fernando B. Oda, Eduardo J. Crevelin, Antônio E. M. Crotti, André G. Santos
Chemistry and Biodiversity, 2021
Growth-inhibitory effects of tris-(1,10-phenanthroline) iron (II) against Mycobacterium tuberculosis in vitro and in vivo
Mariana Cristina Solcia, Débora Leite Campos, Júlia Araújo Grecco, Caio Sander Paiva Silva, Patrícia Bento da Silva, et al.
Tuberculosis, 2021
Geographical chemical variability and processing oxidation of volatile compounds of Casearia sylvestris leaves
Ecletica Quimica, 2021
The antileishmanial activity of the antarctic brown alga Ascoseira mirabilis Skottsberg
Leandro da Costa Clementino, Fernando Bombarda Oda, Thaiz Rodrigues Teixeira, Renata Spagolla Napoleão Tavares, Pio Colepicolo, et al.
Natural Product Research, 2021
Fragmentation study of clerodane diterpenes from Casearia species by tandem mass spectrometry (quadrupole time-of-flight and ion trap)
Amanda Danuello, Rogério Cardoso Castro, Alan Cesar Pilon, Paula Carolina Pires Bueno, Marcos Pivatto, et al.
Rapid Communications in Mass Spectrometry, 2020
Profiling the Cymbopogon nardus Ethanol Extract and Its Antifungal Potential against Candida Species with Different Patterns of Resistance
Luciani de Toledo, Matheus Ramos, Larissa Spósito, Elza Castilho, Fernando Pavan, et al.
Journal of the Brazilian Chemical Society, 2020
In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol
Jolindo A. Freitas, Rodrigo Sorrechia, Flávio A. S. Politi, André G. Santos, Edvânio R. Rodrigues, et al.
Natural Product Research, 2020
Improved in vitro and in vivo anti-candida albicans activity of cymbopogon nardus essential oil by its incorporation into a microemulsion system
Luciani Gaspar de Toledo, Matheus Aparecido dos Santos Ramos, Patrícia Bento da Silva, Camila Fernanda Rodero, Veridiana de Sá Gomes, et al.
International Journal of Nanomedicine, 2020
Acidic and hepatic derivatives of bioactive clerodane diterpenes casearins J and O
Fernando Bombarda Oda, Eduardo José Crevelin, Antônio Eduardo Miller Crotti, Allan Botinhon Orlando, Alexandra Ivo de Medeiros, et al.
Fitoterapia, 2019
UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods as a rational strategy of dereplication of Phyllanthus spp. aiming at the discovery of cytotoxic metabolites
Maria Francilene Souza Silva, Lorena Mara A. Silva, Amanda Lemos Quintela, André Gonzaga dos Santos, Francisca Aliny Nunes Silva, et al.
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2019
Intravaginal delivery of syngonanthus nitens (Bong.) Ruhland fraction based on a nanoemulsion system applied to vulvovaginal candidiasis treatment
Matheus Aparecido dos Santos Ramos, Patrícia Bento da Silva, Luciani Gaspar de Toledo, Fernando Bombarda Oda, Isabel Cristiane da Silva, et al.
Journal of Biomedical Nanotechnology, 2019
In vitro and in vivo anti-Helicobacter pylori activity of Casearia sylvestris leaf derivatives
Larissa Spósito, Fernando Bombarda Oda, Júlia Hunger Vieira, Flávio Alexandre Carvalho, Matheus Aparecido dos Santos Ramos, et al.
Journal of Ethnopharmacology, 2019
Antileishmanial activity of Melampodium divaricatum and Casearia sylvestris essential oils on Leishmania amazonensis
Raquel Regina Duarte Moreira, André Gonzaga dos Santos, Flavio Alexandre Carvalho, Caio Humberto Perego, Eduardo José Crevelin, et al.
Revista do Instituto De Medicina Tropical De Sao Paulo, 2019
Green coffee seed residue: A sustainable source of antioxidant compounds
A.C.C.M. Castro, F.B. Oda, M.G.J. Almeida-Cincotto, M.G. Davanço, B.G. Chiari-Andréo, et al.
Food Chemistry, 2018
Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
Flávio A. Carvalho, Helena S. Uchina, Felipe A. Borges, Márcia H. Oyafuso, Rondinelli D. Herculano, et al.
Revista Brasileira De Farmacognosia, 2018
Chemical variability between different organs of the medicinal plant casearia sylvestris
Revista De Ciencias Farmaceuticas Basica E Aplicada, 2018
Highlights in nanocarriers for the treatment against cervical cancer
Kaila P. Medina-Alarcón, Aline R. Voltan, Bruno Fonseca-Santos, Isabela Jacob Moro, Felipe de Oliveira Souza, et al.
Materials Science and Engineering C, 2017
Estudo do potencial antitumoral de cordialina a em sistema nanoemulsionado para tratamento de linhagens celulares de tumor cervical humano
Revista De Ciencias Farmaceuticas Basica E Aplicada, 2017
Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives
Isabela Jacob Moro, Gabrielle Demmany Gualberto Alexandre Gondo, Elaíse Gonçalves Pierri, Rosemeire Cristina Linharis Rodrigues Pietro, Christiane Pienna Soares, et al.
Brazilian Journal of Pharmaceutical Sciences, 2017
Organic cocoa extract -loaded surfactant-based systems intended to skin bioadhesion
Bruno Fonseca-Santos, Erica Emi Funagoshi, José Ricardo Soares de Oliveira, Luis Vitor Silva do Sacramento, André Gonzaga dos Santos, et al.
Brazilian Journal of Pharmaceutical Sciences, 2017
Anti-inflammatory action of ethanolic extract and clerodane diterpenes from casearia sylvestris
Elaise G. Pierri, Rogério C. Castro, Ednir O. Vizioli, Carla M.R. Ferreira, Alberto J. Cavalheiro, et al.
Revista Brasileira De Farmacognosia, 2017
Evaluation of the population's knowledge about toxic plants in visitors of the 19th SAFE in Araraquara-SP
Revista De Ciencias Farmaceuticas Basica E Aplicada, 2017
Essential oil of Cymbopogon nardus (L.) Rendle: A strategy to combat fungal infections caused by Candida species
Luciani De Toledo, Matheus Ramos, Larissa Spósito, Elza Castilho, Fernando Pavan, et al.
International Journal of Molecular Sciences, 2016
Cordia verbenacea DC. (Boraginaceae): quality control parameters, phytochemical screening and evaluation of anti-Candida activity
Revista Brasileira De Plantas Medicinais, 2016
Counteracting effects on free radicals and histological alterations induced by a fraction with casearins
ÉVERTON JOSÉ FERREIRA DE ARAÚJO, GUILHERME ANTÔNIO LOPES DE OLIVEIRA, LÍVIA QUEIROZ DE SOUSA, VANDERLAN DA SILVA BOLZANI, ALBERTO JOSÉ CAVALHEIRO, et al.
Anais Da Academia Brasileira De Ciencias, 2015
Morphological and biochemical alterations activated by antitumor clerodane diterpenes
Paulo Michel Pinheiro Ferreira, Gardenia Carmen Gadelha Militão, Daisy Jereissati Barbosa Lima, Nagilla Daniela de Jesus Costa, Kátia da Conceição Machado, et al.
Chemico Biological Interactions, 2014
Analysis of casearia sylvestris swartz extract release from natural rubber latex membranes
Revista De Ciencias Farmaceuticas Basica E Aplicada, 2014
Evaluation of morpho-anatomical and chemical differences between varieties of the medicinal plant Casearia sylvestris Swartz
JOSIANE C. CLAUDINO, LUIS V.S. DO SACRAMENTO, INGRID KOCH, HELEN A. SANTOS, ALBERTO J. CAVALHEIRO, et al.
Anais Da Academia Brasileira De Ciencias, 2013
Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae)
Aline M. Prieto, André G. dos Santos, Ana Paula S. Oliveira, Alberto J. Cavalheiro, Dulce H.S. Silva, et al.
Food and Chemical Toxicology, 2013
Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil
A.M. Prieto, A.G. Santos, A.R. Csipak, C.M. Caliri, I.C. Silva, et al.
Toxicology and Applied Pharmacology, 2012
Pothomorphe umbellata: Antifungal activity against strains of Trichophyton rubrum
E.R. Rodrigues, N.G.P. Nogueira, G.J. Zocolo, F.S. Leite, A.H. Januario, et al.
Journal De Mycologie Medicale, 2012
Folk uses and pharmacological properties of casearia sylvestris: A medicinal review
Paulo Michel P. Ferreira, Leticia V. Costa-Lotufo, Manoel O. Moraes, Francisco W.A. Barros, Aline M.A. Martins, et al.
Anais Da Academia Brasileira De Ciencias, 2011
Casearin X exhibits cytotoxic effects in leukemia cells triggered by apoptosis
Paulo M. Pinheiro Ferreira, André G. Santos, Aristeu G. Tininis, Patricia M. Costa, Alberto J. Cavalheiro, et al.
Chemico Biological Interactions, 2010
Casearin X, its degradation product and other clerodane diterpenes from leaves of Casearia sylvestris: Evaluation of cytotoxicity against normal and tumor human cells
André Gonzaga dos Santos, Paulo Michel Pinheiro Ferreira, Gerardo Magela Vieira Júnior, Carla Cristina Perez, Aristeu Gomes Tininis, et al.
Chemistry and Biodiversity, 2010
Ethanolic extract of Casearia sylvestris and its clerodane diterpen (caseargrewiin F) protect against DNA damage at low concentrations and cause DNA damage at high concentrations in mice's blood cells
A. M. de Oliveira, A. G. dos Santos, R. A. dos Santos, A. R. Csipak, C. Olivato, et al.
Mutagenesis, 2009
Identification of clerodane diterpenes in different organs of Casearia sylvestris Swartz
Revista De Ciencias Farmaceuticas Basica E Aplicada, 2009
Protease inhibition activity of extracts from Salicaceae species from Brazilian Cerrado and Atlantic Rain Forest and of an enriched fraction of clerodane diterpenes (casearins)
Otavio Flausino Jr, Barbara M. Abissi, Gerardo Magela Vieira Jr, André Gonzaga dos Santos, Dulce Helena da Silva, et al.
Revista Brasileira De Farmacognosia, 2009
Evaluation of micronuclei frequency in Tradescantia pallida pollen mother cells treated with ethanolic extracts isolated from Cryptocarya mandioccana, Cryptocarya moschata and Pterogyne nitens
Revista Brasileira De Toxicologia, 2007
Clerodane diterpenes from leaves of Casearia sylvestris swartz
André G. dos Santos, Carla C. Perez, Aristeu G. Tininis, Vanderlan da S. Bolzani, Alberto J. Cavalheiro
Quimica Nova, 2007

Andre Gonzaga dos Santos

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Scopus Publications