Senthil Raja Ayyannan

Scopus Publications

Multi-targeted benzylpiperidine–isatin hybrids: Design, synthesis, biological and in silico evaluation as monoamine oxidases and acetylcholinesterase inhibitors for neurodegenerative disease therapies
Nikita Negi, Senthil R. Ayyannan, Rati K. P. Tripathi
Journal of Computer Aided Molecular Design, 2025
Design, synthesis and evaluation of benzothiazole-derived phenyl thioacetamides as dual inhibitors of monoamine oxidases and cholinesterases
Sandeep Kumar, Rangan Mitra, Senthil Raja Ayyannan
Molecular Diversity, 2025
Design and Synthesis of S-Acetophenylhydrazones of 5-Methyl-1,3,4-Thiadiazole-2-Thiol as SHP2 Inhibitory Agents
Rangan Mitra, Sandeep Kumar, Aiswarya Chaudhuri, Shreyasi Majumdar, Sairam Krishnamurthy, et al.
Chemistry and Biodiversity, 2025
We report herein the rational design, synthesis and evaluation of a library of 21 S‐acetophenylhydrazones of 5‐methyl‐1,3,4‐thiadiazole‐2‐thiol bearing a substituted benzylidene moiety (compounds 5a–5u). Compound 5f ((E)‐N'‐(2,6‐dichlorobenzylidene)‐2‐((5‐methyl‐1,3,4‐thiadiazol‐2‐yl)thio)acetohydrazide) emerged as the most potent SHP2 inhibitor (IC50 = 0.120 ± 0.006 µM). Further, cell‐based studies revealed its moderate yet best‐in‐library cytotoxicity against MCF‐7 cells (IC50 = 86.46 ± 2.32 µM) in a dose‐dependent manner. Compound 5f also exhibited in vitro anti‐survival (33% colony formation) and anti‐migratory effect (45% wound closure) on MCF‐7 cells upon treatment with sub‐IC50 dose. In vivo toxicological evaluation of compound 5f revealed excellent safety profile in mice at an oral dose of 2000 mg/kg BW. Our current study yielded a novel heterocyclic scaffold designed through systematic lead‐guided optimization displaying submicromolar SHP2 inhibitory activity. The lead molecule identified from in vitro studies was effective against the proliferation, survival and migration of human breast cancer cells with an excellent in vivo safety profile.
Synthesis and Anticonvulsant Evaluation of Some Heterocyclic Tethered Aryl Carbohydrazone and Semicarbazone Analogs
Samarth Dwivedi, Harish J, Omprakash Goshain, Sandeep Kumar, Senthil Raja Ayyannan
Pharmaceutical Chemistry Journal, 2025
Design, synthesis, and evaluation of benzylpiperidine-derived hydrazones as dual inhibitors of monoamine oxidases and acetylcholinesterase
Nikita Negi, Senthil R. Ayyannan, Rati K. P. Tripathi
Medicinal Chemistry Research, 2025
Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold
Shivani Jaiswal, Senthil Raja Ayyannan
Mini Reviews in Medicinal Chemistry, 2025
Carbamate has been extensively used as a scaffold in the recent era of drug discovery and is a common structural motif of many approved drugs. The carbamate moiety's unique amide-ester hybrid (-O-CO-NH-) feature offers the designing of specific drug-target interactions. Despite the discovery of numerous carbamate derivatives that act on the endocannabinoid system (ECS), the development of clinically effective carbamates remains a challenge. In this review, we highlight the therapeutic potential of carbamate inhibitors of endocannabinoid degrading enzymes as a breakthrough in discovering neurotherapeutic drugs. We discuss the design strategies and medicinal chemistry aspects involved in developing carbamate-based molecular architectures that modulate the endocannabinoid signaling pathway by interfering with fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and α/β-Hydrolase domain-containing 6 (ABHD6). Additionally, we highlight the dual activity profile of carbamates against FAAH and MAGL, FAAH and cholinesterase, and FAAH and TRPV1 channels. Furthermore, we illustrate the pharmacophores of O-functionalized carbamates and N-cyclic carbamates that are crucial for FAAH and MAGL inhibitory activities, respectively.
Synthesis and biological evaluation of methylene spacer incorporated 4-methylsulfonyl phenyl semicarbazones as dual FAAH-MAGL inhibitors
Shivani Jaiswal, Senthil Raja Ayyannan
Phosphorus Sulfur and Silicon and the Related Elements, 2025
Identification of new small molecule allosteric SHP2 inhibitor through pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation studies, synthesis and in vitro evaluation
Rangan Mitra, Sandeep Kumar, Senthil Raja Ayyannan
Journal of Biomolecular Structure and Dynamics, 2025
Src homology-2 (SH2) domain-containing phosphatase-2 (SHP2) is the first identified protooncogene and is a promising target for developing small molecule inhibitors as cancer chemotherapeutic agents. Pharmacophore-based virtual screening (PBVS) is a pharmacoinformatics methodology that employs physicochemical knowhow of the chemical space into the dynamic environs of computational technology to extract virtual molecular hits that are precise and promising for a drug target. In the current study, PBVS has been applied on EnamineTM Advanced Collection of 551,907 molecules by using a pharmacophore model developed upon SHP099 by Molecular Operating Environment (MOE) software to identify potential small molecule allosteric SHP2 inhibitors. Obtained 37 hits were further filtered through DruLiTo software for drug-likeness and PAINS remover which yielded 35 hits. These were subjected to molecular docking studies against the tunnel allosteric site of SHP2 (PDB ID: 5EHR) to screen them according to their binding affinity for the enzyme. Top 5 molecules having highest binding affinity for 5EHR were passed through an ADMET prediction screening and the top 2 hits (ligands 111675 and 546656) with the most favourable ADMET profile were taken for post screening molecular docking and MD simulation studies. From the protein-ligand interaction pattern, conformational stability and energy parameters, ligand 111675 (SHP2 Ki = 0.118 µM) resulted as the most active molecule. Further, the synthesis and in vitro evaluation of the lead compound 111675 unveiled its potent inhibitory activity (IC50 = 0.878 ± 0.008 µM) against SHP2.Communicated by Ramaswamy H. Sarma.
Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases
Sandeep Kumar, Rangan Mitra, Senthil Raja Ayyannan
Medicinal Chemistry Research, 2024
Development and validation of machine learning models for the prediction of SH-2 containing protein tyrosine phosphatase 2 inhibitors
Nilanjan Adhikari, Senthil Raja Ayyannan
Molecular Diversity, 2024
Design, Synthesis and Evaluation of Thioacetamide-Tethered Thiadiazole-1,2,4-Triazole Hybrids as SHP2 Inhibitors for Cancer Therapy
Rangan Mitra, Sandeep Kumar, Aiswarya Chaudhuri, Ashish Kumar Agrawal, Senthil Raja Ayyannan
Chemistryselect, 2024
Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation
Sandeep Kumar, Shivani Jaiswal, Sukesh Kumar Gupta, Senthil Raja Ayyannan
Journal of Biomolecular Structure and Dynamics, 2024
Exploration of a library of piperonylic acid-derived hydrazones possessing variable aryl functionalities as potent dual cholinesterase and monoamine oxidase inhibitors
V. Pavan Kumar, M. S. Vishnu, Sandeep Kumar, Shivani Jaiswal, Senthil Raja Ayyannan
Molecular Diversity, 2023
Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor
Shivani Jaiswal, Akhilesh, Vinod Tiwari, Senthil Raja Ayyannan
Pharmacological Reports, 2023
Lead optimization study on indoline-2,3-dione derivatives as potential fatty acid amide hydrolase inhibitors
Shivani Jaiswal, Senthil Raja Ayyannan
Journal of Biomolecular Structure and Dynamics, 2023
Identification of new small molecule monoamine oxidase-B inhibitors through pharmacophore-based virtual screening, molecular docking and molecular dynamics simulation studies
Sandeep Kumar, Senthil Raja Ayyannan
Journal of Biomolecular Structure and Dynamics, 2023
Tracing the Anti-cancer Mechanism of Pleurotus osteratus by the Integrative Approach of Network Pharmacology and Experimental Studies
Singh Shreya, Dulla Naveen Kumar, Debadatta Mohapatra, Shivani Jaiswal, Gaurav Gopal Naik, et al.
Applied Biochemistry and Biotechnology, 2023
Role of Lysine-specific Demethylase 1 and Its Small Molecule Inhibitors in Glioblas-toma Multiforme Therapy
Senthil Raja Ayyannan, Rangan Mitra
Anti Cancer Agents in Medicinal Chemistry, 2022
Synthesis and evaluation of carbamate derivatives as fatty acid amide hydrolase and monoacylglycerol lipase inhibitors
Shivani Jaiswal, Garima Gupta, Senthil R. Ayyannan
Archiv Der Pharmazie, 2022
Synthesis and evaluation of dual fatty acid amide hydrolase-monoacylglycerol lipase inhibition and antinociceptive activities of 4-methylsulfonylaniline-derived semicarbazones
Shivani Jaiswal, Akhilesh, Ankit Uniyal, Vinod Tiwari, Senthil Raja Ayyannan
Bioorganic and Medicinal Chemistry, 2022
Discovery of Isatin-Based Carbohydrazones as Potential Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase
Shivani Jaiswal, Senthil Raja Ayyannan
Chemmedchem, 2022
Emerging three-dimensional neuronal culture assays for neurotherapeutics drug discovery
Rahul S Rathore, Senthil R Ayyannan, Sanjeev K Mahto
Expert Opinion on Drug Discovery, 2022
Anticancer Potential of Small-Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase
Shivani Jaiswal, Senthil Raja Ayyannan
Chemmedchem, 2021
Small-Molecule Inhibitors of Shp2 Phosphatase as Potential Chemotherapeutic Agents for Glioblastoma: A Minireview
Rangan Mitra, Senthil R. Ayyannan
Chemmedchem, 2021
Emerging chemical scaffolds with potential SHP2 phosphatase inhibitory capabilities – A comprehensive review
Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan
Chemical Biology and Drug Design, 2021
Exploration of dual fatty acid amide hydrolase and cholinesterase inhibitory potential of some 3-hydroxy-3-phenacyloxindole analogs
Rati K. P. Tripathi, Senthil R. Ayyannan
Archiv Der Pharmazie, 2020
X-ray powder diffraction spectroscopy as a robust tool in early predicting bioavailability of pharmaceutical formulation containing polymorphic drug substance
Abhishesh K. Mehata, Deepa Dehari, Senthil R. Ayyannan, Madaswamy S. Muthu
Drug Delivery Letters, 2020
Monoamine oxidase-B inhibitors as potential neurotherapeutic agents: An overview and update
Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan
Medicinal Research Reviews, 2019
Experimental and Computational Evaluation of Piperonylic Acid Derived Hydrazones Bearing Isatin Moieties as Dual Inhibitors of Cholinesterases and Monoamine Oxidases
M. S. Vishnu, V. Pavankumar, Sandeep Kumar, A. Senthil Raja
Chemmedchem, 2019
Scaffold hopping-guided design of some isatin based rigid analogs as fatty acid amide hydrolase inhibitors: Synthesis and evaluation
Shivani Jaiswal, Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan
Biomedicine and Pharmacotherapy, 2018
Evaluation of 2-amino-6-nitrobenzothiazole derived hydrazones as acetylcholinesterase inhibitors: in vitro assays, molecular docking and theoretical ADMET prediction
Rati K. P. Tripathi, Senthil Raja Ayyannan
Medicinal Chemistry Research, 2018
Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the size of aryl binding site
Rati K. P. Tripathi, Vishnu M. Sasi, Sukesh K. Gupta, Sairam Krishnamurthy, Senthil R. Ayyannan
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Anticonvulsant activity, organotypic hippocampal neuroprotection assay and in-silico sodium channel blocking potential of 2-amino-6-nitrobenzothiazole derived semicarbazones
Rati Kailash Prasad Tripathi, Senthil Raja Ayyannan
Biomedicine and Pharmacotherapy, 2017
Discovery of 3-Hydroxy-3-phenacyloxindole Analogues of Isatin as Potential Monoamine Oxidase Inhibitors
Rati K. P. Tripathi, Sairam Krishnamurthy, Senthil R. Ayyannan
Chemmedchem, 2016
Design, Synthesis, and Evaluation of 2-Amino-6-nitrobenzothiazole-Derived Hydrazones as MAO Inhibitors: Role of the Methylene Spacer Group
Rati K. P. Tripathi, Senthil R. Ayyannan
Chemmedchem, 2016
Exploration of a Library of 3,4-(Methylenedioxy)aniline-Derived Semicarbazones as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase: Design, Synthesis, and Evaluation
Rati K. P. Tripathi, Gopal K. Rai, Senthil R. Ayyannan
Chemmedchem, 2016
Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design
Pankaj Mishra, Senthil R. Ayyannan, Gautam Panda
Chemmedchem, 2015
Design, Synthesis, invitro MAO-B Inhibitory Evaluation, and Computational Studies of Some 6-Nitrobenzothiazole-Derived Semicarbazones
Rati K. P. Tripathi, Omprakash Goshain, Senthil Raja Ayyannan
Chemmedchem, 2013
Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2010
Synthesis and anticonvulsant evaluation of semicarbazones of acetophenone Mannich bases
A. S. Raja, S. N. Pandeya, S. S. Panda, J. P. Stables
Pharmaceutical Chemistry Journal, 2007
Synthesis and antimicrobial evaluation of some 4- or 6-chloroisatin derivatives
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2006
Synthesis of isatin semicarbazones as novel anticonvulsants - Role of hydrogen bonding
Journal of Pharmacy and Pharmaceutical Sciences, 2002

RECENT SCHOLAR PUBLICATIONS

Multi-targeted benzylpiperidine–isatin hybrids: Design, synthesis, biological and in silico evaluation as monoamine oxidases and acetylcholinesterase inhibitors for …
N Negi, SR Ayyannan, RKP Tripathi
Journal of Computer-Aided Molecular Design 39 (1), 10 , 2025
2025
Citations: 8
Design, synthesis and evaluation of benzothiazole-derived phenyl thioacetamides as dual inhibitors of monoamine oxidases and cholinesterases
S Kumar, R Mitra, SR Ayyannan
Molecular Diversity 29 (5), 4231-4253 , 2025
2025
Citations: 3
Design and Synthesis of S ‐Acetophenylhydrazones of 5‐Methyl‐1,3,4‐Thiadiazole‐2‐Thiol as SHP2 Inhibitory Agents
R Mitra, S Kumar, A Chaudhuri, S Majumdar, S Krishnamurthy, ...
Chemistry & Biodiversity 22 (9), e202402997 , 2025
2025
Synthesis and Anticonvulsant Evaluation of Some Heterocyclic Tethered Aryl Carbohydrazone and Semicarbazone Analogs
S Dwivedi, O Goshain, S Kumar, SR Ayyannan
Pharmaceutical Chemistry Journal 59 (2), 203-215 , 2025
2025
Citations: 1
Synthesis and biological evaluation of methylene spacer incorporated 4-methylsulfonyl phenyl semicarbazones as dual FAAH-MAGL inhibitors
S Jaiswal, SR Ayyannan
Phosphorus, Sulfur, and Silicon and the Related Elements 200 (3), 274-296 , 2025
2025
Design, synthesis, and evaluation of benzylpiperidine-derived hydrazones as dual inhibitors of monoamine oxidases and acetylcholinesterase
N Negi, SR Ayyannan, RKP Tripathi
Medicinal Chemistry Research 34 (3), 583-601 , 2025
2025
Citations: 3
Identification of new small molecule allosteric SHP2 inhibitor through pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation studies …
R Mitra, S Kumar, SR Ayyannan
Journal of Biomolecular Structure and Dynamics 43 (3), 1352-1371 , 2025
2025
Citations: 6
Promising inhibitors of endocannabinoid degrading enzymes sharing a carbamate scaffold
S Jaiswal, SR Ayyannan
Mini-Reviews in Medicinal Chemistry , 2024
2024
Citations: 1
Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases
S Kumar, R Mitra, SR Ayyannan
Medicinal Chemistry Research 33 (10), 1974-1991 , 2024
2024
Citations: 1
Development and validation of machine learning models for the prediction of SH-2 containing protein tyrosine phosphatase 2 inhibitors
N Adhikari, SR Ayyannan
Molecular Diversity 28 (4), 1889-1905 , 2024
2024
Citations: 6
Design, Synthesis and Evaluation of Thioacetamide‐Tethered Thiadiazole‐1, 2, 4‐Triazole Hybrids as SHP2 Inhibitors for Cancer Therapy
R Mitra, S Kumar, A Chaudhuri, AK Agrawal, SR Ayyannan
ChemistrySelect 9 (27), e202401602 , 2024
2024
Citations: 1
A HETEROCYCLIC THIOACETAMIDE DERIVATIVE AND A METHOD OF SYNTHESIS THEREOF
R Mitra, S Kumar, A Chaudhuri, AK Agrawal, SR Ayyannan
IN Patent 566,836 , 2024
2024
Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation
S Kumar, S Jaiswal, SK Gupta, SR Ayyannan
Journal of Biomolecular Structure and Dynamics 42 (9), 4710-4729 , 2024
2024
Citations: 17
Exploration of a library of piperonylic acid-derived hydrazones possessing variable aryl functionalities as potent dual cholinesterase and monoamine oxidase inhibitors
VP Kumar, MS Vishnu, S Kumar, S Jaiswal, SR Ayyannan
Molecular Diversity 27 (6), 2465-2489 , 2023
2023
Citations: 7
Lead optimization study on indoline-2, 3-dione derivatives as potential fatty acid amide hydrolase inhibitors
S Jaiswal, SR Ayyannan
Journal of Biomolecular Structure and Dynamics 41 (19), 9632-9650 , 2023
2023
Citations: 5
Identification of new small molecule monoamine oxidase-B inhibitors through pharmacophore-based virtual screening, molecular docking and molecular dynamics simulation studies
S Kumar, SR Ayyannan
Journal of Biomolecular Structure and Dynamics 41 (14), 6789-6810 , 2023
2023
Citations: 25
Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor
S Jaiswal, Akhilesh, V Tiwari, SR Ayyannan
Pharmacological Reports, 1-9 , 2023
2023
Citations: 1
Tracing the Anti-cancer Mechanism of Pleurotus osteratus by the Integrative Approach of Network Pharmacology and Experimental Studies
S Shreya, DN Kumar, D Mohapatra, S Jaiswal, GG Naik, SK Guru, ...
Applied Biochemistry and Biotechnology 195 (1), 152-171 , 2023
2023
Citations: 18
Synthesis and evaluation of carbamate derivatives as fatty acid amide hydrolase and monoacylglycerol lipase inhibitors
S Jaiswal, G Gupta, SR Ayyannan
Archiv der Pharmazie 355 (11), 2200081 , 2022
2022
Citations: 4
Role of lysine-specific demethylase 1 and its small molecule inhibitors in glioblastoma multiforme therapy
R Mitra, SR Ayyannan
Anti-Cancer Agents in Medicinal Chemistry-Anti-Cancer Agents) 22 (18), 3062-3085 , 2022
2022
Citations: 5

MOST CITED SCHOLAR PUBLICATIONS

Synthesis of isatin semicarbazones as novel anticonvulsants-role of hydrogen bonding
SN Pandeya, AS Raja, JP Stables
J Pharm Pharm Sci 5 (3), 266-271 , 2002
2002
Citations: 238
Monoamine oxidase‐B inhibitors as potential neurotherapeutic agents: An overview and update
RKP Tripathi, SR Ayyannan
Medicinal research reviews 39 (5), 1603-1706 , 2019
2019
Citations: 136
Design, synthesis, and pharmacological evaluation of 2-amino-5-nitrothiazole derived semicarbazones as dual inhibitors of monoamine oxidase and cholinesterase: effect of the …
RKP Tripathi, V M. Sasi, SK Gupta, S Krishnamurthy, SR Ayyannan
Journal of Enzyme Inhibition and Medicinal Chemistry 33 (1), 37-57 , 2018
2018
Citations: 55
Design, synthesis, in vitro MAO‐B inhibitory evaluation, and computational studies of some 6‐nitrobenzothiazole‐derived semicarbazones
RKP Tripathi, O Goshain, SR Ayyannan
ChemMedChem 8 (3), 462-474 , 2013
2013
Citations: 53
Discovery of 3‐hydroxy‐3‐phenacyloxindole analogues of isatin as potential monoamine oxidase inhibitors
RKP Tripathi, S Krishnamurthy, SR Ayyannan
ChemMedChem 11 (1), 119-132 , 2016
2016
Citations: 52
Design, Synthesis, and Evaluation of 2‐Amino‐6‐nitrobenzothiazole‐Derived Hydrazones as MAO Inhibitors: Role of the Methylene Spacer Group
RKP Tripathi, SR Ayyannan
ChemMedChem 11 (14), 1551-1567 , 2016
2016
Citations: 39
Anticancer Potential of Small‐Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase
S Jaiswal, SR Ayyannan
ChemMedChem 16 (14), 2172-2187 , 2021
2021
Citations: 34
Exploration of a library of 3, 4‐(methylenedioxy) aniline‐derived semicarbazones as dual inhibitors of monoamine oxidase and acetylcholinesterase: Design, synthesis, and evaluation
RKP Tripathi, GK Rai, SR Ayyannan
ChemMedChem 11 (11), 1145-1160 , 2016
2016
Citations: 31
Antibacterial and antitubercular activities of some diphenyl hydrazones and semicarbazones
A RAJ, AK Agarwal, N Mahajan, SN Pandeya, S Ananthan
Indian journal of chemistry. Sect. B: Organic chemistry, including medical … , 2010
2010
Citations: 31
Experimental and computational evaluation of piperonylic acid derived hydrazones bearing isatin moieties as dual inhibitors of cholinesterases and monoamine oxidases
MS Vishnu, V Pavankumar, S Kumar, AS Raja
ChemMedChem 14 (14), 1359-1376 , 2019
2019
Citations: 30
Scaffold hopping-guided design of some isatin based rigid analogs as fatty acid amide hydrolase inhibitors: Synthesis and evaluation
S Jaiswal, RKP Tripathi, SR Ayyannan
Biomedicine & Pharmacotherapy 107, 1611-1623 , 2018
2018
Citations: 28
Perspectives on Inhibiting β‐Amyloid Aggregation through Structure‐Based Drug Design
P Mishra, SR Ayyannan, G Panda
ChemMedChem 10 (9), 1467-1474 , 2015
2015
Citations: 28
Identification of new small molecule monoamine oxidase-B inhibitors through pharmacophore-based virtual screening, molecular docking and molecular dynamics simulation studies
S Kumar, SR Ayyannan
Journal of Biomolecular Structure and Dynamics 41 (14), 6789-6810 , 2023
2023
Citations: 25
Evaluation of 2-amino-6-nitrobenzothiazole derived hydrazones as acetylcholinesterase inhibitors: in vitro assays, molecular docking and theoretical ADMET prediction
RKP Tripathi, SR Ayyannan
Medicinal Chemistry Research 27 (3), 709-725 , 2018
2018
Citations: 25
Synthesis and antimicrobial evaluation of some 4-or 6-chloroisatin derivatives
SN Pandeya, AS Raja, G Nath
Indian journal of chemistry. Sect. B: Organic chemistry, including medical … , 2006
2006
Citations: 21
Synthesis and anticonvulsant evaluation of semicarbazones of acetophenone Mannich bases
AS Raja, SN Pandeya, SS Panda, JP Stables
Pharmaceutical chemistry journal 41 (6), 302-307 , 2007
2007
Citations: 20
Tracing the Anti-cancer Mechanism of Pleurotus osteratus by the Integrative Approach of Network Pharmacology and Experimental Studies
S Shreya, DN Kumar, D Mohapatra, S Jaiswal, GG Naik, SK Guru, ...
Applied Biochemistry and Biotechnology 195 (1), 152-171 , 2023
2023
Citations: 18
Emerging chemical scaffolds with potential SHP2 phosphatase inhibitory capabilities–A comprehensive review
RKP Tripathi, SR Ayyannan
Chemical Biology & Drug Design 97 (3), 721-773 , 2021
2021
Citations: 18
Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation
S Kumar, S Jaiswal, SK Gupta, SR Ayyannan
Journal of Biomolecular Structure and Dynamics 42 (9), 4710-4729 , 2024
2024
Citations: 17
Small‐Molecule Inhibitors of Shp2 Phosphatase as Potential Chemotherapeutic Agents for Glioblastoma: A Minireview
R Mitra, SR Ayyannan
ChemMedChem 16 (5), 777-787 , 2021
2021
Citations: 16

Senthil Raja Ayyannan

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Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS