He has experience in the area of Collective Health, with emphasis on Epidemiology, and research area include the following topics: epidemiology of chronic diseases, primary health care, health service evaluation, evidence based medicine, implementation of clinical guidelines and health technology as
Locally adapted guidelines: a scoping review Dawid Pieper, Alexander Pachanov, Carolin Bahns, Robert Prill, Christian Kopkow, et al. Systematic Reviews, 2025 Background Clinical practice guidelines (CPGs) often fail to be fully implemented in practice. One barrier to CPG implementation is inconsistency between recommendations and existing practice patterns. This can include patients, personnel, structure, availability of resources, cultural and ethical values. To account for this, it is feasible to tailor national CPGs to a regional or local context (e.g. hospital). Local ownership can be beneficial and help to implement the guideline without affecting guideline validity. This process is also known as guideline adaptation. We aimed to identify randomized controlled trials (RCTs) investigating the effectiveness of locally adapted CPGs. Methods We performed a scoping review, following the JBI guidance. The scoping review was registered with the Open Science Framework (https://osf.io/3ed2w). The intervention had to be a locally adapted guideline (locally meaning adapted to any delineated area and/or entity at subnational and/or transnational level). Co-interventions were accepted. We did not restrict the control group. As we considered locally adapted guidelines as an intervention, and it seems feasible to test locally adapted guidelines in trials, we only considered RCTs, including cluster-RCTs. PubMed and Embase were searched in November 2024. Two reviewers independently screened titles and abstracts, full-text articles, and charted data. Conflicts were resolved by involving a third reviewer. Data were summarized descriptively. The findings were discussed with knowledge users. Results Five cluster RCTs reported in 8 publications and published between 2000 and 2010, were included. The trials originated from the UK, Scotland, Australia, the US, and the Netherlands. The adapted CPGs focused on diabetes, asthma, smoking cessation, mental disorders, and menorrhagia and urinary incontinence. The number of sites (e.g. practices) ranged from 4 to 30. Reporting was mostly insufficient to understand how adaptation was performed. Interventions always included some form of dissemination, such as educational meetings or workshops. Conclusions There is a lack of RCTs investigating the effectiveness of locally adapted guidelines. A systematic review is unwarranted due to the clinical and methodological heterogeneity of these trials. The identified studies were largely conducted over 20 years ago, highlighting a significant knowledge gap. The reasons for the lack of similar studies today are unclear, which is surprising given advances in adaptation frameworks in guideline development. As the importance of contextualization is emphasized, future studies on locally adapted guidelines should be conducted with strong rationale supported by local data. Without a sound rationale, there is a risk that evidence-based, high-quality guidelines could be undermined. In future trials, authors should closely adhere to reporting guidelines. Systematic review registration https://osf.io/3ed2w.
Roraima on Alert: hospitalizations for conditions sensitive to primary care in children Airton Tetelbom Stein, Juvenal Soares Dias da Costa, Rafaela Soares Rech Revista Brasileira De Epidemiologia, 2025 This ecological study analyzes hospitalizations due to pri - mary care-sensitive conditions (HPCSC), an indicator widely used to assess the quality of primary health care and the organization of local health systems. The findings present a concerning situation: contrary to national trends showing a
Epidemiological profile of surgical treatment of lung cancer: retrospective analysis, Brazil, 2014-2023 Arthur Minas Alberti, Lucas Kieling, Pedro Bortoluzzi Escobar da Silva, Fernando Silvestre Azambuja, Luísa Godoy, et al. Epidemiologia E Servicos De Saude, 2025 Objective To analyze the socioeconomic influences on the surgical treatment of lung cancer in Brazil and to provide reflection points to propose more effective strategies for tackling this disease. Methods Data from 2014 to 2023 were extracted from the Hospital Information System of the Brazilian Unified Health System and the Brazilian Institute of Geography and Statistics. Sex and region of origin of patients who underwent surgical procedures for lung cancer were analyzed. Statistical analyses were performed using GraphPadPrism software version 8.0.1 and R software version 4.4.2. Results 20,805 surgical procedures and 112,118 diagnoses of malignant neoplasms of the bronchi and lungs in Brazil were analyzed between 2014 and 2023. Women accounted for 50.6% of the procedures. Men accounted for 54.7% of the diagnoses. There was no significant difference between sexes in terms of procedures performed or consultations (p-value>0.05). The South region had the highest rate of procedures (20.1/1 million inhabitants/year). The North region had the lowest rate of procedures (3.5/1 million). A 51.6% increase in procedures was identified over the decade, with positive correlations between the Human Development Index (r=0.62; p-value<0.001) and per capita income (r=0.48; p-value 0.010) with procedures. Conclusion Socioeconomic factors appear to influence access to surgical treatment of lung cancer in Brazil, with significant regional disparities, especially in the North and Northeast regions. The increase in surgical procedures reflects technological advances and public policies, but inequalities in access persist. Investments in infrastructure and equitable policies are essential to address these inequalities.
Estimating an EQ-5D-Y-3L Value Set for Brazil Caique Melo Espirito Santo, Gisela Cristiane Miyamoto, Verônica Souza Santos, Ângela Jornada Ben, Aureliano Paolo Finch, et al. Pharmacoeconomics, 2024
Burden of disease and life expectancy decomposition in Brazil and its federated units, 1990–2023: an analysis based on the global burden of disease study 2023 LC Brant, MS Felisbino-Mendes, RA Teixeira, AMN Vasconcelos, ... The Lancet Regional Health–Americas 57 , 2026 2026
Transvaginal Radiofrequency Ablation for Symptomatic Uterine Fibroids: A Systematic Review and Meta-analysis of Effectiveness, Safety, and Reproductive Outcomes GDGR Thomaz, LG Kautz, GP Macelaro, MM Borges, BL Garmatz, ... Journal of Minimally Invasive Gynecology , 2026 2026
Minimally invasive surgery (robot‐assisted or laparoscopic) versus open surgery for presumed benign ovarian tumours LRF Medeiros, MI da Rosa, T Colonetti, AJ Grande, MLR Uggioni, ... The Cochrane Database of Systematic Reviews 2026 (1), CD015717 , 2026 2026
ID 47-Caracterização Técnica de Profissionais Atuando em ATS no Âmbito Estadual de Saúde: dados preliminares BC da Silva, B Marmett, AP Blankenheim, RP de Almeida, RB Carvalho, ... Epidemiologia e Serviços de Saúde: Revista do Sistema Unico de Saúde do … , 2025 2025
ID 170-Desenvolvimento de uma Tecnologia Educacional sobre Protocolo de Uso CE da Silva, AGC Arais, AT Stein, RCA Caregnato Epidemiologia e Serviços de Saúde: Revista do Sistema Unico de Saúde do … , 2025 2025
ID 320-Adaptação Transcultural Brasileira de Declarações Informativas para Comunicar os Resultados de Revisões Sistemáticas de Intervenções Indicadas pelo Sistema GRADE SM Parahiba, CP de Araújo, GP Dorneles, A Stein, D Pachito, ... Epidemiologia e Serviços de Saúde: Revista do Sistema Unico de Saúde do … , 2025 2025
Towards early diagnosis of Preeclampsia: Emerging roles of circulating microRNAs GB Grezzana, AT Stein, MM Markoski European Journal of Obstetrics & Gynecology and Reproductive Biology, 114822 , 2025 2025
GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses (vol 81, 111494, 2024) M Klugar, T Lotfi, AJ Darzi, M Reinap, J Klugarova, L Kantorova, J Xia, ... JOURNAL OF CLINICAL EPIDEMIOLOGY 187 , 2025 2025
Corrigendum to GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses [Journal of … M Klugar, T Lotfi, AJ Darzi, M Reinap, J Klugarová, L Kantorová, J Xia, ... Journal of Clinical Epidemiology 187 , 2025 2025
Informative statements to communicate the findings of systematic reviews of interventions: cross-cultural translation of Grading of Recommendations, Assessment, Development and … S Parahiba, G Dorneles, AT Stein, HA de Oliveira Junior, JC Ferreira, ... Journal of Clinical Epidemiology 187, 111923 , 2025 2025 Citations: 1
Integrating planetary health considerations into health guidelines: decision-making bodies must show leadership MI Metzendorf, M Aloosh, L Benton, JB Pérez, M Cumpston, FK de’Donato, ... BMJ leader, leader-2025-001277 , 2025 2025 Citations: 3
Epidemiological profile of surgical treatment of lung cancer: retrospective analysis, Brazil, 2014-2023 AM Alberti, L Kieling, PBE Silva, FS Azambuja, L Godoy, FP Concolatto, ... Epidemiologia e Serviços de Saúde 34, e20240427 , 2025 2025
Perfil epidemiológico do tratamento cirúrgico do câncer de pulmão: análise retrospectiva, Brasil, 2014-2023 AM Alberti, L Kieling, PBE Silva, FS Azambuja, L Godoy, FP Concolatto, ... Epidemiologia e Serviços de Saúde 34, e20240427 , 2025 2025
Roraima on Alert: hospitalizations for conditions sensitive to primary care in children AT Stein, JSD da Costa, RS Rech Revista Brasileira de Epidemiologia 28, e250017 , 2025 2025
Extreme climate event in Rio Grande do Sul in May 2024: impacts, adaptation and vulnerabilities AT Stein, E Barros, TS de Camargo, RAC Santiago Trends in Health Sciences 67 (1) , 2025 2025
Surge uma nova revista científica brasileira FM Shansis, AT Stein, D Rovaris, E Puga, J Herbert, L Nunes, RK Celeste Trends in Health Sciences 67 (1) , 2025 2025
Developing competencies in planetary health: integrating systems thinking and interconnection within nature into medical education RB Zandavalli, AT Stein, TS Camargo Revista Brasileira de Educação Médica 49 (3) , 2025 2025 Citations: 1
Desenvolvendo competências em saúde planetária: integrando pensamento sistêmico e interconexão através da natureza na formação médica RB Zandavalli, AT Stein, TS Camargo Revista Brasileira de Educação Médica 49 (3) , 2025 2025
Roraima em alerta: internações sensíveis à atenção primária na população infantil AT Stein, JSD da Costa, RS Rech Revista Brasileira de Epidemiologia 28, e250017 , 2025 2025
How do machine learning models perform in the detection of depression, anxiety, and stress among undergraduate students? A systematic review BL Schaab, PÜ Calvetti, S Hoffmann, GB Diaz, M Rech, SC Cazella, ... Cadernos de Saúde Pública 40, e00029323 , 2024 2024 Citations: 16
MOST CITED SCHOLAR PUBLICATIONS
World Allergy Organization (WAO) diagnosis and rationale for action against cow's milk allergy (DRACMA) guidelines A Fiocchi, J Brozek, H Schünemann, SL Bahna, A von Berg, K Beyer, ... World Allergy Organization Journal 3 (4), 57-161 , 2010 2010 Citations: 1299
Avaliação de desempenho do Self-Reporting Questionnaire como instrumento de rastreamento psiquiátrico: um estudo comparativo com o Structured Clinical Interview for DSM-IV-TR DM Gonçalves, AT Stein, F Kapczinski Cadernos de saúde pública 24, 380-390 , 2008 2008 Citations: 678
Phlebotonics for venous insufficiency MJ Martinez‐Zapata, XB Cosp, RM Moreno, E Vargas, D Capellà Cochrane Database of Systematic Reviews , 2005 2005 Citations: 551
Laparoscopy versus laparotomy for benign ovarian tumour L Medeiros, DD Rosa, MC Bozzetti, JMG Fachel, S Furness, R Garry, ... Cochrane Database of Systematic Reviews , 2005 2005 Citations: 395
Prevalence and risk factors of Hepatitis C virus infection in Brazil, 2005 through 2009: a cross-sectional study LMMB Pereira, CMT Martelli, RC Moreira, E Merchan-Hamman, AT Stein, ... BMC infectious diseases 13 (1), 60 , 2013 2013 Citations: 298
Protocol for the development of guidance for stakeholder engagement in health and healthcare guideline development and implementation J Petkovic, A Riddle, EA Akl, J Khabsa, L Lytvyn, P Atwere, P Campbell, ... Systematic reviews 9 (1), 21 , 2020 2020 Citations: 270
Consistência interna e confiabilidade da versão em português do Instrumento de Avaliação da Atenção Primária (PCATool-Brasil) para serviços de saúde infantil E Harzheim, B Starfield, L Rajmil, C Álvarez-Dardet, AT Stein Cadernos de Saúde Pública 22, 1649-1659 , 2006 2006 Citations: 230
Application of GRADE: making evidence-based recommendations about diagnostic tests in clinical practice guidelines J Hsu, JL Brożek, L Terracciano, J Kreis, E Compalati, AT Stein, A Fiocchi, ... Implementation science 6 (1), 62 , 2011 2011 Citations: 173
Performance of the Self-Reporting Questionnaire as a psychiatric screening questionnaire: a comparativestudy with Structured Clinical Interview for DSM-IV-TR DM Gonçalves, AT Stein, F Kapczinski Cadernos de saude publica 24, 380-390 , 2008 2008 Citations: 173
Accuracy of frozen-section analysis in the diagnosis of ovarian tumors: a systematic quantitative review LR Medeiros, DD Rosa, MI Edelweiss, AT Stein, MC Bozzetti, ... International Journal of Gynecological Cancer 15 (2), 192-202 , 2005 2005 Citations: 163
Validação do instrumento de avaliação da atenção primária à saúde: PCATool-Brasil adultos E Harzheim, MMC Oliveira, MRA Rech, L Hauser, AT Stein, ... Revista brasileira de medicina de família e comunidade. Rio de Janeiro. Vol … , 2013 2013 Citations: 161
Day hospital versus outpatient care for people with schizophrenia E Shek, AT Stein, FM Shansis, M Marshall, R Crowther, P Tyrer Cochrane Database of Systematic Reviews , 2009 2009 Citations: 151
Laparoscopy versus laparotomy for benign ovarian tumor: a systematic review and meta-analysis LR Medeiros, AT Stein, J Fachel, R Garry, S Furness International Journal of Gynecological Cancer 18 (3), 387-399 , 2008 2008 Citations: 150
Prevalence of scoliosis among school students in a town in southern Brazil LS Nery, R Halpern, PC Nery, KP Nehme, A Tetelbom Stein Sao Paulo medical journal 128 (2), 69-73 , 2010 2010 Citations: 149
The influence of mothers' and fathers' sensitivity in the first year of life on children's cognitive outcomes at 18 and 36 months LE Malmberg, S Lewis, A West, E Murray, K Sylva, A Stein Child: care, health and development 42 (1), 1-7 , 2016 2016 Citations: 141
Quality and effectiveness of different approaches to primary care delivery in Brazil E Harzheim, BB Duncan, AT Stein, CRH Cunha, MR Goncalves, ... BMC health services research 6 (1), 156 , 2006 2006 Citations: 140
Correlation between drug treatment adherence and lithium treatment attitudes and knowledge by bipolar patients AR Rosa, M Marco, JMG Fachel, F Kapczinski, AT Stein, HMT Barros Progress in Neuro-Psychopharmacology and Biological Psychiatry 31 (1), 217-224 , 2007 2007 Citations: 130
Challenges and opportunities in planetary health for primary care providers E Xie, EF de Barros, A Abelsohn, AT Stein, A Haines The lancet Planetary health 2 (5), e185-e187 , 2018 2018 Citations: 123
Internal consistency and reliability of Primary Care Assessment Tool (PCATool-Brasil) for child health services E Harzheim, B Starfield, L Rajmil, C Álvarez-Dardet, AT Stein Cadernos de Saúde Pública 22, 1649-1659 , 2006 2006 Citations: 122
Adjuvant platinum‐based chemotherapy for early stage cervical cancer DD Rosa, LRF Medeiros, MI Edelweiss, MC Bozzetti, PR Pohlmann, ... Cochrane Database of Systematic Reviews , 2009 2009 Citations: 118