Dr. Udeze Augustine O.

Dr. UDEZE Augustine Okechukwu is a Senior Lecturer in the department of Microbiology, Faculty of Life Sciences, University of Ilorin. He is a teaching and research Virologist. He was once the Departmental SIWES coordinator; Secretary Departmental Academic Board; Seminar/Project Coordinator; 400 Level Adviser; Sub-dean, Faculty of Life Sciences. He has represented the Faculty at the Senate; Boards of Faculties of Basic Medical and Physical Sciences; Member, Faculty Ethical Review Committee; Member, Time-table and Room Usages Committee. He is currently the departmental Post Graduate Coordinator; Representative of the Faculty of Life Sciences at the Board of Faculty of Pharmaceutical Sciences and at Staff Disciplinary Committee, University of Ilorin. My research interests are focused on Serological and Molecular Epidemiology of Viral Infections especially Human Immunodeficiency Virus (HIV) and its co-morbidities, Arboviral Infections and Determination of Antiviral Resistance Patterns.

RESEARCH, TEACHING, or OTHER INTERESTS

Virology, Immunology, Microbiology, Immunology and Microbiology

Scopus Publications

Sero-evidence of silent Japanese Encephalitis Virus infection among inhabitants of Ilorin, North-central Nigeria: a call for active surveillance
Augustine Okechukwu Udeze and Mutiat B Odebisi-Omokanye
Informa UK Limited
ABSTRACT Infection by Japanese Encephalitis Virus (JEV) causes viral encephalitis in humans. It is endemic in Asia and western Pacific regions with no reported case in Nigeria so far. This study aimed at detecting evidence of circulation and pattern of exposure of individuals in Ilorin, Nigeria to JEV. A total of 139 febrile patients attending outpatient departments of Sobi specialist hospital, Civil service hospital and University of Ilorin health center participated in the study. About 5 ml of venous blood was collected from each participant and the plasma tested for the presence of anti-JEV IgG antibody using Enzyme Linked Immunosorbent Assay (ELISA) technique. Anti-JEV IgG antibody was detected in 32% (45/139) of the participants. Males were more exposed (37%) than female participants (27.3%). Similarly, participants with travel history outside of the country were more exposed (44.4%) than those without travel history (29.5%). Further analysis on the basis of age, marital and working status showed no statistical association between these variables and anti-JEV positivity (p˃0.05). This study has provided serological evidence of the circulation of JEV among Ilorin inhabitants and therefore calls for active surveillance for the infection in order to forestall any future major outbreak.


Phylogeny of partial gag, pol and env genes show predominance of HIV-1G and CRF02_AG with emerging recombinants in south-eastern Nigeria
Augustine O. Udeze, David O. Olaleye, and Georgina N. Odaibo
Elsevier BV



Polymorphisms and drug resistance analysis of HIV-1 isolates from patients on first line antiretroviral therapy (ART) in South-eastern Nigeria
Augustine O. Udeze, David O. Olaleye, and Georgina N. Odaibo
Public Library of Science (PLoS)
Acquisition of resistance mutations by HIV-1 isolates causes treatment failure among infected patients receiving antiretroviral therapy (ART). This study determined patterns of drug-resistance mutations (DRMs) among HIV-1 isolates from patients receiving first-line ART in South-eastern Nigeria. Blood samples were collected from HIV-1 infected patients accessing antiretroviral treatment centers at General Hospital Awo-Omamma, Imo state, State Hospital Asaba, Delta state and St Joseph’s Catholic Hospital Adazi, Anambra state and used for HIV-1 DNA sequencing and phylogenetic analysis. DRMs were scored using combination of Stanford algorithm and the 2015 International Antiviral Society-USA list while drug susceptibility was predicted using Stanford algorithm. Twenty eight of the HIV-1 isolates were sequenced and identified as subtypes G (35.7%), CRF02_AG (57.1%) and unclassifiable, UG (7.1%). Major PI resistance-associated mutations were identified at two sites including M46L (16.7% of subtype G/UG) and V82L (6.3% of CRF02_AG). Minor PI resistance-associated mutations identified among subtype G/UG are L10V/I (8.3%) and K20I (100%) while L10V/I (50%), K20I (100%), L33F (6.3%) and N88D (6.3%) were identified among CRF02_AG. Other polymorphisms found include; I13V/A, E35Q, M36I/L, N37D/S/E/H, R57K/G, L63T/P/S/Q, C67E/S, H69K/R, K70R, V82I and L89M in the range of 28.6% to 100% among the different subtypes. Interpretation based on Stanford algorithm showed that Darunavir/ritonavir is the only regimen whose potency was not compromised by the circulating mutations. Identification of major and minor PI resistance mutations in this study underscores the need for drug resistance testing prior to initiation of second line antiretroviral therapy in Nigeria.


Serological detection of human T-cell lymphotropic virus types I and II among pregnant women in Ilorin, Nigeria
Augustine Okechukwu Udeze, Mutiat B. Odebisi-Omokanye, Adedayo Faneye, Babatunde Adebiyi Olusola, Olukunle Ogunsemowo, Cecilia Iwuoha, and Victoria Atoyebi
Informa UK Limited
ABSTRACT Human T-cell lymphotropic virus types I/II (HTLV-I/II) is endemic in some parts of the world including Nigeria. Reported prevalence rates in Nigeria have largely focused on blood donors. This study aims at determining the prevalence of HTLV infection among pregnant women in Ilorin North-central Nigeria. Serum samples from 276 pregnant women who were antenatal clinic attendees at General and Civil Service Hospitals in Ilorin were tested for the presence of HTLV-I/II antibodies using Enzyme Linked Immunosorbent Assay test kits from Diagnostic Automation INC., USA. Out of the 276 women tested, 3 tested positive giving a prevalence rate of 1.1%. The result was analyzed on the basis of age, marital status, nature of family, educational status, occupation, religion, parity, and gestational stage of the women. There was no statistical association of HTLV positivity with any of the variables. Although relatively lower than prevalence rate recorded among similar study groups in other parts of the country, the 1.1% prevalence in this study underscores the need for proper education and creation of awareness among antenatal clinic attendees, so as to reduce viral transmission and incidence of HTLV-related diseases.


Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
Augustine Udeze, Mutiat Odebisi-Omokanye, and Toluwani Ajileye
African Journals Online (AJOL)
Background Cytomegalovirus (CMV) infection is common among HIV-infected individuals. Its contribution to morbidity and mortality became more apparent following introduction of highly active anti-retroviral therapy (HAART) which improved survival among HIV-infected individuals. Objectives This study aimed at determining the prevalence of both active and latent CMV infections among HIV-infected individuals on HAART in Ilorin, Nigeria. Methods A total of 360 consented HIV-1 patients were recruited for the study. About 5ml of blood and socio-demographic data were collected from each patient. Plasma from the blood was tested for anti-CMV IgM and IgG presence using ELISA. Results Of the 360 participants tested, 42 (11.7%) and 265 (73.6%) were respectively anti-CMV IgM and IgG antibodies positive representing active and latent infection rates respectively. Gender and age were the correlates of IgM seropositivity while age, occupation and marital status correlated with IgG seropositivity. Occupation, marital status, use of HAART and CD4+ count were not statistically associated with IgM level while gender, use of HAART and CD4+ count did not correlate with IgG level. Conclusions This study has demonstrated high level of latent and active CMV infection among HAART recipients in Ilorin and highlighted the need for incorporation of anti-herpes drugs in the treatment regimen.


In vitro antimicrobial activities of Tithonia diversifolia (Hemsl) A. gray extracts on two bacteria and fungus isolates




Incidence of multi-drug resistant (MDR) organisms in some poultry feeds sold in Calabar metropolis, Nigeria




Assessment of bacteriological quality of fresh meats sold in Calabar Metropolis, Nigeria




Detection of urinary tract infection (UTI) among pregnant women in Oluyoro Catholic Hospital, Ibadan, South-Western Nigeria




The role of laboratory confirmations and molecular epidemiology in global eradication of measles




Incidence of urinary tract infection (UTI) among pregnant women in Ibadan, South-Western Nigeria




The role of vaccines in elimination and global eradication of measles: A review of literature




Circulating vaccine-derived poliovirus and its implications for polio surveillance and eradication in Nigeria: A review of the literature

RECENT SCHOLAR PUBLICATIONS

PREVALENCE AND RISK FACTORS OF HEPATITIS C INFECTION AMONG PREGNANT WOMEN IN ILORIN, KWARA STATE, NIGERIA
M Odebisi-Omokanye, A Udeze, S Mustapha, AO Ahmad-Tijani, ...
ABUAD International Journal of Natural and Applied Sciences 4 (2), 81-87 2024



The global burden of chikungunya virus and the potential benefit of vaccines
G Ribeiro dos Santos, F Jawed, C Mukandavire, A Deol, D Scarponi, ...
medRxiv, 2024.10. 24.24315872 2024



Hepatitis B and C viral infections and correlates among pregnant women in Ilorin, Nigeria: a cross-sectional study: Infections virales des hpatites B et C et corrlats chez
AO Udeze, CN Udeze-Okey, MB Odebisi-Omokanye, GC Njoku
African Journal of Clinical and Experimental Microbiology 25 (4), 393-400 2024



Comparative gender analysis of the seroprevalence of varicella zoster virus among HIV-infected individuals receiving care at Offa, north-central Nigeria
AO Udeze, M Odebisi-Omokanye
African Journal of Clinical and Experimental Microbiology 24 (2), 177-183 2023



Sero-evidence of silent Japanese Encephalitis Virus infection among inhabitants of Ilorin, North-central Nigeria: a call for active surveillance
AO Udeze, MB Odebisi-Omokanye
Journal of Immunoassay and Immunochemistry 43 (3), 250-258 2022



Anti-West Nile virus immunoglobulin G and M profiles of patients with Pyrexia of unknown origin In Ilorin, Nigeria
AO Udeze, HK Shittu, OS Ashaka, A Jakkari, AOB Oyefolu
Society for Experimental Biology of Nigeria 2022



Prevalence of enteric Adenovirus among diarrheic children less than five years in Children’s Specialist Hospital, Ilorin, Kwara State, Nigeria
MB Odebisi-Omokanye, AO Udeze, OD Akinfaye, ST Agbaje
Society for Experimental Biology of Nigeria 2022



Phylogeny of partial gag, pol and env genes show predominance of HIV-1G and CRF02_AG with emerging recombinants in south-eastern Nigeria
AO Udeze, DO Olaleye, GN Odaibo
Heliyon 6 (8) 2020



Polymorphisms and drug resistance analysis of HIV-1 isolates from patients on first line antiretroviral therapy (ART) in South-eastern Nigeria
AO Udeze, DO Olaleye, GN Odaibo
PLoS One 15 (4), e0231031 2020



Screening of immunoglobulin G antibodies against chikungunya virus among urban population in Ilorin Nigeria
AO Udeze, BM Odebisi-Omokanye, AB Onoja, DM Daodu, OJ Olasomi
Nigerian Veterinary Journal 40 (3), 227-238 2019



GENETIC DIVERSITY AND DRUG RESISTANCE PATTERNS OF HIV-1 ISOLATES FROM DELTA, ANAMBRA AND IMO STATES, NIGERIA
AO UDEZE
2019



High Burden of On-Going HSV-1 and -2 Infections in Human Immunodeficiency Virus-Infected Individuals in a Secondary Healthcare Facility in Imo State, Nigeria
SWF Udeze A.O, Adeoti O.T, Ogunrinola O.T
Nigerian Journal of Microbiology 33 (1), 4387-4396 2019



Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
A Udeze, M Odebisi-Omokanye, T Ajileye
African health sciences 18 (4), 1057-1065 2018



Serological detection of human T-cell lymphotropic virus types I and II among pregnant women in Ilorin, Nigeria
AO Udeze, MB Odebisi-Omokanye, A Faneye, BA Olusola, ...
Journal of Immunoassay and Immunochemistry 39 (4), 428-438 2018



Morphometric phenotypes and molecular identification of Fasciola species isolated from cattle in Ilorin, North-Central Nigeria
OA Iyiola, O Shittu, OA Owolodun, DA Animasaun, AO Udeze
Sri Lankan Journal of Biology 3 (2) 2018



Laboratory Practicals in Microbiology II
AB Olayemi, A Sani, GP Oyeyiola, PF Omojasola, MO Kolawole, ...
The Department of Microbiology, University of Ilorin, Ilorin 2018



Seroprevalence of serum IgG of HSV-1 coinfected with HIV infected patients who attended offa highly active anti retroviral therapy (HAART) clinic
MB Odebisi-Omonkanye, A Udeze, ST Agbaje, MF Adeyemi, HA Adeyemi, ...
Nigerian Journal of Family Practice 8 (4), 49-55 2017



High seroprevalence of cytomegalovirus infection among pregnant women in Ilorin, Kwara state, Nigeria
MB Odebisi-Omokanye, AO Udeze, AA AbdulRaheem, NE AbdulRazaq, ...
Ilorin Journal of Science 4 (1), 77–91-77–91 2017



Basic Laboratory Practicals in Microbiology
AB Olayemi, GP Oyeyiola, PF Omojasola, RN Ahmed, BK Saliu, ...
Department of Microbiology, University of Ilorin, Nigeria 2017



Serosurvey of Herpes simplex virus type-2 infection among HIV infected individuals accessing a secondary health care facility in Kwara State, North Central Nigeria.
MB Odebisi-Omokanye, AO Udeze, K Akanbi, NK Jimoh, MA Imam
Faculties of Life and Physical Sciences, University of Ilorin 2017

MOST CITED SCHOLAR PUBLICATIONS

Antimicrobial activity of Carica papaya (pawpaw leaf) on some pathogenic organisms of clinical origin from South-Western Nigeria
II Anibijuwon, AO Udeze
Ethnobotanical leaflets 2009 (7), 4 2009
Citations: 205



Incidence of urinary tract infection (UTI) among pregnant women in Ibadan, South-Western Nigeria
AON IO Okonko, LA Ijandipe, OA Ilusanya, OB Donbraye-Emmanuel, J Ejembi, AO ...
African Journal of Biotechnology 8 (23) 2009
Citations: 205



Assessment of bacteriological quality of fresh meats sold in Calabar metropolis, Nigeria.
IO Ukut, IO Okonko, IS Ikpoh, AO Nkang, AO Udeze, TA Babalola, ...
Electronic Journal of Environmental, Agricultural & Food Chemistry 9 (1) 2010
Citations: 139



Antibiotics sensitivity and resistance patterns of uropathogens to nitrofurantoin and nalidixic acid in pregnant women with urinary tract infections in Ibadan, Nigeria
IO Okonko, OB Donbraye-Emmanuel, LA Ijandipe, AA Ogun, AO Adedeji, ...
Middle-East J. Sci. Res 4 (2), 105-109 2009
Citations: 92



Detection of urinary tract infection (UTI) among pregnant women in Oluyoro Catholic Hospital, Ibadan, South-Western Nigeria
IO Okonko, LA Ijandipe, AO Ilusanya, OB Donbraye-Emmanuel, J Ejembi, ...
Malaysian journal of Microbiology 6 (1), 16-24 2010
Citations: 91



Prevalence of malaria plasmodium in Abeokuta, Nigeria
IO Okonko, FA Soleye, TA Amusan, AA Ogun, AO Udeze, AO Nkang, ...
Malaysian Society for Microbiology 2009
Citations: 73



Assessment of antibiotics susceptibility profiles of some selected clinical isolates from laboratories in Nigeria
AO Nkang, IO Okonko, OK Mejeha, OG Adewale, AO Udeze, A Fowotade, ...
Journal of Microbiology and Antimicrobials 1 (2), 019-026 2009
Citations: 53



Incidence of multi-drug resistant (MDR) organisms in some poultry feeds sold in Calabar Metropolis, Nigeria.
IO Okonko, AO Nkang, EA Fajobi, OK Mejeha, AO Udeze, BO Motayo, ...
Electronic Journal of Environmental, Agricultural & Food Chemistry 9 (3) 2010
Citations: 50



Comparative prevalence level of Plasmodium in freshmen (first year students) of Nnamdi Azikwe University in Awka, South-Eastern, Nigeria
AC Ibekwe, IO Okonko, AI Onunkwo, AA Ogun, AO Odeze
Malaysian Journal of Microbiology 5 (1), 51-54 2009
Citations: 45



Seroprevalence of Salmonella typhi and Salmonella paratyphi among the first year students of University of Ilorin, Ilorin - Nigeria.
AO Udeze, F Abdulrahman, IO Okonko, II Anibijuwon
2010
Citations: 33



Global eradication of measles: a highly contagious and vaccine preventable disease-what went wrong in Africa
IO Okonko, AO Nkang, AO Udeze, AO Adedeji, J Ejembi, BA Onoja, ...
J Cell Anim Biol 3 (8), 119-40 2009
Citations: 33



The effect of Klebsiella pneumoniae on catfish (Clarias gariepinus)
AO Udeze, M Talatu, MN Ezediokpu, JC Nwanze, C Onoh, IO Okonko
Researcher 4 (4), 51-59 2012
Citations: 31



Seroprevalence of hepatitis C virus antibodies amongst blood donors in Ibadan, Southwestern, Nigeria
AO Udeze, IO Okonko, E Donbraye, WF Sule, A Fadeyi, LN Uche
World Appl Sci J 7, 1023-1028 2009
Citations: 26



Cytomegalovirus infection among Human Immunodeficiency Virus (HIV) infected individuals on highly active anti-retroviral therapy in North-Central Nigeria
A Udeze, M Odebisi-Omokanye, T Ajileye
African health sciences 18 (4), 1057-1065 2018
Citations: 24



Detection of hepatitis B surface antigen (HBsAg) among pregnant women attending antenatal clinic at OLA Catholic Hospital, Oluyoro, Ibadan, Oyo State, Southwestern Nigeria
IO Okonko, AO Udeze
Nature and Science 9 (11), 54-60 2011
Citations: 24



Seroprevalence of HBsAg among patients in Abeokuta, South western Nigeria
IO Okonko, FA Soleye, TA Amusan, AO Udeze, JA Alli, MO Ojezele, ...
Global Journal of Medical Research 10 (2), 40-49 2010
Citations: 23



Hepatitis C virus (HCV) antibody detection among first year students of University of Ilorin, Ilorin, Nigeria
AO Udeze, RA Bamidele, IO Okonko, WF Sule
World J of Med Sci 6, 162-167 2011
Citations: 22



Antibiotics susceptibility profiles of bacteria from clinical samples in Calabar, Nigeria
AO Nkang, IO Okonko, A Fowotade, AO Udeze, TA Ogunnusi, EA Fajobi, ...
Journal of Bacteriology Research 1 (8), 089-096 2009
Citations: 22



HBV infection among intending blood donors who incidentally tested positive to HIV antibody in two blood banks in Ibadan, Nigeria
OA Lawal, AS Bakarey, LN Uche, AO Udeze, IO Okonko
World Applied Science Journal 7 (10), 1269-1274 2009
Citations: 17



Farming and Non-Farming Individuals Attending Grimard Catholic Hospital, Anyigba, Kogi State, Nigeria were Comparable in Hepatitis B Surface Antigen Seroprevalence
WF Sule, IO Okonko, AJ Ebute, E Donbraye, A Fadeyi, AO Udeze, JA Alli
Current Research Journal of Biological Sciences 2 (4), 278-282 2010
Citations: 15