Balavigneswaran C K

Scopus Publications

Zwitterionic hydrogels as antibiofouling, adhesive coatings: Effects of gelatin methacrylate crosslinking on physicochemical, mechanical, and adhesive properties
Sowmya Selvaraj, Samyuktha Sivakumar, Manoj Kumar Sundaram, Varshiny Gopinath, Iniyan Saravanakumar, et al.
European Polymer Journal, 2025
Recombinant hyaluronic acid-incorporated self-healing injectable hydrogels for cartilage tissue engineering: a case study on effects of molecular weight
Manoj Kumar Sundaram, Chelladurai Karthikeyan Balavigneswaran, Iniyan Saravanakumar, Guhan Jayaraman, Vignesh Muthuvijayan
Journal of Materials Chemistry B, 2025
A self-healing injectable hydrogel with recombinant HA was developed for cartilage repair. Balanced covalent and non-covalent interactions enabled efficient self-healing, and HA improved shear-thinning behavior and collagen deposition.
High-Performance Biosorbent from Pyrolyzed Themeda arundinacea for Effective Removal of Textile Dyes: Isotherm, Kinetic, and Thermodynamic Studies
Shanmugam Kanchana, Karuppiah Prakash Shyam, Chelladurai Karthikeyan Balavigneswaran, Srinivasan Venkatesan
Industrial and Engineering Chemistry Research, 2025
Lauric acid-loaded biomimetic, biocompatible, and antioxidant jelly fig (Ficus awkeotsang Makino) pectin hydrogel accelerates wound healing in diabetic rats
Ponrasu Thangavel, Iniyan Saravanakumar, Manoj Kumar Sundaram, Chelladurai Karthikeyan Balavigneswaran, Rathinam Balamurugan, et al.
International Journal of Biological Macromolecules, 2025
Polysaccharide-Based Self-Healing Hydrogel for pH-Induced Smart Release of Lauric Acid to Accelerate Wound Healing
Chelladurai Karthikeyan Balavigneswaran, Manoj Kumar Sundaram, Venkatesan Ramya, Karuppiah Prakash Shyam, Iniyan Saravanakumar, et al.
ACS Applied Bio Materials, 2025
It is highly desirable yet significantly challenging to fabricate an injectable, self-healing, controlled-release wound dressing that is responsive to the alkaline pH of the wounds. Herein, we propose a facile approach to prepare pH-responsive chitosan-oxidized carboxymethyl cellulose (CS-o-CMC) hydrogel constructs in which gelation was achieved via electrostatic and Schiff base formation. Importantly, the Schiff base was formed in acidic medium and the final pH of pregel solution was intrinsically raised to 7.0-7.4 due to the cross-linking by β-glycerol phosphate. The self-healing behavior of the hydrogel was an enthalpy-driven process and efficient in alkaline compared to acidic pH. The pH responsiveness offered a controlled release of lauric acid (LA) from CS-o-CMC/LA hydrogel and regulated the M2 polarization. Overall, reduction in inflammation led to rapid vascularization, reepithelialization, and significantly accelerated wound healing in rats. Our findings demonstrate a promising strategy for developing injectable, immunomodulatory wound dressings tailored to the challenging environment of wounds.
Carbon Quantum Dots for Medical Applications
Chelladurai Karthikeyan Balavigneswaran, Vignesh Muthuvijayan
Nanotechnology in the Life Sciences, 2024
Tissue engineered skin substitutes: A comprehensive review of basic design, fabrication using 3D printing, recent advances and challenges
Chelladurai Karthikeyan Balavigneswaran, Sowmya Selvaraj, T.K. Vasudha, Saravanakumar Iniyan, Vignesh Muthuvijayan
Biomaterials Advances, 2023
Mussel-Inspired Adhesive Hydrogels Based on Laponite-Confined Dopamine Polymerization as a Transdermal Patch
Chelladurai Karthikeyan Balavigneswaran, Vaibhav Jaiswal, Ramya Venkatesan, Prakash Shyam Karuppiah, Manoj Kumar Sundaram, et al.
Biomacromolecules, 2023
Transdermal patch for local drug delivery has attained huge attention as an attractive alternative to existing drug delivery techniques as it is painless and user-friendly. However, most adhesive hydrogels either do not have adequate adhesion with the skin or cause discomfort while being removed from the skin surface due to excessive adhesion. To address this challenge, we developed an adhesive hydrogel based on laponite-confined dopamine polymerization as a transdermal patch. Laponite RDS nanoclay was used to control the hydrogel's viscous behavior and dopamine polymerization. The laponite polymerized polydopamine (l-PDA) was incorporated into poly(vinyl alcohol) (PVA) to make the PVA-l-PDA hydrogel. The laponite-confined polymerization improved the hydrogels' water contact angle and adhesion strength. The adhesion strength of the PVA-l-PDA hydrogel was adequate to adhere to the evaluated goat skin, glass, and polypropylene surfaces. Notably, the PVA-l-PDA hydrogel was easy to peel off from the skin. Further, we evaluated the drug release profile in goat skin using lidocaine as a model drug. We observed the controlled release of lidocaine from the PVA-l-PDA hydrogel compared to the PVA-PDA hydrogel. In addition, the nanoclay-confined adhesive hydrogel did not show any cytotoxic effect in fibroblasts. Altogether, PVA-l-PDA hydrogels offer appropriate adhesive strength, toughness, and biocompatibility. Thus, the PVA-l-PDA hydrogel has the potential to be an efficient transdermal patch.
Dual Roles of Coconut Oil and Its Major Component Lauric Acid on Redox Nexus: Focus on Cytoprotection and Cancer Cell Death
Venkatesan Ramya, Karuppiah Prakash Shyam, Eshwaran Kowsalya, Chelladurai Karthikeyan Balavigneswaran, Balamuthu Kadalmani
Frontiers in Neuroscience, 2022
It has been reported that coconut oil supplementation can reduce neuroinflammation. However, coconut oils are available as virgin coconut oil (VCO), crude coconut oil (ECO), and refined coconut oil (RCO). The impact of coconut oil extraction process (and its major fatty acid component lauric acid) at cellular antioxidant level, redox homeostasis and inflammation in neural cells is hitherto unexplained. Herein, we have shown the antioxidant levels and cellular effect of coconut oil extracted by various processes in human neuroblastoma cells (SH-SY5Y) cultured in vitro. Results indicate VCO and ECO treated cells displayed better mitochondrial health when compared to RCO. Similar trend was observed for the release of reactive oxygen species (ROS), key oxidative stress response genes (GCLC, HO-1, and Nqo1) and inflammatory genes (IL6, TNFα, and iNOS) in SH-SY5Y cells. Our results signified that both VCO and ECO offer better neural health primarily by maintaining the cellular redox balance. Further, RCO prepared by solvent extraction and chemical refining process lacks appreciable beneficial effect. Then, we extended our study to find out the reasons behind maintaining the cellular redox balance in neuroblastoma cells by VCO and ECO. Our GC-MS results showed that lauric acid (C14:0) (LA) content was the major difference in the fatty acid composition extracted by various processes. Therefore, we evaluated the efficacy of LA in SH-SY5Y cells. The LA showed dose-dependent effect. At IC50 concentration (11.8 μM), LA down regulated the oxidative stress response genes and inflammatory genes. The results clearly indicate that the LA inhibited the neuroinflammation and provided an efficient cellular antioxidant activity, which protects the cells. The efficiency was also evaluated in normal cell line such as fibroblasts (L929) to cross-validate that the results were not false positive. Different concentration of LA on L929 cells showed high compatibility. From our observation, we conclude that VCO and ECO offers better cellular protection owing to their powerful antioxidant system. Therefore, we advocate the inclusion of either VCO and/or ECO in the diet for a healthy lifestyle.
Aluminium Oxide Thin-Film Based in Vitro Cell-Substrate Sensing Device for Monitoring Proliferation of Myoblast Cells
Uvanesh Kasiviswanathan, Chelladurai Karthikeyan Balavigneswaran, Chandan Kumar, Suruchi Poddar, Satyabrata Jit, et al.
IEEE Transactions on Nanobioscience, 2021
We demonstrate cell-substrate interaction on aluminium oxide thin-film in metal-insulator-metal structure followed by the change in dielectric characteristics of Al2O3 as a function of progression of cellular growth. The theoretical calculation of the fabricated biosensor reveals that the changes in the intrinsic elemental parameters are mainly attributed to the cell-induced behavioural changes.
Nanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications
Chelladurai Karthikeyan Balavigneswaran, Vignesh Muthuvijayan
ACS Applied Bio Materials, 2021
Synthesis of cyclodextrin-derived star poly(N-vinylpyrrolidone)/poly(lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin
Kalyan Ramesh, Chelladurai Karthikeyan Balavigneswaran, Sonita A.P. Siboro, Vignesh Muthuvijayan, Kwon Taek Lim
Polymer, 2021
Biomaterials for Soft Tissue Engineering: Concepts, Methods, and Applications
Chelladurai Karthikeyan Balavigneswaran, Vignesh Muthuvijayan
Biomaterials in Tissue Engineering and Regenerative Medicine from Basic Concepts to State of the Art Approaches, 2021
Gelatin grafted poly(D,L-lactide) as an inhibitor of protein aggregation: An in vitro case study
Chelladurai Karthikeyan Balavigneswaran, Gaurav Kumar, Chandrasekaran Vignesh Kumar, Satheeshkumar Sellamuthu, Uvanesh Kasiviswanathan, et al.
Biopolymers, 2020
Silica Release from Silane Cross-Linked Gelatin Based Hybrid Scaffold Affects Cell Proliferation
Chelladurai Karthikeyan Balavigneswaran, Ramya Venkatesan, Prakash Shyam Karuppiah, Gaurav Kumar, Pankaj Paliwal, et al.
ACS Applied Bio Materials, 2020
Culturing melanocytes and fibroblasts within three-dimensional macroporous PDMS scaffolds: towards skin dressing material
Neelima Varshney, Ajay Kumar Sahi, Kiran Yellappa Vajanthri, Suruchi Poddar, Chelladurai Karthikeyan Balavigneswaran, et al.
Cytotechnology, 2019
Cell proliferation influenced by matrix compliance of gelatin grafted poly(D,L-Lactide) three dimensional scaffolds
Chelladurai Karthikeyan Balavigneswaran, Sanjeev Kumar Mahto, Arun Kumar Mahanta, Rajshree Singh, Mahalingam Rajamanickam Vijayakumar, et al.
Colloids and Surfaces B Biointerfaces, 2018
Polymeric gels for the controlled drug delivery applications
Chelladurai Karthikeyan Balavigneswaran, Nira Misra
Polymeric Gels Characterization Properties and Biomedical Applications, 2018
Osteoconductive Amine-Functionalized Graphene-Poly(methyl methacrylate) Bone Cement Composite with Controlled Exothermic Polymerization
Rakesh Sharma, Govinda Kapusetti, Sayali Yashwant Bhong, Partha Roy, Santosh Kumar Singh, et al.
Bioconjugate Chemistry, 2017
Tailored Chemical Properties of 4-Arm Star Shaped Poly(d, l -lactide) as Cell Adhesive Three-Dimensional Scaffolds
Chelladurai Karthikeyan Balavigneswaran, Sanjeev Kumar Mahto, Bano Subia, Arumugam Prabhakar, Kheyanath Mitra, et al.
Bioconjugate Chemistry, 2017
Pharmacokinetics, biodistribution, in vitro cytotoxicity and biocompatibility of Vitamin E TPGS coated trans resveratrol liposomes
Mahalingam Rajamanickam Vijayakumar, Kiran Yellappa Vajanthri, Chelladurai Karthikeyan Balavigneswaran, Sanjeev Kumar Mahto, Nira Mishra, et al.
Colloids and Surfaces B Biointerfaces, 2016
Rapid detection of Cr(VI) by AgNPs probe produced by Anacardium occidentale fresh leaf extracts
C. K. Balavigneswaran, T. Sujin Jeba Kumar, R. Moses Packiaraj, S. Prakash
Applied Nanoscience Switzerland, 2014
Green Synthesis of Silver Nanoparticles by Plumbago indica and Its Antitumor Activity Against Dalton's Lymphoma Ascites Model
T. Sujin Jeba Kumar, C. K. Balavigneswaran, R. Moses Packiaraj, A. Veeraraj, S. Prakash, et al.
Bionanoscience, 2013
Anti-oxidant activity of polysaccharides extracted from Isocrysis galbana using RSM optimized conditions
C.K. Balavigneswaran, T. Sujin Jeba Kumar, R. Moses Packiaraj, A. Veeraraj, S. Prakash
International Journal of Biological Macromolecules, 2013
Uranium and thorium upake by live and dead cells of Bacillus sp.
International Journal of Pharma and Bio Sciences, 2012

RECENT SCHOLAR PUBLICATIONS

Zwitterionic hydrogels as antibiofouling, adhesive coatings: Effects of gelatin methacrylate crosslinking on physicochemical, mechanical, and adhesive properties
S Selvaraj, S Sivakumar, MK Sundaram, V Gopinath, I Saravanakumar, ...
European Polymer Journal, 114401 , 2025
2025
Citations: 2
High-Performance Biosorbent from Pyrolyzed Themeda arundinacea for Effective Removal of Textile Dyes: Isotherm, Kinetic, and Thermodynamic Studies
S Kanchana, K Prakash Shyam, CK Balavigneswaran, S Venkatesan
Industrial & Engineering Chemistry Research , 2025
2025
Citations: 1
Lauric acid-loaded biomimetic, biocompatible, and antioxidant jelly fig (Ficus awkeotsang Makino) pectin hydrogel accelerates wound healing in diabetic rats
P Thangavel, I Saravanakumar, MK Sundaram, CK Balavigneswaran, ...
International Journal of Biological Macromolecules 294, 139484 , 2025
2025
Citations: 4
Polysaccharide-Based Self-Healing Hydrogel for pH-Induced Smart Release of Lauric Acid to Accelerate Wound Healing
CK Balavigneswaran, MK Sundaram, V Ramya, K Prakash Shyam, ...
ACS Applied Bio Materials 8 (2), 1343-1361 , 2025
2025
Citations: 7
Recombinant hyaluronic acid-incorporated self-healing injectable hydrogels for cartilage tissue engineering: a case study on effects of molecular weight
MK Sundaram, CK Balavigneswaran, I Saravanakumar, G Jayaraman, ...
Journal of Materials Chemistry B 13 (31), 9589-9606 , 2025
2025
Citations: 7
Influence Of Different Molecular Weights Of Recombinant Hyaluronic Acid In Self-healing Hydrogels On Collagen Deposition For Cartilage Tissue Engineering
M Sundaram, C Balavigneswaran, G Jayaraman, V Muthuvijayan
TISSUE ENGINEERING PART A 30 (15-16), S451-S451 , 2024
2024
Carbon Quantum Dots for Medical Applications
CK Balavigneswaran, V Muthuvijayan
Nanoparticles in Modern Antimicrobial and Antiviral Applications, 367-387 , 2024
2024
Citations: 2
Mussel-Inspired Adhesive Hydrogels Based on Laponite-Confined Dopamine Polymerization as a Transdermal Patch
CK Balavigneswaran, V Jaiswal, R Venkatesan, PS Karuppiah, ...
Biomacromolecules 24 (2), 724-738 , 2023
2023
Citations: 30
Tissue engineered skin substitutes: A comprehensive review of basic design, fabrication using 3D printing, recent advances and challenges
CKBSSTKVSIV Muthuvijayan
Biomaterials Advances , 2023
2023
Citations: 51
Dual roles of coconut oil and its major component lauric acid on redox nexus: focus on cytoprotection and cancer cell death
V Ramya, KP Shyam, E Kowsalya, CK Balavigneswaran, B Kadalmani
Frontiers in Neuroscience 16, 833630 , 2022
2022
Citations: 56
Nanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications
CK Balavigneswaran, V Muthuvijayan
ACS Applied Bio Materials 4 (6), 5362-5377 , 2021
2021
Citations: 38
Aluminium Oxide Thin-Film Based In Vitro Cell-Substrate Sensing Device for Monitoring Proliferation of Myoblast Cells
U Kasiviswanathan, CK Balavigneswaran, C Kumar, S Poddar, S Jit, ...
IEEE Transactions on NanoBioscience 20 (3), 331-337 , 2021
2021
Citations: 4
Synthesis of cyclodextrin-derived star poly (N-vinylpyrrolidone)/poly (lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin
K Ramesh, CK Balavigneswaran, SAP Siboro, V Muthuvijayan, KT Lim
Polymer 214, 123243 , 2021
2021
Citations: 22
Biomaterials for Soft Tissue Engineering: Concepts, Methods, and Applications
CK Balavigneswaran, V Muthuvijayan
Biomaterials in Tissue Engineering and Regenerative Medicine: From Basic … , 2021
2021
Citations: 1
Gelatin grafted poly(D,L‐lactide) as an inhibitor of protein aggregation: An in vitro case study
CK Balavigneswaran, G Kumar, C Vignesh Kumar, S Sellamuthu, ...
Biopolymers 111 (8), e23383 , 2020
2020
Citations: 5
Silica release from silane cross-linked gelatin based hybrid scaffold affects Cell proliferation
CK Balavigneswaran, R Venkatesan, PS Karuppiah, G Kumar, P Paliwal, ...
ACS Applied Bio Materials 3 (1), 197-207 , 2019
2019
Citations: 25
Culturing melanocytes and fibroblasts within three-dimensional macroporous PDMS scaffolds: towards skin dressing material
NVAKSKYVSPCKBAPVRSK Mahto
Cytotechnology, 1-17 , 2019
2019
Citations: 45
Versatility of Poly (Lactic Acid) and Modified Poly (Lactic Acid) for Nanobioengineering Applications
CK Balavigneswaran, K Ramesh, R Kaur, N Misra
NanoBioEngineering, 145-166 , 2018
2018
Citations: 1
Cell proliferation influenced by matrix compliance of gelatin grafted poly (d, l-Lactide) three dimensional scaffolds
CK Balavigneswaran, SK Mahto, AK Mahanta, R Singh, MR Vijayakumar, ...
Colloids and Surfaces B: Biointerfaces 166, 170-178 , 2018
2018
Citations: 20
Polymeric gels for the controlled drug delivery applications
CK Balavigneswaran, N Misra
Polymeric Gels, 331-356 , 2018
2018
Citations: 5

MOST CITED SCHOLAR PUBLICATIONS

Pharmacokinetics, biodistribution, in vitro cytotoxicity and biocompatibility of Vitamin E TPGS coated trans resveratrol liposomes
MR Vijayakumar, KY Vajanthri, CK Balavigneswaran, SK Mahto, N Mishra, ...
Colloids and Surfaces B: Biointerfaces 145, 479-491 , 2016
2016
Citations: 135
Anti-oxidant activity of polysaccharides extracted from Isocrysis galbana using RSM optimized conditions
CK Balavigneswaran, TSJ Kumar, RM Packiaraj, A Veeraraj, S Prakash
International journal of biological macromolecules 60, 100-108 , 2013
2013
Citations: 79
Rapid detection of Cr (VI) by AgNPs probe produced by Anacardium occidentale fresh leaf extracts
CK Balavigneswaran, T Sujin Jeba Kumar, R Moses Packiaraj, S Prakash
Applied Nanoscience 4 (3), 367-378 , 2014
2014
Citations: 75
Dual roles of coconut oil and its major component lauric acid on redox nexus: focus on cytoprotection and cancer cell death
V Ramya, KP Shyam, E Kowsalya, CK Balavigneswaran, B Kadalmani
Frontiers in Neuroscience 16, 833630 , 2022
2022
Citations: 56
Tissue engineered skin substitutes: A comprehensive review of basic design, fabrication using 3D printing, recent advances and challenges
CKBSSTKVSIV Muthuvijayan
Biomaterials Advances , 2023
2023
Citations: 51
Culturing melanocytes and fibroblasts within three-dimensional macroporous PDMS scaffolds: towards skin dressing material
NVAKSKYVSPCKBAPVRSK Mahto
Cytotechnology, 1-17 , 2019
2019
Citations: 45
Nanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications
CK Balavigneswaran, V Muthuvijayan
ACS Applied Bio Materials 4 (6), 5362-5377 , 2021
2021
Citations: 38
osteoconductive amine-functionalized graphenepoly(methyl methacrylate) bone cement composite with controlled exothermic polymerization
NM Rakesh Sharma, Govinda Kapusetti, Sayali Yashwant Bhong, Partha Roy ...
Bioconjugate chemistry , 2017
2017
Citations: 33
Mussel-Inspired Adhesive Hydrogels Based on Laponite-Confined Dopamine Polymerization as a Transdermal Patch
CK Balavigneswaran, V Jaiswal, R Venkatesan, PS Karuppiah, ...
Biomacromolecules 24 (2), 724-738 , 2023
2023
Citations: 30
Silica release from silane cross-linked gelatin based hybrid scaffold affects Cell proliferation
CK Balavigneswaran, R Venkatesan, PS Karuppiah, G Kumar, P Paliwal, ...
ACS Applied Bio Materials 3 (1), 197-207 , 2019
2019
Citations: 25
Synthesis of cyclodextrin-derived star poly (N-vinylpyrrolidone)/poly (lactic-co-glycolide) supramolecular micelles via host-guest interaction for delivery of doxorubicin
K Ramesh, CK Balavigneswaran, SAP Siboro, V Muthuvijayan, KT Lim
Polymer 214, 123243 , 2021
2021
Citations: 22
Cell proliferation influenced by matrix compliance of gelatin grafted poly (d, l-Lactide) three dimensional scaffolds
CK Balavigneswaran, SK Mahto, AK Mahanta, R Singh, MR Vijayakumar, ...
Colloids and Surfaces B: Biointerfaces 166, 170-178 , 2018
2018
Citations: 20
Tailored Chemical Properties of 4 arm star shaped poly(D,L-Lactide) as Cell Adhesive Three-Dimensional Scaffolds
MN Balavigneswaran CK, Mahto SK, Bano S, Prabhakar A, Mitra K, Rao V ...
Bioconjug Chem , 2017
2017
Citations: 19
Green synthesis of silver nanoparticles by Plumbago indica and its antitumor activity against Dalton's lymphoma ascites model
T Sujin Jeba Kumar, CK Balavigneswaran, R Moses Packiaraj, A Veeraraj, ...
BioNanoScience 3 (4), 394-402 , 2013
2013
Citations: 19
Biodiesel fuel production from marine microalgae Isochrysis galbana, Pavlova lutheri, Dunaliella salina and measurement of its viscosity and density
TSJ Kumar, CK Balavigneswaran, KP Srinivasakumar
International Journal of Marine Science 3 , 2013
2013
Citations: 15
Polysaccharide-Based Self-Healing Hydrogel for pH-Induced Smart Release of Lauric Acid to Accelerate Wound Healing
CK Balavigneswaran, MK Sundaram, V Ramya, K Prakash Shyam, ...
ACS Applied Bio Materials 8 (2), 1343-1361 , 2025
2025
Citations: 7
Recombinant hyaluronic acid-incorporated self-healing injectable hydrogels for cartilage tissue engineering: a case study on effects of molecular weight
MK Sundaram, CK Balavigneswaran, I Saravanakumar, G Jayaraman, ...
Journal of Materials Chemistry B 13 (31), 9589-9606 , 2025
2025
Citations: 7
Gelatin grafted poly(D,L‐lactide) as an inhibitor of protein aggregation: An in vitro case study
CK Balavigneswaran, G Kumar, C Vignesh Kumar, S Sellamuthu, ...
Biopolymers 111 (8), e23383 , 2020
2020
Citations: 5
Polymeric gels for the controlled drug delivery applications
CK Balavigneswaran, N Misra
Polymeric Gels, 331-356 , 2018
2018
Citations: 5
Lauric acid-loaded biomimetic, biocompatible, and antioxidant jelly fig (Ficus awkeotsang Makino) pectin hydrogel accelerates wound healing in diabetic rats
P Thangavel, I Saravanakumar, MK Sundaram, CK Balavigneswaran, ...
International Journal of Biological Macromolecules 294, 139484 , 2025
2025
Citations: 4

Balavigneswaran C K

RESEARCH INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS