Analysis of visual evoked potentials in patients with neurofibromatosis type 1: new concepts Jasna Jancic, Nikola Zarkovic, Blazo Nikolic, Nikola Ivancevic, Branislav Rovcanin, et al. Frontiers in Neurology, 2024 IntroductionNeurofibromatosis type 1 (NF type 1) is an autosomal dominant disease with typical clinical manifestations, such as skin lesions, Lisch nodules, optic pathway gliomas, and neurofibromas, caused by the mutation of the NF1 gene. Visual evoked potentials (VEP) present a measure of the electrophysiological response of visual cortex to a visual stimulus. The role of VEP in the pathophysiology of NF type 1 is very complex and requires additional research.The AimWe examined the differences between NF type 1 patients with normal and altered VEP and analyzed the correlation between the prolongation of P100 latency and disease severity.Materials and methodsTwo groups were formed: a control group and a study group with NF type 1 patients. Based on the control group analysis, a threshold value for a normal VEP finding of 116 ms was obtained, and it was used to divide the study group into subgroups with normal and altered VEP. We proceeded with examining the differences in clinical manifestations of the disease between the subgroups, after which we checked if there is a correlation between the prolongation of the P100 latency and the severity of the clinical picture according to the Riccardi scale. Statistical analysis was performed using the Pearson chi-square test and the Spearman correlation test in the program SPSS 28.0, with levels of statistical significance p = 0.05 and p = 0.001.ResultsIn the group with the abnormal VEP we found a statistically significant more frequent occurrence of optic tract glioma (p = 0.008), tumors (p = 0.032), epilepsy (p = 0.043), and cognitive disorders (p = 0.028), while the other clinical signs had an equal prevalence in both groups. A moderately strong correlation (rs = 0.665) was observed between the prolongation of P100 latency and the severity of the clinical picture.ConclusionOur results showed the important role of VEP in the description of clinical phenotypes of NF type 1. The authors of the study propose VEP to be included in the diagnostic algorithms designed for patients with NF type 1.
Acute Peripheral Facial Nerve Palsy in Children and Adolescents: Clinical Aspects and Treatment Modalities Jasna Jančić, Janko Zeković, Mila Ćetković, Blažo Nikolić, Nikola Ivančević, et al. CNS and Neurological Disorders Drug Targets, 2023 Background: Peripheral facial nerve palsy is a relatively frequent, rather idiopathic, and isolated nonprogressive disorder with a tendency toward spontaneous recovery in children. It is primarily characterized by unilateral paresis or paralysis of the mimic musculature, affecting verbal communication, social interactions, and quality of life. Objective: This study aimed to evaluate the clinical aspects and efficacy of different therapeutic modalities in the population of children and adolescents with acute peripheral facial nerve palsy, the quality and recovery rate in comparison to different therapy modalities and etiological factors as well as to determine parameters of recovery according to the age of patients. Methods: The retrospective study included children and adolescents (n=129) with an acute onset of peripheral facial nerve palsy, diagnosed and treated in the Clinic of Neurology and Psychiatry for Children and Youth in Belgrade (2000-2018). The mean age of the patients was 11.53 years (SD±4.41). Gender distribution was 56.6% female and 43.4% male patients. Results: There were 118 (91.5%) patients with partial and 11 (8.5%) patients with complete paralysis. Left-sided palsy occurred in 67 (51.9%) patients, right-sided in 58 (45.0%), while there were 4 (3.1%) bilateral paralyses. The most common etiological factor was idiopathic (Bell’s palsy), i.e., 74 (57.4%) patients, followed by middle ear infections, i.e., 16 (12.4%). Regardless of etiology, age, and therapy protocols, there was a significant recovery in most of the patients (p<0.001), without significant differences in recovery rate. Comparison of inpatient and outpatient populations showed significant differences regarding the number of relapses, the severity of clinical presentation, and the recovery rate in relation to etiology. Conclusion: Bell’s palsy is shown to be the most common cause of peripheral facial nerve palsy in children and adolescents, regardless of gender. It is followed by mid-ear infections, respiratory infections, and exposure to cold. Most children and adolescents recovered three weeks after initial presentation, regardless of etiology, age, and therapy.
Child Neurology: Bartonella henselae Neuroretinitis in 2 Patients Blazo Nikolic, Nikola Ivancevic, Ana Pepic, Marijana Kovacevic, Jelena Mladenovic, et al. Neurology, 2022 Neuroretinitis due toBartonella henselaeinfection is a rare cause of vision loss in children. Two pediatric cases of acute unilateral vision loss accompanied by edema of the optic nerve on fundoscopic examination are presented. Severe causes of vision loss were excluded. During the course of the disease, macular stellate exudates emerged on control fundoscopic examinations, and diagnosis of neuroretinitis was made. A causative agent was confirmed by serologic examination, as high titers of IgM and IgG antibodies toBartonella henselaewere detected. Both patients significantly recovered after oral antibiotic treatment.
Characteristics of pediatric multiple sclerosis: A tertiary referral center study Blažo Nikolić, Nikola Ivančević, Ivan Zaletel, Branislav Rovčanin, Janko Samardžić, et al. Plos One, 2020 Objective The present study represents one of the largest series of pediatric multiple sclerosis (PedMS) in Western Balkan region. This is the first study aimed to evaluate the characteristics of PedMS in the Serbian population. Methods This retrospective study on 54 PedMS, aged 7–17 years, was performed at the Clinic of Neurology and Psychiatry for Children and Youth in Belgrade, Serbia, a tertiary center for the diagnosis and treatment of children with neurological and psychiatric diseases. Results Female to male ratio was 37 (68.5%): 17 (31.5%). Family history of MS was noted in 9.3% and autoimmune diseases in 24.1% patients. Co-occurring migraine was in 7,4%. Monofocal onset of disease was present in 77.8% patients. The most common initial symptoms were optic neuritis (37%), sensory disturbances (31.5%), motor deficit (24.1%), cerebellar (18.5%) and brainstem lesions (16.7%), pain (9.3%), acute disseminated encephalomyelitis like symptoms (1.9%), and hearing loss (3.7%). Visual evoked potentials were pathological in 75.9% of patients. Oligoclonal bands were positive in 68.5% of patients. Magnetic resonance imaging showed periventricular (94.4%), infratentorial (77.8%), juxtacortical and cortical changes (55.6%) and changes in the cervical spinal cord (33.3%). The median EDSS score was 2.0. Conclusion Our cohort significantly differs from the literature data regarding more frequent occurrence of optic neuritis, hearing loss as a first symptom, the relapsing-remitting course of the disease, higher proportion of early onset of disease, presence of co-occurring migraine and the frequent occurrence of epilepsy and other autoimmune diseases in the family.
Glut1 deficiency syndrome: A case report with a novel SLC2A1 mutation Nikola Ivancevic, Natasa Cerovac, Blazo Nikolic, Goran Cuturilo, Ana Marjanovic, et al. Vojnosanitetski Pregled, 2019 Introduction. GLUT1 deficiency syndrome (GLUT1 DS, OMIM 606777) is a metabolic brain disorder caused by mutations in SLC2A1 gene (chromosome 1) encoding glucose transporter type 1 located on blood-brain membrane. The ?classic? phenotype in children includes early onset generalized farmacoresistant epilepsy, developmental delay, complex movement disorders and acquired microcephaly. However, there are milder phenotypes without epilepsy which could be seen in older children. The ketogenic diet is a treatment of choice. Case report. We present a four-yearold female patient with farmacoresistant generalized epilepsy, paroxysmal dystonic posturing, ataxia, hypotonia, developmental delay (motor, attention and speech disturbances), and microcephaly. The genetic testing revealed a novel point mutation at c.156T > A (p.Y52X) in exon 3 of SLC2A1 gene. The patient responded excellent on ketogenic diet. Conclusion. GLUT1 DS is treatable, and likely to be under-diagnosed neurological disorder. The ketogenic diet is resulting in good control of seizures in the patients, and it has certain benefit for the neurodevelopmental disability.
Significant Advances in the Diagnosis and Treatment of Pediatric Multiple Sclerosis 12 Year Single Center Experience B Nikolic, N Ivancevic, I Zaletel, D Nesic, J Jancic MULTIPLE SCLEROSIS JOURNAL 32 (2), 243-243 , 2026 2026
The Great Imitator Diagnostic Challenges and Risks of Misdiagnosis in Pediatric Multiple Sclerosis B Nikolic, N Ivancevic, I Zaletel, D Nesic, J Jancic MULTIPLE SCLEROSIS JOURNAL 32 (2), 235-235 , 2026 2026
Comparison of feature selection approaches in youth depression determination based on handwriting kinematics V Džepina, N Ivančević, S Rosić, B Nikolić, D Stevanović, J Jančić, ... E-business technologies conference proceedings 4 (1) , 2025 2025
579PThe effects of nusinersen on the motor function of children with spinal muscular atrophy type 2 and 3 A Kosac, D Vucinic, N Cerovac, N Ivancevic, B Nikolic, M Brkusanin, ... Neuromuscular Disorders 53, 106134 , 2025 2025
Detection of Psychomotor Retardation in Youth Depression: A Machine Learning Approach to Kinematic Analysis of Handwriting V Džepina, N Ivančević, S Rosić, B Nikolić, D Stevanović, J Jančić, ... Applied Sciences 15 (14), 7634 , 2025 2025 Citations: 2
Suicidality and depression in pediatric multiple sclerosis B Nikolic, N Ivancevic, D Stevanovic, K Markovic, I Zaletel, D Nesic, ... EUROPEAN JOURNAL OF NEUROLOGY 32 , 2025 2025
DILEME U DIFERENCIJALNOJ DIJAGNOZI PEDIJATRIJSKE MULTIPLE SKLEROZE J Drulović, J Jančić, B Nikolić, T Pekmezovic, Š Mesaroš Medicinska istraživanja 58 (1) , 2025 2025
Dilemmas in the differential diagnosis of pediatric multiple sclerosis J Drulović, J Jančić, B Nikolić, T Pekmezović, Š Mesaroš Medicinska istraživanja 58 (1), 75-81 , 2025 2025
Timed 25-foot walk test and 6-minute walk test in Paediatric Multiple Sclerosis B Nikolic, N Ivancevic, I Zaletel, J Jancic MULTIPLE SCLEROSIS JOURNAL 30 (3), 827-827 , 2024 2024
The Diagnostic Value of Evoked Potentials in the Assessment of the Pediatric Multiple Sclerosis B Nikolic, N Ivancevic, I Zaletel, J Jancic MULTIPLE SCLEROSIS JOURNAL 30 (3), 764-765 , 2024 2024
Analysis of visual evoked potentials in patients with neurofibromatosis type 1: new concepts J Jancic, N Zarkovic, B Nikolic, N Ivancevic, B Rovcanin, D Nesic Frontiers in Neurology 15, 1410101 , 2024 2024
Acute peripheral facial nerve palsy in children and adolescents: clinical aspects and treatment modalities J Jančić, J Zeković, M Ćetković, B Nikolić, N Ivančević, D Vučević, Z Nešić, ... CNS & Neurological Disorders-Drug Targets-CNS & Neurological Disorders) 22 … , 2023 2023 Citations: 3
Child Neurology: Bartonella henselae Neuroretinitis in 2 Patients JJ Blazo Nikolic, Nikola Ivancevic, Ana Pepic, Marijana Kovacevic, Jelena ... Neurology , 2022 2022 Citations: 9
The usefulness of visual evoked potentials in the assessment of the pediatric multiple sclerosis B Nikolic, I Zaletel, N Ivancevic, B Rovcanin, A Pepic, J Samardzic, ... European Journal of Paediatric Neurology 36, 130-136 , 2022 2022 Citations: 7
Mehanizmi uticaja kliničkih i parakliničkih parametara na nastanak onesposobljenosti i progresiju moždanog oštećenja u korelaciji sa primenjenim terapijskim modalitetima kod … B Nikolić University of Belgrade, School of Medicine , 2021 2021
Oxidative stress profile in genetically confirmed cases of Leber’s hereditary optic neuropathy B Rovcanin, J Jancic, J Pajic, M Rovcanin, J Samardzic, V Djuric, ... Journal of Molecular Neuroscience 71 (5), 1070-1081 , 2021 2021 Citations: 13
In silico model of mtDNA mutations effect on secondary and 3D structure of mitochondrial rRNA and tRNA in Leber’s hereditary optic neuropathy B Rovcanin, J Jancic, J Samardzic, M Rovcanin, B Nikolic, N Ivancevic, ... Experimental Eye Research 201, 108277 , 2020 2020 Citations: 19
Writing kinematics and graphic rules in children with ADHD N Ivančević, V Miler-Jerković, D Stevanović, J Jančić, MB Popović Srpski arhiv za celokupno lekarstvo 148 (7-8), 462-468 , 2020 2020 Citations: 1
Characteristics of pediatric multiple sclerosis: A tertiary referral center study JJ Blazo Nikolić, Nikola Ivančević, Ivan Zaletel, Branislav Rovčanin, Janko ... PLOS ONE , 2020 2020 Citations: 15
Analysis of secondary mtDNA mutations in families with Leber’s hereditary optic neuropathy: four novel variants and their association with clinical presentation J Jancic, B Rovcanin, V Djuric, A Pepic, J Samardzic, B Nikolic, ... Mitochondrion 50, 132-138 , 2020 2020 Citations: 16
MOST CITED SCHOLAR PUBLICATIONS
Multiple sclerosis in pediatrics: current concepts and treatment options J Jancic, B Nikolic, N Ivancevic, V Djuric, I Zaletel, D Stevanovic, S Peric, ... Neurology and therapy 5 (2), 131-143 , 2016 2016 Citations: 53
In silico model of mtDNA mutations effect on secondary and 3D structure of mitochondrial rRNA and tRNA in Leber’s hereditary optic neuropathy B Rovcanin, J Jancic, J Samardzic, M Rovcanin, B Nikolic, N Ivancevic, ... Experimental Eye Research 201, 108277 , 2020 2020 Citations: 19
A 6-month follow-up of disability, quality of life, and depressive and anxiety symptoms in pediatric migraine with magnesium prophylaxis G Kovacevic, D Stevanovic, D Bogicevic, D Nikolic, S Ostojic, BV Tadic, ... Magnesium research 30 (4), 133-141 , 2017 2017 Citations: 19
Analysis of secondary mtDNA mutations in families with Leber’s hereditary optic neuropathy: four novel variants and their association with clinical presentation J Jancic, B Rovcanin, V Djuric, A Pepic, J Samardzic, B Nikolic, ... Mitochondrion 50, 132-138 , 2020 2020 Citations: 16
Characteristics of pediatric multiple sclerosis: A tertiary referral center study JJ Blazo Nikolić, Nikola Ivančević, Ivan Zaletel, Branislav Rovčanin, Janko ... PLOS ONE , 2020 2020 Citations: 15
Oxidative stress profile in genetically confirmed cases of Leber’s hereditary optic neuropathy B Rovcanin, J Jancic, J Pajic, M Rovcanin, J Samardzic, V Djuric, ... Journal of Molecular Neuroscience 71 (5), 1070-1081 , 2021 2021 Citations: 13
Multiple sclerosis therapies in pediatric patients: Challenges and opportunities J Jančić, B Nikolić, N Ivančević, B Henčić, J Samardžić Exon Publications, 39-52 , 2017 2017 Citations: 13
Child Neurology: Bartonella henselae Neuroretinitis in 2 Patients JJ Blazo Nikolic, Nikola Ivancevic, Ana Pepic, Marijana Kovacevic, Jelena ... Neurology , 2022 2022 Citations: 9
Visual evoked potentials-current concepts and future perspectives J Jančić, N Ivančević, B Nikolić, M Popović, Ž Martinović, D Stevanović, ... Vojnosanitetski pregled 75 (5), 496-503 , 2018 2018 Citations: 8
Leber's hereditary optic neuropathy: novel views and persisting challenges J Jancic, J Samardzic, S Stojanovic, A Stojanovic, AM Milanovic, B Nikolic, ... CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS … , 2017 2017 Citations: 8
The usefulness of visual evoked potentials in the assessment of the pediatric multiple sclerosis B Nikolic, I Zaletel, N Ivancevic, B Rovcanin, A Pepic, J Samardzic, ... European Journal of Paediatric Neurology 36, 130-136 , 2022 2022 Citations: 7
Does handedness matter? Writing and tracing kinematic analysis in healthy adults N Ivančević, M Novičić, V Miler-Jerković, M Janković, D Stevanović, ... psihologija 52 (4), 413-435 , 2019 2019 Citations: 7
Current use of mTOR inhibitors for the treatment of subependymal giant cell astrocytomas and epilepsy in patients with TSC J Jancic, V Duric, N Ivancevic, B Nikolic, J N. van den Anker, J Samardzic Current Medicinal Chemistry 23 (37), 4260-4269 , 2016 2016 Citations: 6
Acute peripheral facial nerve palsy in children and adolescents: clinical aspects and treatment modalities J Jančić, J Zeković, M Ćetković, B Nikolić, N Ivančević, D Vučević, Z Nešić, ... CNS & Neurological Disorders-Drug Targets-CNS & Neurological Disorders) 22 … , 2023 2023 Citations: 3
Detection of Psychomotor Retardation in Youth Depression: A Machine Learning Approach to Kinematic Analysis of Handwriting V Džepina, N Ivančević, S Rosić, B Nikolić, D Stevanović, J Jančić, ... Applied Sciences 15 (14), 7634 , 2025 2025 Citations: 2
Multiple sclerosis in children and adolescents Multipla skleroza kod dece i adolescenata J Jančić, B Nikolić, Š Mesaroš, MM Stojković, T Pekmezović, J Drulović Medicinska istraživanja 52, 7-13 , 2018 2018 Citations: 2
Writing kinematics and graphic rules in children with ADHD N Ivančević, V Miler-Jerković, D Stevanović, J Jančić, MB Popović Srpski arhiv za celokupno lekarstvo 148 (7-8), 462-468 , 2020 2020 Citations: 1
GLUT1 deficiency syndrome: a case report with a novel SLC2A1 mutation N Ivančević, N Cerovac, B Nikolić, G Čuturilo, A Marjanović, M Branković, ... Vojnosanitetski pregled 76 (5) , 2019 2019 Citations: 1
What is hidden behind handwriting of children with ADHD?, Kinematic analysis N Ivančević, V Miler-Jerković, V Kojić, D Stevanović, B Nikolić, J Jančić, ... Proceedings of 3rd International Conference on Electrical, Electronic and … , 2016 2016 Citations: 1
Significant Advances in the Diagnosis and Treatment of Pediatric Multiple Sclerosis 12 Year Single Center Experience B Nikolic, N Ivancevic, I Zaletel, D Nesic, J Jancic MULTIPLE SCLEROSIS JOURNAL 32 (2), 243-243 , 2026 2026
