Cobalt-catalyzed deallylation of amines Branislav Kokić, Ljiljana Koračak, Marina Pećinar, Timothy R. Newhouse, Bogdan Šolaja, et al. Tetrahedron Letters, 2026
Positional isomerization of N-allyl compounds with a practical low-valent cobalt catalyst system Branislav Kokić, Ljiljana Koračak, Marina Pećinar, Timothy R. Newhouse, Bogdan Šolaja, et al. Organic and Biomolecular Chemistry, 2026 Herein, we report a practical cobalt-catalyzed method for the ( E )-stereoselective synthesis of enamides and N -alkenyl heterocycles via positional isomerization of N -allyl amides and nitrogen heterocycles.
Introductory concept for teaching chirality – Symmetry of the asymmetric Branislav Kokic, Vladimir Ajdacic, Igor Opsenica, Mario Zlatovic Journal of the Serbian Chemical Society, 2024 Chirality is traditionally a problematic subject for undergraduate students at the beginning of learning organic chemistry, yet it is of great importance in life sciences. If the initial introduction of chirality is conducted carelessly, students will face ambiguity through the rest of the course and education every time they come across chirality-related subjects. Although there are numerous methods for overcoming the problems of visualization of chiral molecules in 3D space, the connection of chirality with molecular changes like vibrations and conformations is usually not explained thoroughly. In this work, chirality is introduced on dynamic (real) systems, because students from the start should perceive molecules in their natural state of constant motion and change. Apart from the proposition of the lecture concept, exercises are also included, that employ free and readily available software.
Strategies for Carbon Electrophile Addition to Carbonyls and Imines by Cobalt Catalysis Branislav Kokić, Bojan Vulović, Miloš Jović, Ana Andrijević, Vladimir Ajdačić, et al. European Journal of Organic Chemistry, 2023 The addition of carbon electrophiles to carbonyls and imines has emerged as a valuable strategy for the construction of C−C bonds. The merger of this concept with sustainable cobalt catalysis has yielded numerous innovative methodologies. Remarkable functional group tolerance and selectivity have been observed in many cases, providing reliable methods for bond construction. The cobalt‐catalyzed additions of carbon electrophiles to carbonyls, imines and carboxylic acid derivatives described in this review include the earliest reports, such as Takai‐Utimoto Co/Cr co‐catalyzed additions and their progression, as well as modern variants, exemplified by recent Co/photoredox co‐catalyzed protocols. The systematic appraisal of this modern strategy provides a clearer perspective and inspiration for its further development.
