Braxton Norwood PhD is a scientist-entrepreneur focused on transforming the diagnosis and treatment of human health disorders. Driven more by data and (potential) impact than by revenue or investment returns. I enjoy taking calculated risks and attacking big problems with creative solutions. Firm believer in responsible capitalism.
Dr. Braxton Norwood is founder of four biopharma/medtech companies, served in executive/director roles, e.g. CEO and Director of R&D. I've led drug and radiotracer development from discovery to Phase II clinical trials. These ventures have been funded by public (NIH SBIR grants) and private (Angel and VC) sources. 20+ peer-reviewed scientific articles and multiple filed/granted patents.
He enjoys rock climbing, aviation, and whisky (not simultaneously).
EDUCATION
Bachelor of Arts in Anthropology, University of Arizona, 2004. Minors: Biochemistry, Pre-health
PhD in Medical Pharmacology, University of Arizona, 2009. Minor: Neuroscience
RESEARCH, TEACHING, or OTHER INTERESTS
Drug Discovery, Neuroscience
FUTURE PROJECTS
Medical imaging of chronic pain
Applications Invited
1676
Scholar Citations
18
Scholar h-index
21
Scholar i10-index
RECENT SCHOLAR PUBLICATIONS
A Neuroscience (Vol 121, 29, 2024) MT Veno, CR Reschke, G Morris, N Connolly, J Su, Y Yan, T Engel, ... PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF … , 2024 2024
Radiotracers in the Diagnosis of Pain: A Mini Review J Hascalovici, A Babb, BA Norwood Seminars in Musculoskeletal Radiology 27 (06), 655-660 , 2023 2023
Radiocaine: an imaging marker of neuropathic injury ND Bartolo, SE Reid, HS Krishnan, A Haseki, M Renganathan, ... ACS Chemical Neuroscience 13 (24), 3661-3667 , 2022 2022 Citations: 8
Radiocaine: An Imagining Marker of Neuropathic Injury N Bartolo, S Reid, H Krishnan, A Haseki, M Renganathan, ... Journal of Nuclear Medicine 63 (supplement 2), 2904-2904 , 2022 2022
Enrichment of circular RNA expression deregulation at the transition to recurrent spontaneous seizures in experimental temporal lobe epilepsy A Gomes-Duarte, S Bauer, MT Venø, BA Norwood, DC Henshall, J Kjems, ... Frontiers in genetics 12, 627907 , 2021 2021 Citations: 27
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy GP Brennan, S Bauer, T Engel, EM Jimenez-Mateos, F Del Gallo, ... Neurobiology of Disease 144, 105048 , 2020 2020 Citations: 74
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy MT Venø, CR Reschke, G Morris, NMC Connolly, J Su, Y Yan, T Engel, ... Proceedings of the National Academy of Sciences 117 (27), 15977-15988 , 2020 2020 Citations: 75
Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances AM do Canto, AS Vieira, A HB Matos, BS Carvalho, B Henning, ... Scientific reports 10 (1), 4412 , 2020 2020 Citations: 24
the developmental seizure-induced hippocampal mossy fiber sprouting: target for epilepsy therapies? H Ni, T Kirschstein, BA Norwood, CL Hsieh Frontiers in Neurology 10, 1212 , 2019 2019 Citations: 2
Ago2-seq identifies new microRNA targets for seizure control MT Venø, CR Reschke, G Morris, NMC Connolly, J Su, Y Yan, T Engel, ... bioRxiv, 777144 , 2019 2019
Personalized translational epilepsy research—Novel approaches and future perspectives: Part I: Clinical and network analysis approaches F Rosenow, N van Alphen, A Becker, A Chiocchetti, R Deichmann, ... Epilepsy & behavior 76, 13-18 , 2017 2017 Citations: 38
Personalized translational epilepsy research—novel approaches and future perspectives: part II: experimental and translational approaches S Bauer, N van Alphen, A Becker, A Chiocchetti, R Deichmann, T Deller, ... Epilepsy & behavior 76, 7-12 , 2017 2017 Citations: 23
Neuroinflammatory targets and treatments for epilepsy validated in experimental models E Aronica, S Bauer, Y Bozzi, M Caleo, R Dingledine, JA Gorter, ... Epilepsia 58, 27-38 , 2017 2017 Citations: 241
A microRNA‐129‐5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses M Rajman, F Metge, R Fiore, S Khudayberdiev, A Aksoy‐Aksel, S Bicker, ... The EMBO journal 36 (12), 1770-1787 , 2017 2017 Citations: 119
Validation of reference genes for quantitative gene expression analysis in experimental epilepsy C Sadangi, F Rosenow, BA Norwood Journal of Neuroscience Research , 2017 2017 Citations: 15
Potent anti-seizure effects of locked nucleic acid antagomirs targeting miR-134 in multiple mouse and rat models of epilepsy CR Reschke, LFA Silva, BA Norwood, K Senthilkumar, G Morris, ... Molecular therapy Nucleic acids 6, 45-56 , 2017 2017 Citations: 105
A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam F Kienzler‐Norwood, L Costard, C Sadangi, P Müller, V Neubert, S Bauer, ... Epilepsia 58 (2), 222-230 , 2017 2017 Citations: 44
Role of endosomal toll-like receptors in epilepsy C Sadangi Philipps-Universität Marburg , 2017 2017
MiRNA-135a regulates the expression of small conductance calcium-activated potassium (SK3) channels in epilepsy-like conditions B Honrath, B Norwood, G Tanrioever, K Kuter, DC Henshall, ... 8th Annual Alliance for Healthy Aging Conference , 2017 2017
Removing entorhinal cortex input to the dentate gyrus does not impede low frequency oscillations, an EEG-biomarker of hippocampal epileptogenesis M Meyer, F Kienzler-Norwood, S Bauer, F Rosenow, BA Norwood Scientific reports 6 (1), 25660 , 2016 2016 Citations: 10
MOST CITED SCHOLAR PUBLICATIONS
Cytokines and epilepsy G Li, S Bauer, M Nowak, B Norwood, B Tackenberg, F Rosenow, S Knake, ... Seizure 20 (3), 249-256 , 2011 2011 Citations: 377
Neuroinflammatory targets and treatments for epilepsy validated in experimental models E Aronica, S Bauer, Y Bozzi, M Caleo, R Dingledine, JA Gorter, ... Epilepsia 58, 27-38 , 2017 2017 Citations: 241
A microRNA‐129‐5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses M Rajman, F Metge, R Fiore, S Khudayberdiev, A Aksoy‐Aksel, S Bicker, ... The EMBO journal 36 (12), 1770-1787 , 2017 2017 Citations: 119
Potent anti-seizure effects of locked nucleic acid antagomirs targeting miR-134 in multiple mouse and rat models of epilepsy CR Reschke, LFA Silva, BA Norwood, K Senthilkumar, G Morris, ... Molecular therapy Nucleic acids 6, 45-56 , 2017 2017 Citations: 105
Classic hippocampal sclerosis and hippocampal‐onset epilepsy produced by a single “cryptic” episode of focal hippocampal excitation in awake rats BA Norwood, AV Bumanglag, F Osculati, A Sbarbati, P Marzola, ... Journal of Comparative Neurology 518 (16), 3381-3407 , 2010 2010 Citations: 104
Interictal alterations of cytokines and leukocytes in patients with active epilepsy M Nowak, S Bauer, A Haag, S Cepok, A Todorova-Rudolph, ... Brain, behavior, and immunity 25 (3), 423-428 , 2011 2011 Citations: 93
Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation‐induced status epilepticus in the mouse F Kienzler, BA Norwood, RS Sloviter Journal of Comparative Neurology 515 (2), 181-196 , 2009 2009 Citations: 90
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy MT Venø, CR Reschke, G Morris, NMC Connolly, J Su, Y Yan, T Engel, ... Proceedings of the National Academy of Sciences 117 (27), 15977-15988 , 2020 2020 Citations: 75
Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy GP Brennan, S Bauer, T Engel, EM Jimenez-Mateos, F Del Gallo, ... Neurobiology of Disease 144, 105048 , 2020 2020 Citations: 74
Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy M Nowak, A Strzelczyk, PS Reif, K Schorlemmer, S Bauer, BA Norwood, ... Seizure 21 (3), 227-228 , 2012 2012 Citations: 64
On the relevance of prolonged convulsive status epilepticus in animals to the etiology and neurobiology of human temporal lobe epilepsy. RS Sloviter, CA Zappone, AV Bumanglag, BA Norwood, H Kudrimoti Epilepsia (Series 4) 48 , 2007 2007 Citations: 58
A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam F Kienzler‐Norwood, L Costard, C Sadangi, P Müller, V Neubert, S Bauer, ... Epilepsia 58 (2), 222-230 , 2017 2017 Citations: 44
Personalized translational epilepsy research—Novel approaches and future perspectives: Part I: Clinical and network analysis approaches F Rosenow, N van Alphen, A Becker, A Chiocchetti, R Deichmann, ... Epilepsy & behavior 76, 13-18 , 2017 2017 Citations: 38
Electrical stimulation‐induced seizures in rats: a “dose‐response” study on resultant neurodegeneration BA Norwood, S Bauer, S Wegner, HM Hamer, WH Oertel, RS Sloviter, ... Epilepsia 52 (9), e109-e112 , 2011 2011 Citations: 33
Enrichment of circular RNA expression deregulation at the transition to recurrent spontaneous seizures in experimental temporal lobe epilepsy A Gomes-Duarte, S Bauer, MT Venø, BA Norwood, DC Henshall, J Kjems, ... Frontiers in genetics 12, 627907 , 2021 2021 Citations: 27
RNA sequencing reveals region-specific molecular mechanisms associated with epileptogenesis in a model of classical hippocampal sclerosis AS Vieira, AH De Matos, AM Do Canto, CS Rocha, BS Carvalho, ... Scientific reports 6 (1), 22416 , 2016 2016 Citations: 26
Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances AM do Canto, AS Vieira, A HB Matos, BS Carvalho, B Henning, ... Scientific reports 10 (1), 4412 , 2020 2020 Citations: 24
Personalized translational epilepsy research—novel approaches and future perspectives: part II: experimental and translational approaches S Bauer, N van Alphen, A Becker, A Chiocchetti, R Deichmann, T Deller, ... Epilepsy & behavior 76, 7-12 , 2017 2017 Citations: 23
Validation of reference genes for quantitative gene expression analysis in experimental epilepsy C Sadangi, F Rosenow, BA Norwood Journal of Neuroscience Research , 2017 2017 Citations: 15
Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis JL Will, MT Eckart, F Rosenow, S Bauer, WH Oertel, RKW Schwarting, ... Behavioural brain research 247, 65-72 , 2013 2013 Citations: 13
STARTUP
Lutroo Imaging is developing a proprietary PET radiotracer to enable pain visualization for the first time. This will make pain diagnosis faster, cheaper, and more accurate, thereby dramatically improving pain care and quality of life. By being able to see the pain source, healthcare professionals will be able to treat it appropriately with earlier, targeted Imaging is developing a proprietary PET radiotracer to enable pain visualization for the first time. This will make pain diagnosis faster, cheaper, and more accurate, thereby dramatically improving pain care and quality of life. By being able to see the pain source, healthcare professionals will be able to treat it appropriately with earlier, targeted therapy.
Unbreakables Foundation is a 501(c)(3) nonprofit that exists to help give those at the greatest disadvantage the chance for a brighter future. Our purpose is to improve the welfare and self-reliance of people living underprivileged lives, both in the United States and former conflict Foundation is a 501(c)(3) nonprofit that exists to help give those at the greatest disadvantage the chance for a brighter future. Our purpose is to improve the welfare and self-reliance of people living underprivileged lives, both in the United States and former conflict zones.
Redpoint Imaging is a nuclear medicine company focused on providing radiotracers to an under-served healthcare market.
