Braxton Norwood

Braxton Norwood PhD is a scientist-entrepreneur focused on transforming the diagnosis and treatment of human health disorders. Driven more by data and (potential) impact than by revenue or investment returns. I enjoy taking calculated risks and attacking big problems with creative solutions. Firm believer in responsible capitalism.

Dr. Braxton Norwood is founder of four biopharma/medtech companies, served in executive/director roles, e.g. CEO and Director of R&D. I've led drug and radiotracer development from discovery to Phase II clinical trials. These ventures have been funded by public (NIH SBIR grants) and private (Angel and VC) sources. 20+ peer-reviewed scientific articles and multiple filed/granted patents.

He enjoys rock climbing, aviation, and whisky (not simultaneously).

EDUCATION

Bachelor of Arts in Anthropology, University of Arizona, 2004. Minors: Biochemistry, Pre-health
PhD in Medical Pharmacology, University of Arizona, 2009. Minor: Neuroscience

RESEARCH, TEACHING, or OTHER INTERESTS

Drug Discovery, Neuroscience

FUTURE PROJECTS

RECENT SCHOLAR PUBLICATIONS

Radiotracers in the Diagnosis of Pain: A Mini Review
J Hascalovici, A Babb, BA Norwood
Seminars in Musculoskeletal Radiology 27 (06), 655-660 2023



Radiocaine: an imaging marker of neuropathic injury
ND Bartolo, SE Reid, HS Krishnan, A Haseki, M Renganathan, ...
ACS Chemical Neuroscience 13 (24), 3661-3667 2022



Enrichment of circular RNA expression deregulation at the transition to recurrent spontaneous seizures in experimental temporal lobe epilepsy
A Gomes-Duarte, S Bauer, MT Ven, BA Norwood, DC Henshall, J Kjems, ...
Frontiers in genetics 12, 627907 2021



Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy
GP Brennan, S Bauer, T Engel, EM Jimenez-Mateos, F Del Gallo, ...
Neurobiology of Disease 144, 105048 2020



A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy
MT Ven, CR Reschke, G Morris, NMC Connolly, J Su, Y Yan, T Engel, ...
Proceedings of the National Academy of Sciences 117 (27), 15977-15988 2020



Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances
AM do Canto, AS Vieira, A HB Matos, BS Carvalho, B Henning, ...
Scientific Reports 10 (1), 4412 2020



the developmental seizure-induced hippocampal mossy fiber sprouting: target for epilepsy therapies?
H Ni, T Kirschstein, BA Norwood, CL Hsieh
Frontiers in Neurology 10, 1212 2019



Ago2-seq identifies new microRNA targets for seizure control
MT Ven, CR Reschke, G Morris, NMC Connolly, J Su, Y Yan, T Engel, ...
bioRxiv, 777144 2019



Personalized translational epilepsy research—Novel approaches and future perspectives: Part I: Clinical and network analysis approaches
F Rosenow, N van Alphen, A Becker, A Chiocchetti, R Deichmann, ...
Epilepsy & Behavior 76, 13-18 2017



Personalized translational epilepsy research—novel approaches and future perspectives: part II: experimental and translational approaches
S Bauer, N van Alphen, A Becker, A Chiocchetti, R Deichmann, T Deller, ...
Epilepsy & Behavior 76, 7-12 2017



Neuroinflammatory targets and treatments for epilepsy validated in experimental models
E Aronica, S Bauer, Y Bozzi, M Caleo, R Dingledine, JA Gorter, ...
Epilepsia 58, 27-38 2017



A microRNA‐129‐5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses
M Rajman, F Metge, R Fiore, S Khudayberdiev, A Aksoy‐Aksel, S Bicker, ...
The EMBO journal 36 (12), 1770-1787 2017



Validation of reference genes for quantitative gene expression analysis in experimental epilepsy
C Sadangi, F Rosenow, BA Norwood
Journal of Neuroscience Research 2017



Potent anti-seizure effects of locked nucleic acid antagomirs targeting miR-134 in multiple mouse and rat models of epilepsy
CR Reschke, LFA Silva, BA Norwood, K Senthilkumar, G Morris, ...
Molecular Therapy-Nucleic Acids 6, 45-56 2017



A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam
F Kienzler‐Norwood, L Costard, C Sadangi, P Mller, V Neubert, S Bauer, ...
Epilepsia 58 (2), 222-230 2017



MiRNA-135a regulates the expression of small conductance calcium-activated potassium (SK3) channels in epilepsy-like conditions
B Honrath, B Norwood, G Tanrioever, K Kuter, DC Henshall, ...
8th Annual Alliance for Healthy Aging Conference 2017



Removing entorhinal cortex input to the dentate gyrus does not impede low frequency oscillations, an EEG-biomarker of hippocampal epileptogenesis
M Meyer, F Kienzler-Norwood, S Bauer, F Rosenow, BA Norwood
Scientific reports 6 (1), 25660 2016



RNA sequencing reveals region-specific molecular mechanisms associated with epileptogenesis in a model of classical hippocampal sclerosis
AS Vieira, AH De Matos, AM Do Canto, CS Rocha, BS Carvalho, ...
Scientific reports 6 (1), 22416 2016



A COMPARATIVE STUDY OF PERFORANT PATHWAY STIMULATION IN C57BL/6 MICE AND SPRAGUE-DAWLEY RATS
F Kienzler-Norwood, F Rosenow, BA Norwood
EPILEPSIA 55, 120-120 2014



THE EFFECTS OF ENTORHINAL CORTEX LESION ON EPILEPTOGENESIS IN A TOXIN-FREE ANIMAL MODEL OF TEMPORAL LOBE EPILEPSY
M Meyer, S Bauer, F Rosenow, B Norwood
EPILEPSIA 55, 54-54 2014

MOST CITED SCHOLAR PUBLICATIONS

Cytokines and epilepsy
G Li, S Bauer, M Nowak, B Norwood, B Tackenberg, F Rosenow, S Knake, ...
Seizure 20 (3), 249-256 2011
Citations: 343



Neuroinflammatory targets and treatments for epilepsy validated in experimental models
E Aronica, S Bauer, Y Bozzi, M Caleo, R Dingledine, JA Gorter, ...
Epilepsia 58, 27-38 2017
Citations: 191



Classic hippocampal sclerosis and hippocampal‐onset epilepsy produced by a single “cryptic” episode of focal hippocampal excitation in awake rats
BA Norwood, AV Bumanglag, F Osculati, A Sbarbati, P Marzola, ...
Journal of Comparative Neurology 518 (16), 3381-3407 2010
Citations: 103



A microRNA‐129‐5p/Rbfox crosstalk coordinates homeostatic downscaling of excitatory synapses
M Rajman, F Metge, R Fiore, S Khudayberdiev, A Aksoy‐Aksel, S Bicker, ...
The EMBO journal 36 (12), 1770-1787 2017
Citations: 97



Potent anti-seizure effects of locked nucleic acid antagomirs targeting miR-134 in multiple mouse and rat models of epilepsy
CR Reschke, LFA Silva, BA Norwood, K Senthilkumar, G Morris, ...
Molecular Therapy-Nucleic Acids 6, 45-56 2017
Citations: 90



Interictal alterations of cytokines and leukocytes in patients with active epilepsy
M Nowak, S Bauer, A Haag, S Cepok, A Todorova-Rudolph, ...
Brain, behavior, and immunity 25 (3), 423-428 2011
Citations: 87



Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation‐induced status epilepticus in the mouse
F Kienzler, BA Norwood, RS Sloviter
Journal of Comparative Neurology 515 (2), 181-196 2009
Citations: 85



A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy
MT Ven, CR Reschke, G Morris, NMC Connolly, J Su, Y Yan, T Engel, ...
Proceedings of the National Academy of Sciences 117 (27), 15977-15988 2020
Citations: 56



Minocycline as potent anticonvulsant in a patient with astrocytoma and drug resistant epilepsy
M Nowak, A Strzelczyk, PS Reif, K Schorlemmer, S Bauer, BA Norwood, ...
Seizure 21 (3), 227-228 2012
Citations: 56



On the relevance of prolonged convulsive status epilepticus in animals to the etiology and neurobiology of human temporal lobe epilepsy.
RS Sloviter, CA Zappone, AV Bumanglag, BA Norwood, H Kudrimoti
Epilepsia (Series 4) 48 2007
Citations: 55



Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy
GP Brennan, S Bauer, T Engel, EM Jimenez-Mateos, F Del Gallo, ...
Neurobiology of Disease 144, 105048 2020
Citations: 52



A novel animal model of acquired human temporal lobe epilepsy based on the simultaneous administration of kainic acid and lorazepam
F Kienzler‐Norwood, L Costard, C Sadangi, P Mller, V Neubert, S Bauer, ...
Epilepsia 58 (2), 222-230 2017
Citations: 38



Personalized translational epilepsy research—Novel approaches and future perspectives: Part I: Clinical and network analysis approaches
F Rosenow, N van Alphen, A Becker, A Chiocchetti, R Deichmann, ...
Epilepsy & Behavior 76, 13-18 2017
Citations: 36



Electrical stimulation‐induced seizures in rats: a “dose‐response” study on resultant neurodegeneration
BA Norwood, S Bauer, S Wegner, HM Hamer, WH Oertel, RS Sloviter, ...
Epilepsia 52 (9), e109-e112 2011
Citations: 31



RNA sequencing reveals region-specific molecular mechanisms associated with epileptogenesis in a model of classical hippocampal sclerosis
AS Vieira, AH De Matos, AM Do Canto, CS Rocha, BS Carvalho, ...
Scientific reports 6 (1), 22416 2016
Citations: 23



Enrichment of circular RNA expression deregulation at the transition to recurrent spontaneous seizures in experimental temporal lobe epilepsy
A Gomes-Duarte, S Bauer, MT Ven, BA Norwood, DC Henshall, J Kjems, ...
Frontiers in genetics 12, 627907 2021
Citations: 22



Laser microdissection-based microproteomics of the hippocampus of a rat epilepsy model reveals regional differences in protein abundances
AM do Canto, AS Vieira, A HB Matos, BS Carvalho, B Henning, ...
Scientific Reports 10 (1), 4412 2020
Citations: 20



Personalized translational epilepsy research—novel approaches and future perspectives: part II: experimental and translational approaches
S Bauer, N van Alphen, A Becker, A Chiocchetti, R Deichmann, T Deller, ...
Epilepsy & Behavior 76, 7-12 2017
Citations: 20



Validation of reference genes for quantitative gene expression analysis in experimental epilepsy
C Sadangi, F Rosenow, BA Norwood
Journal of Neuroscience Research 2017
Citations: 14



Enhanced sequential reaction time task performance in a rat model of mesial temporal lobe epilepsy with classic hippocampal sclerosis
JL Will, MT Eckart, F Rosenow, S Bauer, WH Oertel, RKW Schwarting, ...
Behavioural brain research 247, 65-72 2013
Citations: 12

STARTUP

Lutroo Imaging is developing a proprietary PET radiotracer to enable pain visualization for the first time. This will make pain diagnosis faster, cheaper, and more accurate, thereby dramatically improving pain care and quality of life. By being able to see the pain source, healthcare professionals will be able to treat it appropriately with earlier, targeted Imaging is developing a proprietary PET radiotracer to enable pain visualization for the first time. This will make pain diagnosis faster, cheaper, and more accurate, thereby dramatically improving pain care and quality of life. By being able to see the pain source, healthcare professionals will be able to treat it appropriately with earlier, targeted therapy.

Unbreakables Foundation is a 501(c)(3) nonprofit that exists to help give those at the greatest disadvantage the chance for a brighter future. Our purpose is to improve the welfare and self-reliance of people living underprivileged lives, both in the United States and former conflict Foundation is a 501(c)(3) nonprofit that exists to help give those at the greatest disadvantage the chance for a brighter future. Our purpose is to improve the welfare and self-reliance of people living underprivileged lives, both in the United States and former conflict zones.

Redpoint Imaging is a nuclear medicine company focused on providing radiotracers to an under-served healthcare market.