BRINDHA BANU B

 Since June 2011, I have been working as an Assistant Professor in the Department of Biochemistry at Dr. MGR Janaki College of Arts and Sciences in Adyar, Tamilnadu.
 From June 2006 to March 2008, I worked as a lecturer at Nilgiri College of Arts and Sciences.

EDUCATION

• PhD (Biochemistry), Kongunadu Arts and Science College, Coimbatore affiliated to Bharathiar University, Coimbatore, completed in 2020.
• M.phil (Biochemistry), Bharathidasan University, Trichy, completed in August 2006, Percentage – 75.6 %.
• M.Sc (Biochemistry), Kongunadu Arts and Science College Coimbatore affiliated to Bharathiar University, Bharathidasan University. Completed in May 2005, Percentage – 62.6%.
• B.Sc (Biochemistry), Ponnaiyah Ramajayam College of arts and science, Thanjavur. Affiliated to Bharathidasan University, completed in May 2003, Percentage – 64.5%

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Cell Biology, Clinical Biochemistry, General Biochemistry, Genetics and Molecular Biology

Scopus Publications

Nicotine sensing behavior of nickel(II) complexes catalyzed oxidation and coupling reactions
Madaselvi Rathinam, Paranthaman Vijayan, Selvakumar Balasubramanian, Sasikumar Ponnusamy, Arunachalam SaravanaVadivu, Mohamed Abbas, Brindha Banu Balakrishnan
Heliyon, 2024
One of the main source of demise during the next ten years will be coronary heart disease and stroke, which are brought on by smoking (nicotine). To identify the percentage (%) of nicotine consumption by electrocatalytic sensor towards nicotine for target-specific prevent stroke, four uninuclear Ni 2+ complexes of substituted butanimidamide Schiff base ligands [H 2 L 1-4 ] was prepared. All the complexes were thoroughly analyzed by using several spectroscopic techniques such as CHNS analysis, FT-IR, NMR ( 1 H & 13 C) UV–Vis and NMR. The analyses showed tetradentate binding mode of ligand around nickel(II) metal ion leads to the structure of square planar with N 2 X 2 (X = O, S) donor fashion. In addition, the well-defined nickel(II) complexes were utilized for oxidation of various alcohols such as cyclohexanol, and benzyl alcohol were produced to the assorted oxidized products with high yield respectively using greener co-oxidant (molecular oxygen). In addition, Nickel(II) complexes was further utilized as catalyst for aryl-aryl coupling reaction via Suzuki-Mayura method to obtain biphenyl compound. Furthermore, nickel(II) complexes were exploited for electrochemical detection of nicotine sensing in μM concentration.
Effects of quercetin on ultrafine petrol exhaust nanoparticles induced DNA damage, oxidative stress and inflammation in different sections of rat brain
Mohan Durga, Mayakrishnan Vijayakumar, Kannappan Priya, Shenbaga Vidhya Kanagarajan, Balakrishnan Brindha Banu, Victoriya Salomi Michael Abraham, Thiyagarajan Devasena, Mohamed A. Abdelaziz, Abubucker Peer Mohideen, Nasraddin Othman Bahakim, Mohammad Shahid, Shaban Ragab Ibrahim, Thiyagarajan Ramesh
Journal of King Saud University Science, 2022
The major constituent of air pollution is petrol exhaust a complex mixture of particles, gases and chemicals. The aim of the current research was to evaluate whether ultrafine petrol exhaust nanoparticles (PENPs), the particle component of exhaust from petrol engines can induce neurotoxicity in rats. We administered rats with repeated doses of PENPs (90 μg/rat and 180 μg/rat for 6 days (every second day) intratracheally (i.t.). This was followed by the evaluation of several neurotoxicity parameters in various sections of rat brain. PENP exposure caused surge in levels of inflammatory mediators such as reactive oxygen species (ROS) and neurodegenerative disorder indicators like amyloid beta 42 (Aβ42) levels in rat brain. Each section of the brain responded differently upon PENP exposure. Prior treatment with quercetin (60 mg/kg b.wt) inhibited elevation in the aforementioned parameters. Hence, PENP exposure was closely linked to neurotoxicity and the neuroprotective capacity of quercetin was also proved.
Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats
Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Vijayakumar Mayakrishnan, Arokiyaraj Selvaraj
Biomedicine and Pharmacotherapy, 2019
The current study investigates the effects of ethanolic extract of M. concanensis Nimmo leaves (EEMCNL) with respect to its potent protective tissue damage, antioxidant properties in serum, liver and kidney, histopathological evaluation, and PPARγ and GLUT4 gene expression in liver and pancreatic tissue of Streptozotocin-Nicotinamide (STZ-NA) induced diabetic rats. Animals were divided into five groups (n = 5): control; diabetic; diabetic + EEMCNL; control + EEMCNL; and diabetic + glibenclamide. After 45 days of treatment with EEMCNL, MDA levels were significantly decreased in the diabetic-induced group when compared with the STZ-induced diabetic group (P < 0.05). The activities of serum enzymes AST, ALT, ALP, ACP and LDH were significantly decreased in serum and kidney, and increased in liver tissues of the EEMCNL-treated group as compared with the STZ-NA induced diabetic group (P < 0.05). The levels of total protein, urea, creatinine and uric acid observed in the diabetic group returned to normal by administration of EEMCNL (250 mg/kg) as relative to the STZ-NA induced diabetic group (P < 0.05). Furthermore, EEMCNL upregulated PPARγ and GLUT4 expression in liver and pancreatic tissue of the STZ-NA induced diabetic group rats. Taken together, these findings contribute to a better understanding of the hepatoprotective and renoprotective potential of EEMCNL against oxidative stress in the diabetic state, which was evidenced by the capacity of EEMCNL to modulate the antioxidant defence and to decrease lipid peroxidation in these tissues.
Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-γ, C/EBP-α via Akt signaling pathway and STZ-induced diabetic rats
Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Ki Choon Choi
Biomedicine and Pharmacotherapy, 2018

RECENT SCHOLAR PUBLICATIONS

Nicotine sensing behavior of nickel (II) complexes catalyzed oxidation and coupling reactions
M Rathinam, P Vijayan, S Balasubramanian, S Ponnusamy, ...
Heliyon 10 (6) , 2024
2024
Citations: 2
Catechin, as an Emerging Front-line Defense Flavonoid against Stress-Related Disorders: An Updated Review
BBBDR Vaishnavi M, Raksha B, Durga M*
International Journal of Pharmacy and Biological Sciences 13 (3), 14 , 2023
2023
Nanoencapsulation of luteolin: enhancing bioavailability and medicinal benefits
B Raksha, M Vaishnavi, M Durga, BB Brindha, R Deepikaa
Int J Pharm Pharm Sci https://doi. org/10.22159/ijpps. 2023v15i12 49440 , 2023
2023
Citations: 6
Effects of quercetin on ultrafine petrol exhaust nanoparticles induced DNA damage, oxidative stress and inflammation in different sections of rat brain
M Durga, M Vijayakumar, K Priya, SV Kanagarajan, BB Banu, ...
Journal of King Saud University-Science 34 (2), 101813 , 2022
2022
Citations: 8
Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin …
BB Balakrishnan, K Krishnasamy, V Mayakrishnan, A Selvaraj
Biomedicine & pharmacotherapy 112, 108688 , 2019
2019
Citations: 51
Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-γ, C/EBP-α via Akt signaling pathway and STZ-induced diabetic rats
BB Balakrishnan, K Krishnasamy, KC Choi
Biomedicine & Pharmacotherapy 103, 719-728 , 2018
2018
Citations: 43
Evaluation of free radical screening and antioxidant potential of Moringa concanensis nimmo-a …
BB Balakrishnan, K Krishnasamy
Int J Pharm Pharm Sci 10, 91-7 , 2018
2018
Citations: 11
Toxicity study of the ethanolic extract of Moringa concanensis Nimmo leaves in Wistar rats
BBBK Krishnasamy.
international journal of pharma and bio sciences 9 (2), 57-62 , 2017
2017
Citations: 3
In silico Molecular docking study on the interaction between adenosine monophosphate-activated protein kinase (AMPK) and bioactive compounds of Moringa concanensis Nimmo as a …
BB Banu, K Jenifer
Int.J.Curr.Res.Aca.Rev. 4 (Special Issue), 8 , 2017
2017
Insilico Docking Analysis of Bioactive ompounds from Moringa concanesis Nimmo against MabA (FabG1) Protein to Predict it Antibacterial Activity
BB Banu, S Santhi, R Tobika
Int.J.Curr.Res.Aca.Rev. 3 (Special Issue), 8 , 2016
2016
In-Silico Approach to Predict the Antifungal Activity of Compounds from Moringa concanesis Nimmo against Flavohemoprotein (YHB1)
BB Banu, R Tobika, S Santhi
Int.J.Curr.Res.Aca.Rev. 3 (Special Issue), 8 , 2016
2016

MOST CITED SCHOLAR PUBLICATIONS

Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin …
BB Balakrishnan, K Krishnasamy, V Mayakrishnan, A Selvaraj
Biomedicine & pharmacotherapy 112, 108688 , 2019
2019
Citations: 51
Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-γ, C/EBP-α via Akt signaling pathway and STZ-induced diabetic rats
BB Balakrishnan, K Krishnasamy, KC Choi
Biomedicine & Pharmacotherapy 103, 719-728 , 2018
2018
Citations: 43
Evaluation of free radical screening and antioxidant potential of Moringa concanensis nimmo-a …
BB Balakrishnan, K Krishnasamy
Int J Pharm Pharm Sci 10, 91-7 , 2018
2018
Citations: 11
Effects of quercetin on ultrafine petrol exhaust nanoparticles induced DNA damage, oxidative stress and inflammation in different sections of rat brain
M Durga, M Vijayakumar, K Priya, SV Kanagarajan, BB Banu, ...
Journal of King Saud University-Science 34 (2), 101813 , 2022
2022
Citations: 8
Nanoencapsulation of luteolin: enhancing bioavailability and medicinal benefits
B Raksha, M Vaishnavi, M Durga, BB Brindha, R Deepikaa
Int J Pharm Pharm Sci https://doi. org/10.22159/ijpps. 2023v15i12 49440 , 2023
2023
Citations: 6
Toxicity study of the ethanolic extract of Moringa concanensis Nimmo leaves in Wistar rats
BBBK Krishnasamy.
international journal of pharma and bio sciences 9 (2), 57-62 , 2017
2017
Citations: 3
Nicotine sensing behavior of nickel (II) complexes catalyzed oxidation and coupling reactions
M Rathinam, P Vijayan, S Balasubramanian, S Ponnusamy, ...
Heliyon 10 (6) , 2024
2024
Citations: 2
Catechin, as an Emerging Front-line Defense Flavonoid against Stress-Related Disorders: An Updated Review
BBBDR Vaishnavi M, Raksha B, Durga M*
International Journal of Pharmacy and Biological Sciences 13 (3), 14 , 2023
2023
In silico Molecular docking study on the interaction between adenosine monophosphate-activated protein kinase (AMPK) and bioactive compounds of Moringa concanensis Nimmo as a …
BB Banu, K Jenifer
Int.J.Curr.Res.Aca.Rev. 4 (Special Issue), 8 , 2017
2017
Insilico Docking Analysis of Bioactive ompounds from Moringa concanesis Nimmo against MabA (FabG1) Protein to Predict it Antibacterial Activity
BB Banu, S Santhi, R Tobika
Int.J.Curr.Res.Aca.Rev. 3 (Special Issue), 8 , 2016
2016
In-Silico Approach to Predict the Antifungal Activity of Compounds from Moringa concanesis Nimmo against Flavohemoprotein (YHB1)
BB Banu, R Tobika, S Santhi
Int.J.Curr.Res.Aca.Rev. 3 (Special Issue), 8 , 2016
2016