COSTANZA MONTAGNA

@unicamillus.org

UniCamillus



                 

https://researchid.co/costanzamontagna
2

Scopus Publications

1178

Scholar Citations

1

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation
    Salvatore Rizza, Luca Di Leo, Chiara Pecorari, Paola Giglio, Fiorella Faienza, Costanza Montagna, Emiliano Maiani, Michele Puglia, Francesca M. Bosisio, Trine Skov Petersen,et al.
    Elsevier BV


  • Autophagy guards tendon homeostasis
    Costanza Montagna, Rene B. Svensson, Monika L. Bayer, Salvatore Rizza, Emiliano Maiani, Ching-Yan Chloé Yeung, Giuseppe Filomeni, and Michael Kjær
    Springer Science and Business Media LLC
    AbstractTendons are vital collagen-dense specialized connective tissues transducing the force from skeletal muscle to the bone, thus enabling movement of the human body. Tendon cells adjust matrix turnover in response to physiological tissue loading and pathological overloading (tendinopathy). Nevertheless, the regulation of tendon matrix quality control is still poorly understood and the pathogenesis of tendinopathy is presently unsolved. Autophagy, the major mechanism of degradation and recycling of cellular components, plays a fundamental role in the homeostasis of several tissues. Here, we investigate the contribution of autophagy to human tendons’ physiology, and we provide in vivo evidence that it is an active process in human tendon tissue. We show that selective autophagy of the endoplasmic reticulum (ER-phagy), regulates the secretion of type I procollagen (PC1), the major component of tendon extracellular matrix. Pharmacological activation of autophagy by inhibition of mTOR pathway alters the ultrastructural morphology of three-dimensional tissue-engineered tendons, shifting collagen fibrils size distribution. Moreover, autophagy induction negatively affects the biomechanical properties of the tissue-engineered tendons, causing a reduction in mechanical strength under tensile force. Overall, our results provide the first evidence that autophagy regulates tendon homeostasis by controlling PC1 quality control, thus potentially playing a role in the development of injured tendons.

  • AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
    Emiliano Maiani, Giacomo Milletti, Francesca Nazio, Søs Grønbæk Holdgaard, Jirina Bartkova, Salvatore Rizza, Valentina Cianfanelli, Mar Lorente, Daniele Simoneschi, Miriam Di Marco,et al.
    Springer Science and Business Media LLC
    Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance. The key cell-fate decision to replicate the genome is controlled by two major signalling pathways that act in parallel-the MYC pathway and the cyclin D-cyclin-dependent kinase (CDK)-retinoblastoma protein (RB) pathway1,2. Both MYC and the cyclin D-CDK-RB axis are commonly deregulated in cancer, and this is associated with increased genomic instability. The autophagic tumour-suppressor protein AMBRA1 has been linked to the control of cell proliferation, but the underlying molecular mechanisms remain poorly understood. Here we show that AMBRA1 is an upstream master regulator of the transition from G1 to S phase and thereby prevents replication stress. Using a combination of cell and molecular approaches and in vivo models, we reveal that AMBRA1 regulates the abundance of D-type cyclins by mediating their degradation. Furthermore, by controlling the transition from G1 to S phase, AMBRA1 helps to maintain genomic integrity during DNA replication, which counteracts developmental abnormalities and tumour growth. Finally, we identify the CHK1 kinase as a potential therapeutic target in AMBRA1-deficient tumours. These results advance our understanding of the control of replication-phase entry and genomic integrity, and identify the AMBRA1-cyclin D pathway as a crucial cell-cycle-regulatory mechanism that is deeply interconnected with genomic stability in embryonic development and tumorigenesis.

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
    D. Klionsky, Amal Abdelaziz, Sara Abdelfatah, M. Abdellatif, A. Abdoli, S. Abel, H. Abeliovich, Marie H Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena,et al.

    In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

  • Comparison of tenocyte populations from the core and periphery of equine tendons
    Cheng Zhang, Rene B. Svensson, Costanza Montagna, Helena Carstensen, Rikke Buhl, Erwin M. Schoof, Michael Kjaer, S. Peter Magnusson, and Ching-Yan Chloé Yeung
    American Chemical Society (ACS)
    Tendon is a highly organized, dense connective tissue that has been demonstrated to have very little turnover. In spite of the low turnover, tendon can grow in response to loading, which may take place primarily at the periphery. Tendon injuries and recurrence of injuries are common in both human and animal in sports. It is unclear why some areas of the tendon are more susceptible to such injury and whether this is due to intrinsic regional differences in extracellular matrix (ECM) production or tissue turnover. This study aimed to compare populations of tenocytes derived from the tendon core and periphery. Tenocytes were isolated from equine superficial digital flexor tendons (SDFT), and the proliferation capacity was determined. ECM production was characterized by immuno- and histological staining and by liquid chromatography-mass spectrometry-based proteomics. Core and periphery SDFT cultures exhibited comparable proliferation rates and had very similar proteome profiles, but showed biological variation in collagen type I deposition. In conclusion, the intrinsic properties of tenocytes from different regions of the tendon are very similar and other factors in the tissue may contribute to how specific areas respond to loading or injury.

  • When S-Nitrosylation gets to mitochondria: From signaling to age-related diseases
    Costanza Montagna, Claudia Cirotti, Salvatore Rizza, and Giuseppe Filomeni
    Mary Ann Liebert Inc
    SIGNIFICANCE Cysteines have an essential role in redox signaling, transforming an oxidant signal into a biological response. Among reversible cysteine post-translational modifications, S-nitrosylation acts as a redox-switch in several patho-physiological events, such as ischemia-reperfusion, synaptic transmission, cancer, and muscular dysfunctions. Recent Advances: Growing pieces of in vitro and in vivo evidence argue for S-nitrosylation being deeply involved in development and aging, and playing a role in the onset of different pathological states. New findings suggest it being an enzymatically regulated cellular process, with deep impact on mitochondrial structure and function, and in cellular metabolism. In light of this, the recent discovery of the new denitrosylase S-nitrosoCoA reductase takes on even greater importance and opens new perspectives on S-nitrosylation as general mechanism of cellular homeostasis. CRITICAL ISSUES Based on these recent findings, we aim at summarizing and elaborating on the established and emerging crucial roles of S-nitrosylation in mitochondrial metabolism and mitophagy, and provide an overview of the patho-physiological effects induced by its deregulation. FUTURE DIRECTIONS The identification of new S-nitrosylation targets, and the comprehension of the mechanisms through which S-nitrosylation modulates specific classes of proteins, i.e. those impinging on diverse mitochondrial functions, may help better understand the pathophysiology of aging, and propose lines of intervention to slow down or extend the onset of aging-related diseases.

  • nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis
    Costanza Montagna, Salvatore Rizza, Claudia Cirotti, Emiliano Maiani, Maurizio Muscaritoli, Antonio Musarò, Maria Teresa Carrí, Elisabetta Ferraro, Francesco Cecconi, and Giuseppe Filomeni
    Springer Science and Business Media LLC
    Neuronal nitric oxide synthase (nNOS) plays a crucial role in the maintenance of correct skeletal muscle function due, at least in part, to S-nitrosylation of specific protein targets. Similarly, we recently provided evidence for a muscular phenotype in mice lacking the denitrosylase S-nitrosoglutathione reductase (GSNOR). Here, we demonstrate that nNOS and GSNOR are concomitantly expressed during differentiation of C2C12. They colocalizes at the sarcolemma and co-immunoprecipitate in cells and in myofibers. We also provide evidence that GSNOR expression decreases in mouse models of muscular dystrophies and of muscle atrophy and wasting, i.e., aging and amyotrophic lateral sclerosis, suggesting a more general regulatory role of GSNOR in skeletal muscle homeostasis.

  • S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy
    Salvatore Rizza, Simone Cardaci, Costanza Montagna, Giuseppina Di Giacomo, Daniela De Zio, Matteo Bordi, Emiliano Maiani, Silvia Campello, Antonella Borreca, Annibale A. Puca,et al.
    Proceedings of the National Academy of Sciences
    S-nitrosylation, a prototypic redox-based posttranslational modification, is frequently dysregulated in disease. S-nitrosoglutathione reductase (GSNOR) regulates protein S-nitrosylation by functioning as a protein denitrosylase. Deficiency of GSNOR results in tumorigenesis and disrupts cellular homeostasis broadly, including metabolic, cardiovascular, and immune function. Here, we demonstrate that GSNOR expression decreases in primary cells undergoing senescence, as well as in mice and humans during their life span. In stark contrast, exceptionally long-lived individuals maintain GSNOR levels. We also show that GSNOR deficiency promotes mitochondrial nitrosative stress, including excessive S-nitrosylation of Drp1 and Parkin, thereby impairing mitochondrial dynamics and mitophagy. Our findings implicate GSNOR in mammalian longevity, suggest a molecular link between protein S-nitrosylation and mitochondria quality control in aging, and provide a redox-based perspective on aging with direct therapeutic implications.

  • To eat, or NOt to eat: S-nitrosylation signaling in autophagy
    Costanza Montagna, Salvatore Rizza, Emiliano Maiani, Lucia Piredda, Giuseppe Filomeni, and Francesco Cecconi
    Wiley
    Autophagy is the main catabolic cellular process through which cells adapt their needs (e.g., growth and proliferation) to environmental availability of nutrients (e.g., amino acid and glucose) and growth factors. The rapid activation of the autophagy response essentially depends on protein post‐translational modifications (PTMs), which act as molecular switches triggering signaling cascades. Deregulation of autophagy contributes to pathological conditions, such as cancer and neurodegeneration. Therefore, understanding how PTMs affect the occurrence of autophagy is of the highest importance for clinical applications. Besides phosphorylation and ubiquitylation, which represent the best known examples of PTMs, redox‐based modifications are also emerging as contributing to the regulation of intracellular signaling. Of note, S‐nitrosylation of cysteine residues is a redox PTM and is the principal mechanism of nitric oxide‐based signaling. Results emerging in recent years suggest that NO has a role in modulating autophagy. However, the function of S‐nitrosylation in autophagy regulation remains still unveiled. By this review, we describe the upstream events regulating autophagy activation focusing on recently published evidence implying a S‐nitrosylation‐dependent regulation.

  • Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP<sup>+</sup>
    Barbara Benassi, Giuseppe Filomeni, Costanza Montagna, Caterina Merla, Vanni Lopresto, Rosanna Pinto, Carmela Marino, and Claudia Consales
    Springer Science and Business Media LLC
    Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss, with an etiopathogenesis involving both genetic and environmental factors. The occupational/residential exposure to the electromagnetic fields has been recently associated with an increased risk of neurodegenerative diseases; it has been thus proposed that the extremely low frequency magnetic field (ELF-MF) may contribute to neurodegenerative etiopathogenesis, as its interaction with biological systems directly impairs redox homeostasis in specific areas of the brain. The molecular mechanisms elicited by ELF-MF, and their potential involvement in PD onset, still remain unclear. To this end, we set up a generator of ELF-MF able to stably and homogeneously reproduce environmental prolonged exposure to ELF-MF (50 Hz, 1 mT). Results obtained indicate that ELF-MF exposure alters cell response of SH-SY5Y cells to MPP+. We demonstrate that ELF-MF does not affect per se survival, shape, and morphology of both proliferating and differentiated SH-SY5Y cells but significantly impairs redox homeostasis and thiol content, triggering an increase in protein carbonylation. As a result, toxicity of MPP+, even at low doses, is highly enhanced in ELF-MF-exposed cells due to a significant increase in ROS levels, potentiation of oxidative damage, and induction of a caspase-dependent apoptosis. Pre-incubation with the thiol antioxidants N-acetyl-l-cysteine and GSH ethyl-ester significantly reduces the extent of oxidative damage and protects cells from death induced by the combined treatment ELF-MF/MPP+. Taken overall, our results demonstrate the redox-based molecular interaction between ELF-MF and PD neurotoxins in vitro, and open a new scenario for defining the synergy of environmental factors in PD onset.

  • S-nitrosylation of the mitochondrial chaperone TRAP1 sensitizes hepatocellular carcinoma cells to inhibitors of succinate dehydrogenase
    Salvatore Rizza, Costanza Montagna, Simone Cardaci, Emiliano Maiani, Giuseppina Di Giacomo, Virginia Sanchez-Quiles, Blagoy Blagoev, Andrea Rasola, Daniela De Zio, Jonathan S. Stamler,et al.
    American Association for Cancer Research (AACR)
    S-nitrosoglutathione reductase (GSNOR) represents the best-documented denitrosylase implicated in regulating the levels of proteins posttranslationally modified by nitric oxide on cysteine residues by S-nitrosylation. GSNOR controls a diverse array of physiologic functions, including cellular growth and differentiation, inflammation, and metabolism. Chromosomal deletion of GSNOR results in pathologic protein S-nitrosylation that is implicated in human hepatocellular carcinoma (HCC). Here we identify a metabolic hallmark of aberrant S-nitrosylation in HCC and exploit it for therapeutic gain. We find that hepatocyte GSNOR deficiency is characterized by mitochondrial alteration and by marked increases in succinate dehydrogenase (SDH) levels and activity. We find that this depends on the selective S-nitrosylation of Cys(501) in the mitochondrial chaperone TRAP1, which mediates its degradation. As a result, GSNOR-deficient cells and tumors are highly sensitive to SDH inhibition, namely to α-tocopheryl succinate, an SDH-targeting molecule that induced RIP1/PARP1-mediated necroptosis and inhibited tumor growth. Our work provides a specific molecular signature of aberrant S-nitrosylation in HCC, a novel molecular target in SDH, and a first-in-class therapy to treat the disease. Cancer Res; 76(14); 4170-82. ©2016 AACR.

  • S -Nitrosoglutathione Reductase Plays Opposite Roles in SH-SY5Y Models of Parkinson's Disease and Amyotrophic Lateral Sclerosis
    Salvatore Rizza, Claudia Cirotti, Costanza Montagna, Simone Cardaci, Claudia Consales, Mauro Cozzolino, Maria Teresa Carrì, Francesco Cecconi, and Giuseppe Filomeni
    Hindawi Limited
    Oxidative and nitrosative stresses have been reported as detrimental phenomena concurring to the onset of several neurodegenerative diseases. Here we reported that the ectopic modulation of the denitrosylating enzymeS-nitrosoglutathione reductase (GSNOR) differently impinges on the phenotype of two SH-SY5Y-basedin vitromodels of neurodegeneration, namely, Parkinson’s disease (PD) and familial amyotrophic lateral sclerosis (fALS). In particular, we provide evidence that GSNOR-knocking down protects SH-SY5Y against PD toxins, while, by contrast, its upregulation is required for G93A-SOD1 expressing cells resistance to NO-releasing drugs. Although completely opposite, both conditions are characterized by Nrf2 localization in the nuclear compartment: in the first case induced by GSNOR silencing, while in the second one underlying the antinitrosative response. Overall, our results demonstrate that GSNOR expression has different effect on neuronal viability in dependence on the stimulus applied and suggest that GSNOR could be a responsive gene downstream of Nrf2 activation.

  • S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction
    Costanza Montagna, Giuseppina Di Giacomo, Salvatore Rizza, Simone Cardaci, Elisabetta Ferraro, Paolo Grumati, Daniela De Zio, Emiliano Maiani, Carolina Muscoli, Filomena Lauro,et al.
    Mary Ann Liebert Inc
    AIMS Nitric oxide (NO) production is implicated in muscle contraction, growth and atrophy, and in the onset of neuropathy. However, many aspects of the mechanism of action of NO are not yet clarified, mainly regarding its role in muscle wasting. Notably, whether NO production-associated neuromuscular atrophy depends on tyrosine nitration or S-nitrosothiols (SNOs) formation is still a matter of debate. Here, we aim at assessing this issue by characterizing the neuromuscular phenotype of S-nitrosoglutathione reductase-null (GSNOR-KO) mice that maintain the capability to produce NO, but are unable to reduce SNOs. RESULTS We demonstrate that, without any sign of protein nitration, young GSNOR-KO mice show neuromuscular atrophy due to loss of muscle mass, reduced fiber size, and neuropathic behavior. In particular, GSNOR-KO mice show a significant decrease in nerve axon number, with the myelin sheath appearing disorganized and reduced, leading to a dramatic development of a neuropathic phenotype. Mitochondria appear fragmented and depolarized in GSNOR-KO myofibers and myotubes, conditions that are reverted by N-acetylcysteine treatment. Nevertheless, although atrogene transcription is induced, and bulk autophagy activated, no removal of damaged mitochondria is observed. These events, alongside basal increase of apoptotic markers, contribute to persistence of a neuropathic and myopathic state. INNOVATION Our study provides the first evidence that GSNOR deficiency, which affects exclusively SNOs reduction without altering nitrotyrosine levels, results in a clinically relevant neuromuscular phenotype. CONCLUSION These findings provide novel insights into the involvement of GSNOR and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states; for example, diabetes and cancer.

  • S -nitrosation and ubiquitin-proteasome system interplay in neuromuscular disorders
    Salvatore Rizza, Costanza Montagna, Giuseppina Di Giacomo, Claudia Cirotti, and Giuseppe Filomeni
    Hindawi Limited
    ProteinS-nitrosation is deemed as a prototype of posttranslational modifications governing cell signaling. It takes place on specific cysteine residues that covalently incorporate a nitric oxide (NO) moiety to formS-nitrosothiol derivatives and depends on the ratio between NO produced by NO synthases and nitrosothiol removal catalyzed by denitrosating enzymes. A large number of cysteine-containing proteins are found to undergoS-nitrosation and, among them, the enzymes catalyzing ubiquitination, mainly the class of ubiquitin E3 ligases and the 20S component of the proteasome, have been reported to be redox modulated in their activity. In this review we will outline the processes regulatingS-nitrosation and try to debate whether and how it affects protein ubiquitination and degradation via the proteasome. In particular, since muscle and neuronal health largely depends on the balance between protein synthesis and breakdown, here we will discuss the impact ofS-nitrosation in the efficiency of protein quality control system, providing lines of evidence and speculating about its involvement in the onset and maintenance of neuromuscular dysfunctions.

  • Reticulon1-C modulates protein disulphide isomerase function
    P Bernardoni, B Fazi, A Costanzi, R Nardacci, C Montagna, G Filomeni, M R Ciriolo, M Piacentini, and F Di Sano
    Springer Science and Business Media LLC
    Endoplasmic reticulum (ER) is the primary site for the synthesis and folding of secreted and membrane-bound proteins. Accumulation of unfolded and misfolded proteins in ER underlies a wide range of human neurodegenerative disorders. Hence, molecules regulating the ER stress response represent potential candidates as drug targets for tackling these diseases. Protein disulphide isomerase (PDI) is a chaperone involved in ER stress pathway, its activity being an important cellular defense against protein misfolding. Here, we demonstrate that human neuroblastoma SH-SY5Y cells overexpressing the reticulon protein 1-C (RTN1-C) reticulon family member show a PDI punctuate subcellular distribution identified as ER vesicles. This represents an event associated with a significant increase of PDI enzymatic activity. We provide evidence that the modulation of PDI localization and activity does not only rely upon ER stress induction or upregulation of its synthesis, but tightly correlates to an alteration in its nitrosylation status. By using different RTN1-C mutants, we demonstrate that the observed effects depend on RTN1-C N-terminal region and on the integrity of the microtubule network. Overall, our results indicate that RTN1-C induces PDI redistribution in ER vesicles, and concomitantly modulates its activity by decreasing the levels of its S-nitrosylated form. Thus RTN1-C represents a promising candidate to modulate PDI function.

  • Established principles and emerging concepts on the interplay between mitochondrial physiology and S -(De)nitrosylation: Implications in cancer and neurodegeneration
    Giuseppina Di Giacomo, Salvatore Rizza, Costanza Montagna, and Giuseppe Filomeni
    Hindawi Limited
    S-nitrosylation is a posttranslational modification of cysteine residues that has been frequently indicated as potential molecular mechanism governing cell response upon redox unbalance downstream of nitric oxide (over)production. In the last years, increased levels ofS-nitrosothiols (SNOs) have been tightly associated with the onset of nitroxidative stress-based pathologies (e.g., cancer and neurodegeneration), conditions in which alterations of mitochondrial homeostasis and activation of cellular processes dependent on it have been reported as well. In this paper we aim at summarizing the current knowledge of mitochondria-related proteins undergoingS-nitrosylation and how this redox modification might impact on mitochondrial functions, whose impairment has been correlated to tumorigenesis and neuronal cell death. In particular, emphasis will be given to the possible, but still neglected implication of denitrosylation reactions in the modulation of mitochondrial SNOs and how they can affect mitochondrion-related cellular process, such as oxidative phosphorylation, mitochondrial dynamics, and mitophagy.

RECENT SCHOLAR PUBLICATIONS

  • miRNAs Boost Breast Cancer Aggressiveness by Regulating S-Nitrosoglutathione Reductase (GSNOR) Levels
    G Matrullo, V Fiorentini, C Montagna, G Filomeni, S Rizza
    Free Radical Biology and Medicine 218, 48 2024

  • GSNOR safeguards G1/S check-point, and controls proliferation in embryonal rhabdomyosarcoma
    G Larotondo, P Giglio, G Matrullo, C Pecorari, E Maiani, G Filomeni, ...
    Free Radical Biology and Medicine 218, 52-53 2024

  • GSNOR safeguards S-phase entry and genomic stability in rhabdomyosarcoma cells: unraveling new molecular players
    P Giglio, G Larotondo, C Pecorari, E Maiani, S Rizza, G Filomeni, ...
    Free Radical Biology and Medicine 201, 60-61 2023

  • S-nitrosoglutathione reductase (GSNOR) downregulation in Breast Cancer: a possible involvement of miRNAs in controlling GSNOR expression
    G Matrullo, V Fiorentini, C Montagna, G Filomeni, S Rizza
    Free Radical Biology and Medicine 201, 56 2023

  • Targeting GSNOR deficiency as a new therapeutic approach in rhabdomyosarcoma
    G Larotondo, P Giglio, G Matrullo, E Maiani, G Filomeni, C Montagna
    Free Radical Biology and Medicine 201, 59-60 2023

  • GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation
    S Rizza, L Di Leo, C Pecorari, P Giglio, F Faienza, C Montagna, E Maiani, ...
    Cell Reports 42 (1) 2023

  • Looking at denitrosylation to understand the myogenesis gone awry theory of rhabdomyosarcoma
    C Montagna, G Filomeni
    Nitric Oxide 122, 1-5 2022

  • Autophagy guards tendon homeostasis
    C Montagna, RB Svensson, ML Bayer, S Rizza, E Maiani, CYC Yeung, ...
    Cell death & disease 13 (4), 402 2022

  • AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
    E Maiani, G Milletti, F Nazio, SG Holdgaard, J Bartkova, S Rizza, ...
    Nature 592 (7856), 799-803 2021

  • Guidelines for the use and interpretation of assays for monitoring autophagy .
    J Quadrilatero, DW Walker, MJ Walker, SA Walker, J Walter, ...
    Autophagy 2021

  • Guidelines for the use and interpretation of assays for monitoring autophagy
    DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
    autophagy 17 (1), 1-382 2021

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
    J Błasiak
    Autophagy 17 (1) 2021

  • Comparison of tenocyte populations from the core and periphery of equine tendons
    C Zhang, RB Svensson, C Montagna, H Carstensen, R Buhl, EM Schoof, ...
    Journal of Proteome Research 19 (10), 4137-4144 2020

  • When S-Nitrosylation Gets to Mitochondria: From Signaling to Age-Related Diseases
    C Montagna, C Cirotti, S Rizza, G Filomeni
    Antioxidants & Redox Signaling 32 (12), 884-905 2020

  • nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis
    C Montagna, S Rizza, C Cirotti, E Maiani, M Muscaritoli, A Musar, ...
    Cell Death & Disease 10 (5), 354 2019

  • Autophagy gets to the tendons: implications in mechanobiology and injury
    C Montagna, ML Bayer, RB Svensson, M Kjaer
    Physical Activity in Disease Prevention, Treatment and Rehabilitation 2019

  • Autophagy gets to the tendons: role in mechanobiology and injury.
    C Montagna, M Bayer, M Svensson RB and Kjaer
    Lassen Dagen, Bispebjerg Hospital, December 2019. 2019

  • La genetica da W&C ai sequenziatori NGS
    C Montagna
    AURO-Associazione Urologi Italiana 2019

  • S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy
    S Rizza, S Cardaci, C Montagna, G Di Giacomo, D De Zio, M Bordi, ...
    Proceedings of the National Academy of Sciences 115 (15), E3388-E3397 2018

  • To eat, or NOt to eat: S‐nitrosylation signaling in autophagy
    C Montagna, S Rizza, E Maiani, L Piredda, G Filomeni, F Cecconi
    The FEBS journal 283 (21), 3857-3869 2016

MOST CITED SCHOLAR PUBLICATIONS

  • Guidelines for the use and interpretation of assays for monitoring autophagy
    DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ...
    autophagy 17 (1), 1-382 2021
    Citations: 11081

  • S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy
    S Rizza, S Cardaci, C Montagna, G Di Giacomo, D De Zio, M Bordi, ...
    Proceedings of the National Academy of Sciences 115 (15), E3388-E3397 2018
    Citations: 180

  • AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
    E Maiani, G Milletti, F Nazio, SG Holdgaard, J Bartkova, S Rizza, ...
    Nature 592 (7856), 799-803 2021
    Citations: 111

  • S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase
    S Rizza, C Montagna, S Cardaci, E Maiani, G Di Giacomo, ...
    Cancer research 76 (14), 4170-4182 2016
    Citations: 77

  • Extremely Low Frequency Magnetic Field (ELF-MF) Exposure Sensitizes SH-SY5Y Cells to the Pro-Parkinson’s Disease Toxin MPP+
    B Benassi, G Filomeni, C Montagna, C Merla, V Lopresto, R Pinto, ...
    Molecular neurobiology 53, 4247-4260 2016
    Citations: 62

  • S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction
    C Montagna, G Di Giacomo, S Rizza, S Cardaci, E Ferraro, P Grumati, ...
    Antioxidants & redox signaling 21 (4), 570-587 2014
    Citations: 52

  • To eat, or NOt to eat: S‐nitrosylation signaling in autophagy
    C Montagna, S Rizza, E Maiani, L Piredda, G Filomeni, F Cecconi
    The FEBS journal 283 (21), 3857-3869 2016
    Citations: 44

  • Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S‐(De)nitrosylation: Implications in Cancer and
    G Di Giacomo, S Rizza, C Montagna, G Filomeni
    International Journal of Cell Biology 2012 (1), 361872 2012
    Citations: 38

  • Reticulon1-C modulates protein disulphide isomerase function
    P Bernardoni, B Fazi, A Costanzi, R Nardacci, C Montagna, G Filomeni, ...
    Cell death & disease 4 (4), e581-e581 2013
    Citations: 31

  • When S-Nitrosylation Gets to Mitochondria: From Signaling to Age-Related Diseases
    C Montagna, C Cirotti, S Rizza, G Filomeni
    Antioxidants & Redox Signaling 32 (12), 884-905 2020
    Citations: 26

  • S‐Nitrosoglutathione Reductase Plays Opposite Roles in SH‐SY5Y Models of Parkinson’s Disease and Amyotrophic Lateral Sclerosis
    S Rizza, C Cirotti, C Montagna, S Cardaci, C Consales, M Cozzolino, ...
    Mediators of Inflammation 2015 (1), 536238 2015
    Citations: 18

  • nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis
    C Montagna, S Rizza, C Cirotti, E Maiani, M Muscaritoli, A Musar, ...
    Cell Death & Disease 10 (5), 354 2019
    Citations: 16

  • S‐Nitrosation and Ubiquitin‐Proteasome System Interplay in Neuromuscular Disorders
    S Rizza, C Montagna, G Di Giacomo, C Cirotti, G Filomeni
    International journal of cell biology 2014 (1), 428764 2014
    Citations: 14

  • Autophagy guards tendon homeostasis
    C Montagna, RB Svensson, ML Bayer, S Rizza, E Maiani, CYC Yeung, ...
    Cell death & disease 13 (4), 402 2022
    Citations: 13

  • GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation
    S Rizza, L Di Leo, C Pecorari, P Giglio, F Faienza, C Montagna, E Maiani, ...
    Cell Reports 42 (1) 2023
    Citations: 7

  • Comparison of tenocyte populations from the core and periphery of equine tendons
    C Zhang, RB Svensson, C Montagna, H Carstensen, R Buhl, EM Schoof, ...
    Journal of Proteome Research 19 (10), 4137-4144 2020
    Citations: 6

  • (339) Spontaneous pain response in S-nitrosoglutathione reductase (GSNOR) deficient mice: the role of S-nitrosylation
    S Ilari, F Lauro, C Montagna, G Di Giacomo, S Rizza, S Cardaci, M Allegri, ...
    The Journal of Pain 15 (4), S60 2014
    Citations: 1