Dalal Z. Husein
@nvu.edu.eg
Faculty of Science - Chemistry Department
New Valley University
RESEARCH INTERESTS
Water quality, water treatment, adsorption, low cost adsorbent, nanomaterials
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Hazem Elkady, Walid E. Elgammal, Hazem A. Mahdy, Susi Zara, Simone Carradori, Dalal Z. Husein, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Ahmed M. Metwaly,et al.
Elsevier BV
Hazem A. Mahdy, Hazem Elkady, Walid E. Elgammal, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Dalal Z. Husein, Mohamed A. Elkady, Ahmed M. Metwaly, and Ibrahim H. Eissa
Elsevier BV
Ibrahim H. Eissa, Walid E. Elgammal, Hazem A. Mahdy, Susi Zara, Simone Carradori, Dalal Z. Husein, Maymounah N. Alharthi, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Hazem Elkady,et al.
Royal Society of Chemistry (RSC)
This study aims to investigate the potential of designed 2,3-dihydro-1,3,4-thiadiazole derivatives as anti-proliferative agents targeting VEGFR-2, utilizing a multidimensional approach combining in vitro and in silico analyses.
Ibrahim H. Eissa, Hazem Elkady, Walid E. Elgammal, Hazem.A. Mahdy, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Dalal Z. Husein, and Ahmed M. Metwaly
Elsevier BV
Tongtong Wang, Di Zhang, Hui Shi, Sen Wang, Bo Wu, Junchao Jia, Zhizhen Feng, Wenjuan Zhao, Zhangyue Chang, and Dalal Z. Husein
MDPI AG
As a common necessity, masks have been used a lot in recent years, and the comprehensive utilization of waste masks has become a research priority in the post-COVID-19 pandemic era. However, traditional disposal methods suffer from a range of problems, including poor utilization and insecurity. To explore new solution ideas and efficiently utilize waste resources, waste masks and biomass wastes were used as raw materials to prepare mask-based biochar (WMB), bio-oil, and pyrolytic gas via oxygen-limited co-pyrolysis in this study. The obtained solid–liquid–gas product was systematically characterized to analyze the physicochemical properties, and the adsorption properties and mechanisms of WMB on the environmental endocrine bisphenol A (BPA) were investigated. The co-pyrolysis mechanisms were also studied in depth. Furthermore, the strengths and weaknesses of products prepared by co-pyrolysis and co-hydrothermal synthesis were discussed in comparison. The results indicated that the waste masks could shape the microsphere structure, leading to richer surface functional groups and stable mesoporous of WMB. Here, the risk of leaching of secondary pollutants was not detected. The theoretical maximum adsorption of BPA by WMB was 28.73 mg·g−1. The Langmuir and Pseudo-second-order models optimally simulated the isothermal and kinetic adsorption processes, which are a composite of physicochemical adsorption. Simultaneous pyrolysis of mask polymers with biomass polymers produces bio-oil and pyrolytic gas, which is rich in high-quality aliphatic and aromatic compounds. This could have potential as an energy source or chemical feedstock. The co-pyrolysis mechanisms may involve the depolymerization of waste masks to produce hydrocarbons and H radicals, which in turn undergo multi-step cleavage and oligomerization reactions with biomass derivatives. It is recommended to use the co-pyrolysis method to dispose of waste masks, as the products obtained are significantly better than those obtained by the co-hydrothermal method. This work provides a new contribution to the resourcing of waste masks into high-quality products.
Tongtong Wang, Dalal Z. Husein, Siyan Guo, Xinle Zhang, Jiarui Kang, Huixia Wang, Shumiao Cao, Zhonghua Shangguan, and Hui Shi
Springer Science and Business Media LLC
Hazem Elkady, Hazem A. Mahdy, Mohammed S. Taghour, Mohammed A. Dahab, Alaa Elwan, Mohamed Hagras, Mona H. Hussein, Ibrahim M. Ibrahim, Dalal Z. Husein, Eslam B. Elkaeed,et al.
Elsevier BV
Ibrahim H. Eissa, Reda G.Yousef, Hazem Elkady, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Nehal El-Deeb, Ahmed M. Kenawy, Wagdy M. Eldehna, Eslam B. Elkaeed,et al.
Springer Science and Business Media LLC
Souad A. El-Metwally, Mariam Omara, Hazem Elkady, Eslam B. Elkaeed, Hanan A. Al-ghulikah, Mohammed S. Taghour, Hesham A. El-Mahdy, Ibrahim M. Ibrahim, Dalal Z. Husein, Ahmed M. Metwaly,et al.
Elsevier BV
Ibrahim H. Eissa, Reda G. Yousef, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Ahmed Ismail, Hazem Elkady, and Ahmed M. Metwaly
American Chemical Society (ACS)
Ibrahim Eissa, Hazem Elkady, Mohammed S. Taghour, Alaa Elwan, Mohammed A. Dahab, Mohamed Hagras, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Dalal Z. Husein,et al.
Wiley
AbstractIn this work novel 2,4‐dioxothiazolidine‐derived compounds targeting VEGFR‐2 were designed and synthesized. Such compounds were evaluated for their anti‐proliferative and VEGFR‐2 inhibitory abilities. Compound 17 specifically demonstrated the strongest anti‐proliferative activity against the HCT‐116 cell line, with an IC50 value of 10.09 μM. Additionally, compounds 15, 18, and 19 revealed good anti‐proliferative effects with IC50 values of 12.46, 16.87, and 12.35 μM, respectively. Compound 17 demonstrated potent anti‐VEGFR‐2 efficacy, with an IC50 value of 0.068 μM, which was comparable to sorafenib (IC50 value of 0.058 μM). Compound 17 induced apoptosis in HCT‐116 cancer cells and caused G0‐G1 phase cell cycle arrest. Furthermore, it upregulated BAX levels (5.1‐fold) and downregulated Bcl‐2 levels (4.2‐fold), indicating its pro‐apoptotic effects. Compound 17 also increased caspase‐8 and caspase‐9 levels by 3.3‐fold and 4.7‐fold, respectively, compared to the control. The computational studies provided insights into the kinetic, structural properties, and binding mode of the VEGFR‐2‐17 complex. The DFT calculations elucidated compound 17′s structural and electronic properties, while computational ADMET and toxicity tests suggested acceptable degrees of drug‐likeness potential for the synthesized compounds. Our findings suggest that compound 17 holds promise as a potent apoptotic VEGFR‐2 inhibitor and may guide future efforts in developing new anticancer drugs.
Ibrahim H. Eissa, Hazem Elkady, Mahmoud Rashed, Alaa Elwan, Mohamed Hagras, Mohammed A. Dahab, Mohammed S. Taghour, Ibrahim M. Ibrahim, Dalal Z. Husein, Eslam B. Elkaeed,et al.
Elsevier BV
Ibrahim H. Eissa, Muhammad Abd ElGayed Bkrah, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, and Dalal Z. Husein
Hindawi Limited
A new nicotinamide derivative, (E)-N-(4-(1-(2-(4-benzamidobenzoyl)hydrazone)ethyl)phenyl)nicotinamide, was designed as a VEGFR-2 inhibitor. Utilizing the density functional theory (DFT) calculations, the three-dimensional structure of the designed compound was determined, shedding light on its stability and reactivity. Molecular docking revealed its capability to inhibit VEGFR-2, which was further supported by molecular dynamics (MD) simulations confirming its binding to the target protein. In addition, molecular mechanics-generalized born surface area (MM-GBSA), protein-ligand interactions profiler (PLIP), and essential dynamics studies provided further validation of the compound’s precise binding with optimal energy. Then, the “compound 10” was synthesized and subjected to in vitro assays. Compound 10 inhibited VEGFR-2 with an IC50 value of 105.4 ± 0.896 nM, comparing sorafenib’s IC50 value of 61.65 ± 0.934 nM. Besides, it exhibited cytotoxicity against HepG2 and MCF-7 cancer cell lines, with IC50 values of 35.78 ± 0.863 μM and 57.62 μM ± 0.871, comparing sorafenib’s IC50 values of 5.95 ± 0.917 μM and 8.45 ± 0.912 μM. Furthermore, compound 10 demonstrated a lower level of toxicity towards Vero cell lines, with an IC50 value of 127.3 μM. Likewise, compound 10 induced apoptosis in HepG2 cell lines through a flow cytometric analysis in addition to an increase in the levels of caspase-3 and caspase-9. Moreover, compound 10 hindered the migration and healing abilities of HepG2 cells. In conclusion, our study positions compound 10 as a promising candidate for further chemical modifications and biological evaluations.
Ibrahim H. Eissa, Reda G.Yousef, Hazem Elkady, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mostafa A. Asmaey, and Ahmed M. Metwaly
Springer Science and Business Media LLC
Walid E. Elgammal, Hazem Elkady, Hazem A. Mahdy, Dalal Z. Husein, Aisha A. Alsfouk, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Ahmed M. Metwaly, and Ibrahim H. Eissa
Royal Society of Chemistry (RSC)
This work presents the synthesis and in vitro, and in silico analyses of new thiadiazole derivatives that are designed to mimic the pharmacophoric characteristics of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors.
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Dalal Z. Husein, Ibrahim M. Ibrahim, Bshra A. Alsfouk, Ahmed S. Doghish, Hesham A. El-Mahdy, Ahmed M. Kenawy,et al.
Elsevier BV
Ibrahim H. Eissa, Reda G. Yousef, Mostafa A. Asmaey, Hazem Elkady, Dalal Z. Husein, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Mohamed A. Elkady, Eslam B. Elkaeed, and Ahmed M. Metwaly
Elsevier BV
Ibrahim H. Eissa, Reda G. Yousef, Muhammad Sami, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Dalal Z. Husein, Hazem Elkady, and Ahmed M. Metwaly
Elsevier BV
Hazem Elkady, Abdelrahman A. Abuelkhir, Mahmoud Rashed, Mohammed S. Taghour, Mohammed A. Dahab, Hazem A. Mahdy, Alaa Elwan, Hanan A. Al-ghulikah, Eslam B. Elkaeed, Ibrahim M. Ibrahim,et al.
Elsevier BV
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mostafa.A. Elhendawy, Murrell Godfrey, and Ahmed M. Metwaly
Elsevier BV
Souad A El-Metwally, Hazem Elkady, Mohamed Hagras, Eslam B Elkaeed, Bshra A Alsfouk, Ahmed S Doghish, Ibrahim M Ibrahim, Mohammed S Taghour, Dalal Z Husein, Ahmed M Metwaly,et al.
Future Science Ltd
Background: VEGFR-2 is a key regulator of cancer cell proliferation, migration and angiogenesis. Aim: Development of thieno[2,3- d]pyrimidine derivatives as potential anti-cancer agents targeting VEGFR-2. Methods: Seven in vitro and nine in silico studies were conducted. Results: Compound 10d demonstrated strong anticancer potential, boosting apoptosis based on VEGFR-2 inhibition. It arrested the S phase of the cell cycle and upregulated the apoptotic factors. Docking and molecular dynamics simulation studies confirm the stability of the VEGFR-2–10d complex and suggest that these compounds have good binding affinities to VEGFR-2. In addition, the drug-likeness was confirmed. Conclusion: Thieno[2,3- d]pyrimidines, particularly compound 10d, has good anticancer effects and may contribute to the development of new anticancer therapies.
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Dalal Z. Husein, Mostafa A. Asmaey, Ibrahim M. Ibrahim, and Ahmed M. Metwaly
Elsevier BV
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mohamed M. Radwan, and Ahmed M. Metwaly
Wiley
AbstractA computer‐assisted drug design (CADD) approach was utilized to design a new acetamido‐N‐(para‐fluorophenyl)benzamide) derivative of the naturally occurring alkaloid, theobromine, (T‐1‐APFPB), following the pharmacophoric features of VEGFR‐2 inhibitors. The stability and reactivity of T‐1‐AFPB were assessed through density functional theory (DFT) calculations. Molecular docking assessments showed T‐1‐AFPB’s potential to bind with and inhibit VEGFR‐2. The precise binding of T‐1‐AFPB against VEGFR‐2 with optimal energy was further confirmed through several molecular dynamics (MD) simulations, PLIP, MM‐GBSA, and PCA studies. Then, T‐1‐AFPB (4‐(2‐(3,7‐Dimethyl‐2,6‐dioxo‐2,3,6,7‐tetrahydro‐1H‐purin‐1‐yl)acetamido)‐N‐(4‐fluorophenyl)benzamide) was semi‐synthesized and the in vitro assays showed its potential to inhibit VEGFR‐2 with an IC50 value of 69 nM (sorafenib's IC50 was 56 nM) and to inhibit the growth of HepG2 and MCF‐7 cancer cell lines with IC50 values of 2.24±0.02 and 3.26±0.02 μM, respectively. Moreover, T‐1‐AFPB displayed very high selectivity indices against normal Vero cell lines. Furthermore, T‐1‐AFPB induced early (from 0.72 to 19.12) and late (from 0.13 to 6.37) apoptosis in HepG2 cell lines. In conclusion, the combined computational and experimental approaches demonstrated the efficacy and safety of T‐1‐APFPB providing it as a promising lead VEGFR‐2 inhibitor for further development aiming at cancer therapy.
Souad A. El-Metwally, Abdelrahman A. Abuelkhir, Hazem Elkady, Mohammed S. Taghour, Ibrahim M. Ibrahim, Dalal Z. Husein, Aisha A. Alsfouk, Ahlam Sultan, Ahmed Ismail, Samy Y. Elkhawaga,et al.
Elsevier BV
Hazem Elkady, Osama A. El-Dardir, Alaa Elwan, Mohammed S. Taghour, Hazem A. Mahdy, Mohammed A. Dahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Dalal Z. Husein,et al.
Royal Society of Chemistry (RSC)
Design, synthesis, in vitro and in silico studies of novel thiazolidine-2,4-diones as antitumor VEGFR-2 inhibitors with apoptotic activities.