Multimodal imaging features to diagnose abdominal complications of sickle cell disease Luana Lemos Alves, André Barboza Ferreira, Pedro Bernardo Berriel, Pietra Desirée Bourdon Fuentes Azevedo Vianna, Eleonora Salles-Silva, et al. Abdominal Radiology, 2026 Sickle cell disease (SCD) is a hereditary hemoglobinopathy, marked by chronic hemolysis and recurrent vaso-occlusive crises, which frequently leads to a wide range of abdominal complications. Sickled erythrocytes have reduced deformability and increased adhesion to vessel walls, leading to chronic vascular occlusion, inflammation, and hemolysis. Comprehensive imaging plays a pivotal role in the early detection and assessment of these complications, thereby mitigating morbidity and severe outcomes. Ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) are the three modalities commonly used on SCD patients to evaluate hepatosplenic involvement, renal pathology, pancreatobiliary disorders, gastrointestinal ischemia, extramedullary hematopoiesis, and genital abnormalities. The US is a first-line imaging tool due to its accessibility and low cost. CT offers high-resolution, cross-sectional imaging and is often utilized in emergency settings. MRI, with its superior soft tissue contrast, is excellent for problem-solving. A thorough understanding of the abdominal manifestations of SCD is essential for radiologists to provide accurate diagnoses, guide clinical decision-making, and reduce morbidity and mortality. This review highlights the most significant imaging findings from SCD abdominal complications, emphasizing their clinical implications, underlying pathophysiology, and radiological features in all three modalities.
Agreement between single and multiple ROI strategies for hepatic T1 and ECV mapping in tetralogy of Fallot and Fontan circulation Adriana Macintyre Innocenzi, Fernanda Padrão Fernandes, José Carlos Pizzolante Secco, Igor Costa Costermani, José Lucas Rebelo, et al. Abdominal Radiology, 2026 Purpose Native T1 and extracellular volume (ECV) mapping have emerged as promising tools for noninvasive assessment of hepatic congestion and fibrosis; however, optimal strategies for region-of-interest (ROI) selection remain uncertain. The aim was to evaluate the level of agreement between two methods for quantifying hepatic native T1 and ECV: single wide ROI versus multiple small ROIs, in patients with repaired tetralogy of Fallot (TOF) and Fontan circulation. Methods This agreement study prospectively enrolled outpatients with repaired TOF or Fontan circulation between 2022 and 2025. All participants underwent hepatic evaluation using a cardiac Magnetic Resonance Imaging (MRI) protocol on a 3.0-T scanner. Native and post-contrast T1 mapping were acquired using Modified Look-Locker Inversion Recovery (MOLLI) sequences. Hepatic T1 and ECV were measured using (1) one wide ROI avoiding vascular structures and (2) three small circular ROIs placed in distinct parenchymal regions. Agreement was assessed using intraclass correlation coefficients (ICC) and survival-agreement plots. Results A total of 61 patients was included (31 with TOF; 30 with Fontan circulation). Agreement between single-ROI and multiple-ROI strategies was excellent in TOF patients for both native T1 and ECV (ICC = 0.98), and good in patients with Fontan circulation for both parameters (ICC = 0.79). Survival-agreement analysis demonstrated that in TOF patients, all measurements differed by less than 80 ms for native T1 and less than 5% for ECV. In Fontan patients, 86% of measurements showed differences < 80 ms for native T1 and < 5% for ECV, reflecting greater hepatic heterogeneity while preserving overall concordance between ROI strategies. Conclusions Hepatic native T1 and ECV measurements showed excellent agreement between single-wide and multiple-small ROI strategies in repaired TOF, supporting interchangeable use for longitudinal follow-up. In Fontan patients, concordance between methods was also good, as demonstrated by both ICC and survival-agreement analyses, indicating that either strategy remains feasible; nonetheless, the greater hepatic heterogeneity in this population warrants some caution when comparing measurements obtained with different ROI approaches. Graphical abstract
Assessing liver disease in cyanotic CHD using multiparametric MRI: a call to prevent future burden Mariana Póvoa-Corrêa, Adriana M. Innocenzi, Fernanda P. Fernandes, Igor Costermani, José Carlos P. Secco, et al. Cardiology in the Young, 2026 Background & aims: Patients with cyanotic CHD and those with metabolic dysfunction–associated steatotic liver disease are at risk of liver fibrosis. We compared hepatic extracellular volumes and native T1 values to better understand the burden of liver disease in these populations. Methods: The sample comprised 136 patients in 5 groups: control ( n = 23), metabolic dysfunction–associated steatotic liver disease [mild (F0–F1) and significant (F2–F4) fibrosis; n = 45], repaired tetralogy of Fallot ( n = 30), and Fontan circulation ( n = 38). Differences were assessed using linear regression models, with adjustment for the body mass index and sex. Results: The hepatic extracellular volume was significantly larger in the Fontan group (43.96% ± 4.22%) than in the other groups, even with adjustment. Patients with Fallot had significantly larger extracellular volumes (36.77% ± 5.63%) than did controls and mild liver disease ( p < 0.001 and p = 0.011, respectively), although smaller extracellular volumes than patients with significant liver disease ( p = 0.042). These trends were corroborated by native T1 values, which were highest in patients with Fontan (1013.7 ± 86.1 ms), although not significantly different from patients with F2–F4 steatotic liver disease. Conclusions: The potential burden of CHD-related hepatic injury and steatotic liver disease highlights the importance of early identification. Given the possible additional risk of liver fibrosis in patients with coexisting metabolic dysfunction and CHD, comprehensive clinical management should prioritise regular metabolic risk assessment and the promotion of a healthy lifestyle to reduce the likelihood of liver disease development in this vulnerable population.
Rare Non-Tumoral Lesions of the Liver: A Pictorial Review Sthefane Louise Gomes Nunes, Eleonora Salles-Silva, Luiza Carvalho Ambrozino, Paula Lemos de Castro, Mayra Veloso Ayrimoraes Soares, et al. Seminars in Ultrasound CT and MRI, 2025
Mortality Outcomes of Combined Heart and Liver Transplantation and Isolated Heart Transplantation Following Fontan Procedures: A Systematic Review and Meta-Analysis Oscar Holmvard, Mariana Póvoa‐Corrêa, Adriana Macintyre Innocenzi, Lucio Filgueiras Pacheco, Daniella Braz Parente, et al. Pediatric Transplantation, 2025 Background Fontan‐associated liver disease can progress to advanced fibrosis, raising the potential need for combined heart–liver transplantation (CHLT) in selected patients. However, the benefits of CHLT over isolated orthotopic heart transplantation (HT), particularly in terms of mortality, remain uncertain. In this systematic review, we compared mortality outcomes following CHLT versus HT in patients with Fontan circulation, with the aim of supporting clinical decision‐making. Methods This systematic review was conducted according to the 2020 PRISMA guidelines and registered in PROSPERO. PubMed, Scopus, and Embase were searched. Studies examining HT or CHLT in patients with Fontan circulation that provided information about total and/or 1‐year mortality were included. Bias risks were assessed using the Newcastle‐Ottawa Scale. We used random‐ and fixed‐effect models, depending on heterogeneity, to estimate pooled effects. Results Sixteen studies were included in this analysis. CHLT was associated with a lower mortality rate per patient‐year compared to HT (0.03 vs. 0.09; p < 0.01). However, after excluding studies in which transplantations were performed before the year 2000, the difference between groups was no longer statistically significant. One‐year mortality rates were also not significantly different between CHLT and HT (0.09 vs. 0.14; p = 0.28), with similar results observed after excluding pre‐2000 studies. Conclusion Overall, this systematic review suggests that CHLT may result in mortality rates comparable to those of isolated HT. These findings support the consideration of CHLT in patients with concomitant liver disease and reinforce the importance of comprehensive liver evaluation in transplant candidates.
Imaging of Gallbladder Cancer Luiza Labrunie, Luiza Nahoum, Pedro Carpentieri-Primo, Gustavo Mendes, Viviane Brandão Amorim, et al. Gallbladder Cancer A Comprehensive Guide to Management, 2025
Fat-containing liver lesions: A pictorial review Daniella Braz Parente, Jaime Araújo Oliveira Neto, Antonio Luis Eiras de Araújo, Rosana Souza Rodrigues, Renata Mello Perez, et al. Radiologia Brasileira, 2018
Pheochromocytoma of the urinary bladder André Martins Fernandes, Bernardo Vieira Paim, Ana Paula Aguiar Vidal, Edson Marchiori, Daniella Braz Parente Radiologia Brasileira, 2017
Pulmonary fat embolism of neoplastic origin Flávia Pinto, Universidade Federal do Rio de Janeiro, Brazil, Miriam Menna Barreto, Daniela Braz Parente, Edson Marchiori Jornal Brasileiro De Pneumologia, 2016
Agreement between single and multiple ROI strategies for hepatic T1 and ECV mapping in tetralogy of Fallot and Fontan circulation AM Innocenzi, FP Fernandes, JCP Secco, IC Costermani, JL Rebelo, ... Abdominal Radiology, 1-10 , 2026 2026
Multimodal imaging features to diagnose abdominal complications of sickle cell disease L Lemos Alves, A Barboza Ferreira, P Bernardo Berriel, ... Abdominal Radiology 51 (2), 1004-1015 , 2026 2026
Assessing liver disease in cyanotic CHD using multiparametric MRI: a call to prevent future burden M Póvoa-Corrêa, AM Innocenzi, FP Fernandes, I Costermani, JCP Secco, ... Cardiology in the Young 35 (12), 2537-2543 , 2025 2025 Citations: 1
Mortality Outcomes of Combined Heart and Liver Transplantation and Isolated Heart Transplantation Following Fontan Procedures: A Systematic Review and Meta‐Analysis O Holmvard, M Póvoa‐Corrêa, A Macintyre Innocenzi, LF Pacheco, ... Pediatric transplantation 29 (7), e70174 , 2025 2025 Citations: 3
MRI-derived extracellular volume to assess liver fibrosis in patients with metabolic-associated steatotic liver disease FV de Oliveira Terzi, DB Parente, GC Camargo, AM Pittella, ... Abdominal Radiology 50 (11), 5223-5231 , 2025 2025 Citations: 5
Rare Non-Tumoral Lesions of the Liver: A Pictorial Review SLG Nunes, E Salles-Silva, LC Ambrozino, PL de Castro, MVA Soares, ... Seminars in Ultrasound, CT and MRI , 2025 2025 Citations: 1
Intraductal Papillary Neoplasm of the Bile Duct: Simplifying Findings NG Dias, J de Toledo Mendes, BA Kozlowski, DB Parente, DL Martins, ... Seminars in Ultrasound, CT and MRI , 2025 2025 Citations: 3
Periportal Space Lesions: Imaging Spectrum and Differential Diagnosis MM Gomes, GT Lingiardi, CLP Borborema, EO Pacheco, DB Parente, ... Seminars in Ultrasound, CT and MRI , 2025 2025
Coleção CBR Volume 3-Gastrointestinal RH Baroni, A Liguori, DB Parente, G D'Ippolito Editora dos Editores , 2025 2025
Rare benign liver tumors: current insights and imaging challenges E Salles-Silva, PL de Castro, LC Ambrozino, L Labrunie, M Zapparoli, ... Seminars in Ultrasound, CT and MRI 46 (3), 154-160 , 2025 2025 Citations: 4
Rare malignant liver tumors: current insights and imaging challenges E Salles-Silva, PL de Castro, LC Ambrozino, ALE de Araújo, ... Seminars in Ultrasound, CT and MRI 46 (3), 161-176 , 2025 2025 Citations: 4
Cardiac and liver fibrosis assessed by multiparametric MRI in patients with Fontan circulation A Innocenzi, I Rangel, M Póvoa-Corrêa, DB Parente, R Perez, ... Pediatric Cardiology 46 (4), 966-975 , 2025 2025 Citations: 7
Imaging of gallbladder cancer L Labrunie, L Nahoum, P Carpentieri-Primo, G Mendes, VB Amorim, ... Gallbladder Cancer: A Comprehensive Guide to Management, 67-84 , 2025 2025 Citations: 1
Clear cell likelihood score may improve diagnosis and management of renal masses E Salles-Silva, EM Lima, VB Amorim, M Milito, DB Parente Abdominal Radiology 49 (12), 4494-4506 , 2024 2024 Citations: 3
Decoding the Prevalent High-Risk Breast Cancers: Demographics, Pathological, Imaging Insights, and Long-Term Outcome P Alvarenga, JY Park, R Pinto, D Parente, K Lajkosz, S Westergard, ... Canadian Association of Radiologists Journal 75 (4), 855-867 , 2024 2024
Multiparametric magnetic resonance imaging of the liver and spleen in Gaucher disease DB Parente, FCM de Melo Malta, R de Souza Cravo, RR Luiz, V Rotman, ... Abdominal Radiology 49 (9), 3069-3077 , 2024 2024 Citations: 4
How cardiac fibrosis assessed via T1 mapping is associated with liver fibrosis in patients with non-alcoholic fatty liver disease FVO Terzi, GC Camargo, DB Parente, AM Pittella, G Silva-Junior, ... Journal of Clinical Medicine 12 (23), 7381 , 2023 2023 Citations: 3
Relative enhancement index can be used to quantify liver function in cirrhotic patients that undergo gadoxetic acid–enhanced MRI AL Eiras-Araújo, DB Parente, AC da Silva, GF da Motta Rezende, ... European Radiology 33 (7), 5142-5149 , 2023 2023 Citations: 15
Crohn’s disease: review and standardization of nomenclature FCB Magalhães, EM Lima, P Carpentieri-Primo, MM Barreto, ... Radiologia Brasileira 56 (2), 95-101 , 2023 2023 Citations: 13
Madame Bouveret: Duodenal Obstruction due to a Large Isoattenuating Gallstone L Nahoum, P Carpentieri-Primo, DB Parente Official journal of the American College of Gastroenterology| ACG 118 (5), 769 , 2023 2023
MOST CITED SCHOLAR PUBLICATIONS
Potential role of diffusion tensor MRI in the differential diagnosis of mild cognitive impairment and Alzheimer's disease D B. Parente, EL Gasparetto, LCH Cruz Jr, RC Domingues, AC Baptista, ... American Journal of Roentgenology 190 (5), 1369-1374 , 2008 2008 Citations: 104
Accuracy of the ADNEX MR scoring system based on a simplified MRI protocol for the assessment of adnexal masses PN Pereira, LO Sarian, A Yoshida, KG Araújo, RHO Barros, AC Baião, ... Diagnostic and Interventional Radiology 24 (2), 63 , 2018 2018 Citations: 90
Intravoxel incoherent motion diffusion weighted MR imaging at 3.0 T: assessment of steatohepatitis and fibrosis compared with liver biopsy in type 2 diabetic patients DB Parente, FF Paiva, JA Oliveira Neto, L Machado-Silva, FAF Figueiredo, ... Plos one 10 (5), e0125653 , 2015 2015 Citations: 52
MR imaging of hypervascular lesions in the cirrhotic liver: a diagnostic dilemma DB Parente, RM Perez, A Eiras-Araujo, JA Oliveira Neto, E Marchiori, ... Radiographics 32 (3), 767-787 , 2012 2012 Citations: 51
Is MR spectroscopy really the best MR-based method for the evaluation of fatty liver in diabetic patients in clinical practice? DB Parente, RS Rodrigues, FF Paiva, JA Oliveira Neto, L Machado-Silva, ... PloS one 9 (11), e112574 , 2014 2014 Citations: 45
Hepatobiliary contrast agents: differential diagnosis of focal hepatic lesions, pitfalls and other indications FAF Francisco, ALE Araújo, JA Oliveira Neto, DB Parente Radiologia brasileira 47, 301-309 , 2014 2014 Citations: 45
Preperitoneal fat as a non‐invasive marker of increased risk of severe non‐alcoholic fatty liver disease in patients with type 2 diabetes DB Parente, JA Oliveira Neto, PEAA Brasil, FF Paiva, JPR Ravani, ... Journal of gastroenterology and hepatology 33 (2), 511-517 , 2018 2018 Citations: 39
Everolimus for cardiac rhabdomyomas in children with tuberous sclerosis. The ORACLE study protocol (everOlimus for caRdiac rhAbdomyomas in tuberous sCLErosis): a randomised … EV Stelmaszewski, DB Parente, A Farina, A Stein, A Gutierrez, ... Cardiology in the Young 30 (3), 337-345 , 2020 2020 Citations: 32
Pulmonary arterial hypertension: an imaging review comparing MR pulmonary angiography and perfusion with multidetector CT angiography FP Junqueira, C Lima, AC Coutinho, DB Parente, LK Bittencourt, ... The British Journal of Radiology 85 (1019), 1446-1456 , 2012 2012 Citations: 27
Multiparametric magnetic resonance imaging of the prostate JAO Neto, DB Parente Magnetic Resonance Imaging Clinics 21 (2), 409-426 , 2013 2013 Citations: 25
O risco da radiação no uso indiscriminado da tomografia computadorizada DB Parente Radiologia Brasileira 46, v-vi , 2013 2013 Citations: 22
Fat-containing liver lesions: a pictorial review DB Parente, JA Oliveira, ALE Araújo, RS Rodrigues, RM Perez, ... Radiologia Brasileira 51 (1), 52-57 , 2018 2018 Citations: 20
Optimizing the decellularized porcine liver scaffold protocol L Alaby Pinheiro Faccioli, G Suhett Dias, V Hoff, M Lemos Dias, ... Cells Tissues Organs 211 (4), 385-394 , 2022 2022 Citations: 16
Relative enhancement index can be used to quantify liver function in cirrhotic patients that undergo gadoxetic acid–enhanced MRI AL Eiras-Araújo, DB Parente, AC da Silva, GF da Motta Rezende, ... European Radiology 33 (7), 5142-5149 , 2023 2023 Citations: 15
Crohn’s disease: review and standardization of nomenclature FCB Magalhães, EM Lima, P Carpentieri-Primo, MM Barreto, ... Radiologia Brasileira 56 (2), 95-101 , 2023 2023 Citations: 13
Radiation risk in the indiscriminate use of CT scan DB Parente Radiologia Brasileira 46, v-vi , 2013 2013 Citations: 13
Computed tomography and magnetic resonance enterography findings in Crohn's disease: what does the clinician need to know from the radiologist? C Pesce Lamas Constantino, R Souza Rodrigues, J Araujo Oliveira Neto, ... Canadian Association of Radiologists Journal 65 (1), 42-51 , 2014 2014 Citations: 11
Pheochromocytoma of the urinary bladder AM Fernandes, BV Paim, APA Vidal, E Marchiori, DB Parente Radiologia brasileira 50, 199-200 , 2017 2017 Citations: 10
Contraste hepatobiliar: diagnóstico diferencial das lesões hepáticas focais, armadilhas e outras indicações FAF Francisco, ALE Araújo, JA Oliveira Neto, DB Parente Radiologia Brasileira 47, 301-309 , 2014 2014 Citations: 10
Higher cut-off values of non-invasive methods might be needed to detect moderate-to-severe steatosis in morbid obese patients: a pilot study DB Parente, H Perazzo, FF Paiva, CFF Campos, CJ Saboya, SE Pereira, ... Scientific Reports 10 (1), 15007 , 2020 2020 Citations: 8
