Dr. Palakollu Venkata Narayana
@reva.edu.in
Assistant Professor
REVA University
EDUCATION
M.Sc. Ph.D
Scopus Publications
Scopus Publications
Srinivas Birudukota, Bhaskar Mangalapu, Ramesha Andagar Ramakrishn, Swagata Halder, and Venkata Narayana Palakollu
Open Science Publishers LLP
This study presents an innovative gas chromatographic-flame ionization detection (GC-FID) method, developed and validated in accordance with The International Council for Harmonisation (ICH) guidelines, for the quantitative analysis of chloroacetyl chloride, a potentially genotoxic impurity, in chlordiazepoxide hydrochloride active pharmaceutical ingredient. Due to the reactive and genotoxic nature of chloroacetyl chloride, precise quantification is imperative in the active pharmaceutical ingredient. The proposed method involves the conversion of chloroacetyl chloride into methyl 2-chloroacetate (MCA), enabling indirect quantification via a GC-FID approach employing a DB wax column. The validated GC-FID method displays exceptional features, such as remarkable linearity, ranging from 0.38 to 1.8 ppm with a correlation coefficient of 0.9998, as well as low detection and quantification limits of 0.19 and 0.38 ppm, and the method is specific without interference. The precision of the method expressed as the % RSD was 0.53%. The sample recovery ranging from 97.3% to 101.5%, confirms the method’s accuracy. Furthermore, three different batches of chlordiazepoxide hydrochloride underwent evaluation using this method. In conclusion, this method offers a highly sensitive approach for the precise quantification of chloroacetyl chloride in chlordiazepoxide hydrochloride drug substance, thereby ensuring compliance with the stringent safety standards of the pharmaceutical industry.
Venkata Narayana Palakollu, Y. Veera Manohara Reddy, Mehdihasan I. Shekh, S.V. Prabhakar Vattikuti, Jaesool Shim, and Rajshekhar Karpoormath
Elsevier BV
Sowjanya Bandlapalli, Reddi Mohan Naidu Kalla, Venkata Narayana Palakollu, Gouthami Kuruvalli, Vaddi Damodara Reddy, Kholood A. Dahlous, and Jaewoong Lee
Springer Science and Business Media LLC
Manjunatha Kumara K. S., D. H. Nagaraju, Zhoveta Yhobu, Nayan Kumar H. N., Srinivasa Budagumpi, Shubhankar Kumar Bose, Shivakumar P., and Venkata Narayana Palakollu
MDPI AG
The functionalization of materials for ultrasensitive detection of heavy metal ions (HMIs) in the environment is crucial. Herewith, we have functionalized inexpensive and environmentally friendly Fe3O4 nanoparticles with D-valine (Fe3O4–D–Val) by a simple co-precipitation synthetic approach characterized by XRD, FE-SEM, and FTIR spectroscopy. The Fe3O4–D–Val sensor was used for the ultrasensitive detection of Cd+2, Pb+2, and Cu+2 in water samples. This sensor shows a very low detection limit of 11.29, 4.59, and 20.07 nM for Cd+2, Pb+2, and Cu+2, respectively. The detection limits are much lower than the values suggested by the world health Organization. The real water samples were also analyzed using the developed sensor.
Y. Veera Manohara Reddy, Jae Hwan Shin, Venkata Narayana Palakollu, Bathinapatla Sravani, Chang-Hyung Choi, Kyeongsoon Park, Sun-Ki Kim, G. Madhavi, Jong Pil Park, and Nagaraj P. Shetti
Elsevier BV
Venkata Narayana Palakollu, Dazhu Chen, Jiao-Ning Tang, Lei Wang, and Chen Liu
Springer Science and Business Media LLC
Venkata Narayana Palakollu, Rajshekhar Karpoormath, Lei Wang, Jiao-Ning Tang, and Chen Liu
MDPI AG
The excessive intake of chlorpromazine (CPZ) adversely affects human health profoundly, leading to a series of severe diseases such as hepatomegaly and dyskinesia. The rapid and precise detection of CPZ in real samples is of great significance for its effective surveillance. Herein, a versatile and sensitive electrochemical sensor was developed for the detection of antipsychotic drug CPZ based on a Nafion (Nf)-supported nitrogen-doped carbon dots/cuprous oxide (N-CDs/Cu2O) composite. The as-synthesized N-CDs/Cu2O composite was systematically characterized using various physicochemical techniques. The developed composite-based sensor displayed excellent performance towards CPZ determination in a dynamic linear range of 0.001–230 µM with the detection limit of 25 nM. Remarkably, the developed sensor displayed good performance in terms of sensitivity and selectivity. Furthermore, good anti-interference properties toward CPZ determination were attained despite the presence of highly concentrated interfering compounds. Therefore, this composite could be a notable potential modifier to enhance electrocatalytic activity onto the surface of the electrode. Finally, N-CDs/Cu2O/Nf-based sensor was effectively applied for quantification of CPZ in human urine and pharmaceutical formulation samples.
Venkata Narayana Palakollu, Tirivashe E. Chiwunze, Chen Liu, and Rajshekhar Karpoormath
Elsevier BV
P. Shaikshavali, T. Madhusudana Reddy, T. Venu Gopal, G. Venkataprasad, Venkata S. Kotakadi, V.N. Palakollu, and R. Karpoormath
Elsevier BV
P. Shaikshavali, T. Madhusudana Reddy, V.N. Palakollu, R. Karpoormath, Y. Subba Rao, G. Venkataprasad, T. Venu Gopal, and P. Gopal
Elsevier BV
Tirivashe Elton Chiwunze, Venkata Narayana Palakollu, Atal A.S. Gill, Francis Kayamba, Neeta Bachheti Thapliyal, and Rajshekhar Karpoormath
Elsevier BV
Venkata Narayana Palakollu and Rajshekhar Karpoormath
Elsevier BV
Venkata Narayana Palakollu, Tirivashe E. Chiwunze, Atal A.S. Gill, Neeta Thapliyal, Shital M. Maru, and Rajshekhar Karpoormath
Elsevier BV
Tirivashe Elton Chiwunze, Neeta Bachheti Thapliyal, Venkata Narayana Palakollu, and Rajshekhar Karpoormath
Wiley
Mefloquine (MQ) is a quinoline based antimalarial drug, which is potent against multiple drug-resistant Plasmodium falciparum. It is widely prescribed for the prophylactic treatment of malaria. Due to extensive usage of MQ, constant monitoring of the drug level in human body is of paramount importancein order to ensure that optimum drug exposure is achieved. The present work describes a gold nanourchins (AuNUs) based electrochemical sensor for the determination of MQ.AuNUs were synthesized via seed-mediated method and characterized using ultraviolet-visible spectroscopy, energy-dispersive X-ray spectroscopy, field emission scanning electron microscopy, zeta-sizer and electrochemical techniques (electrochemical impedance spectroscopy and cyclic voltammetry). Fabrication of the sensor was done by drop-coating the synthesized AuNUs onto a glassy carbon electrode. The fabricated sensor exhibited enhanced voltammetric response, which was attributed to the excellent conductivity and high surface area of AuNUs. Under optimum square wave voltammetric conditions, the sensor displayed two linear response ranges (from 2.0×10−9 to 1.0×10−6 M and from 1.0×10−6 to 1.0×10−3 M) with a detection limit of 1.4 nM. The electrode demonstrated good reproducibility, stability and selectivity over common interferents. The utility of the sensor was successfully assessed for quantification of the drug in pharmaceutical preparation and spiked human urine sample. Thus, the present study demonstrates a promising approach for determination of MQ with practical utility in quality control and clinical analysis.
Venkata Narayana Palakollu, Neeta Thapliyal, Tirivashe E. Chiwunze, Rajshekhar Karpoormath, Sivanandhan Karunanidhi, and Srinivasulu Cherukupalli
Elsevier BV
Palla Gopal, Tukiakula Madhusudana Reddy, and Venkata Narayana Palakollu
Wiley
Gallic acid (GA) is an important organic acid, found in many natural plants and in food beverages. Here in, we have developed a chemical sensor for the monitoring of GA in wine, green tea and fruit juices. The oxidation of GA was found to be an irreversible process and the corresponding mechanism was proposed. The effect of pH on the oxidation behavior was studied and pH-6.0 was selected as an optimum pH. Based on the scan rate results a linear relation was observed between the square root of scan rate and peak currents for GA, confirming the oxidation of GA as a diffusion controlled process. The kinetic parameters such as diffusion coefficient, heterogeneous rate constant and charge transfer coefficient values were determined. The limit of detection (LOD) and quantification (LOQ) values were calculated as 4.39 × 10-7 M and 1.46 × 10-6 M. The repeatability, reproducibility and stability of the developed sensor were examined and the results confirmed that the developed sensor was in superior in condition. Finally, the practical application of the developed sensor was scrutinized for the quantitative estimation of GA in wine, green tea and fruit juices.
Srinivasulu Cherukupalli, Rajshekhar Karpoormath, Balakumar Chandrasekaran, Girish. A. Hampannavar, Neeta Thapliyal, and Venkata Narayana Palakollu
Elsevier BV
P.V. Narayana, T. Madhusudana Reddy, P. Gopal, M. Mohan Reddy, and G. Ramakrishna Naidu
Elsevier BV
P. V. Narayana, T. Madhusudana Reddy, P. Gopal, and G. Ramakrishna Naidu
Royal Society of Chemistry (RSC)
Facile and sensitive nanocomposite sensor based on the electropolymerization of glycine onto the surface of a glassy carbon electrode using cyclic voltammetry followed by drop casting multi-walled carbon nanotubes.
P. Gopal, T. Madhusudana Reddy, K. Reddaiah, P. Raghu, and P.V. Narayana
Elsevier BV