Wiwik Winarningsih

Verified email at unusa.ac.id

FAKULTAS KEDOKTERAN
UNIVERSITAS NAHDLATUL ULAMA SURABAYA



                             

https://researchid.co/drwiwik
1

Scopus Publications

3

Scholar Citations

1

Scholar h-index

Scopus Publications

  • Potential therapy of Sambiloto plant (Andrographis paniculata) using multi-compounds analysis
    Handayani and Wiwik Winarningsih

    Gaceta Medica de Caracas, ISSN: 03674762, Volume: 129, Pages: 814-822, Published: October 2021 Saber CDCH-UCV
    Introduction: Sambiloto plant (Andrographis paniculata) is often used as herbal medicine plant in Indonesia. Previous evidence indicates the use of a whole plant or single-compound approach. Analysis of multi-compounds is needed to determine the therapeutic potential for standardizing herbal medicine to provide a reliable effect. Methods: An exploratory study searching for the active content of A. paniculata was carried out in the Knapsack program. The chemical structure is analyzed computationally using Prediction of Activity Spectra for Substances (PASS) software. The analysis of the mechanism of action of drug molecules was analyzed using the Search Tool for Interacting Chemicals (STITCH) software. Results: The active content of A. paniculata is 46 types, with 5 of them having 6 effects based on chemical bonds and targeting 12 receptor proteins. Five active contents of A. paniculata include andrographidin A, caffeic acid, chlorogenic acid, wogonin 5-glucoside, and cinnamic acid. Analysis of the mechanism of action of A. paniculata based on 12 target proteins from active ingredients using a multi-compound approach shows 6 unique biological processes. Based on the chemical bonds, 5 active contents of A. paniculata have six effects, including anaphylatoxin receptor antagonist, a beta-adrenergic receptor kinase inhibitor, GABA C receptor agonist, G-protein-coupled receptor kinase inhibitor, Aryl hydrocarbon receptor agonist, and Nicotinic alpha6beta3beta4alpha5 receptor antagonist. Conclusion: There is a therapeutic potential of A. paniculata with multi-compounds analysis. A molecular docking analysis is needed to predict the affinity between the ligand (active ingredient) and the target protein.

RECENT SCHOLAR PUBLICATIONS

  • SANITASI MAKANAN DAN POLA MAKAN DI PONDOK PESANTREN SUNAN DRAJAD LAMONGAN
    MW Lestari, W Winarningsih
    Dharmakarya 11 (2), 86-88 2022

  • Pencegahan Stunting di Kabupaten Pasuruan dengan Pelatihan Pengolahan Ikan Gabus
    H Handayani, W Winarningsih, MF Kombih
    Journal of Dedicators Community 6 (1) 2022

  • Webinar Penyuluhan Dan Sosialisasi Tentang Vaksin Covid 19 Untuk Pengurus Mulimat NU Wilayah Jawa Timur
    W Winarningsih, MW Lestari, F Nuriannisa, ADS Ramadhana
    SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT 2021 1 (1), 1016-1022 2022

  • Pelatihan Budidaya Tanaman Herbal di Lingkungan Pondok Pesantren Zainul Hasan Genggong
    MW Lestari, W Winarningsih, PS Ardiansyah
    SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT 2021 1 (1), 1033-1036 2022

  • Multiple Strategies For Reducing Open Defecation In Pasuruan Regency, East Java, Indonesia
    W Winarningsih, Z Fanani, E Setyowati, J Rubijoso
    International Journal of Advanced Research (IJAR) 7 (7), 639-646 2019

  • Reducing Escherichia Coli Contamination On Dringking Water Stations In Pasuruan, East Java, Indonesia
    W Winarningsih, Z Fanani, E Setyowati, J Rubijoso
    International Journal of Advanced Research (IJAR) 7 (7), 19-27 2019

  • Community Knowledge About Poskestren As A Community Based Health Initiative At Darussalam Al-Faisholiyah Islamic Boarding School. Sampang, Madura
    MW Lestari, W Winarningsih
    Proceedings International Conference of Public Health 2019

  • Screening Kesehatan Penyakit Asam Urat & Diabetes Mellitus Pada Lansia Di Panti Werdha Mojopahit Mojokerto
    WH Santy, W Winarningsih
    Community Development Journal 2 (1) 2018

  • PENGARUH KUALITAS PELAYANAN, TARIF KAMAR DAN FASILITAS TERHADAP KEPUASAN PASIEN RAWAT INAP RUMAH SAKIT HAJI
    IS Rakhmandhani, W Winarningsih
    Jurnal Ilmu dan Riset Manajemen (JIRM) 6 (11) 2017

MOST CITED SCHOLAR PUBLICATIONS

  • Multiple Strategies For Reducing Open Defecation In Pasuruan Regency, East Java, Indonesia
    W Winarningsih, Z Fanani, E Setyowati, J Rubijoso
    International Journal of Advanced Research (IJAR) 7 (7), 639-646 2019
    Citations: 2

  • Reducing Escherichia Coli Contamination On Dringking Water Stations In Pasuruan, East Java, Indonesia
    W Winarningsih, Z Fanani, E Setyowati, J Rubijoso
    International Journal of Advanced Research (IJAR) 7 (7), 19-27 2019
    Citations: 1