Statistics and Probability, Rheumatology, Immunology and Allergy
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Scopus Publications
Scopus Publications
Mortality in orthopedic patients: a retrospective review of 333 medical records Kamran Shirbache, Asma Mafhoumi, Nazanin Anaraki, Elham Madreseh, Seyyed Hossein Shafiei, Nima Bagheri, Leila Oryadi Zanjani, Ahmadreza Nezameslami, Gholamreza Garmroudi, Mohammad Hossein Nabian European Journal of Orthopaedic Surgery and Traumatology, 2025
Self-reported Adherence to Treatment and Disease Activity in Patients with Rheumatoid Arthritis from Iran; Based on RHEUMATRY-RA Registry: A Cross-sectional Study Mojtaba Fazel, Peyvand Parhizkar Roudsari, Alireza Mirzamohamadi, Samaneh Soltani, Marzieh Asgari, et al. Indian Journal of Rheumatology, 2025 Background: Poor medication adherence challenges efficacy and costs in achieving treatment goals for rheumatoid arthritis (RA). This study aimed to determine the prevalence of treatment adherence and its related factors in Iranian RA patients. Methods: This cross-sectional study included RA outpatients referred to the rheumatology clinic of Shariati Hospital between March 2017 and September 2018, with the diagnosis based on the American College of Rheumatology (2010 ACR/EULAR) criteria. Treatment adherence was evaluated using the standardized Persian version of the 8-item Morisky Medication Adherence Scale (MMAS-8). Demographic and clinical information was extracted through the Iranian RA registry system (RHEUMATRY-RA). Results: Of 275 participants (222(81%) female), 20(7%) patients had active RA. Medication adherence was low in 138(50%) of patients, moderate in 81(30%) and high in 56(20%). In patients with disease duration ≤ 10 years, medication adherence was significantly associated with sex and occupation. It was observed that older patients (adjusted odds ratio (aOR) (95% confidence interval (CI): 1.01(0.98, 1.03)) and women (aOR (95% CI): 1.64(0.60, 4.45)) had more adherence. Patients on glucocorticoids demonstrated higher (aOR (95% CI): 1.76(0.81, 3.84)) and on methotrexate lower (aOR (95% CI): 0.58(0.18, 1.86)) adherence. The odds of disease activity were 21% lower in people who had adhered to medication (aOR (95% CI): 0.79(0.29, 2.15)). Conclusion: Despite the inherent complexity of adherence behaviors, this study identified a high prevalence of poor medication adherence among RA patients. Patients with better adherence may have lower disease activity, underscoring its role in effective disease management.
Comparative analysis of mental workload and performance between young and elderly drivers: Implications for road safety and age-related driving challenges Elham Entezarizarch, Seyed Abolfazl Zakerian, Elham Madreseh, Marzieh Abbasinia, Hanieh Abdi Work, 2025 Background Driving represents a multifaceted cognitive endeavor, demanding heightened vigilance and swift responses. Considering the high statistics of driving accidents and heavy loads, as well as the effect of the driver’s age on the occurrence of accidents, it is important to investigate these factors to reduce accidents. Objective This study investigates the impact of mental workload on the performance of young and older drivers in a dynamic driving scenario to compare cognitive performance, workload perception, and driving outcomes between the two age groups. Methods Cognitive tests including the Stroop test, Continuous Performance test, and Focused Attention test were conducted, alongside the use of the DALI questionnaire to measure workload levels. Participants encompassed twenty male drivers, divided into two age groups: 20 to 35 years and 55 to 70 years, with varying years of driving experience. The study entailed a dynamic driving scenario involving a designated route in Tehran, Iran. Results Results exhibited differences in workload scores between the age groups, particularly in dimensions such as visual demand, auditory demand, attention, and interference. Older drivers demonstrated heightened cognitive and physical demands during driving, implying a greater need for attention and cognitive effort. Conclusion The findings of this study indicated that navigating through congested roads and dense urban traffic significantly elevates the mental workload for drivers, consequently impacting their cognitive functioning. Given the critical need for attention in driving, this heightened workload can manifest as increased fatigue, increasing stress levels, and diminished concentration, all of which substantially raise the risk of vehicular accidents. Furthermore, the study highlighted a particular concern for older drivers, whose diminished cognitive capacities further raise their vulnerability to accidents under such demanding driving conditions.
The Association of Interleukin 6 Receptor Gene Variant (Rs4129267) with Susceptibility to Ankylosing Spondylitis and Soluble IL-6 Receptor Level in Iranian Patients Samaneh Enayati, Maryam Akhtari, Farideh Darabi, Nooshin Ahmadzadeh, Shayan Mostafaei, Yousef Vojgani, Elham Madreseh, Elham Farhadi, Masoomeh Akhlaghi, Ahmadreza Jamshidi, Mahdi Mahmoudi Indian Journal of Rheumatology, 2025 Objectives: Ankylosing spondylitis (AS) is an axial skeleton-related auto-inflammatory arthritis. Interleukin 6 (IL-6) and its receptor (IL-6R) play a role in the etiopathology of AS. The recent genome-wide association studies (GWASs) revealed that rs4129267; an intrinsic variant of IL6-R is associated with the risk of AS. We aimed to study the rs4129267 IL6R variant in Iranian AS patients and the correlation of this variant with the soluble interleukin-6 receptor (sIL-6R) serum level. Materials and Methods: In this case-control study, we genotyped rs4129267 IL6-R variant in extracted DNA from 498 AS patients and 495 matched healthy controls by Amplification-Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR). The serum level of sIL-6R and IL-6 was also analysed in 39 controls and 42 AS patients by the ELISA method. The correlation between rs4129267 IL-6R variants and patients’ clinical manifestations and sIL-6R level was also investigated. Results: In comparison to the AS individuals, C allele were significantly less prevalent in the healthy control group (OR = 1.23 [1.01 –1.48], P value = .034). Patients had significantly elevated levels of IL-6 serum levels. There was a significant correlation between the presence of the rs4129267 T allele and increased sIL-6R level. Conclusions: Our study confirmed the significant association between the rs4129267 T variant and the protection against AS disease susceptibility. Increased IL-6 level and reduced frequency of sIL-6R rs4129267 T allele in patients which contributes to reduced sIL-6R serum level, highlights the significant role of IL-6 signalling pathway in AS pathogenesis.
Investigation of the effects of combined exercises and self-management education, with and without functional exercises, on pain and functional outcomes in patients with avascular necrosis of the femoral head: a protocol for a single-blind, randomised controlled trial with a parallel design and a 4 month follow-up Zohreh Gholami, Seyedeh Tahereh Faezi, Raghad Mimar, Elham Madreseh BMJ Open Sport and Exercise Medicine, 2025 Non-traumatic avascular necrosis of the femoral head (AVNFH) is a progressive condition that often affects young individuals, leading to bone death and eventual collapse. This degeneration is causing pain and limited function in daily activities over time. This study will plan to enrol 53 male and female participants, aged 18–50 years, who have been diagnosed with AVNFH. Participants will be randomly assigned to one of two groups: (1) the Exe+Functional group, which will receive 12 weeks of mixed therapeutic exercises combined with functional resistance exercises and self-management education and (2) the control group, which will receive the same interventions but without functional exercises. The Exe+Functional group will engage in two times per week sessions of low-intensity resistance, and mobility exercises, along with a one time per week functional exercise session. The control group will have 3 weekly sessions of low-intensity exercises (resistance and mobility) without functional exercises. The primary outcomes of the study will be pain, measured using a Visual Analogue Scale (VAS) and functional pain, assessed using a Numeric Rating Scale (NRS). Secondary outcomes will include the Harris Hip Score, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for hip osteoarthritis, the Timed Up and Go (TUG) test, the 30 s Chair Stand Test, active range of motion, muscle strength and the 10-metre walk test. Data will be collected at baseline (preintervention), postintervention at 12 weeks and at a 4 month follow-up. Trial registration number: IRCT20220510054814N2.
Monitoring of laboratory reared of Phlebotomus papatasi (Diptera: Psychodidae), main vector of zoonotic cutaneous leishmaniasis to different imagicides in hyper endemic areas, Isfahan Province, Iran Journal of Arthropod Borne Diseases, 2020
A descriptive study of medicinal plants and polyherbal formulation prescribed for patients in Persian medicine clinic (Salamatkadeh) affiliated to Tehran University of Medical Sciences (2016) Journal of Reports in Pharmaceutical Sciences, 2018
