Drug Discovery, Pharmacology, Toxicology and Pharmaceutics, Food Science, Pharmaceutical Science
91
Scopus Publications
2774
Scholar Citations
30
Scholar h-index
65
Scholar i10-index
Scopus Publications
Beyond the Shadow of Indole: Medicinal Chemistry of Indolizines and Isoindolinones in the Fight Against Infectious Diseases Mirko Pineschi, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani Archiv Der Pharmazie, 2026 Infectious diseases remain a major global health challenge, accounting for millions of deaths annually and placing an increasing burden on healthcare systems worldwide. The rapid emergence of multidrug‐resistant (MDR) and extensively drug‐resistant (XDR) bacterial strains, together with recurrent outbreaks of viral infections such as SARS‐CoV‐2, Ebola, Zika, Monkeypox, and influenza, underscores the urgent need for novel therapeutic agents with diverse mechanisms of action. In this context, indolizines, isoindoles, and isoindolinones represent promising scaffolds in anti‐infective drug discovery due to their unique structural features, versatile reactivity, and ability to engage multiple biological targets. This review provides an updated overview of the medicinal chemistry of indolizine and isoindoles, with particular emphasis on compounds demonstrating activities against infectious pathogens. Representative examples are highlighted to illustrate structure–activity relationships (SARs), scaffold‐based optimization strategies, and emerging mechanistic insights. Relevant synthetic methodologies are discussed only in the context of biologically active compounds to provide a framework for rational design. Collectively, this review underscores the therapeutic potential of indolizine‐ and isoindole‐derived scaffolds as versatile frameworks for anti‐infective drug development and highlights opportunities for further chemical and biological exploration.
Quinazolinone-Based PqsR Modulators Suppress Quorum-Sensing–Driven Virulence in Pseudomonas aeruginosa Valeria Tudino, Marta Mellini, Leonardo Milioni, Gabriele Carullo, Sara Rossi, Francesca Maria Pia Rita Giammarino, Stefania Butini, Simone Brogi, Valerio Ciccone, Paolo Visca, Livia Leoni, Giordano Rampioni, Sandra Gemma, Giuseppe Campiani ACS Infectious Diseases, 2026 Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen for which new antimicrobial strategies are urgently needed. To facilitate the establishment of the infection, P. aeruginosa produces a remarkable assortment of both cell-associated and extracellular virulence factors. The expression of numerous virulence traits is regulated by the pqs quorum sensing (QS) system, which relies on multiple enzymes for the biosynthesis of 2-alkyl-4-quinolone (AQ) signal molecules and on the transcriptional regulator PqsR, whose activity is triggered by AQ binding. Herein, we report on the design and synthesis of novel quinazolinone-based PqsR modulators, which led to the identification of two novel compounds endowed with anti-PqsR activity in the submicromolar range. Additionally, these derivatives inhibited the production of PqsR-controlled virulence factors in laboratory strains and clinical isolates of P. aeruginosa.
Oxyprenyl–chalcones as antibacterial hits: design of experiments-optimized synthesis, antibacterial evaluation, early drug-like profiling and biodegradability prediction Ludovica Marotta, Francesca Maria Pia Rita Giammarino, Brondon Brandly Senenou Tambou, Valeria Tudino, Stefania Butini, Lorenza Broccardo, Sacha Michèle Idriss Cancade, Jean-Denis Docquier, Federica Perego, Nicoletta Basilico, Lorenzo Raffellini, Sheraz Gul, Gabriele Carullo, Sandra Gemma, Giuseppe Campiani Rsc Medicinal Chemistry, 2026 The escalating threat of antimicrobial resistance (AMR) compels the development of novel antibiotics with broad spectrum activity and environmentally responsible degradation profiles.
Targeting Class I Histone Deacetylases Triggers Antitumor Responses in Colorectal Cancer In Vitro and In Vivo Gabriele Carullo, Federica Falbo, Valeria Tudino, Jiazhao Song, Marianna Fava, Anna Fontana, Adrian Koch, Anita Heiß, Katharina Erlenbach-Wuensch, Giovanna Panzeca, Simone Brogi, Alessia Bichicchi, Simona Saponara, Fabio Fusi, Fabrizio Vincenzi, Katia Varani, Martina Cappello, Silvia Pasquini, Anna Ramunno, Giacomo Pepe, Stefania Butini, Francesca Aiello, Sandra Gemma, Regine Schneider-Stock, Giuseppe Campiani Journal of Medicinal Chemistry, 2026 Class I histone deacetylases (HDACs) are frequently overexpressed in colorectal cancer (CRC). Combining computational, synthetic, and biological efforts, we developed novel o-aminobenzamide-based HDAC inhibitors (HDACis) optimized for class I enzyme-specific targeting. Compounds 5d and 5i emerged as lead candidates, showing strong antiproliferative effects in CRC cells with low toxicity in healthy colon epithelium. Both compounds disrupted the G2/M checkpoint through distinct mechanisms. 5i, although less potent (HDAC1 IC50 = 1508 nM), retained selectivity, upregulated p21, and triggered pronounced apoptosis. 5d (Colrestat), one of the most selective class I HDACis to date (HDAC1 IC50 = 41.2 nM, HDAC2 IC50 = 52.5 nM, and HDAC3 IC50 = 74.3 nM), induced H3K9 acetylation, p21 upregulation, and G2/M arrest. The short-term in vitro effects of 5d were modulated by a compensatory upregulation of autophagy. However, in long-term, this protective mechanism becomes insufficient to sustain tumor survival, resulting in strong antitumor efficacy in vivo in the CAM assay for both compounds even outperforming entinostat.
Unveiling the Role of Pseudomonas aeruginosa Quorum Sensing Inhibitors: The Road So Far Valeria Tudino, Sara Rossi, Leonardo Milioni, Chiara Cosenza, Gabriele Carullo, Sandra Gemma, Stefania Butini, Giuseppe Campiani Chemical Record, 2026 ESKAPE bacteria represent a global threat to public health. These microorganisms employ a type of cell–cell communicationnamed “quorum sensing (QS) system,” which involves the activation of specific signals to modulate drug resistance and pathogenic behaviors. Noteworthy, resistance of Pseudomonas aeruginosa to antibiotics is increasing, thus leading to a greater interest in the development of new antibacterial compounds by exploring valuable targets such as its complex QS system. This review intends to provide an extensive report about the advances in the identification of promising P. aeruginosa QS inhibitors as potential novel therapeutic options. This work represents a comprehensive analysis of research articles available on Pubmed, Scopus, and Google Scholar, from January 2020 to July 2025, referring to promising antivirulence compounds, affecting P. aeruginosa QS system.
A Focus on Natural Autophagy Modulators as Potential Host-Directed Weapons Against Emerging and Re-Emerging Viruses Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani Medicinal Research Reviews, 2025 Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads. Among them, phytocompounds have been amply exploited in the search for new autophagy modulators to tackle diseases like cancer and degenerative disorders, while their use as potential antiviral agents has been explored to a limited extent. The modulation of autophagy in viral infections may play a dual and contraposing role. Depending on the replication mechanism of the virus, it may serve as an adjuvant in the innate immune response of the host, or it may be hijacked by viruses, favoring their replication. This review is intended to present an overview of antiviral natural compounds and extracts capable of modulating autophagy, and it seeks to provide a solid foundation for researchers to further investigate the mechanisms of autophagy modulation during viral infections and to identify diverse molecular entities for antiviral drug discovery.
New Vanillyl-capped HDAC inhibitors exhibit anti-tumor efficacy in neuroblastoma and glioblastoma cells Ilaria Cursaro, Luca Frattaruolo, Laura Scalvini, Chiara Contri, Alessia Bichicchi, Nicola Tardiolo, Valeria Tudino, Sara Rossi, Eugenia Nicol Manti, Martina Cappello, Chiara Papulino, Emilia Maellaro, Paola Marcolongo, Rosaria Benedetti, Lucia Altucci, Katia Varani, Marco Mor, Maria Frosini, Fabrizio Vincenzi, Anna Rita Cappello, Alessio Lodola, Simona Saponara, Stefania Butini, Gabriele Carullo, Sandra Gemma, Giuseppe Campiani Bioorganic Chemistry, 2025
The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity Fabio Fusi, Simona Saponara, Gabriele Carullo, Alice Panti, Alessia Bichicchi, Alice Pifferi, Beatrice Gianibbi, Ottavia Spiga, Federica Falbo, Umile Gianfranco Spizzirri, Giuseppe Campiani, Francesca Aiello European Journal of Pharmacology, 2025 ABSTRACT The synthetic derivative quercetin-3-oleate (AV2), a partial agonist of the G-protein-coupled receptor 40 (GPR40), and its parent compound quercetin, a stimulator of Ca V 1.2 channels, promote insulin secretion from INS-1 pancreatic β cells. An in vitro and in silico approach was pursued to assess whether the incorporation of oleic acid at the C3 position maintains quercetin stimulation of Ca V 1.2 channels (key to triggering insulin release) while reducing its vasorelaxant properties. In rat tail main artery myocytes, AV2, like quercetin, stimulated Ba 2+ currents via Ca V 1.2 channels (I Ba1.2 ), demonstrating favourable interaction in molecular docking analyses and molecular dynamics simulations. Although AV2 also stimulated K + currents via K Ca 1.1 channels (I KCa1.1 ), its vasorelaxant effect in vascular rings was significantly lower than that of quercetin. AV2 exhibited a positive inotropic effect and increased the frequency of Langendorff-perfused isolated rat hearts, albeit at concentrations one order of magnitude higher than those required for significant I Ba1.2 stimulation. In in vitro settings, AV2 maintained a significant H 2 O 2 -induced radical scavenging activity. In conclusion, the conjugation of oleic acid with the dietary flavonoid quercetin in AV2 attenuated its spasmolytic effects on vascular smooth muscle, without affecting its I Ba1.2 stimulatory activity. This, along with its GPR40 activation, highlights AV2 as a bifunctional agent with the potential to improve selective insulin secretion with minimal vascular effect.
Uncovering a Mutation-Independent Therapeutic Strategy against Inherited Retinal Diseases: Development of Class I HDAC/LSD1 Hybrid Inhibitors Gabriele Carullo, Ilaria Piano, Giulia Salamone, Francesca Corsi, Noemi Orsini, Maria Dichiara, Ilaria Cursaro, Anna Fontana, Alessia Galante, Chiara Contri, Ludovica Guadagno, Jonatan Caroli, Andrea Mattevi, Fabrizio Vincenzi, Katia Varani, Simone Brogi, Sandra Gemma, Stefania Butini, Claudia Gargini, Enrica Strettoi, Giuseppe Campiani ACS Chemical Neuroscience, 2025 Among genetic retinal disorders, retinitis pigmentosa (RP) is characterized by degeneration of rod photoreceptors caused by a large number of diverse mutations, most of which act through different pathways to which epigenetic targets also contribute. The eraser enzymes lysine demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) play major roles in the development of rod photoreceptors, and their inhibitors were shown to block inherited rod degeneration, preserving vision and contributing to a general anti-inflammatory profile at the retinal level. In this work, we proposed the development of polypharmacological agents targeting class I HDAC/LSD1 enzymes with the aim of treating the rd10 mice model of RP. The new small library of compounds is typified by hybrid (±)- 3d, which showed IC 50 values of 1702, 842, and 358 nM against HDAC1, HDAC2, and HDAC3, respectively, while inhibiting LSD1 with an IC 50 value of 1074 nM. When tested on hydrogen peroxide-stressed ARPE-19 and 661W retinal cells at a concentration of 10 μM, (±)- 3d showed a promising antioxidant profile, increasing the cellular levels of acetylated and methylated histone H3, and was selected for further studies also in light of its calculated IH-L. In the rd10 mice RP model, a single intravitreal injection of (±)- 3d, at the same concentration used in cells, enhanced photoreceptor survival, downregulated retinal expression of the inflammatory genes GFAP, Ccl2, and Ccl12, and effectively preserved the retinal pigment epithelium barrier. Furthermore, (±)- 3d promoted the acetylation and methylation of histone H3, thus confirming the engagement of both class I HDAC and LSD1.
Agri-food traceability today: Advancing innovation towards efficiency, sustainability, ethical sourcing, and safety in food supply chains Sara Rossi, Sandra Gemma, Francesca Borghini, Matteo Perini, Stefania Butini, Gabriele Carullo, Giuseppe Campiani Trends in Food Science and Technology, 2025 The increasing globalization and complexity of agri-food supply chains have heightened the demand for transparency, safety, and traceability in food systems. The integrity, authenticity, and safety of food products are critical, and the implementation of specific and reliable protocols for tracing and tracking is becoming the priority in food industry. Food supply chains often lack efficiency and consumers are becoming more conscious of the origin and quality of the foods they purchase, demanding more accurate systems for data delivery. In this light a straightforward understanding of agri-food supply chain traceability has become necessary. This review provides a roadmap for food traceability systems from legal requirements, to technological and analytical perspectives. The review explores key concepts such as tracking and tracing, outlines international regulatory frameworks, and introduces a novel taxonomy that classifies traceability systems by technological maturity and data granularity. Particular focus is given to innovative analytical technologies, such as proteomics, metabolomics/volatilomics, genomics, stable isotope and elemental profiling, as well as emerging digital technologies including AI and AsI, blockchain, IoT and FCM. Case studies for wine, garlic, and coffee traceability, demonstrate the application of these tools in real-world industrial and local scenarios. By integrating regulatory insights with innovative technologies, the review highlights best practices and strategic directions for boosting efficiency for end-to-end traceability. The review addresses innovative technologies for advanced food supply chains and underscores the role of traceability systems in building consumer trust, supporting public health, and advancing sustainable food production. • Technological and analytical roadmap for a comprehensive agri-food traceability system • New proposed bi-dimensional taxonomy for unambiguous food trace&tracking protocols • Improving efficiency and safety of agri-food supply chains by blockchain, AI and AsI • Best practices and challenges for an advanced global food system • Case studies: traceability for food products by innovative techniques empowered by AI
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization Stefania Butini, Uwe Grether, Kwang-Mook Jung, Alessia Ligresti, Marco Allarà, Annemarieke G. J. Postmus, Samuele Maramai, Simone Brogi, Alessandro Papa, Gabriele Carullo, David Sykes, Dmitry Veprintsev, Stefano Federico, Alessandro Grillo, Bruno Di Guglielmo, Anna Ramunno, Anna Floor Stevens, Dominik Heer, Stefania Lamponi, Sandra Gemma, Jörg Benz, Vincenzo Di Marzo, Mario van der Stelt, Daniele Piomelli, Giuseppe Campiani Journal of Medicinal Chemistry, 2024
Design and Synthesis of Oligopeptidic Parvulin Inhibitors Nicola Relitti, A. Prasanth Saraswati, Gabriele Carullo, Alessandro Papa, Alessandra Monti, Rosaria Benedetti, Eugenia Passaro, Simone Brogi, Vincenzo Calderone, Stefania Butini, Sandra Gemma, Lucia Altucci, Giuseppe Campiani, Nunzianna Doti Chemmedchem, 2022
Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy Giuseppe Campiani, Tuhina Khan, Cristina Ulivieri, Leopoldo Staiano, Chiara Papulino, Stefania Magnano, Seema Nathwani, Anna Ramunno, Daniel Lucena-Agell, Nicola Relitti, Stefano Federico, Luca Pozzetti, Gabriele Carullo, Alice Casagni, Simone Brogi, Francesca Vanni, Paola Galatello, Magda Ghanim, Niamh McCabe, Stefania Lamponi, Massimo Valoti, Ola Ibrahim, Jeffrey O'Sullivan, Richard Turkington, Vincent P. Kelly, Ruben VanWemmel, J. Fernando Díaz, Sandra Gemma, Daniela Zisterer, Lucia Altucci, Maria Antonietta De Matteis, Stefania Butini, Rosaria Benedetti European Journal of Medicinal Chemistry, 2022
Beyond the Shadow of Indole: Medicinal Chemistry of Indolizines and Isoindolinones in the Fight Against Infectious Diseases M Pineschi, S Rossi, S Butini, S Gemma, G Carullo, G Campiani Archiv der Pharmazie 359 (4), e70233 , 2026 2026
Quinazolinone-Based PqsR Modulators Suppress Quorum-Sensing–Driven Virulence in Pseudomonas aeruginosa V Tudino, M Mellini, L Milioni, G Carullo, S Rossi, FMPR Giammarino, ... ACS Infectious Diseases 12 (3), 1176-1191 , 2026 2026
Targeting Class I Histone Deacetylases Triggers Antitumor Responses in Colorectal Cancer In Vitro and In Vivo G Carullo, F Falbo, V Tudino, J Song, M Fava, A Fontana, A Koch, A Heiß, ... Journal of Medicinal Chemistry , 2026 2026
Towards more effective Glioblastoma Multiforme therapies: HDAC6 and HDAC8 combined targeting G Galassi, S Carbone, L Brioschi, I Tagliabue, A Vutera Cuda, A Pezzotta, ... 2026
Unveiling the Role of Pseudomonas aeruginosa Quorum Sensing Inhibitors: The Road So Far V Tudino, S Rossi, L Milioni, C Cosenza, G Carullo, S Gemma, S Butini, ... The Chemical Record, e202500359 , 2026 2026
Oxyprenyl–chalcones as antibacterial hits: design of experiments-optimized synthesis, antibacterial evaluation, early drug-like profiling and biodegradability prediction L Marotta, FMPR Giammarino, BBS Tambou, V Tudino, S Butini, ... RSC Medicinal Chemistry 17 (3), 1573-1585 , 2026 2026
HDAC6 and HDAC8 orchestrate sphingolipid metabolic reprogramming to regulate glioma cell fate I Tagliabue, L Brioschi, G Galassi, S Carbone, A Vutera Cuda, A Pezzotta, ... 2025
A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses I Cursaro, S Rossi, S Butini, S Gemma, G Carullo, G Campiani Medicinal Research Reviews 45 (6), 1850-1882 , 2025 2025 Citations: 3
New Vanillyl-capped HDAC inhibitors exhibit anti-tumor efficacy in neuroblastoma and glioblastoma cells I Cursaro, L Frattaruolo, L Scalvini, C Contri, A Bichicchi, N Tardiolo, ... Bioorganic Chemistry, 109085 , 2025 2025 Citations: 3
Towards more effective Glioblastoma Multiforme therapies: HDAC6 and HDAC8 combined targeting S Carbone, G Galassi, L Brioschi, I Tagliabue, A Vutera Cuda, A Pezzotta, ... 2025
The insulin-releasing agent quercetin-3-oleate stimulates CaV1. 2 channels similarly to quercetin, though with a reduced vasorelaxant activity F Fusi, S Saponara, G Carullo, A Panti, A Bichicchi, A Pifferi, B Gianibbi, ... European Journal of Pharmacology 1003, 177902 , 2025 2025
HDAC6 and HDAC8 inhibition enhances the efficacy of Temozolomide by rewiring sphingolipid metabolism and glioma cell fate I Tagliabue, L Brioschi, G Galassi, S Carbone, A Pezzotta, A Marozzi, ... 2025
Unveiling Wound Healing Properties of Biostimulated Walnut Kernel Extracts via Epithelial Mesenchymal Transition: Switching a Nutritional Matrix into a Therapeutic Remedy R Fedeli, E Ranzato, S Martinotti, MG Basilicata, L Marotta, M Fava, ... Antioxidants 14 (9), 1079 , 2025 2025 Citations: 3
Agri-food traceability today: Advancing innovation towards efficiency, sustainability, ethical sourcing, and safety in food supply chains S Rossi, S Gemma, F Borghini, M Perini, S Butini, G Carullo, G Campiani Trends in Food Science & Technology 163, 105154 , 2025 2025 Citations: 31
Uncovering a Mutation-Independent Therapeutic Strategy against Inherited Retinal Diseases: Development of Class I HDAC/LSD1 Hybrid Inhibitors G Carullo, I Piano, G Salamone, F Corsi, N Orsini, M Dichiara, I Cursaro, ... ACS Chemical Neuroscience 16 (17), 3364-3384 , 2025 2025 Citations: 1
Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor I Cursaro, V Ciccone, V Tudino, C Papulino, L Scalvini, S Donnini, ... European Journal of Medicinal Chemistry Reports 14, 100276 , 2025 2025 Citations: 2
HDAC8 and HDAC6 combined inhibition: a new frontier in glioblastoma treatment G Galassi, S Carbone, L Brioschi, I Tagliabue, A Pezzotta, A Marozzi, ... 2025
Discovery of p -Trifluoromethylbenzohydrazide Derivatives as Potent Antiviral Agents against Monkeypox Virus S Rossi, L Pozzetti, G Carullo, M Dichiara, S Butini, M Radi, A Ramunno, ... ACS Medicinal Chemistry Letters 16 (5), 837-843 , 2025 2025 Citations: 3
Targeting N ‐Methyl‐lysine Histone Demethylase KDM4 in Cancer: Natural Products Inhibitors as a Driving Force for Epigenetic Drug Discovery I Cursaro, L Milioni, K Eslami, H Sirous, G Carullo, S Gemma, S Butini, ... ChemMedChem 20 (4), e202400682 , 2025 2025 Citations: 9
Synthesis and biological investigation of peptidomimetic SARS‐CoV‐2 main protease inhibitors bearing quinoline‐based heterocycles at P 3 S Rossi, G Deidda, L Fiaschi, R Ibba, M Pieroni, M Dichiara, G Carullo, ... Archiv der Pharmazie 358 (1), e2400812 , 2025 2025 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Quercetin and derivatives: useful tools in inflammation and pain management G Carullo, AR Cappello, L Frattaruolo, M Badolato, B Armentano, F Aiello Future medicinal chemistry 9 (1), 79-93 , 2017 2017 Citations: 247
Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator … L Frattaruolo, G Carullo, M Brindisi, S Mazzotta, L Bellissimo, V Rago, ... Antioxidants 8 (6), 186 , 2019 2019 Citations: 187
From the hive: Honey, a novel weapon against cancer M Badolato, G Carullo, E Cione, F Aiello, MC Caroleo European journal of medicinal chemistry 142, 290-299 , 2017 2017 Citations: 139
Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists S Federico, L Pozzetti, A Papa, G Carullo, S Gemma, S Butini, ... Journal of medicinal chemistry 63 (22), 13466-13513 , 2020 2020 Citations: 121
Quercetin and its natural sources in wound healing management N Polerà, M Badolato, F Perri, G Carullo, F Aiello Current Medicinal Chemistry 26 (31), 5825-5848 , 2019 2019 Citations: 109
Improving kefir bioactive properties by functional enrichment with plant and agro-food waste extracts F Aiello, D Restuccia, UG Spizzirri, G Carullo, M Leporini, MR Loizzo Fermentation 6 (3), 83 , 2020 2020 Citations: 76
Evaluation of the in vitro wound-healing activity of calabrian honeys P Governa, G Carullo, M Biagi, V Rago, F Aiello Antioxidants 8 (2), 36 , 2019 2019 Citations: 73
GPR120/FFAR4 pharmacology: focus on agonists in type 2 diabetes mellitus drug discovery G Carullo, S Mazzotta, M Vega-Holm, F Iglesias-Guerra, JM Vega-Pérez, ... Journal of Medicinal Chemistry 64 (8), 4312-4332 , 2021 2021 Citations: 69
Identification of Breast Cancer Inhibitors Specific for G Protein-Coupled Estrogen Receptor (GPER)-Expressing Cells MR Francesca Aiello,*[a] Gabriele Carullo,[a] Francesca Giordano,[a] Elena ... ChemMedChem 12, 1279-1285 , 2017 2017 Citations: 69
Structure–activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009–2016) G Carullo, F Galligano, F Aiello MedChemComm 8 (3), 492-500 , 2017 2017 Citations: 64
Harnessing the role of HDAC6 in idiopathic pulmonary fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors G Campiani, C Cavella, JD Osko, M Brindisi, N Relitti, S Brogi, ... Journal of medicinal chemistry 64 (14), 9960-9988 , 2021 2021 Citations: 63
Synthesis and characterization of a (+)-catechin and L-(+)-ascorbic acid cocrystal as a new functional ingredient for tea drinks UG Spizzirri, G Carullo, L De Cicco, A Crispini, F Scarpelli, D Restuccia, ... Heliyon 5 (8) , 2019 2019 Citations: 55
Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation G Carullo, M Perri, F Manetti, F Aiello, MC Caroleo, E Cione Bioorganic & Medicinal Chemistry Letters 29 (14), 1761-1764 , 2019 2019 Citations: 55
Quercetin/oleic acid-based G-protein-coupled receptor 40 ligands as new insulin secretion modulators M Badolato, G Carullo, M Perri, E Cione, F Manetti, ML Di Gioia, A Brizzi, ... Future medicinal chemistry 9 (16), 1873-1885 , 2017 2017 Citations: 54
From vegetable waste to new agents for potential health applications: antioxidant properties and effects of extracts, fractions and pinocembrin from Glycyrrhiza glabra L … F Aiello, B Armentano, N Polera, G Carullo, MR Loizzo, M Bonesi, ... Journal of Agricultural and Food Chemistry 65 (36), 7944-7954 , 2017 2017 Citations: 52
An ancient remedial repurposing: Synthesis of new pinocembrin fatty acid acyl derivatives as potential antimicrobial/anti-inflammatory agents R Tundis, L Frattaruolo, G Carullo, B Armentano, M Badolato, MR Loizzo, ... Natural Product Research 33 (2), 162-168 , 2019 2019 Citations: 50
A therapeutic perspective of HDAC8 in different diseases: an overview of selective inhibitors A Fontana, I Cursaro, G Carullo, S Gemma, S Butini, G Campiani International Journal of Molecular Sciences 23 (17), 10014 , 2022 2022 Citations: 49
Nanotechnologies: An innovative tool to release natural extracts with antimicrobial properties UG Spizzirri, F Aiello, G Carullo, A Facente, D Restuccia Pharmaceutics 13 (2), 230 , 2021 2021 Citations: 49
Pinocembrin and its linolenoyl ester derivative induce wound healing activity in HaCaT cell line potentially involving a GPR120/FFA4 mediated pathway S Mazzotta, P Governa, V Borgonetti, P Marcolongo, C Nanni, ... Bioorganic Chemistry 108, 104657 , 2021 2021 Citations: 40
Autochthonous white grape pomaces as bioactive source for functional jams D Restuccia, G Giorgi, U Gianfranco Spizzirri, F Sciubba, G Capuani, ... International Journal of Food Science and Technology 54 (4), 1313-1320 , 2019 2019 Citations: 37
