Dr. E. Gayathiri
@gurunanakcollege.edu.in
Assistant professor Plant Biology and Plant Biotechnology
Guru Nanak College
I’m a botanist with a strong focus on Phytochemistry and Environmental biotechnology. My research activity includes Microbiology, Insilico modeling, and Bioengineering
EDUCATION
Ph.D Botany Madras University (2015)
M.Sc Botany Madras University (2010)
M.Sc. Microbiology Madras University (2003)
B.Ed Thiruvalluvar University (2007)
DFN Annamalai University (2006)
RESEARCH INTERESTS
Phytochemistry, Insilico Modelling, Environmental Biotechnology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Ekambaram Gayathiri, Palanisamy Prakash, Thangaraj Pratheep, Somdatta Y. Chaudhari, Subramanian Deepika Priyadharshini, Thenmozhi Mani, and Periysamy Mahalakshmi
Springer Science and Business Media LLC
Hamza Serina Banu, Ismail sheriff Parvin, Subramanian Deepika Priyadharshini, Ekambaram Gayathiri, Palanisamy Prakash, and Thangaraj Pratheep
Wiley
AbstractPlants are rich sources of therapeutic compounds that often lack the side effects commonly found in synthetic chemicals. Researchers have effectively synthesized pharmaceuticals from natural sources, taking inspiration from traditional medicine, in their pursuit of modern drugs. This study aims to evaluate the phenolic and flavonoid content of Solanum virginianum seeds using different solvent extracts, enzymatic assays including 2,2‐diphenyl‐1‐picrylhydrazyl activity, reducing power, and superoxide activity. Our phytochemical screening identified active compounds, such as phenols, flavonoids, tannins, and alkaloids. The methanol extract notably possesses higher levels of total phenolic and flavonoid content in comparison to the other extracts. The results highlight the superior antioxidant activity of methanol‐extracted leaves, demonstrated by their exceptional IC50 values, which surpass the established standard. In this study, molecular docking techniques were used to assess the binding affinity and to predict the binding conformation of the compounds. Quercetin 3‐O beta‐ d‐galactopyranoside displayed a binding energy of −8.35 kcal/mol with several important amino acid residues, PHE222, TRP440, ILE184, LEU192, VAL221, LEU218, SER185, and ALA188. Kaempferol 3‐O‐beta‐ l‐glucopyranoside exhibited a binding energy of −8.33 kcal/mol, interacting with specific amino acid residues including ALA 441, VAL318, VAL322, MET307, ILI409, GLY442, and PHE439. The results indicate that the methanol extract has a distinct composition of biologically active constituents compared to the other extracts. Overall, seeds exhibit promise as natural antioxidants and potential agents for combating cancer. This study highlights the significance of utilizing the therapeutic capabilities of natural compounds and enhancing our comprehension of their pharmacological characteristics.
Ekambaram Gayathiri, Palanisamy Prakash, Thangaraj Pratheep, Somdatta Y. Chaudhari, and Subramanian Deepika Priyadharshini
Elsevier BV
Venkatachalam Ramasamy, Palanisamy Prakash, Prabhakaran Vasantha‐Srinivasan, Yeon Soo Han, Sengodan Karthi, Sengottayan Senthil‐Nathan, Ekambaram Gayathiri, Ki Beom Park, and Subramaniam Umavathi
Wiley
AbstractThis study investigates the mosquitocidal potential of crude petroleum ether extract fractions derived from Gloriosa superba against the dengue mosquito vector Aedes aegypti. Chemical profiling through gas chromatography identified four major metabolites, with nonadecane showing the highest peak area percentage (70.34%). A lethal dosage of fraction IV of G. superba (Gs‐F4), at a maximum concentration of 5.0 ppm, exhibited high mortality rates in second (78%), third (71%) and fourth (51%) instars of Ae. aegypti. A sublethal dosage of Gs‐F4 (3.0 ppm) significantly altered the larval midgut enzymes of cytochrome P450, esterases and glutathione S‐transferases. The repellent activity of Gs‐F4 was dosage dependent, with repellency percentages decreasing from 96% to 50% as the exposure time increased from 15 to 210 mins. The impact of Gs‐F4 on aquatic mosquito predators was marginally toxic (<50%) compared with the commercial compound temephos (1.0 ppm), which exhibited a higher toxicity (>50%). In silico toxicity screening using the BeeToxAI server indicated that three of the four compounds in Gs‐F4 were safe or non‐toxic to honeybees, except for α‐gurjunene (6.29 μg/bee). Although G. superba demonstrates effective larvicidal and repellent activity against Ae. aegypti, the non‐target toxicity against mosquito predators necessitates further toxicological screening on beneficial species under field conditions.
R Gobinath, G.P. Ganapathy, E. Gayathiri, Mehmet Serkan Kırgız, Nihan Naiboğlu, André Gustavo de Sousa Galdino, and Jamal Khatib
CRC Press
E. Gayathiri, R Gobinath, J. Jayanthij, Paniswamy Prakash, and M.G. Ragunathan
CRC Press
R Gobinath, Gayathiri Ekambaram, Paniswamy Prakash, Kumaravel Priya, and Venkata SSR Marella
CRC Press
Dhivya Viswanathan, Rajakumar Govindasamy, and Ekambaram Gayathiri
Elsevier BV
Ekambaram Gayathiri, Palanisamy Prakash, Kuppusamy Selvam, Thangaraj Pratheep, Somdatta Y. Chaudhari, and Subramanian Deepika Priyadharshini
Springer Science and Business Media LLC
Sundararajan Balasubramani, Ekambaram Gayathiri, Surjeet Kumar Arya, Dhandapani Gurusamy, Palanisamy Prakash, Manikandan Appu, and Anil Kumar Moola
Elsevier
Ekambaram Gayathiri, Palanisamy Prakash, Saravanan Pandiaraj, Ramasamy Ramasubburayan, Arti Gaur, Malathy Sekar, Dhivya Viswanathan, and Rajakumar Govindasamy
Elsevier BV
Ekambaram Gayathiri, Palanisamy Prakash, Maqusood Ahamed, Saravanan Pandiaraj, Baskar Venkidasamy, Haripriya Dayalan, Pratheep Thangaraj, Kuppusamy Selvam, Somdatta Y. Chaudhari, Rajakumar Govindasamy,et al.
Informa UK Limited
According to worldwide health data, cancer, and inflammatory illnesses are on the rise and are among the most common causes of death. Across the world, these types of health problems are now considered top priorities for government health organizations. Hence, this study aimed to investigate medicinal plants' potential for treating cancer and inflammatory disorders. This network pharmacology analysis aims to learn more about the potential targets and mechanisms of action for the bioactive ingredients in Sauropus androgynus (L.) Merr L. The compound-target network and protein-protein interaction analysis were built using the STRING database. Using Network Analyst, Gene Ontology, and Kyoto Encyclopaedia of Genes and Genomes, pathway enrichment was performed on the hub genes. 1-hexadecanol was shown to inhibit drug-metabolizing enzymes in a pharmacokinetic investigation. Those samples of 1-hexadecanol were found to be 1-hexadecanol (BBB 0.783), GI High, Pgp Substrate Yes, CYP2C19 Inhibitor Yes, CYP2D6 Yes, and HI -89.803. The intermolecular binding energies for 1-hexadecanol (4-DRI, -8.2 kcal/mol) are evaluated. These results from a study on S. androgynus used molecular docking and network pharmacology to gain insight into the prime target genes and potential mechanisms identified for AKT1, mTOR, AR, PPID, FKBP5, and NR3C1. The PI3K-Akt signalling pathway has become an important regulatory node in various pathological processes requiring coordinated actions. Stability and favourable conformations have been resolved by considering nonbonding interactions such as electrostatic and hydrogen bonds in MD simulations of the perfect molecules using the Desmond package. Thus, using an appropriate platform of network pharmacology, molecular docking, and in vitro experiments, this study provides for the first time a clearer knowledge of the anti-cancer and anti-inflammatory molecular bioactivities of S. androgynus. Further in vitro and in vivo confirmations are strongly needed to determine the efficacy and therapeutic effects of 1-hexadecanol in the biological process.Communicated by Ramaswamy H. Sarma.
Ekambaram Gayathiri, Palanisamy Prakash, Priya Kumaravel, Jayanthi Jayaprakash, Manikkavalli Gurunathan Ragunathan, Sharmila Sankar, Saravanan Pandiaraj, Natesan Thirumalaivasan, Muthu Thiruvengadam, and Rajakumar Govindasamy
Elsevier BV
Palanisamy Prakash, Ekambaram Gayathiri, Mostafizur Rahaman, Govindasami Periyasami, Saravanan Pandiaraj, Thangaraj Pratheep, Kuppusamy Selvam, Somdatta Y. Chaudhari, Natesan Thirumalaivasan, John Thomas,et al.
Elsevier BV
Ekambaram Gayathiri, Palanisamy Prakash, Kuppusamy Selvam, Thangaraj Pratheep, Ravishankar Ram Mani, Sumathi Jones, Deepa Kandaswamy, Daoud Ali, Saud Alarifi, Soon Woong Chang,et al.
Springer Science and Business Media LLC
Ekambaram Gayathiri, Palanisamy Prakash, Kuppusamy Selvam, Thangaraj Pradeep, Ravishankar Ram Mani, Sumathi Jones, Deepa Kandaswamy, Daoud Ali, Saud Alarifi, Soon Woong Chang,et al.
Springer Science and Business Media LLC
Ekambaram Gayathiri, Palanisamy Prakash, Thangaraj Pratheep, Ramasamy Ramasubburayan, Natesan Thirumalaivasan, Arti Gaur, Rajakumar Govindasamy, and Kannan R. R. Rengasamy
Informa UK Limited
Healthy humans and animals commonly harbor lactic acid bacteria (LAB) on their mucosal surfaces, which are often associated with food fermentation. These microorganisms can produce amphiphilic compounds, known as microbial surface-active agents, that exhibit remarkable emulsifying activity. However, the exact functions of these microbial surfactants within the producer cells remain unclear. Consequently, there is a growing urgency to develop biosurfactant production from nonpathogenic microbes, particularly those derived from LAB. This approach aims to harness the benefits of biosurfactants while ensuring their safety and applicability. This review encompasses a comprehensive analysis of native and genetically modified LAB biosurfactants, shedding light on microbial interactions, cell signaling, pathogenicity, and biofilm development. It aims to provide valuable insights into the applications of these active substances in therapeutic use and food formulation as well as their potential biological and other benefits. By synthesizing the latest knowledge and advancements, this review contributes to the understanding and utilization of LAB biosurfactants in the food and nutritional areas.
Sundararajan Balasubramani, Qiyang Chen, Zhiqin Zhou, Anil Kumar Moola, Saravanamoorthy Mutharasanallur Duraisamy, Palanisamy Prakash, Ekambaram Gayathiri, Lakkakula Satish, and Mallappa Kumara Swamy
Springer Nature Singapore
Rajakumar Govindasamy, Ekambaram Gayathiri, Sathish Sankar, Baskar Venkidasamy, Palanisamy Prakash, Kaliaperumal Rekha, Varsha Savaner, Abirami Pari, Natesan Thirumalaivasan, and Muthu Thiruvengadam
MDPI AG
Nanotechnology has the potential to revolutionize various fields of research and development. Multiple nanoparticles employed in a nanotechnology process are the magic elixir that provides unique features that are not present in the component’s natural form. In the framework of contemporary research, it is inappropriate to synthesize microparticles employing procedures that include noxious elements. For this reason, scientists are investigating safer ways to produce genetically improved Cyanobacteria, which has many novel features and acts as a potential candidate for nanoparticle synthesis. In recent decades, cyanobacteria have garnered significant interest due to their prospective nanotechnological uses. This review will outline the applications of genetically engineered cyanobacteria in the field of nanotechnology and discuss its challenges and future potential. The evolution of cyanobacterial strains by genetic engineering is subsequently outlined. Furthermore, the recombination approaches that may be used to increase the industrial potential of cyanobacteria are discussed. This review provides an overview of the research undertaken to increase the commercial avenues of cyanobacteria and attempts to explain prospective topics for future research.
Ekambaram Gayathiri, Periyasamy Mahalakshmi, Thangaraj Pratheep, Palanisamy Prakash, Kuppusamy Selvam, Rengarajan Manivasagaperumal, Manikkavalli Gurunathan Ragunathan, Jayaprakash Jayanthi, and Priya Kumaravel
Elsevier BV
Gayathri Devi Selvaraju, Vidhya Rekha Umapathy, C. SumathiJones, Manraj Singh Cheema, D. Rachael Jayamani, R. Dharani, S. Sneha, M. Yamuna, Ekambaram Gayathiri, and Sudesh Yadav
Elsevier BV
Taimoor Hassan Farooq, Zhongwen Li, Wende Yan, Awais Shakoor, Uttam Kumar, Rubab Shabbir, Yuanying Peng, Ekambaram Gayathiri, Saqer S. Alotaibi, Jacek Wróbel,et al.
Frontiers in Environmental Science Frontiers Media SA
Litterfall, directly and indirectly, affects the soil physicochemical properties, microbial activity, and diversity of soil fauna and flora by adding organic matter and nutrients to the soil. This study explores litterfall dynamics such as litterfall production, litter decomposition rate, and associated nutrient return in three forest types, that is, camphor tree forest (CTF), Masson pine forest (MPF), and camphor tree and Masson pine mixed forest (CMF), in subtropical China. Results showed that CMF had the highest mean annual litterfall production (4.30 ± 0.22 t ha−1), which was significantly higher than that of MPF (3.41 ± 0.25 t ha−1) and CTF (3.26 ± 0.17 t ha−1). Leaf represented the major fraction of litterfall, constituting over 71% of the total litterfall mass in the three forest types. The contribution of branch litter was 16.3, 8.9, and 16.9%, and miscellaneous litter was 12.6, 18.9, and 11.1% in CTF, MPF, and CMF, respectively. The concentration of macronutrients ranked as N &gt; Ca &gt; K &gt; Mg &gt; P in all litter fractions. The total annual macronutrient return to the soil from the litterfall was in order as CTF (74.2 kg ha−1‧yr−1) &gt; CMF (70.7 kg ha−1‧yr−1) &gt; MPF (33.6 kg ha−1‧yr−1). The decomposition rate was higher in leaf litter than in branch litter throughout the three forests. Among the forest types, the leaf and branch decomposition rates were in a pattern: CTF &gt; CMF &gt; MPF. The ratio of C/N in both leaf and branch litters was significantly higher in MPF than in CTF and CMF, while no significant differences in N/P ratio were found in these litters among the three forests. The high N:P ratios in leaf litter (23/30) and the branch (24/32) litter indicated the high N returning and low nutrient returning to the soil. Our results suggested that the broadleaved forests have faster litter decomposition and higher macronutrient returns than conifer forests. Moreover, the litter decomposition rate was mainly associated with litterfall quality and chemical composition. The introduction of broadleaved trees into monoculture coniferous stands could increase litter production nutrients return, and thus, it had advantages in soil nutrients restoration and sustainable forest management.
Palanisamy Prakash, Kuppusamy Selvam, Ekambaram Gayathiri, Thangaraj Pratheep, Rengarajan Manivasagaperumal, Priya Kumaravel, and Saravanan Balameena
Elsevier BV
E. Gayathiri, P. Prakash, N. Karmegam, S. Varjani, M. Awasthi and B. Ravindran
With the present climate change and increasing world population, there is an urgent need to discover creative, efficient, and cost-effective natural products for the benefit of humanity. Biosurfactants are produced by various microorganisms that have several distinct properties compared to other synthetic surfactants, including mild production conditions, multifunctionality, higher biodegradability, and lower toxicity of living cells synthesis of active compounds. Due to their surface tension reducing, emulsion stabilizing, and biodegrading properties of these in place of chemical surfactants, they are generating huge demand in terms of research and usage. Biosurfactants are widely used in the food industry as food-formulation ingredients and antiadhesive agents as emulsifiers, de-emulsifiers, spreading agents, foaming agents, and detergents that find application in various fields such as agriculture, industrial sectors, and environmental recreation. Recent research focused more on heavy metal bioremediation from compost was achieved using biosurfactants-producing bacteria, which resulted in an improvement in compost quality. Although a number of studies on biosurfactants synthesis have been reported, very limited information on its cinematics and the consumption of renewable substrates are available. In this review paper, we made an attempt to critically review biosurfactants, their usage, research related to them, and challenges faced.