Urgent hybrid repair of a symptomatic dissection-related type II thoracoabdominal aortic aneurysm Nicola Monzio-Compagnoni, Andrea Tuveri, Giovanna Russo, Valerio Stefano Tolva European Journal of Cardio Thoracic Surgery, 2024 Emergency repair of type II thoracoabdominal aortic aneurysms is burdened by high perioperative morbidity and mortality. We report the case of a symptomatic type II post-dissection thoracoabdominal aortic aneurysm that was treated using a hybrid technique. The repair was carried out in 2 stages. In the first stage, we deployed 2 imbricated stent grafts in the descending thoracic aorta. A left carotid-to-left subclavian artery bypass was pre-emptively performed to obtain a proper proximal landing zone and as part of the manoeuvres to protect the spinal cord. The endovascular first stage was effective in obtaining proximal sealing but, as expected, it did not prevent distal reperfusion of the aneurysmatic false lumen. A few hours later, we moved on to the second stage in which we repaired the aneurysmal distal thoracic and abdominal aortic segment by means of a multibranched synthetic graft. The repair was carried out through a left thoracophreno-laparotomy in the seventh intercostal space. A left passive arterial bypass and selective cold renal and warm visceral perfusion were adopted to provide organ protection. Technical success was achieved and confirmed radiologically. The patient experienced mild postoperative paraplegia, which almost completely regressed after a neuromotor rehabilitation program.
Fatigue may improve equally after balance and endurance training in multiple sclerosis: a randomised, crossover clinical trial Laura Perucca, Stefano Scarano, Giovanna Russo, Antonio Robecchi Majnardi, Antonio Caronni Frontiers in Neurology, 2024 IntroductionFatigue and poor balance are frequent and severe problems in multiple sclerosis (MS) that may interact. Endurance training is known to be effective on fatigue. This study aims to test if balance training is more effective against MS fatigue.MethodsA randomised crossover trial was run, recruiting 31 MS people (21 women; median age: 46 years, range: 30–64; median EDSS: 4, range: 2.5–5). Participants received balance and endurance training alternately (15 one-to-one sessions, 5 days/week) and were assessed before (T0), after (T1), and 30 days after treatment ended (T2). The Modified Fatigue Impact Scale (MFIS) with scores linearised through Rasch analysis was the primary outcome (the lower the measure, the better the condition, i.e., the lower the fatigue symptoms). The Equiscale balance scale and posturography (EquiTest) were used to assess balance. Linear mixed-effects models with ANOVA were used for significance testing.ResultsThirteen participants had no carryover effect and were included in the primary analysis. Fatigue significantly changed across the three time points (F2,58 = 16.0; p < 0.001), but no difference across treatments was found. Altogether, both treatments significantly improved the MFIS measure at T1 (95%CI: −1.24 logits; mean: −1.67 to −0.81 logits) and T2 (95%CI: −1.04; mean: −1.49 to −0.60) compared to T0 (95%CI: −0.51; mean: −0.95 to −0.08; p ≤ 0.001). Equiscale and posturography highlighted balance improvement after balance training but not after endurance training.ConclusionBalance and endurance training could similarly reduce fatigue in MS patients in the short term. However, only balance training also improved balance in MS.