Pacella Giuseppina

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Interventional Radiology
Fondazione Policlinico Universitario Campus Bio-medico di Roma

Pacella Giuseppina


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https://researchid.co/giusy2308

RESEARCH, TEACHING, or OTHER INTERESTS

Radiology, Nuclear Medicine and imaging, Radiology, Nuclear Medicine and imaging
23

Scopus Publications

Scopus Publications

  • Percutaneous Cryoablation for Sternal Bone Metastases: A Retrospective Study
    Laura Olivieri, Giuseppina Pacella, Elva Vergantino, Gaetano Russo, Caterina Marsella, Eliodoro Faiella, Carlo Altomare, Bruno Zobel Beomonte, Rosario Francesco Grasso
    Journal of Vascular and Interventional Radiology, 2026
  • Commentary on “CT-Guided Percutaneous Cryoablation of Small Renal Masses: General Anesthesia Versus Conscious Sedation with Dexmedetomidine”
    Rosario Francesco Grasso, Giuseppina Pacella, Gaetano Russo
    Cardiovascular and Interventional Radiology, 2026
  • Role and Characteristic of Multidisciplinarity in Hepatocellular Carcinoma Management and Care Pathway Certification: Bottom-Up Approach of the MDT Project in Italy
    Giuseppe Cabibbo, Caterina Cocuzza, Ciro Celsa, Maria Rosaria Attanasio, Antonio Avallone, Rossana Berardi, Roberto Bordonaro, Mariafiorella Brangi, Fabio Cartabellotta, Desiree Lucy Anna Rita Caudullo, Bruno Daniele, Giovan Giuseppe Di Costanzo, Piera Federico, Giovanni Galati, Salvatore Gruttadauria, Francesco Izzo, Anna Nappi, Giuseppina Pacella, Mauro Piccirillo, Ferdinando Riccardi, Laura Schiadà, Marta Schirripa, Marianna Silletta, Gianluca Svegliati Baroni, Emiliano Tamburini, Raffaella Tortora, Martina Assanti, Francesco Deligios, Giada Lodolo, Luca Pinto, Maurizio Russello, on behalf of the M. D. T. Project Working Group
    Oncology and Therapy, 2026
    INTRODUCTION: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, requiring a multidisciplinary approach for effective management. The MDT Project aimed to define and pilot a structured care model for HCC management in Italy, supported by the implementation of integrated care pathways (ICPs), to standardize organizational processes and ensure the organizational requirements needed for appropriate patient management. METHODS: A multi-phase approach included a narrative review, semi-structured interviews with national experts, and the development of an optimal care model operationalized through a maturity model with 15 organizational elements. A total of 13 hospitals, selected to reflect national heterogeneity, participated in a pilot phase involving tailored action plans and hospital-specific ICPs. In total, ten hospitals proceeded to ICP implementation, and eight achieved certification by an external accreditation body. An expert consensus meeting subsequently validated the care model, key performance indicator (KPI) panel, and assessment tools. Organizational changes were assessed pre- and post intervention through the maturity model evaluation and a survey capturing clinicians' perceptions. RESULTS: Organizational improvements were observed primarily in areas directly targeted by the action plans, including the formalization of care-flow processes, multidisciplinary team structuring, case management, and coordination processes. More limited progress was seen in information systems and KPI monitoring, which require structural investments. Clinicians perceived the certification process as helpful in consolidating procedural standardization and documentation quality. CONCLUSIONS: The MDT Project piloted an organizational model for HCC management in Italy, focusing on care-pathway governance, multidisciplinary coordination, and center readiness. These findings represent an initial step toward broader implementation; future phases should incorporate clinical outcomes and patient-reported measures to evaluate the model's long-term impact.
  • C-Arm Cone Beam CT-Guided Preoperative Microcoil Pulmonary Ground Glass Nodule Localization: Diagnostic and Surgical Advantage
    Carlo Altomare, Rebecca Casati, Giuseppina Pacella, Laura Olivieri, Angelo Tirabasso, Annamaria Altomare, Luca Frasca, Filippo Longo, Pierfilippo Crucitti, Eliodoro Faiella, Bruno Beomonte Zobel, Rosario Francesco Grasso
    Thoracic Cancer, 2025
    ObjectiveThis study evaluates the effectiveness and safety of C‐arm cone beam CT (CBCT)‐guided microcoil localization combined with uniportal video‐assisted thoracoscopic surgery (VATS) for the management of small, difficult‐to‐localize ground‐glass opacities (GGOs) and sub‐solid nodules in the lungs.MethodsWe retrospectively analyzed data from 13 patients with single, small, peripheral, non‐subpleural GGOs or SSN. All patients underwent successful microcoil localization using CB‐CT guidance followed by uniportal VATS resection. A microcoil was positioned partly in the lung parenchyma and partly in the extra‐pleural space to assist in intraoperative localization. We evaluated the rate of correct microcoil placement and the technical success of the resection.ResultsMicrocoil placement was successfully performed in all patients, with an average procedure time of 28.8 ± 10.8 min. The mean nodule size was 9.9 ± 5.4 mm, and 76.9% of the nodules were classified as ground‐glass opacities. No intraparenchymal bleeding was observed, and four patients (30.8%) experienced pneumothorax, all of which were self‐limited and required no intervention or coil repositioning. The uniVATS resection success rate was 100%.ConclusionCBCT‐guided microcoil localization, with partial placement of the coil in the extra‐pleural space, proved to be a highly effective technique for the localization and resection of small pulmonary nodules. The procedure demonstrated high accuracy, minimal complications, reduction of procedural time, and short hospital stays. Intraoperative fluoroscopy was never necessary, with a high reduction in radiation exposure for the patient and the operator. Further studies with larger populations and longer follow‐ups are needed to validate these findings.
  • Augmented Reality Navigation System (SIRIO) for Neuroprotection in Vertebral Tumoral Ablation
    Eliodoro Faiella, Rebecca Casati, Matteo Pileri, Giuseppina Pacella, Carlo Altomare, Elva Vergantino, Amalia Bruno, Bruno Beomonte Zobel, Rosario Francesco Grasso
    Current Oncology, 2024
    (1) This study evaluates the impact of the CT-guided SIRIO augmented reality navigation system on the procedural efficacy and clinical outcomes of neuroprotection in vertebral thermal ablation (RTA) for primary and metastatic bone tumors. (2) Methods: A retrospective non-randomized analysis of 28 vertebral RTA procedures was conducted, comparing 12 SIRIO-assisted and 16 non-SIRIO-assisted procedures. The primary outcomes included dose-length product (DLP) and epidural dissection time. The secondary outcomes included technical success, complication rates, and pain scores at procedural time (VAS Time 0) and three months post-procedure (VAS Time 1). The statistical analyses included t-tests, Mann–Whitney U tests, and multiple regression. (3) Results: SIRIO-assisted procedures significantly reduced DLP (307.42 mGycm vs. 460.31 mGycm, p = 2.23 × 10−8) and procedural epidural dissection time (13.48 min vs. 32.26 min, p = 2.61 × 10−12) compared to non-SIRIO-assisted procedures. Multiple regression confirmed these reductions were significant (DLP: β = −162.38, p < 0.001; time: β = −18.25, p < 0.001). Pain scores (VAS Time 1) did not differ significantly between groups, and tumor type did not significantly influence outcomes. (4) Conclusions: The SIRIO system enhances neuroprotection efficacy and safety, reducing radiation dose and procedural time during spine tumoral ablation while maintaining consistent pain management outcomes.
  • Exploring the Efficacy of Combining Radiofrequency Thermal Ablation or Microwave Ablation with Vertebroplasty for Pain Control and Disease Management in Metastatic Bone Disease—A Systematic Review
    Eliodoro Faiella, Federica Vaccarino, Giuseppina Pacella, Domiziana Santucci, Elva Vergantino, Amalia Bruno, Raffaele Ragone, Bruno Beomonte Zobel, Rosario Francesco Grasso
    Current Oncology, 2024
    Background: Interventional radiology techniques have become pivotal in recent years in managing metastatic bone disease, which frequently results in skeletal complications such as fractures and severe pain. Thermoablative methods like radiofrequency ablation (RFA) and microwave ablation (MWA), when combined with vertebroplasty (VP), are proving increasingly beneficial for these patients. Methods: The search was independently conducted by two radiologists on MEDLINE databases, using specified strings up to April 2024. Methodological quality was assessed using PRISMA guidelines. Studies meeting inclusion criteria investigated thermoablation techniques (RFA and/or MWA) combined with VP, focusing on pain management and disease control outcomes in adults. Results: Among 147 results, 42 articles met the criteria, with varied prospective and retrospective designs and sample sizes averaging 49 patients, predominantly involving RFA (30 studies), MWA (11 studies), and one comparative study. Our review highlights significant pain reduction, effective local tumor control, and favorable safety of combined RFA or MWA with VP, supporting its potential in managing vertebral pathologies and warranting further clinical integration. Conclusions: The combined treatment of RFA/MWA with VP demonstrates significant pain reduction and local tumor control, with a rapid onset of analgesic effect. These findings support its crucial role in clinical practice for managing vertebral metastases.
  • The Rendezvous Technique: A Minimally Invasive Non-Surgical Approach for the Management of Iatrogenic Ureteral Injuries
    Eliodoro Faiella, Giuseppina Pacella, Elva Vergantino, Domiziana Santucci, Carlo De Cicco Nardone, Corrado Terranova, Francesco Plotti, Roberto Angioli, Bruno Beomonte Zobel, Rosario Francesco Grasso
    Journal of Clinical Medicine, 2024
    Background/Objectives: The aim of our study is to evaluate the feasibility and efficacy of the rendezvous technique for the treatment of iatrogenic ureteral injuries. Methods: From 2014 to 2019, 29 patients treated with the rendezvous technique for mono- or bilateral iatrogenic ureteral injuries were enrolled in this retrospective study. All the leaks were previously assessed by CT-urography and antegrade pyelography. Ureteral continuity was restored by performing the rendezvous technique, combining antegrade trans-nephrostomic access and a retrograde trans-cystostomic approach. A double J stent was antegradely inserted, and a nephrostomy tube was kept in place at the end of the procedure. A post-procedure CT-urography and a 30-day nephrostogram follow-up were performed. In the absence of a contrast leak, the nephrostomy tube was removed. Patient follow-up was set with CT-urography at 3, 6, and 12 months and stent substitution every 4 months. The CT-urography was performed to confirm the restored integrity of the ureter before stent removal. Results: The rendezvous technique was successful in all cases with the resolution of the ureteral leak. No major complications were observed. In all the patients, the nephrostomy tube was removed after 30 days. After performing CT-urography, the stent was removed permanently after 12 months. Only three cases showed local post-treatment stenosis treated with surgical ureteral reimplantation. Conclusions: The rendezvous technique is a safe and effective minimally invasive procedure that can be used to restore the continuity of the ureter, avoiding open surgery and providing valuable support for the management of complications after gynecological surgery.
  • Thyroid Microwave Ablation Study Based on Fiber Bragg Gratings Thermal Mapping
    Elena De Vita, Francesca De Tommasi, Carlo Altomare, Daniela Lo Presti, Giuseppina Pacella, Agostino Iadicicco, Massimiliano Carassiti, Rosario Francesco Grasso, Carlo Massaroni, Stefania Campopiano, Emiliano Schena
    IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology, 2024
    Thyroid nodules represent a widespread health concern and surgery is often adopted even if the incidence of frequent post-operative complications is not negligible. In recent years, this framework has fostered the growing spread of thermal ablation treatments, in particular microwave ablation (MWA). To date, despite its relevance, state-of-the-art regarding temperature monitoring in thyroid tissue during MWA is lacking. In this paper, the effects of MWA in thyroid by monitoring temperatures have been explored. By using several fiber Bragg gratings (FBGs) temperature sensors, the heat maps in the proximity of the MW antenna have been reconstructed for two different power values set at generator. An increase up to about 4.5 cm3 in ablation volume and up to 24 °C in maximum temperature variation as power rises from 20 W to 30 W has been observed. In addition, the dependency of the temperature evolution on the involved power has been investigated, observing that, with increasing power, some FBGs recorded a ΔT slope increase until the maximum values, resulting in shorter ablation times, and others recorded a plateau phase until the end of the MWA treatment. Such a propensity could be relevant to adjust the clinical settings according to the desired treatment outcome.
  • Percutaneous Cryoablation of Recurrent or Oligometastatic Tumors in Thoracoabdominal Soft Tissues: Safety, Effectiveness, and Technical Aspects
    Giuseppina Pacella, Carlo Altomare, Matteo Pileri, Flavio Andresciani, Caterina Bernetti, Ugo Ferrari, Amalia Bruno, Maria Teresa Bitonti, Bruno Beomonte Zobel, Eliodoro Faiella, Rosario Francesco Grasso
    Journal of Vascular and Interventional Radiology, 2024
  • Percutaneous Biliary Rendez-Vous to Treat Complete Hepatic-Jejunal Anastomosis Dehiscence after Duodeno-Cephalo-Pancreasectomy
    Flavio Andresciani, Giuseppina Pacella, Eliodoro Faiella, Andrea Buoso, Carlo Altomare, Rosario Francesco Grasso
    Gastrointestinal Disorders, 2023
    Hepaticojejunostomy is an essential component of many surgical procedures, including pancreaticoduodenectomy. Biliary leaks after HJS represent a major complication leading to relevant clinical problems: the postoperative mortality rate could reach 70% for surgical re-intervention, whereas endoscopic management is technically difficult due to the postoperative anatomy. Interventional Radiology plays a pivotal role for these patients. The case of a percutaneous biliary rendez-vous procedure performed to treat an HJA dehiscence after duodeno-cephalo-pancreasectomy is presented, which is successfully guaranteed to avoid a new surgical approach.
  • Management of Fallopian Tube’s Obstructions
    Anna Paola Mancini, Rita Stefanucci, Valeria Mancuso, Giuseppina Pacella, Bruno Beomonte Zobel
    Diagnostic and Interventional Radiology in Gynecological and Obstetric Diseases, 2023
  • Microwave ablation using two simultaneous antennas for the treatment of liver malignant lesions: a 3 year single-Centre experience
    Flavio Andresciani, Giuseppina Pacella, Daniele Vertulli, Carlo Altomare, Maria Teresa Bitonti, Amalia Bruno, Laura Cea, Eliodoro Faiella, Bruno Beomonte Zobel, Rosario Francesco Grasso
    International Journal of Hyperthermia, 2023
  • CT, MR, and CEUS imaging features of recurrent GIST of the pre-sacral space: A case report
    Flavio Andresciani, Daniele Vertulli, Giuseppina Pacella, Carlo Altomare, Caterina Bernetti, Maria Teresa Bitonti, Andrea Buoso, Ugo Ferrari, Bruno Beomonte Zobel, Rosario Francesco Grasso
    Radiology Case Reports, 2023
  • Percutaneous Cementoplasty of a Painful Sternal Hemangioma
    Rosario Francesco Grasso, Flavio Andresciani, Carlo Altomare, Giuseppina Pacella, Bruno Beomonte Zobel, Gianluca Vadalà, Rocco Papalia, Vincenzo Denaro
    Journal of Vascular and Interventional Radiology, 2022
  • A comparative analysis of thermal ablation techniques in the treatment of primary and secondary lung tumors: a single-center experience
    Rosario Francesco Grasso, Caterina Bernetti, Giuseppina Pacella, Carlo Altomare, Gennaro Castiello, Flavio Andresciani, Marina Sarli, Bruno Beomonte Zobel, Eliodoro Faiella
    Radiologia Medica, 2022
  • Analysis of Risk Factors of Soft Tissue Bleeding in COVID-19 Patients: A Point of View After Two Years of Pandemic
    Eliodoro Faiella, Gennaro Castiello, Domiziana Santucci, Giuseppina Pacella, Caterina Bernetti, Moises Muley Villamu, Raffaele Antonelli Incalzi, Bruno Beomonte Zobel, Carlo Cosimo Quattrocchi, Rosario Francesco Grasso
    Journal of Clinical Medicine Research, 2022
  • Augmented reality 3D navigation system for percutaneous CT-guided pulmonary ground-glass opacity biopsies: a comparison with the standard CT-guided technique
    Eliodoro Faiella, Laura Messina, Gennaro Castiello, Caterina Bernetti, Giuseppina Pacella, Carlo Altomare, Flavio Andresciani, Marina Sarli, Filippo Longo, Pierfilippo Crucitti, Bruno Beomonte Zobel, Rosario Francesco Grasso
    Journal of Thoracic Disease, 2022
  • Fiber Bragg Gratings for Temperature Monitoring during Thyroid Microwave Ablation: a Preliminary Analysis
    Elena De Vita, Francesca De Tommasi, Carlo Altomare, Sofia Ialongo, Carlo Massaroni, Daniela Lo Presti, Eliodoro Faiella, Flavio Andresciani, Giuseppina Pacella, Andrea Palermo, Massimiliano Carassiti, Agostino Iadicicco, Rosario Francesco Grasso, Emiliano Schena, Stefania Campopiano
    2022 IEEE International Symposium on Medical Measurements and Applications Memea 2022 Conference Proceedings, 2022
  • Lung thermal ablation: Comparison between an augmented reality computed tomography (ct) 3d navigation system (sirio) and standard ct-guided technique
    Rosario Francesco Grasso, Flavio Andresciani, Carlo Altomare, Giuseppina Pacella, Gennaro Castiello, Massimiliano Carassiti, Carlo Cosimo Quattrocchi, Eliodoro Faiella, Bruno Beomonte Zobel
    Biology, 2021
  • Impact of an augmented reality navigation system (SIRIO) on bone percutaneous procedures: A comparative analysis with standard CT-guided technique
    Eliodoro Faiella, Gennaro Castiello, Caterina Bernetti, Giuseppina Pacella, Carlo Altomare, Flavio Andresciani, Bruno Beomonte Zobel, Rosario Francesco Grasso
    Current Oncology, 2021
  • Reversible Electrochemotherapy (ECT) as a Treatment Option for Local RCC Recurrence in Solitary Kidney
    F. Andresciani, E. Faiella, C. Altomare, G. Pacella, B. Beomonte Zobel, R. F. Grasso
    Cardiovascular and Interventional Radiology, 2020
  • Combined trans-arterial embolisation and microwave ablation for the treatment of large unresectable hepatic metastases (>3 cm in maximal diameter)
    Eliodoro Faiella, Domiziana Santucci, Caterina Bernetti, Emiliano Schena, Giuseppina Pacella, Bruno Beomonte Zobel, Rosario Francesco Grasso
    International Journal of Hyperthermia, 2020
  • Gender-based differences of abdominal adipose tissue distribution in non-small cell lung cancer patients
    Carlo Augusto Mallio, Federico Greco, Giuseppina Pacella, Emiliano Schena, Bruno Beomonte Zobel
    Shanghai Chest, 2018