Guilherme Augusto Sanches Roque

Verified @gmail.com

Phd student at Animal Biology Department of State University of Campinas

Guilherme Augusto Sanches Roque


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https://researchid.co/gsanches7
Professor at the Anhanguera College of Sorocaba. Phd candidate at State University of Campinas.

EDUCATION

Master's degree in Animal Biology at State University of Campinas.
Doctor of Veterinary Medicine at University of Sorocaba.

RESEARCH INTERESTS

Immunoparasitology. Vaccine. Leishmania, Genetics. Genetic edition.
6

Scopus Publications

59

Scholar Citations

3

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Macrophage Polarisation During Leishmania (Viannia) braziliensis Infection in Mice
    Marina Floro e Silva, Guilherme Augusto Sanches Roque, Lilian de Oliveira Coser, Genesy Pérez Jorge, Alexandre Leite Rodrigues de Oliveira, Francisca Janaína Soares Rocha, Selma Giorgio
    Parasite Immunology, 2025
    Leishmania (Viannia) braziliensis causes cutaneous and mucocutaneous leishmaniasis. Macrophages are host cells for parasite replication and act as effector cells against the parasite. The two main macrophage phenotypes (M1 and M2) and their polarisation states have been implicated in Leishmania infection despite scarce data on L. (V.) braziliensis. In this study, we investigated the temporal and spatial distribution and predominance of M1 and M2 macrophages during L. (V.) braziliensis infection in Balb/c mice. Animals were infected with L. (V.) braziliensis promastigotes and were monitored for 25 weeks. Histopathological evaluation of footpad lesions, regional lymph nodes, and spleen; cellularity; and macrophage population quantification of M1, and M2 macrophages by flow cytometry were performed in different tissues. The results showed that after infection with either strain of L. (V.) braziliensis the lesions were small and non‐ulcerated. The dissemination of parasites to tissues reinforced the characteristic visualisation of dermotropicL. (V.) braziliensis. The proportion of M2 macrophages in different tissues was significantly higher than that of M1 macrophages. Overall, the results reported here confirm that Leishmania an intracellular parasite, promotes and influences macrophage phenotype polarisation in different tissues over time, and researchers testing therapies based on macrophage phenotype regulation should consider this evidence.
  • Evaluation of prime and prime-boost immunization strategies in BALB/c mice inoculated with Leishmania infantum transfected with toxic plasmids
    Guilherme Augusto Sanches Roque, Nahiara Esteves Zorgi, Francisca Janaína Soares Rocha, Marina Flóro e Silva, Thalita Fernanda Araújo, Daniel Ruiz Abánades, Selma Giorgio
    Vaccine, 2022
  • Leishmania (Viannia) braziliensis replicates in mouse bone marrow
    Marina Floro e Silva, Guilherme Augusto Sanches Roque, Diullia de Andrade Machado, Francisca Janaína Soares Rocha, Selma Giorgio
    Acta Tropica, 2022
  • Leishmania infantum transfected with toxic plasmid induces protection in mice infected with wild type L. infantum or L. amazonensis
    Nahiara Esteves Zorgi, Leonardo V. Arruda, Izadora Paladine, Guilherme A.S. Roque, Thalita F. Araújo, Marcelo Brocchi, Manoel Barral, África Sanchiz, José María Requena, Daniel R. Abánades, Selma Giorgio
    Molecular Immunology, 2020
  • Granulomas in parasitic diseases: the good and the bad
    Selma Giorgio, Pedro Henrique Gallo-Francisco, Guilherme Augusto Sanches Roque, Marina Flóro e Silva
    Parasitology Research, 2020
  • Evaluation of Microbiota and Weight Alterations After the Administration of Tetracycline and Lactobacillus gasseri in Rats
    Fernando S. Olimpio, Fernando Sa Del Fiol, Renata Lima, Karina S. Rosa, Guilherme A. Roque, Cintia V. Santos, John Piletz
    Current Microbiology, 2020

RECENT SCHOLAR PUBLICATIONS

  • Impact of Bacterial Membrane Vesicles on Cellular Responses in Leishmania amazonensis -Infected Macrophages In Vitro
    PH Gallo-Francisco, GP Jorge, GAS Roque, MF e Silva, NS da Silva, ...
    bioRxiv, 2025.07. 08.663775 , 2025
    2025.0
  • Macrophage Polarisation During Leishmania ( Viannia ) braziliensis Infection in Mice
    M Floro e Silva, GAS Roque, L de Oliveira Coser, GP Jorge, ...
    Parasite immunology 47 (1), e70001 , 2025
    2025.0
    Citations: 2
  • Evaluation of prime and prime-boost immunization strategies in BALB/c mice inoculated with Leishmania infantum transfected with toxic plasmids
    GAS Roque, NE Zorgi, FJS Rocha, MF e Silva, TF Araújo, DR Abánades, ...
    Vaccine 40 (31), 4105-4115 , 2022
    2022.0
    Citations: 3
  • Leishmania (Viannia) braziliensis replicates in mouse bone marrow
    MF e Silva, GAS Roque, D de Andrade Machado, FJS Rocha, S Giorgio
    Acta tropica 230, 106407 , 2022
    2022.0
    Citations: 3
  • Leishmania infantum transfected with toxic plasmid induces protection in mice infected with wild type L. infantum or L. amazonensis
    NE Zorgi, LV Arruda, I Paladine, GAS Roque, TF Araujo, M Brocchi, ...
    Molecular Immunology 127, 95-106 , 2020
    2020.0
    Citations: 9
  • Granulomas in parasitic diseases: the good and the bad
    S Giorgio, PH Gallo-Francisco, GAS Roque, M Floro e Silva
    Parasitology research 119 (10), 3165-3180 , 2020
    2020.0
    Citations: 37
  • Evaluation of Microbiota and Weight Alterations After the Administration of Tetracycline and Lactobacillus gasseri in Rats
    FS Olimpio, FS Del Fiol, R Lima, KS Rosa, GA Roque, CV Santos, J Piletz
    Current Microbiology 77 (9), 2449-2455 , 2020
    2020.0
    Citations: 5
  • Avaliação das respostas imunológica e histopatológica de camundongos imunizados com vacina experimental anti" e; Leishmania infantum" e
    GAS Roque
    [sn] , 2020
    2020.0
  • As helmintíases, doenças tropicais negligenciadas, podem afetar a eficácia das vacinas? Com ênfase na COVID-19
    GAS Roque, PH Gallo-Francisco, M Flóro, LF Geres, S Giorgio

MOST CITED SCHOLAR PUBLICATIONS

  • Granulomas in parasitic diseases: the good and the bad
    S Giorgio, PH Gallo-Francisco, GAS Roque, M Floro e Silva
    Parasitology research 119 (10), 3165-3180 , 2020
    2020.0
    Citations: 37
  • Leishmania infantum transfected with toxic plasmid induces protection in mice infected with wild type L. infantum or L. amazonensis
    NE Zorgi, LV Arruda, I Paladine, GAS Roque, TF Araujo, M Brocchi, ...
    Molecular Immunology 127, 95-106 , 2020
    2020.0
    Citations: 9
  • Evaluation of Microbiota and Weight Alterations After the Administration of Tetracycline and Lactobacillus gasseri in Rats
    FS Olimpio, FS Del Fiol, R Lima, KS Rosa, GA Roque, CV Santos, J Piletz
    Current Microbiology 77 (9), 2449-2455 , 2020
    2020.0
    Citations: 5
  • Evaluation of prime and prime-boost immunization strategies in BALB/c mice inoculated with Leishmania infantum transfected with toxic plasmids
    GAS Roque, NE Zorgi, FJS Rocha, MF e Silva, TF Araújo, DR Abánades, ...
    Vaccine 40 (31), 4105-4115 , 2022
    2022.0
    Citations: 3
  • Leishmania (Viannia) braziliensis replicates in mouse bone marrow
    MF e Silva, GAS Roque, D de Andrade Machado, FJS Rocha, S Giorgio
    Acta tropica 230, 106407 , 2022
    2022.0
    Citations: 3
  • Macrophage Polarisation During Leishmania ( Viannia ) braziliensis Infection in Mice
    M Floro e Silva, GAS Roque, L de Oliveira Coser, GP Jorge, ...
    Parasite immunology 47 (1), e70001 , 2025
    2025.0
    Citations: 2
  • Impact of Bacterial Membrane Vesicles on Cellular Responses in Leishmania amazonensis -Infected Macrophages In Vitro
    PH Gallo-Francisco, GP Jorge, GAS Roque, MF e Silva, NS da Silva, ...
    bioRxiv, 2025.07. 08.663775 , 2025
    2025.0
  • Avaliação das respostas imunológica e histopatológica de camundongos imunizados com vacina experimental anti" e; Leishmania infantum" e
    GAS Roque
    [sn] , 2020
    2020.0
  • As helmintíases, doenças tropicais negligenciadas, podem afetar a eficácia das vacinas? Com ênfase na COVID-19
    GAS Roque, PH Gallo-Francisco, M Flóro, LF Geres, S Giorgio