Does zirconium compounds impact glass ionomer cements properties? A scoping review Carolina Mara Geraldino Monteiro, Andréa Vaz Braga Pintor, Mariana Coutinho Sancas, Guido Artemio Marañón-Vásquez, Livia Rodrigues de Menezes, et al. Brazilian Journal of Oral Sciences, 2026 Objective: The aim of this scoping review was to comprehensively search the literature to identify and present available published information regarding the addition of zirconium compounds into glass ionomer cements (GICs), the incorporation methodologies, and the impact of zirconium on the properties of GICs. Methods: The protocol was registered in the Open Science Framework Registries (https://doi.org/10.17605/OSF.IO/BWVJK). The search was conducted across eight databases in June 2023. Selected journals were screened for potential predatory status. Data regarding study design, classification of dental materials, zirconium incorporation, and property assessments were extracted and synthesized. Results: A total of 72 studies, mostly in vitro, were included. Zirconomer, commercially modified GICs, and experimental GICs were identified. Zirconia 10% was the most common added zirconium compound, and nanometric particles resulted in superior mechanical performance. Regarding compressive strength and microhardness, Zirconomer exhibited superior results, while modified or experimental GICs demonstrated lower values compared to commercial GICs lacking zirconium compounds. Zirconomer is the sole commercially available zirconium-based GIC. Among the experimental materials, zirconia nanoparticles at 5% and 10% incorporation ratios presented the most favorable mechanical properties, especially microhardness and compressive strength. Conclusion: These findings suggest a favorable scenario for the clinical application of glass ionomer cements modified with zirconium compounds. Glass ionomer cements modified with zirconium compounds showed enhanced mechanical properties relevant for restorative dentistry.
Assessment of the relationship between facial, skeletal, dental and smile asymmetries: a preliminary investigative analysis Fernanda de Souza do Nascimento DIOGO, Karoline de Melo MAGALHÃES, Luísa Schubach da Costa BARRETO, Paolla Barboza Araujo de ALMEIDA, Guido Artemio MARAÑÓN-VÁSQUEZ, et al. Dental Press Journal of Orthodontics, 2026 Objective: This study aimed to investigate the relationship between asymmetrical faces, smiles, skeletal parameters and dental asymmetries. Material and methods: A total of 20 patients with normal vertical facial pattern (20≤FMA≤30°) were selected to analyze frontal extraoral photographs with natural smiles and 3D frontal images generated by cone beam computed tomography scans (CBCT scans). The facial symmetry was retrieved by tracing the bipupillary line and perpendicular lines, the distance between the right and left frontolacrimal sutures was subsequently transferred to the same area in the photographs (the intercanthal distance) to calibrate all measures in the study. An assessment of mandibular chin deviation was conducted, and lines were traced to evaluate the dental midline and smile parameters. Through the manipulation of the CBCT scan, the presence of malocclusion and its respective subdivision, as well as the presence of unilateral or bilateral posterior crossbites in each patient, were identified. Data normality was checked using the Shapiro-Wilk test, and univariate linear regressions were performed to assess relationships. Results: Individuals with Menton point (Me point) deviation greater than 3.5 mm were considered asymmetrical. Subdivision malocclusions significantly correlated with upper midline dental deviation (UMLDD; R2= 0.25), with individuals without subdivision malocclusions showing 0.66 mm less deviation (95% CI = -1.24, -0.09; P = 0.026). Conclusion: UMLDD have a significant correlation with subdivision malocclusion.
Do Fluoride-Releasing Restorative Materials Prevent the Development of Caries around Restorations in Deciduous and Permanent Teeth? A Systematic Review and Meta-Analysis Gabriella Fernandes Rodrigues, Karla Lorene De França Leite, Marcela Baraúna Magno, Guido Artemio Marañón-Vásquez, Andréa Vaz Braga Pintor, et al. Caries Research, 2026 Introduction: The main cause of failure in restorations is the development of caries around restorations (CARs). Therefore, the aim of this study was to assess the evidence related to the development of CAR with fluoride-releasing restorative materials compared to non-fluoride releasing in deciduous and permanent teeth. Methods: Randomized clinical trials were included. Literature searches were conducted without language/data restrictions in 6 databases and in the grey literature in June 2024. ROB2 tool assessed the risk of bias. Through meta-analyses, expressed by the risk difference (RD) with a 95% confidence interval, the outcome was evaluated considering the follow-up period (12, 18–24, and ≥36 months), type of dentition and fluoride-releasing restorative materials, number of surfaces treated, and the type of dental isolation performed. Meta-regression models were applied with the above variables as moderators. The certainty of the evidence was assessed by GRADE. Results: Forty-six studies were selected. Among them, 29 presented some concerns and 9 showed high risk of bias. The type of dentition and dental materials, number of surfaces, and dental isolation did not influence the outcome (p > 0.05). Although after 36 months of follow-up, deciduous and permanent teeth restored with fluoride-releasing materials had a lower risk of CAR (RD −0.015 [−0.024, −0.006], p = 0.002, I2 = 0%), the moderators did not influence this effect by meta-regression models. The certainty of the evidence ranged from low to moderate. Conclusion: Fluoride-releasing restorative materials were more effective in preventing CAR after 36 months of follow-up. However, this result should be interpreted with caution, considering the low to moderate certainty of the evidence, the included studies’ risk of bias, and the small RD.
Impact of Clinical Consequences of Pulp Involvement due to Caries on Oral Health-Related Quality of Life in Children and Adolescents: A Systematic Review and Meta-Analysis Patricia Papoula Gorni Reis, Roberta Costa Jorge, Guido Artemio Marañón-Vásquez, Tatiana Kelly da Silva Fidalgo, Lucianne Cople Maia, et al. Caries Research, 2025 Introduction: Dental caries with pulp involvement potentially impacts the oral health-related quality of life (OHRQoL). This meta-analysis aimed to evaluate whether clinical consequences of pulp involvement due to dental caries impacts OHRQoL of children and adolescents. Methods: Observational studies evaluating whether children/adolescents (population) with pulp involvement due to caries (exposition) compared with those without it (comparison) have more negative impact on their OHRQoL (outcome) were included. A systematic search was undertaken in August 2022 in seven databases. Alerts were set until August 2023. JBI Critical Appraisal tool for cross-sectional studies was used for methodological quality assessment. Random-effects meta-analyses were performed to calculate mean differences (MD) or standardized mean differences (SMD) of impact on OHRQoL. For studies with dichotomous outcome, meta-analysis calculated the odds ratio (OR). Robustness, heterogeneity, certainty of evidence, and publication bias were evaluated. Results: From 29 included studies, 14 assessed preschoolers, nine assessed schoolchildren, four assessed adolescents, and two assessed children/adolescents. PUFA was the main index used to assess the exposure. ECOHIS (preschoolers) and CPQ (children/adolescents) were the main tools used to assess the outcome. Only five articles fully adhered to the quality criteria. The meta-analyses found the following main results: (a) preschoolers: MD −10.79 (−16.50; −5.09); (b) schoolchildren: MD −5.12 (−7.51; −2.72); (c) adolescents: MD −1.86 (−4.59; 0.87); (d) overall impact: SMD −2.18; (CI: −3.21;−1.15) and OR 0.52 (CI: 0.30; 0.90). Conclusion: Pulp involvement impacted OHRQoL of children negatively. In adolescents, this impact was not observed. Results must be interpreted with caution due to very low certainty of evidence.
Effect of prenatal alcohol consumption on dental enamel formation in offspring—An animal study protocol Roberta Duarte Leme, Guido Artemio Marañón-Vásquez, Juliana de Lima Gonçalves, Fabrício Kitazono de Carvalho, Alexandra Mussolino de Queiroz, et al. Plos One, 2025 Background The etiology of developmental defects of enamel (DDE) remains incompletely understood. Prenatal alcohol exposure has been proposed as a potential risk factor for DDE. Animal studies suggest that in utero ethanol exposure can disrupt ameloblast function, leading to enamel abnormalities. This study aims to: (1) Assess the impact of prenatal alcohol consumption on the clinical and structural properties of dental enamel in offspring; and (2) Investigate the underlying mechanisms of these alterations through histological and molecular analyses. Pregnant Wistar rats will be assigned to two groups: one exposed to ethanol and a control group with no alcohol exposure. Ethanol exposure will follow a binge drinking model, with rats receiving 3 g/kg of ethanol (30% w/v) for 3 consecutive days, followed by 4 days of rest each week. This regimen will begin one week prior to conception and continue throughout pregnancy. The incisors and molars of offspring will be evaluated on the 10th (n = 22 per group) and 28th (n = 22 per group) days of life. Visible enamel changes will be documented through photographs. Enamel volume, thickness, and density will be assessed using micro-CT imaging. Mechanical properties will be evaluated using the Knoop microhardness test, while chemical composition will be analyzed through Scanning Electron Microscopy with Energy Dispersive X-ray (SEM-EDX) and Raman spectroscopy, respectively. The area of the organic enamel matrix will be quantified in histological sections. Genes Amelx, Enam, Ambn, Mmp2, Mmp9, Mmp20, Klk4, Cldn3, Cldn16, and Cldn19 will be evaluated in ameloblasts using real-time RT-PCR and protein synthesis will be confirmed by immunohistochemistry. Gelatinolytic activity in the ameloblast layer will be assessed by in situ zymography.
Response to letter to the Editor Guido Artemio Marañón‐Vásquez, Flares Baratto‐Filho, Christian Kirschneck, Erika Calvano Küchler European Journal of Oral Sciences, 2024
How stable are SLA-printed orthodontic models: a 6-month in vitro evaluation. L Barreto, MKS Malheiros, BCT Barreto, C Marassi, GA Marañón-Vásquez, ... The Angle Orthodontist, e051125-372.1 , 2026 2026
How stable are SLA-printed orthodontic models: a 6-month in vitro evaluation LS da Costa Barreto, MKS Malheiros, BCT Barreto, C Marassi, ... The Angle Orthodontist 1 (aop) , 2026 2026
Does zirconium compounds impact glass ionomer cements properties? A scoping review CMG Monteiro, AVB Pintor, MC Sancas, GA Marañón-Vásquez, ... Brazilian Journal of Oral Sciences 25, e269243 , 2026 2026
Influence of attachment designs in the insertion and removal force of clear aligners: An experimental study of strain sensors LS da Costa Barreto, ALFSR Viana, BCT Barreto, C Marassi, ... 2026
Evaluation of the impact of postnatal maternal separation stress on enamel formation in an experimental murine model JIT Sousa, JL Gonçalves, GA Marañón-Vásquez, RD Leme, LS Sales, ... Archives of Oral Biology, 106487 , 2025 2025
Do fluoride-releasing restorative materials prevent the development of caries around restorations in deciduous and permanent teeth? A systematic review and meta-analysis GF Rodrigues, KL De França Leite, MB Magno, GA Marañón-Vásquez, ... Caries Research , 2025 2025 Citations: 2
Crosstalk Between Hematopoietic and Mesenchymal Cells in Bone and Tooth Immune Response LS Sales, AC Silva-Sousa, GA Marañón-Vásquez, FWG Paula-Silva Oral Immunology, 547-565 , 2025 2025
Effect of 35% hydrogen peroxide in promoting enamel whitening with orthodontic attachments bonded on its surface BCT Barreto, LT Vilela, GA Marañón-Vásquez, MM Pithon, MMG SOUZA Dental Press Journal of Orthodontics 30 (3), e252547 , 2025 2025 Citations: 1
Does the use of sports mouthguards influence salivary parameters and oral health indices? A systematic review MP Costa, N de Araújo Meckelburg, LA Jural, AVB Pintor, ... Evidence-Based Dentistry 26 (3), 146-146 , 2025 2025
Comparison of self-perception in relation to the normative need for orthodontic treatment in a population of dental students in Brazil: A cross-sectional study LR Squeff, F Copello, GA Marañón-Vásquez, RR Luiz, L Nojima, ... International Orthodontics 23 (2), 100963 , 2025 2025
IS THERE A CORRELATION BETWEEN OBJECTIVE AND SUBJECTIVE METHODS TO ASSESS DENTAL ANXIETY? A SYSTEMATIC REVIEW AND META-ANALYSIS CS de Amorim, LSL da Silva, GA Marañón-Vásquez, MB Magno, ... Journal of Evidence-Based Dental Practice 25 (2), 102092 , 2025 2025
Effects of Systemic and Local Anti-tumor Necrosis Factor-α Receptor-1 Administration on Periapical Bone Loss in Mice LA de Almeida-Junior, J de Lima Gonçalves, MFM Arnez, NSR Jimenez, ... Journal of Endodontics , 2025 2025 Citations: 1
Does palatal morphology influence the bone and soft tissue thickness of anterior hard palate? LI Dantas de Andrade Sant’anna, GA Maranón-Vásquez, ... Clinical and Investigative Orthodontics 84 (2), 102-111 , 2025 2025
Effect of prenatal alcohol consumption on dental enamel formation in offspring—An animal study protocol RD Leme, GA Marañón-Vásquez, JL Goncalves, FK de Carvalho, ... Plos one 20 (2), e0317570 , 2025 2025 Citations: 3
Impact of clinical consequences of pulp involvement due to caries on oral health‐related quality of life in children and adolescents: a systematic review and meta-analysis PPG Reis, RC Jorge, GA Marañón-Vásquez, TKS Fidalgo, LC Maia, ... Caries Research 59 (1), 71-83 , 2025 2025 Citations: 12
Does occlusal morphology of artificial teeth improve chewing of removable dentures wearers? A systematic review and meta‐analysis NCS Silva, PHB Oliveira, LT Gama, MB Magno, GA Marañón‐Vásquez, ... Journal of Prosthodontics 34 (2), 120-138 , 2025 2025 Citations: 6
National and subnational plans for primary prevention and early detection of oral and oropharyngeal cancer: a scoping review MFP Marinho, MCFL Marinho, GA Marañón-Vásquez, KBF Simas, ... Cadernos de Saúde Pública 40, e00233923 , 2025 2025 Citations: 5
Assessment of the relationship between facial, skeletal, dental and smile asymmetries: a preliminary investigative analysis FSN DIOGO, KM MAGALHÃES, LSC BARRETO, PBA ALMEIDA, ... Dental Press Journal of Orthodontics 30 (6), e2524202 , 2025 2025
Dimensional changes of alveolar bone after orthodontic expansion with Invisalign ® aligners: study by Cone Beam Computed Tomography BB Vieira, GA Marañón-Vásquez, MA FIGUEIREDO, MBS Stuani, ... Dental Press Journal of Orthodontics 30 (5), e2525225 , 2025 2025
Diagnostic performance of ClinCheck, Dolphin Imaging, and 3D Slicer software for Bolton discrepancy analysis. F Copello, GA Marañón-Vásquez, L Issamu Nojima, E Franzotti Sant'Anna The Angle Orthodontist 95 (1), 51-56 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns A Cunha, P Nelson-Filho, GA Marañón-Vásquez, AG de Carvalho Ramos, ... Archives of Oral Biology 97, 85-90 , 2019 2019.0 Citations: 68
Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis TC Fonsêca, LA Jural, GA Marañón-Vásquez, MB Magno, ALOC Roza, ... Clinical Oral Investigations 28 (1), 62 , 2023 2023.0 Citations: 55
Reasons influencing the preferences of prospective patients and orthodontists for different orthodontic appliances GA Marañón-Vásquez, LS da Costa Barreto, MM Pithon, LI Nojima, ... Korean Journal of Orthodontics 51 (2), 115-125 , 2021 2021.0 Citations: 51
Edad dental según los métodos Demirjian y Nolla en niños peruanos de 4 a 15 años G Marañón-Vásquez, H Gonzáles-Olaza Kiru 9 (1), 42-50 , 2012 2012.0 Citations: 50
Is the buccal alveolar bone less affected by mini‐implant assisted rapid palatal expansion than by conventional rapid palatal expansion?—A systematic review and meta‐analysis FM Copello, GA Marañón‐Vásquez, DP Brunetto, LD Caldas, ... Orthodontics & craniofacial research 23 (3), 237-249 , 2020 2020.0 Citations: 47
Is the buccal alveolar bone less affected by mini‐implant assisted rapid palatal expansion than by conventional rapid palatal expansion?—A systematic review and meta‐analysis FM Copello, GA Marañón‐Vásquez, DP Brunetto, LD Caldas, ... Orthodontics & Craniofacial Research , 0 Citations: 47
Genetic variants in tooth agenesis–related genes might be also involved in tooth size variations AS Cunha, LV Dos Santos, GA Marañón-Vásquez, C Kirschneck, ... Clinical oral investigations 25 (3), 1307-1318 , 2021 2021.0 Citations: 33
Worldwide trends on molar incisor and deciduous molar hypomineralisation research: a bibliometric analysis over a 19-year period T da Costa Rosa, AVB Pintor, MB Magno, GA Marañón-Vásquez, LC Maia, ... European Archives of Paediatric Dentistry 23 (1), 133-146 , 2022 2022.0 Citations: 31
Mandibular and dental measurements for sex determination using machine learning EC Küchler, C Kirschneck, GA Marañón-Vásquez, ÂGD Schroder, ... Scientific Reports 14 (1), 9587 , 2024 2024.0 Citations: 30
Association between craniofacial morphological patterns and tooth agenesis-related genes AS Rodrigues, EC Teixeira, LS Antunes, P Nelson-Filho, AS Cunha, ... Progress in orthodontics 21 (1), 9 , 2020 2020.0 Citations: 29
Effect of treatment of transverse maxillary deficiency using rapid palatal expansion on oral health-related quality of life in children: A randomized controlled trial MM Pithon, GA Maranon-Vasquez, LP da Silva, R da Silva Coqueiro, ... American Journal of Orthodontics and Dentofacial Orthopedics 161 (2), 172-181 , 2022 2022.0 Citations: 26
Are yellow-brownish opacities in hypomineralized teeth more prone to breakage than white-creamy ones? A systematic review RC Jorge, P dos Papoula GorniReis, GA Marañón-Vásquez, D Masterson, ... Clinical Oral Investigations 26 (9), 5795-5808 , 2022 2022.0 Citations: 25
Oral manifestations arising from oral piercings: A systematic review and meta-analyses PF Passos, AVB Pintor, GA Maranon-Vasquez, T Campos, AC Abrahao, ... Oral surgery, oral medicine, oral pathology and oral radiology 134 (3), 327-341 , 2022 2022.0 Citations: 25
Parathyroid Hormone Gene and Genes Involved in the Maintenance of Vitamin D Levels Association with Mandibular Retrognathism EC Küchler, CLB Reis, G Marañón-Vásquez, P Nelson-Filho, ... Journal of Personalized Medicine 11 (5), 369 , 2021 2021.0 Citations: 24
Clinical performance of and patient satisfaction with conventional complete dentures with different occlusal schemes: A systematic review of systematic reviews MHR Borges, LFB Miranda, C Dini, GA Maranon-Vasquez, MB Magno, ... The Journal of Prosthetic Dentistry 130 (3), 341-350 , 2023 2023.0 Citations: 23
Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review YG de Sousa Né, DR Frazão, LO Bittencourt, NCF Fagundes, ... Metabolites 12 (9), 858 , 2022 2022.0 Citations: 23
Effect of ovariectomy on maxilla and mandible dimensions of female rats MA Omori, GA Marañón‐Vásquez, PC Romualdo, EC Martins Neto, ... Orthodontics & craniofacial research 23 (3), 342-350 , 2020 2020.0 Citations: 23
Aesthetic and functional outcomes using a multiloop edgewise archwire for camouflage orthodontic treatment of a severe Class III open bite malocclusion GA Marañón-Vásquez, LC Soldevilla Galarza, FA Tolentino Solis, ... Journal of orthodontics 44 (3), 199-208 , 2017 2017.0 Citations: 23
Do patients with molar incisor hypomineralization have more dental anxiety and behavior management problems? A systematic review with meta-analysis PPG Reis, RC Jorge, DMTP Ferreira, GA Maranon-Vasquez, LC Maia, ... Brazilian Oral Research 37, e069 , 2023 2023.0 Citations: 21
Global gene expression profile of periodontal ligament cells submitted to mechanical loading: A systematic review A Spitz, IO Christovam, GA Marañón-Vásquez, DF Masterson, D Adesse, ... Archives of Oral Biology 118, 104884 , 2020 2020.0 Citations: 20