Halimah Funmilayo Babamale
@unilorin.edu.ng
Lecturer, Faculty of Physical Sciences
Lecturer, Faculty of Physical Sciences
University of Ilorin
Halimah Funmilayo BABAMALE, is a lecturer in the Department of
Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin with about 10 years of university teaching, research, and administrative experience.
She has served as Level Adviser in her department, and Faculty of Physical Science Representative at the Technical Committee on Plastic Production of the Technical and Entrepreneurship Center (TEC). Her areas of research interest cover Synthesis and Characterization of Organic compounds, Biorganic and Medicinal Chemistry.
She has to her credit over Thirty publications in reputable outlets covering journals, edited conference proceedings and chapters in books. She has successfully supervised several undergraduate projects.
Dr. Babamale is a Certified member of the Chemical Society of Nigeria (CSN), Nigerian Institute of Management (NIM), and member of other professional bodies within and outside Nigeria such as Material Society of Nigeria (MSN), Science Association
EDUCATION
Ph.D. Chemistry (Universiti Sains Malaysia)
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Cancer Research, Organic Chemistry, Spectroscopy
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Halimah Funmilayo Babamale, Si Ling Ng, Wai Kit Tang, and WanSinn Yam
Elsevier BV
Halimah Funmilayo Babamale, Boon-Keat Khor, Nelson Jeng-Yeou Chear, and WanSinn Yam
Elsevier BV
Halimah F. Babamale, Boon‐Keat Khor, Nelson Jeng‐Yeou Chear, and Wan Sinn Yam
Wiley
A new series of tetrafluorinated azobenzene‐imidazolium salts is reported. The azobenzene and imidazolium moieties were functionalized with long alkyl chains and connected via a methylene spacer of varying lengths (n = 3–12). They were characterized using FTIR and NMR spectroscopy, and elemental microanalysis. The cytotoxic potential of these ionic dimers against neuroblastoma (SHSY‐5Y), estrogen‐positive breast cancer cells (MCF‐7), triple‐negative breast cancer cells (MDA‐MB‐231), cervical cancer cells (HeLa), and human skin fibroblasts (Hs27) was evaluated using the MTT assay. The cytotoxicity of these ionic liquids (ILs) was dependent on the spacer length. A cut‐off effect was observed, wherein the cytotoxicity of the ILs was enhanced by increasing the nonpolar, hydrophobic spacer length up to a threshold and the potency was leveled off upon chain elongation. All ILs exhibited selective and remarkable inhibition potentials against HeLa cells in a dose‐dependent manner, which was 2–22 times stronger than that of etoposide, a clinical anticancer drug. These ILs were less toxic toward skin fibroblasts as implied by much higher IC50 values. The long‐spacer ILs (n = 7–10) were very selective toward HeLa cells. They had a broad safety window with selectivity indices ranging between 5.6 and 11.0. The selectivity of these compounds toward HeLa cells may serve as a new strategy for the design and development of safe and effective chemotherapeutics.
Halimah Funmilayo Babamale, Boon-Keat Khor, Nelson Jeng-Yeou Chear, Rosenani A. Haque, and WanSinn Yam
Elsevier BV
Yusuf Oloruntoyin Ayipo, Wahab Adesina Osunniran, Halimah Funmilayo Babamale, Monsurat Olabisi Ayinde, and Mohd Nizam Mordi
Elsevier BV
Yusuf Oloruntoyin Ayipo, Sani Najib Yahaya, Waleed A. Alananzeh, Halimah Funmilayo Babamale, and Mohd Nizam Mordi
Elsevier BV
Halimah Funmilayo Babamale, Thiagarajan Sangeetha, Joo Shun Tan, and WanSinn Yam
Elsevier BV
A. O. Rajee, H. F. Babamale, A. Lawal, A. A. Aliyu, W. A. Osunniran, A. O. Sheriff, M. Lawal, and J. A. Obaleye
African Journals Online (AJOL)
Four complexes of Mn(II), Co(II), Ni(II) and Cu(II) with Schiff base ligand (H3L) derived from 2-amino-3-methylbutanoic acid and acetylacetonate were synthesized. All complexes were characterized by elemental analysis, Fourier-transform infrared spectroscopy and electronic spectroscopy. The results confirmed the coordination of the ligand to metals in tridentate fashion via the hydroxyl oxygen, the azomethine nitrogen and the enolic acetylacetonate oxygen. Antimicrobial activities were established for all complexes, free ligand and ciprofloxacin for comparison. Both the ligand and its metal complexes were active against Gram-positive and negative bacterial strains. The Cu(II) complex, showed highest antibacterial activity among the complexes screened. Other complexes displayed considerable antibacterial activity. Octahedral geometry was proposed for the metal(II) complexes with the Schiff base.
 
 KEY WORDS: Schiff base, Amino acid, Metal Complexes, Antibacterial agents
 
 Bull. Chem. Soc. Ethiop. 2021, 35(1), 97-106.
 DOI: https://dx.doi.org/10.4314/bcse.v35i1.8
Yusuf Oloruntoyin AYIPO, Sani Najib YAHAYA, Halimah Funmilayo BABAMALE, Iqrar AHMAD, Harun PATEL, and Mohd Nizam MORDI
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
The nsp3 macrodomain is implicated in the viral replication, pathogenesis and host immune responses through the removal of ADP-ribosylation sites during infections of coronaviruses including the SARS-CoV-2. It has ever been modulated by macromolecules including the ADP-ribose until Ni and co-workers recently reported its inhibition and plasticity enhancement unprecedentedly by remdesivir metabolite, GS-441524, creating an opportunity for investigating other biodiverse small molecules such as β-Carboline (βC) alkaloids. In this study, 1497 βC analogues from the HiT2LEAD chemical database were screened, using computational approaches of Glide XP docking, molecular dynamics simulation and pk-CSM ADMET predictions. Selectively, βC ligands, 129, 584, 1303 and 1323 demonstrated higher binding affinities to the receptor, indicated by XP docking scores of –10.72, –10.01, –9.63 and –9.48 kcal/mol respectively than remdesivir and GS-441524 with –4.68 and –9.41 kcal/mol respectively. Consistently, their binding free energies were –36.07, –23.77, –24.07 and –17.76 kcal/mol respectively, while remdesivir and GS-441524 showed –21.22 and –24.20 kcal/mol respectively. Interestingly, the selected βC ligands displayed better stability and flexibility for enhancing the plasticity of the receptor than GS-441524, especially 129 and 1303. Their predicted ADMET parameters favour druggability and low expressions for toxicity. Thus, they are recommended as promising adjuvant/standalone anti-SARS-CoV-2 candidates for further study.Key words: SARS-CoV-2, nsp3 macrodomain, ADP-ribose, β-carboline, bioinformatics, drug design
Yusuf AYİPO, Wahab OSUNNİRAN, Umar BADEGGİ, Ismaila SAHEED, Akeem JIMOH, and Halimah BABAMALE
The Turkish Chemical Society
Pathogenic microorganisms develop incessant resistance toward antibiotics through various cellular defense mechanisms, thereby creating a search for chemotherapeutic alternatives, the potentials of which metal complexes of small-molecule drugs offer. In this study, Cu(II) and Co(II) complexes of mixed piperaquine and diclofenac were synthesized and characterized via magnetic moment determination, elemental analysis, FTIR, UV-Visible, 1D 1H NMR, 13C NMR spectroscopy and powder XRD, then evaluated for biological activities in silico and in vitro. The results provide evidence of coordination of the metal ions to ligands through N, COO and Cl groups with proposed octahedral geometry, low spin, paramagnetic, polycrystalline complexes. The physicochemical and pharmacokinetic parameters predicted in silico support bio-functionality and safety of the complexes. The complexes demonstrate strong inhibition against bacterial strains especially Staphylococcus aureus in vitro. Specifically, Cu(II) complex at 1% w/w inhibited a zone of 100 mm which is in multi-folds of the effects of piperaquine and diclofenac with 32 and 25 mm respectively, and better than ciprofloxacin with 92 mm. On DPPH assay, both complexes display better antioxidant potentials with respective IC50 of 165.09 and 382.7 µg/mL compared to ascorbic acid with 7526 µg/mL. Thus, the complexes represent therapeutic models for overcoming antibacterial resistance upon further study.