Halimah Funmilayo Babamale

@unilorin.edu.ng

Lecturer, Faculty of Physical Sciences
Lecturer, Faculty of Physical Sciences
University of Ilorin

Halimah Funmilayo BABAMALE, is a lecturer in the Department of
Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin with about 10 years of university teaching, research, and administrative experience.
She has served as Level Adviser in her department, and Faculty of Physical Science Representative at the Technical Committee on Plastic Production of the Technical and Entrepreneurship Center (TEC). Her areas of research interest cover Synthesis and Characterization of Organic compounds, Biorganic and Medicinal Chemistry.
She has to her credit over Thirty publications in reputable outlets covering journals, edited conference proceedings and chapters in books. She has successfully supervised several undergraduate projects.
Dr. Babamale is a Certified member of the Chemical Society of Nigeria (CSN), Nigerian Institute of Management (NIM), and member of other professional bodies within and outside Nigeria such as Material Society of Nigeria (MSN), Science Association

EDUCATION

Ph.D. Chemistry (Universiti Sains Malaysia)

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Cancer Research, Organic Chemistry, Spectroscopy

Scopus Publications

272

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Azobenzene-Imidazolium ionic liquid crystals: Phase properties and photoisomerization in solution state
Halimah Funmilayo Babamale, Si Ling Ng, Wai Kit Tang, and WanSinn Yam
Elsevier BV

Suppressive effects of azobenzene-imidazolium ionic conjugates on human cervical adenocarcinoma cells: Effects of alkyl chains and ortho-fluorination
Halimah Funmilayo Babamale, Boon-Keat Khor, Nelson Jeng-Yeou Chear, and WanSinn Yam
Elsevier BV

Safe and selective anticancer agents from tetrafluorinated azobenzene-imidazolium ionic liquids: Synthesis, characterization, and cytotoxic effects
Halimah F. Babamale, Boon‐Keat Khor, Nelson Jeng‐Yeou Chear, and Wan Sinn Yam
Wiley
A new series of tetrafluorinated azobenzene‐imidazolium salts is reported. The azobenzene and imidazolium moieties were functionalized with long alkyl chains and connected via a methylene spacer of varying lengths (n = 3–12). They were characterized using FTIR and NMR spectroscopy, and elemental microanalysis. The cytotoxic potential of these ionic dimers against neuroblastoma (SHSY‐5Y), estrogen‐positive breast cancer cells (MCF‐7), triple‐negative breast cancer cells (MDA‐MB‐231), cervical cancer cells (HeLa), and human skin fibroblasts (Hs27) was evaluated using the MTT assay. The cytotoxicity of these ionic liquids (ILs) was dependent on the spacer length. A cut‐off effect was observed, wherein the cytotoxicity of the ILs was enhanced by increasing the nonpolar, hydrophobic spacer length up to a threshold and the potency was leveled off upon chain elongation. All ILs exhibited selective and remarkable inhibition potentials against HeLa cells in a dose‐dependent manner, which was 2–22 times stronger than that of etoposide, a clinical anticancer drug. These ILs were less toxic toward skin fibroblasts as implied by much higher IC50 values. The long‐spacer ILs (n = 7–10) were very selective toward HeLa cells. They had a broad safety window with selectivity indices ranging between 5.6 and 11.0. The selectivity of these compounds toward HeLa cells may serve as a new strategy for the design and development of safe and effective chemotherapeutics.

The First tetrafluorinated azobenzene-imidazolium ionic conjugates as potential thermotropic liquid crystalline drugs: Self-assembly properties and cytotoxic effects
Halimah Funmilayo Babamale, Boon-Keat Khor, Nelson Jeng-Yeou Chear, Rosenani A. Haque, and WanSinn Yam
Elsevier BV

Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives
Yusuf Oloruntoyin Ayipo, Wahab Adesina Osunniran, Halimah Funmilayo Babamale, Monsurat Olabisi Ayinde, and Mohd Nizam Mordi
Elsevier BV

Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside
Yusuf Oloruntoyin Ayipo, Sani Najib Yahaya, Waleed A. Alananzeh, Halimah Funmilayo Babamale, and Mohd Nizam Mordi
Elsevier BV

Effect of Ferrochrome Addition on Wear and Hardness Properties of Grey Cast Iron

Synthesis and characterization of azobenzene derivatives and azobenzene-imidazolium conjugates with selective antimicrobial potential
Halimah Funmilayo Babamale, Thiagarajan Sangeetha, Joo Shun Tan, and WanSinn Yam
Elsevier BV

Mn(ii), co(ii), ni(ii), and cu(ii) complexes of amino acid derived schiff base ligand: Synthesis, characterization and in-vitro antibacterial investigations
A. O. Rajee, H. F. Babamale, A. Lawal, A. A. Aliyu, W. A. Osunniran, A. O. Sheriff, M. Lawal, and J. A. Obaleye
African Journals Online (AJOL)
Four complexes of Mn(II), Co(II), Ni(II) and Cu(II) with Schiff base ligand (H3L) derived from 2-amino-3-methylbutanoic acid and acetylacetonate were synthesized. All complexes were characterized by elemental analysis, Fourier-transform infrared spectroscopy and electronic spectroscopy. The results confirmed the coordination of the ligand to metals in tridentate fashion via the hydroxyl oxygen, the azomethine nitrogen and the enolic acetylacetonate oxygen. Antimicrobial activities were established for all complexes, free ligand and ciprofloxacin for comparison. Both the ligand and its metal complexes were active against Gram-positive and negative bacterial strains. The Cu(II) complex, showed highest antibacterial activity among the complexes screened. Other complexes displayed considerable antibacterial activity. Octahedral geometry was proposed for the metal(II) complexes with the Schiff base.  KEY WORDS: Schiff base, Amino acid, Metal Complexes, Antibacterial agents  Bull. Chem. Soc. Ethiop. 2021, 35(1), 97-106. DOI: https://dx.doi.org/10.4314/bcse.v35i1.8

β-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: Computational approach
Yusuf Oloruntoyin AYIPO, Sani Najib YAHAYA, Halimah Funmilayo BABAMALE, Iqrar AHMAD, Harun PATEL, and Mohd Nizam MORDI
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS
The nsp3 macrodomain is implicated in the viral replication, pathogenesis and host immune responses through the removal of ADP-ribosylation sites during infections of coronaviruses including the SARS-CoV-2. It has ever been modulated by macromolecules including the ADP-ribose until Ni and co-workers recently reported its inhibition and plasticity enhancement unprecedentedly by remdesivir metabolite, GS-441524, creating an opportunity for investigating other biodiverse small molecules such as β-Carboline (βC) alkaloids. In this study, 1497 βC analogues from the HiT2LEAD chemical database were screened, using computational approaches of Glide XP docking, molecular dynamics simulation and pk-CSM ADMET predictions. Selectively, βC ligands, 129, 584, 1303 and 1323 demonstrated higher binding affinities to the receptor, indicated by XP docking scores of –10.72, –10.01, –9.63 and –9.48 kcal/mol respectively than remdesivir and GS-441524 with –4.68 and –9.41 kcal/mol respectively. Consistently, their binding free energies were –36.07, –23.77, –24.07 and –17.76 kcal/mol respectively, while remdesivir and GS-441524 showed –21.22 and –24.20 kcal/mol respectively. Interestingly, the selected βC ligands displayed better stability and flexibility for enhancing the plasticity of the receptor than GS-441524, especially 129 and 1303. Their predicted ADMET parameters favour druggability and low expressions for toxicity. Thus, they are recommended as promising adjuvant/standalone anti-SARS-CoV-2 candidates for further study.Key words: SARS-CoV-2, nsp3 macrodomain, ADP-ribose, β-carboline, bioinformatics, drug design

Synthesis, characterization and antibacterial study of co(Ii) and cu(ii) complexes of mixed ligands of piperaquine and diclofenac
Yusuf AYİPO, Wahab OSUNNİRAN, Umar BADEGGİ, Ismaila SAHEED, Akeem JIMOH, and Halimah BABAMALE
The Turkish Chemical Society
Pathogenic microorganisms develop incessant resistance toward antibiotics through various cellular defense mechanisms, thereby creating a search for chemotherapeutic alternatives, the potentials of which metal complexes of small-molecule drugs offer. In this study, Cu(II) and Co(II) complexes of mixed piperaquine and diclofenac were synthesized and characterized via magnetic moment determination, elemental analysis, FTIR, UV-Visible, 1D 1H NMR, 13C NMR spectroscopy and powder XRD, then evaluated for biological activities in silico and in vitro. The results provide evidence of coordination of the metal ions to ligands through N, COO and Cl groups with proposed octahedral geometry, low spin, paramagnetic, polycrystalline complexes. The physicochemical and pharmacokinetic parameters predicted in silico support bio-functionality and safety of the complexes. The complexes demonstrate strong inhibition against bacterial strains especially Staphylococcus aureus in vitro. Specifically, Cu(II) complex at 1% w/w inhibited a zone of 100 mm which is in multi-folds of the effects of piperaquine and diclofenac with 32 and 25 mm respectively, and better than ciprofloxacin with 92 mm. On DPPH assay, both complexes display better antioxidant potentials with respective IC50 of 165.09 and 382.7 µg/mL compared to ascorbic acid with 7526 µg/mL. Thus, the complexes represent therapeutic models for overcoming antibacterial resistance upon further study.

RECENT SCHOLAR PUBLICATIONS

In Silico Medicinal and Pharmacological Evaluation of Phytochemical Constituents from the Root Bark Extract of Enantia Chlorantha as Potential Antimalarial Drugs
S Ibrahim, H Lukman, Y Ayipo, H Babamale, F Abdulkadir, A Hamid, ...
Journal of Pure & Applied Sciences 23 (2), 178-188 2024

Chemoinformatic-aided Antidiabetic Analysis of the Therapeutic Potential of Phytoconstituents in Eremomastax speciosa Extracts
SO Ibrahim, HY Lukman, IE Ebhohimen, HF Babamale, FR Abdulkadir, ...
Borneo Journal of Pharmacy 7 (2), 172-186 2024

Azobenzene-Imidazolium ionic liquid crystals: Phase properties and photoisomerization in solution state
HF Babamale, SL Ng, WK Tang, WS Yam
Journal of Molecular Structure 1303, 137494 2024

Nanoparticles as Antioxidant Agents: A Comprehensive Review
SO Ibrahim, HY Lukman, FR Abdulkadir, MY Bello, YO Ayipo, ...
Al-Bahir Journal for Engineering and Pure Sciences 5 (1), 3 2024

Suppressive effects of azobenzene-imidazolium ionic conjugates on human cervical adenocarcinoma cells: Effects of alkyl chains and ortho-fluorination
HF Babamale, BK Khor, NJY Chear, WS Yam
Journal of Molecular Structure 1270, 133947 2022

Safe and selective anticancer agents from tetrafluorinated azobenzene‐imidazolium ionic liquids: Synthesis, characterization, and cytotoxic effects
HF Babamale, BK Khor, NJY Chear, WS Yam
Archiv der Pharmazie 355 (8), 2200085 2022

The First tetrafluorinated azobenzene-imidazolium ionic conjugates as potential thermotropic liquid crystalline drugs: Self-assembly properties and cytotoxic effects
HF Babamale, BK Khor, NJY Chear, RA Haque, WS Yam
Journal of Molecular Structure 1255, 132470 2022

Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives
YO Ayipo, WA Osunniran, HF Babamale, MO Ayinde, MN Mordi
Coordination Chemistry Reviews 453, 214317 2022

NANOCELLULOSE AS A STABILIZING AGENT IN THE SYNTHESIS OF SILVER NANOPARTICLES UNDER TRACE LEVEL TRISODIUM CITRATE
HF Babamale, OD SALIU, AOLA RAJEE, IA Kuranga, AS FALUYI
Faculty of Pure and Applied Science, Ladoke Akintola University of 2022

Effect of ferrochrome addition on wear and hardness properties of grey cast iron
YO Busari, JA Adebisi, YL Shuaib-Babata, LO Amuzat, HF Babamale
Mindanao Journal of Science and Technology 19 (2) 2021

Removal of orange G dye from aqueous solution by adsorption: A short review
S Imam, AI Muhammad, HF Babamale, ZU Zango
Journal of Environmental Treatment Techniques 9 (1), 318-327 2021

Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside
YO Ayipo, SN Yahaya, WA Alananzeh, HF Babamale, MN Mordi
Infection, Genetics and Evolution 93, 104944 2021

The Roles of Vegetable Fibres in Green Chemistry
AT Ajiboye, KO Otun, LB Babamale, H. F and Abdulra'uf
Vegetable Fiber Composites and their Technological Applications, Composites 2021

Synthesis and characterization of azobenzene derivatives and azobenzene-imidazolium conjugates with selective antimicrobial potential
HF Babamale, T Sangeetha, JS Tan, WS Yam
Journal of Molecular Structure 1232, 130049 2021

Mn (II), Co (II), Ni (II), and Cu (II) complexes of amino acid derived Schiff base ligand: Synthesis, characterization and in-vitro antibacterial investigations
AO Rajee, HF Babamale, A Lawal, AA Aliyu, WA Osunniran, AO Sheriff, ...
Bulletin of the Chemical Society of Ethiopia 35 (1), 97-106 2021

-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: Computational approach
YO Ayipo, SN Yahaya, HF Babamale, I Ahmad, H Patel, MN Mordi
Turkish Journal of Biology 45 (7), 503-517 2021

Synthesis, characterization and antibacterial study of Co (II) and Cu (II) complexes of mixed ligands of piperaquine and diclofenac
Y AYİPO, WA Osunniran, UM Badeggi, IO Saheed, A JIMOH, ...
Journal of the Turkish Chemical Society Section A: Chemistry 8 (2), 633-650 2021

Synthesis, Structural Elucidation and Antimicrobial Activity of Metal (II) Polypyridyl Complexes of 2-Amino-4-(Methylthio) Butanoic Acid
AO Rajee, HF Babamale, AA Aliyu, A Lawal, SO Ayinla, WA Osunniran, ...
Fountain Journal of Natural and Applied Sciences 9 (1) 2020

Kinetic and Thermodynamic Study of Oxidative Decolourisation of a Typical Food Dye (Tartrazine) in an Aqueous Environment
FO Okeola, EO Odebunmi, MA Amoloye, HF Babamale, S Thema, ...
Journal of Applied Sciences and Environmental Management 24 (6), 1021-1026 2020

Preparation, characterization and antibacterial activity of Mn (II), Cu (II) and Zn (II) complexes of methionine and 2, 2-bipyridine co-ligands
AO Rajee, AA Aliyu, HF Babamale, A Lawal, SO Ayinla, WA Osunniran, ...
J. Kenya Chem. Soc 13, 16-21 2020

MOST CITED SCHOLAR PUBLICATIONS

A short review on the removal of rhodamine B dye using agricultural waste-based adsorbents
SS Imam, HF Babamale
Asian J. Chem. Sci 7 (1), 25-37 2020
Citations: 57

Removal of orange G dye from aqueous solution by adsorption: A short review
S Imam, AI Muhammad, HF Babamale, ZU Zango
Journal of Environmental Treatment Techniques 9 (1), 318-327 2021
Citations: 23

Synthesis, characterization and biological activity studies of mixed paracetamol-ascorbic acid metal complexes
HF Babamale, A Lawal, OA Rajee, EA Oloyede
Journal of Applied Sciences and Environmental Management 20 (4), 1157-1161 2016
Citations: 14

Synthesis, Characterization and Biological Studies of Mixed Ligands Nicotinamide-Trimethoprim Metal Complexes
A Lawal, PA Ayanwale, JA Obaleye, AO Rajee, HF Babamale, M Lawal
International Journal of Chemical, Material and Environmental Research 2017
Citations: 12

The First tetrafluorinated azobenzene-imidazolium ionic conjugates as potential thermotropic liquid crystalline drugs: Self-assembly properties and cytotoxic effects
HF Babamale, BK Khor, NJY Chear, RA Haque, WS Yam
Journal of Molecular Structure 1255, 132470 2022
Citations: 8

Synthesis, characterization and antimicrobial activity of mixed ascorbic acid-nicotinamide metal complexes
A Lawal, SA Amolegbe, AO Rajee, HF Babamale, MT Yunus-Issa
Bayero Journal of Pure and Applied Sciences 8 (1), 139–142-139–142 2015
Citations: 8

Mixed metal complexes of isoniazid and ascorbic acid: chelation, characterization and antimicrobial activities
M Lawal, JA Obaleye, MO Bamigboye, GG Nnabuike, SO Ayinla, ...
Nigerian Journal of Chemical Research 22 (1), 20-28 2017
Citations: 7

Chelation, Characterization and Antimicrobial Screening of Some Mixed Antituberculosis–Vitamin Metal Drug Complexes
M Bamigboye, M.O., Obaleye, J.A., Lawal, A., Babamale, H.F., Ajibola, A.A ...
Al-Hikmah Journal of Pure & Applied Sciences 4, 37-42 2017
Citations: 5

Synthesis, Characterization and Antimicrobial activity of Amodiaquine and Sulphadoxine Ligand Metal Complexes
JA Obaleye, A Lawal, AO Rajee, HF Babamale, FB Shittu
Nigerian J. Biochemistry and Molecular Biology 29 (2), p170-178 2014
Citations: 5

Azobenzene-Imidazolium ionic liquid crystals: Phase properties and photoisomerization in solution state
HF Babamale, SL Ng, WK Tang, WS Yam
Journal of Molecular Structure 1303, 137494 2024
Citations: 4

Effect of ferrochrome addition on wear and hardness properties of grey cast iron
YO Busari, JA Adebisi, YL Shuaib-Babata, LO Amuzat, HF Babamale
Mindanao Journal of Science and Technology 19 (2) 2021
Citations: 2

Enrichment of a Nigerian Calcite Ore for Hydroxyapatite Production
AB Alafara, AW Adeola, J Olaide, L Amudat, FB Halimah, GFAFAA Abdul
Journal of The Australian Ceramic Society 52 (2), 62 – 72 2016
Citations: 2