ibrahim ghalib saleh

Verified @gmail.com

Department of Pharmacology, Al-Azhar University, Cairo, Egypt
al-azhar university

ibrahim ghalib saleh


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https://researchid.co/iisaleh

RESEARCH INTERESTS

Molecular biology, Liver and kidney Toxicology, Immunostaining, Animal handling.
21

Scopus Publications

309

Scholar Citations

9

Scholar h-index

9

Scholar i10-index

Scopus Publications

  • ATRA-mediated RAR-α activation attenuates acrylamide-induced testicular toxicity
    Hamada Ahmed Mokhlis, Mohammed Helmy Rashed, Ibrahim Ghalib Saleh, Mahmoud Gomaa Eldeib, Ahmed A. El-Husseiny, Emad Gamil Khidr, Maher H. Gomaa, Hesham S. Gad, Mohamed R. Elnagar, Mahmoud Mohamed Mokhtar, Ahmed Aglan
    Scientific Reports, 2026
    Acrylamide (ACR) is an environmental reproductive toxicant with unclear testicular toxicity mechanisms. Retinoids are a group of vitamin A-related compounds that function by activating retinoid receptors. We aimed in this study to further explore All-trans retinoic acid’s (ATRA) protective response against an acrylamide-induced testicular insult model and the underlying possible mechanisms. Fifty male rats were allocated into control, DMSO, ACR (40 mg/kg bwt, i.p. daily for 14 days), ATRA (7.5 mg/kg bwt, i.p. daily), and ACR + ATRA groups. Body and testes weights, sperm parameters, testosterone level, and lactate dehydrogenase-X (LDH-X) activity were measured. In addition, testicular levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), caspase-3, Bax, and Bcl-2 were determined. Also, tissues were examined for histopathologic changes and immune expression of retinoic acid receptor-alpha (RAR-α). ACR exposure led to reduced body and testicular weights, impaired sperm parameters, and suppressed reproductive hormones (testosterone, FSH, LH). Testicular LDH-X activity decreased, along with reduced testicular RAR-α expression. Oxidative stress resulted in GSH depletion, reduced CAT and SOD activities, and increased MDA. ACR also triggered inflammation and apoptosis, with elevated TNF-α, IL-1β, IL-6, caspase-3, Bax. In contrast, ATRA improved sperm parameters and levels of hormones, restored RAR-α expression, mitigated oxidative stress, and decreased inflammation and apoptosis markers. Morphometric and histopathologic studies supported these biochemical observations. Overall, RAR-α agonist (ATRA) is linked to attenuation against ACR-induced testicular damage, along with a reduction in oxidative stress, inflammation, and cell death. These findings suggest that retinoid signaling might serve as a possible therapeutic target for reproductive toxicities induced by ACR, necessitating further mechanistic exploration.
  • Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR
    Abdel-Aziz S. Shatat, Elsayed M. Mahgoup, Mohammed H. Rashed, Ibrahim G. Saleh, El-Sayed Akool
    Purinergic Signalling, 2024
    One of the leading causes of cancer-related deaths worldwide is colorectal cancer (CRC). Extracellular ATP (e-ATP) and purinergic receptors (P2R) play a central role in CRC proliferation and progression. Human antigen R (HuR) is becoming more and more understood to be essential for the expression of genes linked to cancer. The current study demonstrates that ATP can mediate CRC (Caco-2 cells) progression via induction of HuR nucleocytoplasmic shuttling and subsequent expression of cancer-related genes, a consequence mostly mediated via the P2R receptor. It was also noted that suppression of HuR activity by using dihydrotanshinone I (DHTS) prevents cancer-related gene expression and subsequent CRC (Caco-2 cells) progression induced by ATP. The expression of cyclin A2/cyclin-dependent kinase 2 (CDK2), Bcl-2, ProT-α, hypoxia‐inducible factor1-α (HIF1-α), vascular endothelial growth factor A (VEGF-A), transforming growth factor-β (TGF-β) and matrix metallopeptidase 9 (MMP-9) induced by ATP were highly reduced in the presence of either PPADS (non-selective P2R antagonist) or DHTS. In addition, e-ATP-induced Caco-2 cell proliferation as well as cell survival were highly reduced in the presence of either PPADS or DHTS or selective CDK-2 inhibitor (Roscovitine) or selective Bcl-2 inhibitor (ABT-263). Furthermore, it was found that MMP-9 is critical for Caco-2 cells migration induced by e-ATP as demonstrated by a clear reduction in cells migration in the presence of a selective MMP-9 inhibitor (Marimastat). Collectively, these data demonstrate that ATP through P2R activation can induce HuR nucleocytoplasmic shuttling that could be translated into an increase in cancer-related genes expression and subsequent, cell proliferation and progression.
  • Sorafenib and edaravone protect against renal fibrosis induced by unilateral ureteral obstruction via inhibition of oxidative stress, inflammation, and RIPK-3/MLKL pathway
    Mohamed A. Abou Taha, Fares E.M. Ali, Ibrahim G. Saleh, El-Sayed Akool
    Naunyn Schmiedeberg S Archives of Pharmacology, 2024
    Renal fibrosis is the common endpoint of nearly all chronic and progressive nephropathies. Cell death and sterile inflammation are the main characteristics of renal fibrosis, which can lead to end-stage renal failure. The inflammatory reaction triggered by tissue damage is strongly related to necroptosis, a type of caspase-independent, regulated cell death. Using an animal model of unilateral ureteral obstruction (UUO), the anti-fibrotic effects of sorafenib (SOF), a multi-kinase inhibitor, and edaravone (EDV), a potent antioxidant and free radical scavenger, were examined in rats with obstructive nephropathy. Experimentally, animals were divided randomly into five groups: sham; UUO; UUO + SOF (5 mg/kg/day, P.O.); UUO + EDV (20 mg/kg/day, P.O.); and UUO + SOF + EDV groups. The kidney function biomarkers, oxidant/antioxidant status, renal mRNA expressions of TNF-α, collagen-1α, protein expressions of RIPK-1, RIPK-3, MLKL, caspase-8, HYP, MPO, and TNF-α were all significantly modulated by UUO. Administration of either SOF or EDV significantly attenuated cellular and molecular changes induced by UUO. Also, histopathological changes were improved. Moreover, SOF in combination with EDV, significantly improved UUO-induced renal fibrosis compared with each drug alone. Collectively, administration of either SOF or EDV or both of them significantly attenuated the rats with obstructive nephropathy, possibly by blocking the RIPK-3/MLKL necroptotic pathway and suppressing renal oxidative stress and inflammation.
  • Effect of lithium on chemotherapy-induced neutropenia in Egyptian breast cancer patients; a prospective clinical study
    Ahmed O. ELKasar, Fatma Z. Hussien, Hala E. Abdel-Hamied, Ibrahim G. Saleh, Elsayed M. Mahgoup, Amr A. El-Arabey, Adel R. Abd-Allah
    Cancer Chemotherapy and Pharmacology, 2024
  • Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats
    Gehan El-Akabawy, Sherif Othman Fathy El-Kersh, Ahmed Othman Fathy Othman El-Kersh, Shaimaa Nasr Amin, Laila Ahmed Rashed, Noha Abdel Latif, Ahmed Elshamey, Mohamed Abdallah Abd El Megied Abdallah, Ibrahim G. Saleh, Zaw Myo Hein, Ibrahim El-Serafi, Nabil Eid
    Peerj, 2024
    Background Ageing is a key risk factor for cardiovascular disease and is linked to several alterations in cardiac structure and function, including left ventricular hypertrophy and increased cardiomyocyte volume, as well as a decline in the number of cardiomyocytes and ventricular dysfunction, emphasizing the pathological impacts of cardiomyocyte ageing. Dental pulp stem cells (DPSCs) are promising as a cellular therapeutic source due to their minimally invasive surgical approach and remarkable proliferative ability. Aim This study is the first to investigate the outcomes of the systemic transplantation of DPSCs in a D-galactose (D-gal)-induced rat model of cardiac ageing. Methods. Thirty 9-week-old Sprague-Dawley male rats were randomly assigned into three groups: control, ageing (D-gal), and transplanted groups (D-gal + DPSCs). D-gal (300 mg/kg/day) was administered intraperitoneally daily for 8 weeks. The rats in the transplantation group were intravenously injected with DPSCs at a dose of 1 × 106 once every 2 weeks. Results The transplanted cells migrated to the heart, differentiated into cardiomyocytes, improved cardiac function, upregulated Sirt1 expression, exerted antioxidative effects, modulated connexin-43 expression, attenuated cardiac histopathological alterations, and had anti-senescent and anti-apoptotic effects. Conclusion Our results reveal the beneficial effects of DPSC transplantation in a cardiac ageing rat model, suggesting their potential as a viable cell therapy for ageing hearts.
  • Detection of coumarin derivatives of Viola odorata cultivated in Iraq
    Zainab Aziz Ali, Ibrahim Saleh, Widad MK Alani
    Journal of Pharmacy and Bioallied Sciences, 2023
    Like other members of the viola family, Viola odorata may be found naturally occurring in Europe and Asia. This little plant is tough and perennially herbaceous. It’s also known as sweet violet and English violet. There are several medicinal uses for this flowering plant, including its ability to fight cancer, bacteria, and inflammation., antioxidant activity, and antipyretic activity. The phytochemical studies of different parts of Viola odorata resulted in the isolation of different chemical constituents such as Coumarins, caffeic acid, methyl salicylate, flavonoids (Quercetin, kaempferol), glycosides (Rutin), and terpenoids (stigma sterol). Coumarins are important natural phenolic compounds of the family of benzopyrone. Coumarin’s basic structure consists of a pyrone ring fused with a benzene ring. Umbelliferone and esculetin are the most common simple coumarins in nature. Coumarins become an attractive backbone drug with innovative impacts on illnesses and reduced side effects on healthy cells. Anti-inflammatory, anti-carcinogenic, and other biological properties are among those attributed to coumarins derivatives. In this study, Umbelliferone and esculetin of Viola odorata were identified by TLC, and HPTLC.
  • Hydrogen sulfide alleviates acrylamide-induced testicular toxicity in male rats
    Hamada Ahmed Mokhlis, Mohammed Helmy Rashed, Ibrahim Ghalib Saleh, Mahmoud Gomaa Eldeib, Ahmed A. El-Husseiny, Emad Gamil Khidr, Maher H. Gomaa, Hesham S. Gad, Ahmed Aglan
    Toxicology and Environmental Health Sciences, 2023
  • Olmesartan ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats via Nrf2/HO-1 signaling pathway
    Begad Mohamed Mohamed, Raed Shahat Ismail, Ibrahim Ghalib Saleh, Osama Mohamed Abo-Salem, El-Sayed Mohamed El-Sayed
    Tissue and Cell, 2022
  • The potential role of febrile condition in reversing the hepatoprotective effects of quercetin in the livers of LPS-presensitized mice
    Moamen Adel Mashaly, Ibrahim Ghalib Saleh, Ahmed Amine Ashour, Ahmed Mohamed Mansour
    Life Sciences, 2022
  • Four new phenolics and antiparasitic secondary metabolites from Flacourtia rukam Zoll. & Mortizi
    Naglaa I. Afifi, Abeer S. Moawad, Mohamed A. Zaki, Mostafa E. Rateb, Mohammed H. Rashed, Ibrahim G. Saleh, Mona H. Hetta, Rabab M. Mohammed
    Natural Product Research, 2022
    Phytochemical investigation of Flacourtia rukam Zoll. & Mortizi (F. rukam) leaves and bark led to the isolation and characterization of seventeen compounds of which four phenolics were not previously described; 2-[(benzoyloxy)methyl]-phenyl-O-β-xylosyl-(1→2)-β-glucopyranoside (1), 2-[(benzoyloxy)methyl]-4-hydroxyphenyl-O-β-xylosyl-(1→2)-β-D-glucopyranoside (2), 2-hydroxy-5-(2-hydroxyphenoxy)phenoxy-β-glucopyranoside (3) and biphenyl-1,1′,2,2′-tetraol (5). Interestingly, the later compound is known as a synthetic but this is the first report for its isolation from nature. Chemical structures were established using extensive analysis of spectroscopic data (1 D and 2 D NMR and HRESIMS). Biphenyl-1,1,2,2′-tetrol (5) exhibited a good activity against Trypanosoma brucei trypomastigotes with IC50= 6.66 ug/mL. Compounds 2, 5, 9, 10, 11 and 12 showed a good in-vitro anti-inflammatory activity using proteinase inhibitory assay. On the contrary, all tested compounds were inactive as antileishmanial or antimalarial. Graphical Abstract
  • PEG-SOD attenuates the mitogenic ERK1/2 signaling cascade induced by cyclosporin A in the liver and kidney of albino mice
    Ahmed Yousef, I.G. Saleh, Adel R.A. Abd-Allah, Mohamed R. Elnagar, El-Sayed Akool
    Chemico Biological Interactions, 2020
  • Time course-dependent study on equine herpes virus 9-induced abortion in syrian hamsters
    Osama Abas, Walied Abdo, Samy Kasem, Abdulatif Alwazzan, Asmaa G. Saleh, Ibrahim G. Saleh, Hideto Fukushi, Tokuma Yanai, Mohie Haridy
    Animals, 2020
  • Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway
    Mohammed E. Abo-El Fetoh, Gouda K. Helal, I. G. Saleh, M. Ewees, Mohamed ElShafey, Mohamed R. Elnagar, El-Sayed Akool
    Naunyn Schmiedeberg S Archives of Pharmacology, 2020
  • Whole body electronic cigarette exposure system for efficient evaluation of diverse inhalation conditions and products
    Jay L. Zweier, Mahmoud T. Shalaan, Alexandre Samouilov, Ibrahim G. Saleh, Mohamed A. El-Mahdy
    Inhalation Toxicology, 2020
  • Resveratrol influences platinum pharmacokinetics: A novel mechanism in protection against cisplatin-induced nephrotoxicity
    Mostafa A. Darwish, Amira M. Abo-Youssef, Marwa M. Khalaf, Ali A. Abo-Saif, Ibrahim G. Saleh, Tamer M. Abdelghany
    Toxicology Letters, 2018
  • Vitamin E mitigates cisplatin-induced nephrotoxicity due to reversal of oxidative/nitrosative stress, suppression of inflammation and reduction of total renal platinum accumulation
    Mostafa A. Darwish, Amira M. Abo-Youssef, Marwa M. Khalaf, Ali A. Abo-Saif, Ibrahim G. Saleh, Tamer M. Abdelghany
    Journal of Biochemical and Molecular Toxicology, 2017
  • Effect of a single point mutation on equine herpes virus 9 (EHV-9) neuropathogenicity after intranasal inoculation in a hamster model
    Asmaa G. SALEH, Shehata I. ANWAR, Osama M. ABAS, Hoda A. ABD-ELLATIEFF, Mohamed NASR, Ibrahim SALEH, Hideto FUKUSHI, Tokuma YANAI
    Journal of Veterinary Medical Science, 2017
  • Stem cell intervention ameliorates epigallocatechin-3-gallate/lipopolysaccharide-induced hepatotoxicity in mice
    IG Saleh, Z Ali, MA Hammad, FD Wilson, FM Hamada, MF Abd-Ellah, LA Walker, IA Khan, MK Ashfaq
    Human and Experimental Toxicology, 2015
  • Possible hepatocellular toxicity of EGCG under the influence of an inflammagen
    Ibrahim G. Saleh, Zulfiqar Ali, Naohito Abe, Farid M. Hamada, Mohamed F. Abd-Ellah, Larry A. Walker, Ikhlas A. Khan, Mohammad K. Ashfaq
    Journal of Applied Biomedicine, 2014
  • Effect of green tea on hepatic cells under the influence of inflammatory conditions: In vitro study
    Saleh
    American Journal of Pharmacology and Toxicology, 2013
  • Effect of green tea and its polyphenols on mouse liver
    Ibrahim G. Saleh, Zulfiqar Ali, Naohito Abe, Floyd D. Wilson, Farid M. Hamada, Mohamed F. Abd-Ellah, Larry A. Walker, Ikhlas A. Khan, Mohammad K. Ashfaq
    Fitoterapia, 2013

RECENT SCHOLAR PUBLICATIONS

  • ATRA-mediated RAR-α activation attenuates acrylamide-induced testicular toxicity
    HA Mokhlis, MH Rashed, IG Saleh, MG Eldeib, AA El-Husseiny, EG Khidr, ...
    Scientific Reports 16 (1), 14644 , 2026
    2026
  • Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR
    AAS Shatat, EM Mahgoup, MH Rashed, IG Saleh, ES Akool
    Purinergic Signalling 20 (6), 669-680 , 2024
    2024
    Citations: 13
  • Sorafenib and edaravone protect against renal fibrosis induced by unilateral ureteral obstruction via inhibition of oxidative stress, inflammation, and RIPK-3/MLKL pathway
    MA Abou Taha, FEM Ali, IG Saleh, ES Akool
    Naunyn-Schmiedeberg's Archives of Pharmacology 397 (11), 8961-8977 , 2024
    2024
    Citations: 10
  • Effect of lithium on chemotherapy-induced neutropenia in Egyptian breast cancer patients; a prospective clinical study
    AO Elkasar, FZ Hussien, HE Abdel-Hamied, IG Saleh, EM Mahgoup, ...
    Cancer Chemotherapy and Pharmacology 93 (6), 541-554 , 2024
    2024
    Citations: 1
  • Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats
    G El-Akabawy, SOF El-Kersh, AOFO El-Kersh, SN Amin, LA Rashed, ...
    PeerJ 12, e17299 , 2024
    2024
    Citations: 4
  • Hydrogen sulfide alleviates acrylamide-induced testicular toxicity in male rats
    HA Mokhlis, MH Rashed, IG Saleh, MG Eldeib, AA El-Husseiny, EG Khidr, ...
    Toxicology and Environmental Health Sciences 15 (1), 41-51 , 2023
    2023
    Citations: 10
  • Olmesartan ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats via Nrf2/HO-1 signaling pathway
    BM Mohamed, RS Ismail, IG Saleh, OM Abo-Salem, ESM El-Sayed
    Tissue and Cell 78, 101877 , 2022
    2022
    Citations: 10
  • The potential role of febrile condition in reversing the hepatoprotective effects of quercetin in the livers of LPS-presensitized mice
    MA Mashaly, IG Saleh, AA Ashour, AM Mansour
    Life sciences 302, 120647 , 2022
    2022
    Citations: 6
  • Four new phenolics and antiparasitic secondary metabolites from Flacourtia rukam Zoll. & Mortizi
    NI Afifi, AS Moawad, MA Zaki, ME Rateb, MH Rashed, IG Saleh, MH Hetta, ...
    Natural product research 36 (14), 3626-3637 , 2022
    2022
    Citations: 8
  • Whole body electronic cigarette exposure system for efficient evaluation of diverse inhalation conditions and products
    JL Zweier, MT Shalaan, A Samouilov, IG Saleh, MA El-Mahdy
    Inhalation toxicology 32 (13-14), 477-486 , 2020
    2020
    Citations: 9
  • PEG-SOD attenuates the mitogenic ERK1/2 signaling cascade induced by cyclosporin A in the liver and kidney of albino mice
    A Yousef, IG Saleh, ARA Abd-Allah, MR Elnagar, ES Akool
    Chemico-Biological Interactions 330, 109245 , 2020
    2020
    Citations: 7
  • Time Course-Dependent Study on Equine Herpes Virus 9-Induced Abortion in Syrian Hamsters
    O Abas, W Abdo, S Kasem, A Alwazzan, AG Saleh, IG Saleh, H Fukushi, ...
    Animals 10 (8), 1369 , 2020
    2020
    Citations: 6
  • Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway
    ME Abo-El Fetoh, GK Helal, IG Saleh, M Ewees, M ElShafey, MR Elnagar, ...
    Naunyn-Schmiedeberg's Archives of Pharmacology 393 (5), 897-908 , 2020
    2020
    Citations: 17
  • Interruption of platelets and thrombin function as a new approach against liver fibrosis induced experimentally in rats
    NIMBASMIGSAAASMS Abdel-Bakkyac
    Life Sciences 231 , 2019
    2019
    Citations: 26
  • Resveratrol influences platinum pharmacokinetics: A novel mechanism in protection against cisplatin-induced nephrotoxicity
    MA Darwish, AM Abo-Youssef, MM Khalaf, AA Abo-Saif, IG Saleh, ...
    Toxicology Letters 290, 73-82 , 2018
    2018
    Citations: 42
  • Effect of a single point mutation on equine herpes virus 9 (EHV-9) neuropathogenicity after intranasal inoculation in a hamster model
    AG Saleh, SI Anwar, OM Abas, HA Abd-Ellatieff, M Nasr, I Saleh, ...
    Journal of Veterinary Medical Science 79 (8), 1426-1436 , 2017
    2017
    Citations: 6
  • Vitamin E mitigates cisplatin‐induced nephrotoxicity due to reversal of oxidative/nitrosative stress, suppression of inflammation and reduction of total renal platinum accumulation
    MA Darwish, AM Abo‐Youssef, MM Khalaf, AA Abo‐Saif, IG Saleh, ...
    Journal of biochemical and molecular toxicology 31 (1), 1-9 , 2017
    2017
    Citations: 49
  • Stem cell intervention ameliorates epigallocatechin-3-gallate/lipopolysaccharide-induced hepatotoxicity in mice
    IG Saleh, Z Ali, MA Hammad, FD Wilson, FM Hamada, MF Abd-Ellah, ...
    Human & Experimental Toxicology 34 (11), 1180-1194 , 2015
    2015
    Citations: 5
  • Possible hepatocellular toxicity of EGCG under the influence of an inflammagen
    IG Saleh, Z Ali, N Abe, FM Hamada, MF Abd-Ellah, LA Walker, IA Khan, ...
    journal of applied biomedicine 12 (4), 291-299 , 2014
    2014
    Citations: 7
  • Are Females More Susceptible to EGCG Induced Hepatotoxicity?
    MKA Saleh I. G., Z. Ali, F. D. Wilson, F. M. Hamada, M
    International Journal of Pharmacology and Clinical Trials 26 (1), 1183-1189 , 2014
    2014

MOST CITED SCHOLAR PUBLICATIONS

  • Effect of green tea and its polyphenols on mouse liver
    IG Saleh, Z Ali, N Abe, FD Wilson, FM Hamada, MF Abd-Ellah, LA Walker, ...
    Fitoterapia 90, 151-159 , 2013
    2013
    Citations: 59
  • Vitamin E mitigates cisplatin‐induced nephrotoxicity due to reversal of oxidative/nitrosative stress, suppression of inflammation and reduction of total renal platinum accumulation
    MA Darwish, AM Abo‐Youssef, MM Khalaf, AA Abo‐Saif, IG Saleh, ...
    Journal of biochemical and molecular toxicology 31 (1), 1-9 , 2017
    2017
    Citations: 49
  • Resveratrol influences platinum pharmacokinetics: A novel mechanism in protection against cisplatin-induced nephrotoxicity
    MA Darwish, AM Abo-Youssef, MM Khalaf, AA Abo-Saif, IG Saleh, ...
    Toxicology Letters 290, 73-82 , 2018
    2018
    Citations: 42
  • Interruption of platelets and thrombin function as a new approach against liver fibrosis induced experimentally in rats
    NIMBASMIGSAAASMS Abdel-Bakkyac
    Life Sciences 231 , 2019
    2019
    Citations: 26
  • Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway
    ME Abo-El Fetoh, GK Helal, IG Saleh, M Ewees, M ElShafey, MR Elnagar, ...
    Naunyn-Schmiedeberg's Archives of Pharmacology 393 (5), 897-908 , 2020
    2020
    Citations: 17
  • Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR
    AAS Shatat, EM Mahgoup, MH Rashed, IG Saleh, ES Akool
    Purinergic Signalling 20 (6), 669-680 , 2024
    2024
    Citations: 13
  • Sorafenib and edaravone protect against renal fibrosis induced by unilateral ureteral obstruction via inhibition of oxidative stress, inflammation, and RIPK-3/MLKL pathway
    MA Abou Taha, FEM Ali, IG Saleh, ES Akool
    Naunyn-Schmiedeberg's Archives of Pharmacology 397 (11), 8961-8977 , 2024
    2024
    Citations: 10
  • Hydrogen sulfide alleviates acrylamide-induced testicular toxicity in male rats
    HA Mokhlis, MH Rashed, IG Saleh, MG Eldeib, AA El-Husseiny, EG Khidr, ...
    Toxicology and Environmental Health Sciences 15 (1), 41-51 , 2023
    2023
    Citations: 10
  • Olmesartan ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats via Nrf2/HO-1 signaling pathway
    BM Mohamed, RS Ismail, IG Saleh, OM Abo-Salem, ESM El-Sayed
    Tissue and Cell 78, 101877 , 2022
    2022
    Citations: 10
  • Whole body electronic cigarette exposure system for efficient evaluation of diverse inhalation conditions and products
    JL Zweier, MT Shalaan, A Samouilov, IG Saleh, MA El-Mahdy
    Inhalation toxicology 32 (13-14), 477-486 , 2020
    2020
    Citations: 9
  • Four new phenolics and antiparasitic secondary metabolites from Flacourtia rukam Zoll. & Mortizi
    NI Afifi, AS Moawad, MA Zaki, ME Rateb, MH Rashed, IG Saleh, MH Hetta, ...
    Natural product research 36 (14), 3626-3637 , 2022
    2022
    Citations: 8
  • PEG-SOD attenuates the mitogenic ERK1/2 signaling cascade induced by cyclosporin A in the liver and kidney of albino mice
    A Yousef, IG Saleh, ARA Abd-Allah, MR Elnagar, ES Akool
    Chemico-Biological Interactions 330, 109245 , 2020
    2020
    Citations: 7
  • Possible hepatocellular toxicity of EGCG under the influence of an inflammagen
    IG Saleh, Z Ali, N Abe, FM Hamada, MF Abd-Ellah, LA Walker, IA Khan, ...
    journal of applied biomedicine 12 (4), 291-299 , 2014
    2014
    Citations: 7
  • The potential role of febrile condition in reversing the hepatoprotective effects of quercetin in the livers of LPS-presensitized mice
    MA Mashaly, IG Saleh, AA Ashour, AM Mansour
    Life sciences 302, 120647 , 2022
    2022
    Citations: 6
  • Time Course-Dependent Study on Equine Herpes Virus 9-Induced Abortion in Syrian Hamsters
    O Abas, W Abdo, S Kasem, A Alwazzan, AG Saleh, IG Saleh, H Fukushi, ...
    Animals 10 (8), 1369 , 2020
    2020
    Citations: 6
  • Effect of a single point mutation on equine herpes virus 9 (EHV-9) neuropathogenicity after intranasal inoculation in a hamster model
    AG Saleh, SI Anwar, OM Abas, HA Abd-Ellatieff, M Nasr, I Saleh, ...
    Journal of Veterinary Medical Science 79 (8), 1426-1436 , 2017
    2017
    Citations: 6
  • Stem cell intervention ameliorates epigallocatechin-3-gallate/lipopolysaccharide-induced hepatotoxicity in mice
    IG Saleh, Z Ali, MA Hammad, FD Wilson, FM Hamada, MF Abd-Ellah, ...
    Human & Experimental Toxicology 34 (11), 1180-1194 , 2015
    2015
    Citations: 5
  • Thymoquinone protects against EGCG/LPS induced hepatotoxicity in mice
    MKA Saleh I.G., Z. Ali, F. D. Wilson, F. M. Hamada, M
    International Journal of Pharmacology and Clinical Trials 26 (1), 1165-1174 , 2014
    2014
    Citations: 5
  • Effect of green tea on hepatic cells under the influence of inflammatory conditions: in vitro study
    IG Saleh, Z Ali, FM Hamada, MF Abd-Ellah, LA Walker, IA Khan, ...
    American journal of pharmacology and toxicology 8 (4), 209 , 2013
    2013
    Citations: 5
  • Dental pulp stem cells ameliorate D-galactose-induced cardiac ageing in rats
    G El-Akabawy, SOF El-Kersh, AOFO El-Kersh, SN Amin, LA Rashed, ...
    PeerJ 12, e17299 , 2024
    2024
    Citations: 4