Jorgesotor

Verified email @uc.cl

Department of Molecular Genetics and Microbiology, Faculty of Biological Sciences.
Pontifical Catholic University of Chile, Santiago, Chile.

My name is Jorge Soto Ramírez, I am a Biotechnologist graduated in 2012 from the Santo Tomás University, where my interest in immunology began. During my undergraduate studies, I began my thesis at the Public Health Institute of Chile, in the Biotechnology Section under the tuition of Dr. Abel Vásquez, with whom I worked on the development of a prototype vaccine against Streptococcus agalactiae (GBS) and the development of a detection kit against this same pathogen under the FONDEF D10I1202 project.
Later, in 2014 I entered the doctoral program in Biological Sciences. Molecular Genetic Mention and Microbiology of the Pontifical Catholic University of Chile. Here I started working with Dr. Alexis Kalergis on different projects within which, I ended up evaluating the humoral immune response induced by two recombinant vaccines against the human respiratory syncytial virus (RSV) and human metapneumovirus (MPV). This work allowed me to be awarded at the International Congress of Immunology ALAI 2018 and be considered with the distinction of “Merito” in the congress organized by the Federation of Clinical Immunology Societies (FOCIS) 2019. In addition, during this process, I was able to participate in the development of the first clinical study conducted in Chile to evaluate a vaccine against RSV.
In October 2018, I obtained my Ph.D. degree in Biological Sciences and in January 2019 I awarded my Postdoctoral FONDECYT with the first place on the table, under the direction of Dr. Susan Bueno. My current interests are focused on immunology, more specifically on understanding how respiratory pathogens can modulate an inefficient immune response in the host, suppressing the adaptive immune response (current postdoctoral project)

EDUCATION

1. Postdoctoral Researcher in Pontifical Catholic University of Chile. 2019 to date.
2. PhD in Biological Science. Mention in Molecular Genetic and Microbiology. Pontifical Catholic University of Chile.2014 to 2018.
3. Master’s degree in Biological Science. Pontifical Catholic University of Chile. 2014 to 2015.
4. Biotechnology degree. Santo Tomás University. 2007 to 2012.

RESEARCH INTERESTS

My interests are focused on the study of immunology and the development of vaccines and therapies. However, thanks to this, the study of B cells and how they can be stimulated for maturation and differentiation to plasma or memory cells has become one of my main interests today.

69

Google Scholar Citations

5

Google Scholar h-index

1

Google Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • An inflammatory status in the brain causes behavioral alterations after infection by the human respiratory syncytial virus
    K Bohmwald, J Espinoza, J Soto, MC Opazo, A Fernandez, F Gomez, ...
    EUROPEAN JOURNAL OF IMMUNOLOGY 49, 1073-1073 2019

  • Cellular immune response induced by surface immunogenic protein with AbISCO-100 adjuvant vaccination decreases group B Streptococcus vaginal colonization
    JA Soto, DA Diaz-Dinamarca, DA Soto, MJ Barrientos, F Carrin, ...
    Molecular immunology 111, 198-204 2019

  • Contribution of IDO to human respiratory syncytial virus infection
    FM Benavente, JA Soto, MS Pizarro‐Ortega, K Bohmwald, PA Gonzlez, ...
    Journal of leukocyte biology 2019

  • Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus
    MJ Altamirano-Lagos, FE Daz, MA Mansilla, D Rivera-Prez, D Soto, ...
    Frontiers in microbiology 10 2019

  • Contribution of Animal Models to Understanding the Pathology Caused by the Respiratory Syncytial Virus.
    AM Kalergis, MJ Altamirano-Lagos, FE Daz, MA Mansilla, ...
    Frontiers in Microbiology 10, 873 2019

  • Contribution of Fcγ receptor-mediated immunity to the pathogenesis caused by the Human Respiratory Syncytial Virus
    OA Acevedo, FE Daz, TE Beals, FM Benavente, JA Soto, J Escobar-Vera, ...
    Frontiers in cellular and infection microbiology 9 2019

  • Estudio de la portacin de Streptococcus agalactiae en mujeres embarazadas atendidas en el Hospital Clnico de la Pontificia Universidad Catlica de Chile durante 2011-17.
    M Faras, A Rodriguez, D Diaz-Dinamarca, D Soto, D Bastias, M Quezada, ...
    Revista del Instituto de Salud Pblica de Chile 2 (2) 2018

  • Oral vaccine based on a surface immunogenic protein mixed with alum promotes a decrease in Streptococcus agalactiae vaginal colonization in a mouse model
    DA Diaz-Dinamarca, DA Soto, YY Leyton, MJ Altamirano-Lagos, ...
    Molecular immunology 103, 63-70 2018

  • Evaluation of the cytotoxicity of cocaine and adulterants in precursor cells of the glia
    RA Rocha, J Figueroa, R Manzo, D Diaz, A Vasquez, D Soto, B Duffau, ...
    Toxicology Letters 295, S113 2018

  • Desarrollo de un modelo murino de colonizacin vaginal de Streptococcus agalactiae utilizando una cepa chilena aislada de un recin nacido con septicemia
    DA Soto, MJ Altamirano, DA Daz-Dinamarca, YY Leyton, JO Fernndez, ...
    Revista del Instituto de Salud Pblica de Chile 2 (1) 2018

  • Immunization with a mixture of nucleoprotein from human metapneumovirus and AbISCO-100 adjuvant reduces viral infection in mice model
    DA Diaz-Dinamarca, FJ Ibanez, DA Soto, JA Soto, PF Cespedes, ...
    Viral immunology 31 (4), 306-314 2018

  • The Optimisation of the Expression of Recombinant Surface Immunogenic Protein of Group B Streptococcus in Escherichia coli by Response Surface Methodology
    DA Daz-Dinamarca, JI Jerias, DA Soto, JA Soto, NV Daz, YY Leyton, ...
    Molecular biotechnology 60 (3), 215-225 2018

  • Recombinant BCG vaccines reduce pneumovirus-caused airway pathology by inducing protective cellular and humoral immunity
    JA Soto, N Glvez, CA Rivera, CE Palavecino, PF Cspedes, ...
    Frontiers in immunology 9, 2875 2018

  • The Optimisation of the Expression of Recombinant Surface Immunogenic Protein of Group B Streptococcus in Escherichia coli by Response Surface Methodology Improves Humoral Immunity
    DA Soto, JA Soto, YY Leyton, RA Villegas, AM Kalergis
    2018

  • Human metapneumovirus: mechanisms and molecular targets used by the virus to avoid the immune system
    AM Kalergis, JA Soto, NM Galvez, FM Benavente, MS Pizarro-Ortega, ...
    Frontiers in immunology 9, 2466 2018

  • The humoral immune response induced by two recombinant bacillus Calmette-Gurin vaccines promotes viral clearance against the human respiratory sincytial virus and the human
    JA Soto Ramrez
    2018

  • A safe and efficient BCG vectored vaccine to prevent the disease caused by the human Respiratory Syncytial Virus
    E Rey-Jurado, J Soto, N Glvez, AM Kalergis
    Human vaccines & immunotherapeutics 13 (9), 2092-2097 2017

  • Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection
    AE Gonzlez, MK Lay, EL Jara, JA Espinoza, RS Gmez, J Soto, ...
    Virulence 8 (6), 685-704 2017

  • New insights contributing to the development of effective vaccines and therapies to reduce the pathology caused by hRSV
    N Glvez, JA Soto, AM Kalergis
    International journal of molecular sciences 18 (8), 1753 2017

  • Diferencias de politizacin en las demandas detrabajadores de empresas estratgicas v/s empress de retail: poder disruptivo, organizacin suprasindical y niveles
    D Soto, C Brega, P Iglesias, R Rojas
    O. Aguilar, H. Henrquez, & D. Prez, Huelgas Laborales en Chile. Santiago 2017

MOST CITED SCHOLAR PUBLICATIONS

  • Biomasa zooplanctnica de lagunas Patagnicas y su relacin con el flamenco Chileno (Phoenicopterus chilensis)
    D Soto
    Actas Primer Taller Internacional de Especialistas en Flamencos 1990
    Citations: 10

  • A safe and efficient BCG vectored vaccine to prevent the disease caused by the human Respiratory Syncytial Virus
    E Rey-Jurado, J Soto, N Glvez, AM Kalergis
    Human vaccines & immunotherapeutics 13 (9), 2092-2097 2017
    Citations: 9

  • Relationship between zooplankton biomass and Chilean flamingo population in south Chile Patagonic lagoons
    D Soto
    Proceedings of I International Workshop of South American Flamingos 1990
    Citations: 7

  • Diferencias de politizacin en las demandas detrabajadores de empresas estratgicas v/s empress de retail: poder disruptivo, organizacin suprasindical y niveles
    D Soto, C Brega, P Iglesias, R Rojas
    O. Aguilar, H. Henrquez, & D. Prez, Huelgas Laborales en Chile. Santiago 2017
    Citations: 6

  • Human metapneumovirus: mechanisms and molecular targets used by the virus to avoid the immune system
    AM Kalergis, JA Soto, NM Galvez, FM Benavente, MS Pizarro-Ortega, ...
    Frontiers in immunology 9, 2466 2018
    Citations: 5

  • New insights contributing to the development of effective vaccines and therapies to reduce the pathology caused by hRSV
    N Glvez, JA Soto, AM Kalergis
    International journal of molecular sciences 18 (8), 1753 2017
    Citations: 5

  • Oral administration of recombinant Neisseria meningitidis PorA genetically fused to H. pylori HpaA antigen increases antibody levels in mouse serum, suggesting
    AE Vasquez, RA Manzo, DA Soto, MJ Barrientos, AE Maldonado, ...
    Human vaccines & immunotherapeutics 11 (3), 776-788 2015
    Citations: 5

  • The Optimisation of the Expression of Recombinant Surface Immunogenic Protein of Group B Streptococcus in Escherichia coli by Response Surface Methodology
    DA Daz-Dinamarca, JI Jerias, DA Soto, JA Soto, NV Daz, YY Leyton, ...
    Molecular biotechnology 60 (3), 215-225 2018
    Citations: 4

  • Purification and characterization of saxitoxin from Mytilus chilensis of southern Chile
    DP Rubio, LG Roa, DA Soto, FJ Velasquez, NA Gregorcic, JA Soto, ...
    Toxicon 108, 147-153 2015
    Citations: 4

  • Contribution of Fcγ receptor-mediated immunity to the pathogenesis caused by the Human Respiratory Syncytial Virus
    OA Acevedo, FE Daz, TE Beals, FM Benavente, JA Soto, J Escobar-Vera, ...
    Frontiers in cellular and infection microbiology 9 2019
    Citations: 3

  • Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection
    AE Gonzlez, MK Lay, EL Jara, JA Espinoza, RS Gmez, J Soto, ...
    Virulence 8 (6), 685-704 2017
    Citations: 3

  • Immunization with a mixture of nucleoprotein from human metapneumovirus and AbISCO-100 adjuvant reduces viral infection in mice model
    DA Diaz-Dinamarca, FJ Ibanez, DA Soto, JA Soto, PF Cespedes, ...
    Viral immunology 31 (4), 306-314 2018
    Citations: 2

  • Recombinant BCG vaccines reduce pneumovirus-caused airway pathology by inducing protective cellular and humoral immunity
    JA Soto, N Glvez, CA Rivera, CE Palavecino, PF Cspedes, ...
    Frontiers in immunology 9, 2875 2018
    Citations: 2

  • Current Animal Models for Understanding the Pathology Caused by the Respiratory Syncytial Virus
    MJ Altamirano-Lagos, FE Daz, MA Mansilla, D Rivera-Prez, D Soto, ...
    Frontiers in microbiology 10 2019
    Citations: 1

  • Oral vaccine based on a surface immunogenic protein mixed with alum promotes a decrease in Streptococcus agalactiae vaginal colonization in a mouse model
    DA Diaz-Dinamarca, DA Soto, YY Leyton, MJ Altamirano-Lagos, ...
    Molecular immunology 103, 63-70 2018
    Citations: 1

  • Evaluation of the cytotoxicity of cocaine and adulterants in precursor cells of the glia
    RA Rocha, J Figueroa, R Manzo, D Diaz, A Vasquez, D Soto, B Duffau, ...
    Toxicology Letters 295, S113 2018
    Citations: 1

  • Desarrollo de un modelo murino de colonizacin vaginal de Streptococcus agalactiae utilizando una cepa chilena aislada de un recin nacido con septicemia
    DA Soto, MJ Altamirano, DA Daz-Dinamarca, YY Leyton, JO Fernndez, ...
    Revista del Instituto de Salud Pblica de Chile 2 (1) 2018
    Citations: 1

Publications

1. Jorge A. Soto, Diego A. Diaz-Dinamarca, Daniel A. Soto, Magaly J. Barrientos, Flavio Carrion, Alexis Kalergis, Abel Vasquez. Cellular immune response induced by Surface Immunogenic Protein with AbISCO-100 adjuvant vaccination decreases Group B Streptococcus vaginal colonization. Mol Immunol. 2019 Jul;111:198-204. doi: 10.1016/j.molimm.2019.04.025.
2. Benavente FM, Soto JA, Pizarro-Ortega MS, Bohmwald K, González PA, Bueno SM, Kalergis AM. Contribution of IDO to human respiratory syncytial virus infection. J Leukoc Biol. 2019 May 15. doi: 10.1002/JLB.4RU0219-051RR.
3. Acevedo OA, Díaz FE, Beals TE, Benavente FM, Soto JA, Escobar-Vera J, González PA, Kalergis AM. Contribution of Fcγ Receptor-Mediated Immunity to the Pathogenesis Caused by the Human Respiratory Syncytial Virus. Front Cell Infect Microbiol. 2019 Mar 29;9:75. doi: 10.3389/fcimb.2019.00075.
4. Jorge A. Soto1, Nicolás M. S. Galvez1, Claudia A. Rivera1, Christian E. Palavecino1, Pablo F. Céspedes1, Emma Rey-Jurado1, Susan M. Bueno1, Alexis M. Kalergis*1,2. Recombinant BCG vaccines reduce pneumovirus-caused airway pathology by inducing protective cellular and humoral immunity. Front Immunol. 2018 Dec 6;9:2875. doi: 10.3389/fimmu.2018.02875.
5. Jorge A Soto, Nicolas M Galvez, Felipe M Benavente, Magdalena S Pizarro-Ortega,Margarita Kam-Lem Lay, Claudia Riedel, Susan M Bueno, Pablo Alberto Gonzalez, Alexis M Kalergis*. Human Metapneumovirus: mechanisms and molecular targets used by the virus to avoid the immune system. Front Immunol. 2018 Oct 24;9:2466. doi: 10.3389/fimmu.2018.02466
6. Diaz-Dinamarca DA, Ibañez FJ, Soto DA, Soto JA, Cespedes PF, Muena NA, Garate DS, Kalergis AM, Vasquez AE. Immunization with a Mixture of Nucleoprotein from Human Metapneumovirus and AbISCO-100 Adjuvant Reduces Viral Infection in Mice Model. Viral Immunol. 2018 May;31(4):306-314. doi: 10.1089/vim.2017.0159. Epub 2018 Jan 26.
7. Díaz-Dinamarca DA1,2, Jerias JI1, Soto DA1, Soto JA1,2, Díaz NV1, Leyton YY1, Villegas RA3, Kalergis AM2,4, Vásquez AE5,6. The Optimisation of the Expression of Recombinant Surface Immunogenic Protein of Group B Streptococcus in Escherichia coli by Response Surface Methodology Improves Humoral Immunity. Mol Biotechnol. 2018 Mar;60(3):215-225. doi: 10.1007/s12033-018-0065-8.
8. Magdalena S. Pizarro-Ortega1 , Angelo T. Castiglione1 , Nicolás MS. Gálvez1, Jorge A. Soto1 , Natalia Muñoz-Durango1 y Alexis M. Kalergis1,2.Current context of the disease caused for VRSh and development of new treatments. Revista del Instituto de Salud Pública de Chile. RISPCH, Volumen N°1, Número N°1, Año 2017.
9. Gálvez NMS1, Soto JA1, Kalergis AM3,4. New Insights Contributing to the Development of Effective Vaccines and Therapies to Reduce the Pathology Caused by hRSV. Int J Mol Sci. 2017.
10. Rey-jurado E, Soto J, Gálvez N, Kalergis AM. A safe and efficient BCG vectored vaccine to prevent the disease caused by the humanRespiratory Syncytial Virus. Hum Vaccin Immunother. 2017.
11. Andrea E. González, Margarita K. Lay, Evelyn L. Jara, Janyra A. Espinoza, Roberto S. Gómez, Jorge Soto, Claudia A. Rivera, Katia Abarca, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis. Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection. Virulence. 2017.
12. Rubio DP1, Roa LG2, Soto DA1, Velasquez FJ1, Gregorcic NA1, Soto JA3, Martinez MC4, Kalergis AM5, Vasquez AE6. Purification and characterization of saxitoxin from Mytilus chilensis of southern Chile. Toxicon. 2015

GRANT DETAILS

Funding Agency: FONDECYT
Date: March 2019- March 2022
Role: Postdoctoral Research
Title: Contribution of Myeloid Derived Suppressor Cells (MDSC) in the lung pathology induced by the human metapneumovirus (hMPV) infection

INDUSTRY EXPERIENCE

1. Assistant Research in the project “FONDEF D10I1202”. Biotechnology Section. Department of Environmental Health. Institute of Public Health of Chile. 2012 al 2014.
2.. Assistant Research in the project “CORFO 11IEI-12861”. Virbac-Centrovet Ltda. 2012 al 2014.