Dr. Kommu Pradeep M. Pharm, Ph.D working as an Assistant professor at Villa College, Male, Maldives wishes to share the knowledge acquired over 13 years of teaching and research experience gained over the globe with more than 15 research publications in various National and International journals, 3 books and 5 patents in the field of pharmaceutical has Presented and participated in various national and international conferences. Graduated in pharmacy and earned a master's from JNTU, Kakinada and PhD in pharmaceutical science from Acharya Nagarjuna University Andhra Pradesh. He has guided 20 post graduate students and 75 undergraduate students for their academic research projects. He is also a lifetime member of IPGA and APTI.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacology, Toxicology and Pharmaceutics, Pharmaceutical Science, Pharmacy, Pharmacology (medical)
The Double-Faced Nature of Nanomaterials: The Latest Developments and Outlook on Janus Nanoparticles Onkologia I Radioterapia, 2026
Design, Synthesis, in silico Analysis and Pharmacological Evaluation of Coumarin Derived Mercaptotriazole Derivatives as MCL-1 Inhibitors G. Buela Priyanka, Shaik Harun Rasheed, Rajala Srikala, K. Venkata Swathi Krishna, Y. Prapurna Chandra, et al. Asian Journal of Chemistry, 2026 Design and synthesis of new series of 4-amino-5-mercapto-4H-1,2,4-triazoles connected to coumarin ring and assessed for cytotoxity and the study of docking studies was done against MDA-MB-231 cell lines. Using substituted diols, a series of new coumarin linked 4-amino-5-mercapto-4H-1,2,4-triazoles derivatives were synthesized from substituted diols. Moreover, the elucidation of the newly synthesized mercaptotriazole derivatives was achieved by spectral data. An MTT assay was employed to evaluate the antineoplastic activity against triple-negative breast cancer (TNBC) and the synthesized compounds demonstrated promising, potent, and innovative inhibitory effects, highlighting their potential for the development of new anticancer therapies. Compounds 8h, 8d, 8e, 8b, 8i, 8j and 8a exhibit high binding energies with target receptor MCL-1 enzyme of the MDA-MB231 cells, where remaining compounds exhibit good binding interactions with target protein. In silico Docking studies verified the uncompetitive inhibition of MCL-1 enzyme.
QbD Based Formulation Development of Delayed-Release Beads for Better Management of Nocturnal Asthma Vijaykumar V, Ismail Y, Ubaidulla U, Pradeep K International Journal of Drug Delivery Technology, 2024 The present study discusses about the quality by design (QbD) based formulation development and characterization of delayed release beads for better management of Nocturnal Asthma. Ionotropic gelation technique was used to create Budisonide-loaded pectin-alginate beads, and calcium chloride was added as a crosslinking agent. The central composite design model was used to optimize the beads. The response of beads was 91.9861 % for loading efficiency, 0.998 mm for bead size, and 360 min for time required for 90% drug release. The optimal formulation variables for a formulation were found to be 4.14 mg of pectin, 1.82 mg of alginate, 14.36% of CaCl2, and 5.99 hours of cross-linking time. PEC-ALG beads showed no release in 0.1 N HCl (pH 1.2). In contrast, increased Ca2+ and Na+ ion exchange as well as solvent penetration into the pectin-alginate network have been linked to the quick release from cross-linked beads in phosphate buffer pH 7.4. FTIR results showed that there was no interaction between the medication and the polymers, as evidenced by the significant peaks of BUD detected in the beads. An in vitro study of the toxicity of beads on A549 cell lines revealed significantly higher cell viability than the group of cells treated with pure BUD.BUD loaded PEC-ALG beads could have potential for chrono modulated delivery system for targeting nocturnal asthma.
RECENT SCHOLAR PUBLICATIONS
Marine bacterial metabolites in anticancer drug discovery: Ecological insights, mechanisms of action, and clinical translation P Theivendren, S Panneerselvam, J Swaminathan, V Murugesan, ... Regional Studies in Marine Science, 104935 , 2026 2026.0
Design, Synthesis, in silico Analysis and Pharmacological Evaluation of Coumarin Derived Mercaptotriazole Derivatives as MCL-1 Inhibitors GB Priyanka, SH Rasheed, R Srikala, KVS Krishna, YP Chandra, ... Asian Journal of Chemistry 38 (Issue 1) , 2025 2025.0
Critical Appraisal on “Effectiveness and Safety of Nasal Herbal Steam Therapy for Post-Extubation Respiratory Symptoms: A Methodology of Pragmatic Randomized Controlled … K Pradeep, H Mishra, M Kumar Integrative Cancer Therapies 24, 15347354251388435 , 2025 2025.0
Comment on “Neurovascular bundle preservation improves postoperative continence recovery in robotic-assisted laparoscopic radical prostatectomy after neoadjuvant hormonal … K Pradeep, RH Babu, RK Keservani World Journal of Urology 43 (1), 617 , 2025 2025.0
Comment on” Romiplostim for Chemotherapy-Induced Thrombocytopenia: A Case Cohort Assessment of Safety, Efficacy, and Proposed Future Study in Pediatric Patients With Solid Tumors” K PRADEEP, HG MISHRA, M Kumar Authorea 2025 (0909) , 2025 2025.0
DEVELOPMENT OF AN INNOVATIVE NANOEMULSION-BASED THERAPY AGAINST MULTIDRUG-RESISTANT BACTERIA. K Pradeep, SN Sakarkar, KR Jadhav, MR Walmiki, K Kumar, R Pal, ... Journal of Experimental Zoology India 28 (2) , 2025 2025.0
QbD Based Formulation Development of Delayed-Release Beads for Better Management of Nocturnal Asthma V Vijaykumar, Y Ismail, U Ubaidulla, K Pradeep International Journal of Drug Delivery Technology 14 (4) , 2024 2024.0
Evaluation of Quantity of Salt Utilization among Hypertensive Patients Y Ismail, HN Ahamed, D Chinababu, K Pradeep, ARV Kumar Bull. Env. Pharmacol. Life Sci 12, 214-216 , 2023 2023.0
FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY OF FEXOFENADINE HCL VV Kumar, Y Ismail, M Nandhini, P Shanmugapandiyan, K Pradeep 2023.0
Study on Formulation and In-vitro Characterization of Floating Microspheres of Lamivudine VV Kumar, K Pradeep, RN Kumar, KR Kota, SN Kumar, C Rajaram, ... Current Overview on Pharmaceutical Science Vol. 9 9, 125-141 , 2023 2023.0
Rationalization of Vermicomposting Parameters Of Livestock and Food Wastes A Raghul, KR Pradeep, K Chidambaram, RK Prasad The Journal of Solid Waste Technology and Management 45 (2), 153-161 , 2019 2019.0
International Journal of Modern Pharmaceutical Research K Pradeep, M Gudipati
A REVIEW ON DIETARY SUGGESTIONS DURING COVID-19 VV Kumar, M Nandhini, K Pradeep
MOST CITED SCHOLAR PUBLICATIONS
Marine bacterial metabolites in anticancer drug discovery: Ecological insights, mechanisms of action, and clinical translation P Theivendren, S Panneerselvam, J Swaminathan, V Murugesan, ... Regional Studies in Marine Science, 104935 , 2026 2026.0
Design, Synthesis, in silico Analysis and Pharmacological Evaluation of Coumarin Derived Mercaptotriazole Derivatives as MCL-1 Inhibitors GB Priyanka, SH Rasheed, R Srikala, KVS Krishna, YP Chandra, ... Asian Journal of Chemistry 38 (Issue 1) , 2025 2025.0
Critical Appraisal on “Effectiveness and Safety of Nasal Herbal Steam Therapy for Post-Extubation Respiratory Symptoms: A Methodology of Pragmatic Randomized Controlled … K Pradeep, H Mishra, M Kumar Integrative Cancer Therapies 24, 15347354251388435 , 2025 2025.0
Comment on “Neurovascular bundle preservation improves postoperative continence recovery in robotic-assisted laparoscopic radical prostatectomy after neoadjuvant hormonal … K Pradeep, RH Babu, RK Keservani World Journal of Urology 43 (1), 617 , 2025 2025.0
Comment on” Romiplostim for Chemotherapy-Induced Thrombocytopenia: A Case Cohort Assessment of Safety, Efficacy, and Proposed Future Study in Pediatric Patients With Solid Tumors” K PRADEEP, HG MISHRA, M Kumar Authorea 2025 (0909) , 2025 2025.0
DEVELOPMENT OF AN INNOVATIVE NANOEMULSION-BASED THERAPY AGAINST MULTIDRUG-RESISTANT BACTERIA. K Pradeep, SN Sakarkar, KR Jadhav, MR Walmiki, K Kumar, R Pal, ... Journal of Experimental Zoology India 28 (2) , 2025 2025.0
QbD Based Formulation Development of Delayed-Release Beads for Better Management of Nocturnal Asthma V Vijaykumar, Y Ismail, U Ubaidulla, K Pradeep International Journal of Drug Delivery Technology 14 (4) , 2024 2024.0
Evaluation of Quantity of Salt Utilization among Hypertensive Patients Y Ismail, HN Ahamed, D Chinababu, K Pradeep, ARV Kumar Bull. Env. Pharmacol. Life Sci 12, 214-216 , 2023 2023.0
FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY OF FEXOFENADINE HCL VV Kumar, Y Ismail, M Nandhini, P Shanmugapandiyan, K Pradeep 2023.0
Study on Formulation and In-vitro Characterization of Floating Microspheres of Lamivudine VV Kumar, K Pradeep, RN Kumar, KR Kota, SN Kumar, C Rajaram, ... Current Overview on Pharmaceutical Science Vol. 9 9, 125-141 , 2023 2023.0
Rationalization of Vermicomposting Parameters Of Livestock and Food Wastes A Raghul, KR Pradeep, K Chidambaram, RK Prasad The Journal of Solid Waste Technology and Management 45 (2), 153-161 , 2019 2019.0
International Journal of Modern Pharmaceutical Research K Pradeep, M Gudipati
A REVIEW ON DIETARY SUGGESTIONS DURING COVID-19 VV Kumar, M Nandhini, K Pradeep
