Gene Editing of Olfactory Receptors to Alter Host-Seeking Behaviour in Aedes aegypti Mosquitoes Anisha Chaudhary, Dr. Soham Mahendrabhai Trivedi, Dr. Sandeep Kumar Singh, Babu Lal Chaudhary, Dr.P. Prakash, Vivek Saraswat, Dr. Dharmsheel Shrivastava Journal of Animal Environment, 2026 Over 700,000 deaths are annually caused by the effects of mosquito-borne diseases, Aedes aegypti being the main carrier in the case of dengue, Zika, and chikungunya. The traditional methods to control insects using insecticides have become the cause of significant environmental issues, such as ecological imbalance, non-target toxicity, and development of resistance, and thus, sustainable alternatives are required. The olfactory receptors (ORs) are also important in the mediating host-seeking behaviour in mosquitoes as they detect volatile compounds of human origin. The paper used CRISPR-Cas9 gene editing to silence the genes of two olfactory receptors, Or4 and Or8, on the Ae. aegypti Liverpool strain. The guide RNAs were selected to target conserved domains and microinjection done on 300 embryos showed a survival rate of 47% and 68% editing efficiency was established by molecular analysis through frameshift mutations. In 2022-2023, behavioural assays revealed a 73% decrease in upwind flight response to human odor (p<0.001) of edited mosquitoes. Experiments in human landing catch have shown an 81% reduction in the rate of landing relative to wild-type controls, which implies a significant reduction in the degree of interaction between humans and vectors. Electrophysiological responses indicated that there was considerable attenuation of antennal responses to important human odorants including lactic acid, 1-octen-3-ol and ammonia. Confocal microscopy also demonstrated distressed glomerular targeting in olfactory sensory neurons to the antennal lobes. Notably, no meaningful impacts on the viability of mosquitoes and fecundity were detected, which implies behavioural change does not impair ecological fitness. Environ-wise, this is a non-lethal, eco-friendly approach to controlling vectors that helps to keep the ecosystem stable though the decrease of the disease transmission and the preservation of the mosquito population. The results give a basis in designing gene drive constructs that are used to suppress behaviour and not kill the population as it aims at achieving sustainable and eco-friendly control of vectors that do not cause harm to the environment and is less dependent on chemical intervention.
Artificial intelligence in bread making: Applications in quality control, formulation and sensory prediction Marimuthu Murugesan, Prakash Pandurangan, Anitha Murugesan, Halan Senthilkumar, Krishnamurthy K. Hegde, Sheela Thangaraj, Meivelu Moovendhan Food Chemistry X, 2026 Artificial intelligence (AI) is being applied by the bakery industry to substitute existing practices with data-informed strategies to enhance the accuracy of quality predictions, process optimization, and shelf-life prediction. This review discusses how AI, specifically machine learning (ML) algorithms such as artificial neural networks (ANNs), support vector machines (SVMs), random forests (RF) and deep neural networks (DNNs), can be applied in bread-making and product innovation. With AI models, there is the possibility of analyzing the interactions between formulation, processing and quality features in a complex manner to predict the loaf volume, crumb structure, staling and risk of spoilage. The optimization of formulations with the help of AI is also used to produce cost-effective, nutritionally fortified products without losing the sensory quality. Interest of AI in combination with improved methods like gas chromatography-olfactometry and texture profiling, E -nose/E-tongue systems improves the senses prediction prior to execution. Besides, the combination of AI and digital twins, kinetic models, and IoT systems enhance real-time analysis and operational performance, which can lead to sustainability, less food waste, and individualized and health-focused bakery items.
CRISPR-Cas9 Technology for Unlocking Immunity Against Infectious Pathogens M. Suriya, V. Aarthi, S. S. Meenambiga, P. Prakash, P. Vivek Crispr Cas9 Technology for Precision Medicine, 2026 The development of CRISPR-Cas9 has dramatically changed the field of genome engineering and its utilization in epigenome editing could have profound implications for precision medicine.This ability to precisely target epigenetic marks, including DNA methylation, histone modifications, and chromatin remodeling, allows for exciting therapeutic developments in cancer, neurodegenerative and autoimmune diseases. New developments such as CRISPRi, CRISPRa, and reversible CRISPR off/CRISPR on, allow for complex and multiplexed epigenetic reprogramming with improved specificity and safety. Nonetheless, there are some challenges to delivery off-target effects, stability of epigenetic modification, and moral lines, especially with inheritable epigenetic modification. The essential principles of CRISPR-Cas9-based epigenome editing, its therapeutic prospects for personalized medicine, and the consideration of technological, ethical, and policy aspects associated with epigenome editing are discussed
Collagen-based electrospun materials for drug delivery system Antony V. Samrot, D. Rajalakshmi, Harshaa Rajabalakumar, R. Sanjay Preeth, Madhumitha B.S., P. Prakash, Vinay Kumar Pandey, Gokul Shankar Sabesan Electrospun Biomaterials for Tissue Engineering and Drug Delivery Applications, 2025
Nanomaterials in the pretreatment of biomass Antony V. Samrot, D. Rajalakshmi, Harshaa Rajabalakumar, R. Sanjay Preeth, B.S. Madhumitha, P. Prakash, Vinay Kumar Pandey, Gokul Shankar Sabesan, Faidruz Azura Jam, Theebaa Anasamy Biomass Conversion Through Nanomaterials Green Sustainable Process for Chemical and Environmental Engineering and Science Gspcees, 2025
Correction to: Natural biopolymers as Scaffold Antony V. Samrot, M. Sathiya Sree, D. Rajalakshmi, L. Noel Richard Prakash, P. Prakash Drug Discovery and Design Using Natural Products, 2023
Natural biopolymers as scaffold Antony V. Samrot, M. Sathiya Sree, D. Rajalakshmi, L. Noel Richard Prakash, P. Prakash Drug Discovery and Design Using Natural Products, 2023
Phytomediated Adsorption of Acid Blue 113 using Ananas comosus Crown, Artocarpus heteropyllus Leaves and Spent Tea Leaves Indian Journal of Environmental Protection, 2022
A Review of Different Vaccines and Strategies to Combat COVID-19 Srinivasan Sabitha, Nagarajan Shobana, Pandurangan Prakash, Sathiyamoorthy Padmanaban, Mahendran Sathiyashree, Subramanian Saigeetha, Srikumar Chakravarthi, Saji Uthaman, In-Kyu Park, Antony V. Samrot Vaccines, 2022
Waste-Derived Cellulosic Fibers and Their Applications Antony V. Samrot, Khosa Tariro Ngaakudzwe, D. Rajalakshmi, P. Prakash, S. Suresh Kumar, M. Chandramohan, D. Alex Anand, J. Lilly Mercy, Yishak Simon, S. Saigeetha Advances in Materials Science and Engineering, 2022
Degradation of crude oil using the indigenous isolate Bacillus sp SEA18 Indian Journal of Biochemistry and Biophysics, 2020
Production and utilization of spions for in-vitro drug release and x-ray imaging Antony V. Samrot, Saipriya C, Durga Sruthi P., A. Jenifer Selvarani, Raji P., Prakash P, Paulraj Ponnaiah, Thirumurugan R, Sajeesh Pattammadath, Sajna Keeyari Purayil, Pazhayakath Thevarkattil Mohamed Javad, Iyappan P Journal of Pure and Applied Microbiology, 2020
Green synthesis and antibacterial activity studies of silver nanoparticles from the aqueous extracts of euphorbia hirta Department of Biotechnology, Sathyabama Institute of Science, Technology, Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai - 600 119, Tamil Nadu, India, Bennet Rohan D, Raji P, Department of Biotechnology, Sathyabama Institute of Science, Technology, Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai - 600 119, Tamil Nadu, India, Divya Kumar M, Department of Biotechnology, Sathyabama Institute of Science, Technology, Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai - 600 119, Tamil Nadu, India, Ratna Geethika Gandham, Department of Biotechnology, Sathyabama Institute of Science, Technology, Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai - 600 119, Tamil Nadu, India, Kripu Sharma V, Department of Biotechnology, Sathyabama Institute of Science, et al. Journal of Pure and Applied Microbiology, 2020
Production, characterization, and optimization of rhamnolipids produced by Pseudomonas aeruginosa by solid-state fermentation International Journal of Green Pharmacy, 2017
Bioprospecting endophytic fungus Colletotrichum sp. isolated from Artocarpus heterophyllus for anticancer activity Research Journal of Biotechnology, 2017
Micropropagation of Eclipta alba using humic acid as media component Plant Archives, 2015
Design of medium components for the enhanced production of mycoprotein by Fusarium venenatum using plackett burman model Research Journal of Pharmaceutical Biological and Chemical Sciences, 2015
Evaluation of insecticidal activity of Fusarium venenatum metabolites againstsf-21 cell lines International Journal of Chemtech Research, 2015
Biological synthesis of gold nanoparticles using endophytic fungi Der Pharma Chemica, 2015
Effect of vermiwash and humic acid on the germination and growth of Capsicum annum L and Abelmoschus esculentus Research Journal of Pharmaceutical Biological and Chemical Sciences, 2015
Screenig of bioactive compounds by Gc-Ms from fusarium venenatum International Journal of Pharmtech Research, 2014
Evaluation of protein release rate from mycoprotein - Fusarium venenatum by cell disruption method International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Effect of humic acid on seed germination of Raphanus sativus L International Journal of Chemtech Research, 2014
Optimization of humic acid production using RSM-CCD, its characterization and applications on Vigna mungo International Journal of Chemtech Research, 2014
Optimization of growth promoters on Desmodium gangeticum (l) DC using RSM-CCD and its antioxidants activity International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Optimization of humic acid by Trichoderma viridi and it's effect on sorghum plant Journal of Biopesticides, 2010
RECENT SCHOLAR PUBLICATIONS
Development and Validation of LC-MS Analysis of Microalgal Pigments L Selvam, H Mani, MS Sudharsan, P Pandurangan, R Jaganathan Microalgae-based Pigments: Basic Protocols, 145-163 , 2026 2026
Pigment Stability and Degradation Under Different Storage and Processing Conditions L Madhumitha, MS Sudharsan, N Thajudeen, P Pandurangan, ... Microalgae-based Pigments: Basic Protocols, 135-144 , 2026 2026
Molecular regulation of pollen responses to abiotic stress in flowering plants: Mechanisms, models and future directions N Thajudeen, D Vasudevan, VR Kumar, P Pandurangan, MS Sudharsan, ... Gene Reports, 102512 , 2026 2026
Artificial intelligence in bread making: Applications in quality control, formulation and sensory prediction M Marimuthu, P Pandurangan, A Murugesan, H Senthilkumar, KK Hegde, ... Food Chemistry: X, 103654 , 2026 2026
Integrative Omics Approaches for Bioactive Metabolite Discovery in Marine Macroalgae: Recent Advances and Future Perspectives M Marimuthu, M Anitha, P Prakash, M Moovendhan Journal of Biotechnology , 2026 2026
Automatic Detection of Tropical Cyclones from Satellite Images Using YOLO Models R Thangaraj, P Pandiyan, P Naveen, B Vadivel, P Prakash, SM Kumar Integrating AI for Sustainable Disaster Management: Building Resilience and … , 2026 2026
Exploring the Role of Phytomedicines in Neurodegenerative Disorders V Keerthi, P Jayashree, SS Meenambiga, P Prakash, P Vivek, SI Romauld Recent Breakthroughs in Neurodegenerative Disorders and Enzyme Therapy, 301-320 , 2026 2026
Biodegradable Films for Mitigating Food Contaminants Through Sustainable Packaging SS Meenambiga, Y Kesavan, J Pandurangan, P Pandurangan, ... Mitigation Strategies and Risk Management for Food Contaminants, 181-212 , 2026 2026
Assessing the optimal cultivation sites for Kappaphycus alvarezii and Gracilaria dura in Tamil Nadu's coastal mariculture: Analyzing biomass and daily growth rates M Marimuthu, P Prakash, K Karthikeyan, RA Najimudeen Regional Studies in Marine Science, 104612 , 2025 2025
Harnessing Algae-Derived Bioactive Compounds for Sustainable and Effective Photoprotection in Skincare CA Srinidhiy, J Nellore, P Prakash, M Moovendhan Applied Biochemistry and Biotechnology, 1-33 , 2025 2025 Citations: 1
Dengue virus: structure, genome, evolution and challenges to control and prevent transmission K Umar, T Sutradhar, P Prakash, M Bavanilatha, AU Hemamalani, ... Antonie Van Leeuwenhoek 118 (9), 139 , 2025 2025 Citations: 3
Integrative approaches to network pharmacology studies in wound healing and bone fracture recovery: A comprehensive review RA Najimudeen, C Amaldoss, A Raghu, AA Daniel, DK Shanmugam, ... Biophysical Chemistry 324, 107458 , 2025 2025 Citations: 2
Exploring phenolic compound extraction from marine seaweeds of south coast India: in vitro antioxidant and antimicrobial evaluation M Murugesan, P Pandurangan, AV Samrot, P Sengupta, S Dutta, ... Vegetos 38 (4), 1650-1667 , 2025 2025 Citations: 1
Sustainable pectin extraction: Navigating industrial challenges and opportunities with fruit by-products–A review DG Arumuganainar, DL Ramesh, P Pandurangan, S Sunkar, S Abraham, ... Process Biochemistry 154, 234-245 , 2025 2025 Citations: 16
Effectiveness of pre-treated Lemna minor biomass in removing methyl orange dye from aqueous solutions: adsorption efficacy, kinetics, and ecotoxicity analysis GP Avinash, SKR Namasivayam, P Prakash, SK Shree Biomass Conversion and Biorefinery 15 (13), 20569-20588 , 2025 2025 Citations: 10
Microbial disease resistance mechanisms with special reference to quorum sensing and quorum quenching: a review CV Nachiyar, S Sunkar, J Nellore, K Renugadevi, SKR Namasivayam, ... Discover Biotechnology 2 (1), 9 , 2025 2025 Citations: 7
Correction to: Exploring phenolic compound extraction from marine seaweeds of south coast India: in vitro antioxidant and antimicrobial evaluation (Vegetos,(2024), 10.1007 … M Murugesan, P Pandurangan, AV Samrot, P Sengupta, S Dutta, ... Vegetos 38 (1), 418 , 2025 2025
Starch nanocrystals from cassava peel and their use as carrier system for quercetin N Kabila, A Thirumurugan, AV Samrot, P Prakash Vegetos, 1-10 , 2025 2025 Citations: 1
Collagen-based electrospun materials for drug delivery system AV Samrot, D Rajalakshmi, H Rajabalakumar, RS Preeth, M BS, ... Electrospun Biomaterials for Tissue Engineering and Drug Delivery … , 2025 2025
Nanomaterials in the pretreatment of biomass AV Samrot, D Rajalakshmi, H Rajabalakumar, RS Preeth, ... Biomass Conversion through Nanomaterials, 133-150 , 2025 2025 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
Methods of synthesis, characteristics, and environmental applications of MXene: A comprehensive review JA Kumar, P Prakash, T Krithiga, DJ Amarnath, J Premkumar, ... Chemosphere 286, 131607 , 2022 2022 Citations: 489
A focus to green synthesis of metal/metal based oxide nanoparticles: Various mechanisms and applications towards ecological approach JA Kumar, T Krithiga, S Manigandan, S Sathish, AA Renita, P Prakash, ... Journal of Cleaner Production 324, 129198 , 2021 2021 Citations: 324
The synthesis, characterization and applications of polyhydroxyalkanoates (PHAs) and PHA-based nanoparticles AV Samrot, SK Samanvitha, N Shobana, ER Renitta, P Senthilkumar, ... Polymers 13 (19), 3302 , 2021 2021 Citations: 163
Sources of antibiotic contamination in wastewater and approaches to their removal—an overview AV Samrot, S Wilson, RS Sanjay Preeth, P Prakash, M Sathiyasree, ... Sustainability 15 (16), 12639 , 2023 2023 Citations: 155
A comprehensive review on bio-hydrogen production from brewery industrial wastewater and its treatment methodologies JAKSSTKTRPSLDPAARPPM Rajasimmanf FUEL 319 (1) , 2022 2022 Citations: 86
Influence of seaweed extracts on growth, phytochemical contents and antioxidant capacity of cowpea (Vigna unguiculata L. Walp) R Vasantharaja, LS Abraham, D Inbakandan, R Thirugnanasambandam, ... Biocatalysis and Agricultural Biotechnology 17, 589-594 , 2019 2019 Citations: 84
A review on biohydrogen sources, production routes, and its application as a fuel cell AV Samrot, D Rajalakshmi, M Sathiyasree, S Saigeetha, K Kasipandian, ... Sustainability 15 (16), 12641 , 2023 2023 Citations: 73
Aquatic biomass cellulose fabrication into cellulose nanocomposite and its application in water purification SKR Namasivayam, P Prakash, V Babu, EJ Paul, RSA Bharani, JA Kumar, ... Journal of Cleaner Production 396, 136386 , 2023 2023 Citations: 72
Adsorption efficiency of chemically synthesized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on crystal violet dye AV Samrot, HH Ali, J Selvarani Current Research in Green and Sustainable Chemistry 4, 100066 , 2021 2021 Citations: 68
Biological synthesis of gold nanoparticles using endophytic fungi PPB Valli Nachiyar, Swetha Sunkar* Der Pharma Chemica, 7 (2), 31-38 , 2015 2015 Citations: 63
Biological synthesis of silver nanoparticles by Lantana camara leaf extracts PP A.Thirumurugan*1, Neethu Anns Tomy2, Hema Priyanka International Journal of Nanomaterials and Biostructures 1 (2), 22-24 , 2011 2011 Citations: 54
Production of Extremely Alkaliphilic, Halotolerent, Detergent, and Thermostable Mannanase by the Free and Immobilized Cells of Bacillus halodurans PPKS-2 … S Vijayalaxmi, P Prakash, SK Jayalakshmi, VH Mulimani, K Sreeramulu Applied biochemistry and biotechnology 171 (2), 382-395 , 2013 2013 Citations: 53
Integrating cutting-edge technologies: AI, IoT, blockchain and nanotechnology for enhanced diagnosis and treatment of colorectal cancer-A review P Pandurangan, AD Rakshi, MSA Sundar, AV Samrat, SS Meenambiga, ... Journal of Drug Delivery Science and Technology 91, 105197 , 2024 2024 Citations: 52
Production of alkaliphilic, halotolerent, thermostable cellulase free xylanase by Bacillus halodurans PPKS-2 using agro waste: single step purification and … P Prakash, SK Jayalakshmi, B Prakash, M Rubul, K Sreeramulu World Journal of Microbiology and Biotechnology 28 (1), 183-192 , 2012 2012 Citations: 52
Effect of Ca2+ ions on naphthalene adsorption/desorption onto calcium oxide nanoparticle: Adsorption isotherm, kinetics and regeneration studies JA Kumar, T Krithiga, G Narendrakumar, P Prakash, K Balasankar, ... Environmental Research 204, 112070 , 2022 2022 Citations: 50
Biodegradation of acid blue 113 containing textile effluent by constructed aerobic bacterial consortia: optimization and mechanism CV Nachiyar, S Sunkar, GN Kumar, A Karunya, PB Ananth, P Prakash, ... J Bioremed Biodeg 3 (162), 2 , 2012 2012 Citations: 40
Adsorptive removal of acid blue dye 113 using three agricultural waste biomasses: The possibility of valorization by activation and carbonization–A comparative analysis S Sunkar, P Prakash, B Dhandapani, O Baigenzhenov, JA Kumar, ... Environmental Research 233, 116486 , 2023 2023 Citations: 36
Waste-Derived Cellulosic Fibers and Their Applications ASKTNRDRDS all 10 authorss. Saigeethas. Saigeetha Advances in Materials Science and Engineering, 1-13 , 2022 2022 Citations: 33
Itraconazole coated super paramagnetic iron oxide nanoparticles for antimicrobial studies VS Antony, CS Sahithya, P Durga Sruthi, J Selvarani, P Raji, P Prakash, ... Biointerface Res. Appl. Chem 10, 6218-6225 , 2020 2020 Citations: 33
Purification and Characterization of Gum-Derived Polysaccharides of Moringa oleifera and Azadirachta indica and Their Applications as Plant Stimulants and Bio … N Shobana, P Prakash, AV Samrot, PJ Jane Cypriyana, P Kajal, ... Molecules 27 (12), 3720 , 2022 2022 Citations: 30