Leonid Shafran

@insat.org.ua

hygiene and toxicology
STATE ENTERPRISE UKRAINIAN RESEARCH INSTITUTE FOR MEDICINE OF TRANSPORT (SE UKRRI MT)

Leonid Shafran


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https://researchid.co/lmshafran182

RESEARCH INTERESTS

hygiene, toxicology, psychophysiology, microelementology, biochemistry
45

Scopus Publications

1833

Scholar Citations

18

Scholar h-index

42

Scholar i10-index

Scopus Publications

  • Zinc supply of the population of Ukraine: Consequences for health and reproduction
    Pharmacologyonline, 2021
  • Elements of a systematic approach to hygienic regulation of xenobiotics
    B. M. Shtabskiy, M. R. Gzhegotskiy, Leonid M. Shafran
    Gigiena I Sanitariya, 2016
    Hygienic standardization (HS) of chemicals remains to be the one of the effective ways to ensure chemical safety of the population. At that hygienic standards (such as maximum allowable concentrations--MACs) are interrelated and aggregated into the coherent systems. Therefore, the task of the study was in establishment of the logic of inter- standard relations between the existing standards and actualization of legitimate relations of the interrelations such as MACwz/MACatm, (i.e., to systematize standards) and so as CL₅₀/MACwz (reflecting the ratio of reliability). In the suggested systemic approach the benchmark indices of the proposed HS system are the values of the MACwz. Standards for other media, including atmosphere air may be only some compartments of MACwz. The performed studies and calculations allowed to justify and implement the system approach into the practice of HS in Ukraine. There is need for further search for additional solutions in nonreachability of LC₅₀ in the experiment, justification of standards for the population in the absence of MACwz, comparison with the data of normative databases of other countries. It is necessary to introduce the value of permissible deviation from the requirements of the systemness, to embody conditions (1)-(7) into the general principle of the prohibition of greater deviation and to harmonize acting and newly introduced standards within frameworks of modern ideology and methods of HS of harmful substances. This opens up broad prospects for the new phase of HS and a significant increase in the reliability of results obtained by the various methods and in different laboratories.
  • Hygienic evaluation of working conditions and working process of fire rescue employees
    Gigiena I Sanitariia, 2015
  • Synthesis and biological activity of 7H-benzo[4,5]indolo[2,3-b]-quinoxaline derivatives
    Marina O. Shibinskaya, Alexander S. Karpenko, Sergey A. Lyakhov, Sergey A. Andronati, Nadezhda M. Zholobak, et al.
    European Journal of Medicinal Chemistry, 2011
    New 7-(2-aminoethyl)-7H-benzo[4,5]indolo[2,3-b]quinoxalines (13-20) were synthesized with high yields starting from 3H-benzo[e]indole-1,2-dione. These compounds were screened for the cytotoxicity, anti-viral activity, interferon inducing ability and DNA affinity compared with the corresponding 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxaline derivatives (1-12). It was shown, that compounds 13-20 bind to DNA stronger (lg Кa=6.23-6.87) than compounds 1-12 (lg Кa=5.57-5.89). Anti-viral activity is significantly reduced with annulations of benzene ring in Indoloquinoxaline moiety 13-20.
  • Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
    Elena A. Lyakhova, Yulia A. Gusyeva, Julia V. Nekhoroshkova, Lev M. Shafran, Sergey A. Lyakhov
    European Journal of Medicinal Chemistry, 2009
    Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K a values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives.
  • Dangerous Goods as Ecotoxicants in Ukrainian Ports and after an Accident at the Kherson Area
    Fresenius Environmental Bulletin, 2003
  • The problem of allergy in ecotoxicology of polymeric materials
    B. Kuzminov, V. Turkina, L. Shafran
    Environment International, 2003
    In the program of initial toxicological test, the estimation of allergenic activity of some names of polymeric compositions, which are used in the polygraphic industry and when painting and decorating dwelling houses and social purpose premises, had been carried out. Most of the investigated compositions have different degrees of allergenicity. In order to unify the works in this field, we suggest the basic circuit of the estimation of allergenicity of polymeric materials, the final stage of which provides for the compiling of register of potentially allergenic polymeric materials.
  • The information-search system on industrial ecology of transport
    Meditsina Truda I Promyshlennaia Ekologiia, 1997
  • Effect of bis(n-tributyltin)-oxide on the brain GABA-ergic system in vitro
    Ukrainskii Biokhimicheskii Zhurnal, 1994
  • Scientific and technical progress and the problems of protecting the health of workers in water transport
    Meditsina Truda I Promyshlennaya Ekologiya, 1992
  • Lipid peroxidation and the trace element content of the blood in patients with lichen ruber planus of the oral mucosa
    Stomatologiya, 1991
  • Psycho-hygienic prevention and correction of functional disorders in workers at increased chemical hazard
    Vracebnoe Delo Kiev, 1990
  • Toxicological problems in maritime medicine.
    Bulletin of the Institute of Maritime and Tropical Medicine in Gdynia, 1990
  • Hygienic evaluation of the effectiveness of means for the collective protection of the crews on board gas-carrier ships
    Gigiena I Sanitariia, 1986
  • Experience with using a cell culture method for assessing the toxicity of anticorrosive materials intended for shipbuilding
    Gigiena I Sanitariia, 1986
  • Individual-typologic features of the functioning of the sympatho-adrenal system as a prognostic index of the functional state of the body in complex environmental conditions
    Fiziologiia Cheloveka, 1985
  • Hygienic evaluation of the sorption properties of the synthetic materials used in ship building and ship maintenance
    Gigiena I Sanitariia, 1983
  • Effect of combined exposure to noise, vibration, and high temperatures on sympathico-adrenal system in sailors
    Meditsina Truda I Promyshlennaya Ekologiya, 1982
  • Level of Physiological Reserves of the Body of Sailors Working According to the Ten-hour Schedule.
    Meditsina Truda I Promyshlennaya Ekologiya, 1982
  • Upper airways affection in sailors of the transport fleet and its prophylaxis during the long navigation
    Zhurnal Ushnykh Nosovykh I Gorlovykh Boleznei, 1982
  • Work capacity of sailors with a changed work and rest regimen
    Voenno Meditsinskii Zhurnal, 1981
  • Hygienic studies in the airless spraying of KhV-53-type antifouling paints
    Gigiena I Sanitariia, 1981
  • Complex physiological and hygienic characteristics of a new work and rest regimen for ship's personnel
    Gigiena I Sanitariia, 1981
  • Method for the hygienic evaluation of the toxicity of polymeric material combustion products
    Gigiena I Sanitariia, 1980
  • Lipid peroxidation, peroxidase activity and glutathione antiperoxide systems in rat tissues under conditions of high altitude hypoxia
    Ukrainskii Biokhimicheskii Zhurnal, 1979

RECENT SCHOLAR PUBLICATIONS

  • Основи теорії медицини: монографія
    АІ Гоженко, ВС Бірюков, ОА Гоженко, ЛІ Ковальчук, БА Насібуллін, ...
    2024
  • Охорона праці медичного персоналу: освіта, теорія, практика
    ЛМ Шафран
    Довкілля та здоров'я 103 (2), 71-75 , 2022
    2022
  • Toxicological-hygienic and ecological aspects of safety of rolling stock braking systems of railway transport
    LM Shafran, VL Mazur, DV Bolshoy, OG Pykhtieieva, OV Tretyakova, ...
    Part 2, 15-26 , 2022
    2022
    Citations: 6
  • КОНЦЕПЦІЯ “TOXICITY TESTING-21” У СУЧАСНІЙ ТОКСИКОЛОГІЇ
    ЛМ Шафран, ОВ Третьякова
    Актуальні проблеми профілактичної медицини, 8-42 , 2021
    2021
  • ДИНАМИКА УРОВНЕЙ ЦИНКА В БИОСУБСТРАТАХ НАСЕЛЕНИЯ УКРАИНЫ В ПЕРИОД 2008-2021 гг
    ЛМ Шафран, ЕГ Пыхтеева, ДВ Большой, ЕД Пыхтеева
    2021
  • Zinc supply of the population of Ukraine: consequences for health and reproduction
    EG Pykhtieieva, DV Bolshoy, AD Melenevsky, OM Chaika, ...
    2021
    Citations: 1
  • Анестезиологическое обследование при хирургическом лечении холецистита (обзор литературы и собственные данные)
    ЕН Салех, ЛМ Шафран
    Актуальні проблеми транспортної медицини: навколишнє середовище; професійне … , 2020
    2020
  • Анестезіологічне забезпечення при хірургічному лікуванні холециститу (огляд літератури та власні дані)
    ЕН Салех, ЛМ Шафран
    2020
  • Toxico-ecological Analysis of Mercury-contained Waste Management in Ukraine
    O Pykhtieieva, D Bolshoy, L Shafran
    UKRAINIAN JOURNAL OF MODERN PROBLEMS OF TOXICOLOGY Учредители: Ukrainian … , 2020
    2020
  • Копінг-стратегії в системі відновлюваних заходів на санаторному етапі медико-психологічної реабілітації пожежних-рятувальників після повернення з зони АТО (ООС)
    ЛМ Шафран, ЮВ Чумаєва, ВВ Голікова, ОП Огуленко, ІО Цибулько
    Актуальные проблемы транспортной медицины , 2019
    2019
    Citations: 1
  • Побудова нової концепції безпечного застосування полімерів у світі вимог міжнародного проекту" Токсикологічні випробування–ХХІ століття"
    ОВ Третьякова, ЛМ Шафран
    XVIII–і читання ВВ Підвисоцького: Бюлетень матеріалів науково-практичної … , 2019
    2019
    Citations: 1
  • Бионеорганическая химия с основами медицинской элементологии: учебник
    ТП Максимчук, АВ Скальный, ИВ Радыш, ЛМ Шафран, МГ Скальная, ...
    М.: Российский ун-т дружбы народов 624 , 2019
    2019
    Citations: 12
  • Гигиеническая регламентация полимеров в XXI веке-новая парадигма
    ЛМ Шафран, ЕВ Третьякова
    Актуальні проблеми транспортної медицини: навколишнє середовище; професійне … , 2019
    2019
  • ВНУТРИВЕННЫЕ АНЕСТЕТИКИ С ПОЗИЦИЙ ХИМИЧЕСКОЙ БЕЗОПАСНОСТИ В ХИРУРГИИ
    ЕН САЛЕХ, ЛМ ШАФРАН
    Likarska Sprava 2019 , 2018
    2018
  • Організаційна та економічна психологія в Україні: сучасні проблеми та перспективи розвитку. Тези доповідей XIII Міжнародна науково-практична конференція з організаційної та …
    ЛМ Шафран, ЮВ Чумаева, АП Огуленко, РА Боровицкая
    XIII Міжнародна науково-практична конференція з організаційної та … , 2018
    2018
  • Тяжелые металлы: система биологического транспорта
    ЛМ Шафран, ЕГ Пыхтеева, ДВ Большой
    Монография. Одесса 320, 68 , 2018
    2018
    Citations: 6
  • Seafarer's health savings competencies: goals, professional features, formation and development
    LM Shafran, VV Golikova
    Visnyk Mors' koi'Medycyny 80 (3), 4-12 , 2018
    2018
    Citations: 8
  • УРОКИ МИНАМАТСКОЙ ТРАГЕДИИ И АКТУАЛЬНЫЕ ПРОБЛЕМЫ СОВРЕМЕННОЙ МИКРОЭЛЕМЕНТОЛОГИИ
    ЛМ Шафран
    Микроэлементы в медицине 19 (4), 63-65 , 2018
    2018
  • Професійна компетентність суднових операторів як предиктор хімічної безпеки у морському перевезенні небезпечних вантажів
    ЛМ Шафран
    Актуальні проблеми транспортної медицини: навколишнє середовище; професійне … , 2018
    2018
  • Энергоэффективность, энергосбеоежение и здоровье
    ВЯ Браверман, ВИ Кушнерук, ЕВ Третьякова, ЛМ Шафран
    Актуальні проблеми транспортної медицини: навколишнє середовище; професійне … , 2018
    2018

MOST CITED SCHOLAR PUBLICATIONS

  • Общая токсикология
    БА Курляндский, ВА Филов, ВС Безель, НМ Василенко, ЛВ Дарьина, ...
    Открытое акционерное общество Издательство Медицина , 2002
    2002
    Citations: 244
  • Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo [2, 3-b] quinoxalines
    MO Shibinskaya, SA Lyakhov, AV Mazepa, SA Andronati, AV Turov, ...
    European journal of medicinal chemistry 45 (3), 1237-1243 , 2010
    2010
    Citations: 148
  • Теория и практика профессионального психофизиологического отбора моряков
    ЛМ Шафран, ЭМ Псядло
    Одесса: Феникс , 2008
    2008
    Citations: 97
  • Anti-inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase inhibitor
    IA Schepetkin, LN Kirpotina, D Hammaker, I Kochetkova, AI Khlebnikov, ...
    The Journal of Pharmacology and Experimental Therapeutics 353 (3), 505-516 , 2015
    2015
    Citations: 76
  • Тиоловые яды
    ИМ Трахтенберг, ЛМ Шафран
    Общая токсикология/Под редакцией БА Курляндского, ВА Филова–М.: Медицина … , 2002
    2002
    Citations: 49
  • Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo [1, 2-c] quinazolines
    EA Lyakhova, YA Gusyeva, JV Nekhoroshkova, LM Shafran, SA Lyakhov
    European journal of medicinal chemistry 44 (8), 3305-3312 , 2009
    2009
    Citations: 39
  • Металлотионеины
    ЛМ Шафран, ЕГ Пыхтеева, ДВ Большой
    Издательство" Чорномор'я" , 2011
    2011
    Citations: 37
  • Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides.
    SA Lyakhov, YI Suveyzdis, LA Litvinova, SA Andronati, SL Rybalko, ...
    Die Pharmazie 55 (10), 733-736 , 2000
    2000
    Citations: 34
  • Гигиена обитаемости морских судов
    АМ Войтенко, ЛМ Шафран
    АМ Войтенко, ЛМ Шафран.“К.: Здоров’я , 1989
    1989
    Citations: 32
  • Synthesis and biological activity of 7H-benzo [4, 5] indolo [2, 3-b]-quinoxaline derivatives
    MO Shibinskaya, AS Karpenko, SA Lyakhov, SA Andronati, NM Zholobak, ...
    European journal of medicinal chemistry 46 (2), 794-798 , 2011
    2011
    Citations: 31
  • Synthesis, DNA-binding, and interferon-inducing properties of isatin and benzoisatin hydrazones
    AS Karpenko, MO Shibinskaya, NM Zholobak, ZM Olevinskaya, ...
    Pharmaceutical Chemistry Journal 40 (11), 595-602 , 2006
    2006
    Citations: 29
  • Комплексная гигиеническая оценка условий труда и трудового процесса пожарных-спасателей
    ЛМ Шафран, ЮВ Нехорошкова
    Гигиена и санитария 94 (1), 77-82 , 2015
    2015
    Citations: 28
  • Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents
    K Klimenko, S Lyakhov, M Shibinskaya, A Karpenko, G Marcou, ...
    Bioorganic & Medicinal Chemistry Letters 27 (16), 3915-3919 , 2017
    2017
    Citations: 22
  • Synthesis of 6‐Aminopropyl‐6H‐indolo [2, 3‐b] quinoxaline Derivatives
    MO Shibinskaya, NA Kutuzova, AV Mazepa, SA Lyakhov, SA Andronati, ...
    Journal of Heterocyclic Chemistry 49 (3), 678-682 , 2012
    2012
    Citations: 22
  • Научно-теоретические проблемы медицины транспорта
    ЛМ Шафран
    Актуальные проблемы транспортной медицины, 012-020 , 2005
    2005
    Citations: 21
  • К обоснованию гормезиса как фундаментальной биомедицинской парадигмы (обзор литературы и результатов собственных исследований)
    ЛМ Шафран, АВ Мокиенко, НФ Петренко, АИ Гоженко, БА Насибуллин
    Современные проблемы токсикологии 2 (3), 13-23 , 2010
    2010
    Citations: 19
  • Влияние антипиренов на показатели пожарной опасности эпоксиполимерных материалов
    РА Яковлева, ЕЮ Спирина-Смилка, НВ Саенко, ЮВ Попов, СВ Новак, ...
    Проблемы пожарной безопасности: сборник научных трудов 29, 175-181 , 2011
    2011
    Citations: 18
  • Theory and practice of professional psychophysiological selection of seamen
    LM Shafran, EM Psyadlo
    rus).–Odessa: Phenix , 2008
    2008
    Citations: 18
  • Роль лизосом в механизме защиты и повреждения клеток при действии тяжёлых металлов
    ЛМ Шафран, ДВ Большой, ЕГ Пыхтеева, ЕВ Третьякова
    Современные проблемы токсикологии, 17 , 2004
    2004
    Citations: 18
  • Гармонизация методов оценки токсичности продуктов горения полимеров с международными требованиями
    ЛМ Шафран, ИА Харченко
    Со врем. проблемы токсикологии, 10 , 2003
    2003
    Citations: 18