Syeda Mahwish Bakht

Experienced Associate Researcher in fabrication of a tubular polydimethylsiloxane (PDMS) platform for modeling blood vessels in vitro for organ/tissue on chip applications. Currently working on developing innovative strategies utilizing natural materials for development of microchips via additive manufacturing and microfluidics techniques to generate physiologically relevant in-vitro tissue models for disease modeling and drug testing applications.

EDUCATION

2017-Present: 3Bs Research Group, University of Minho, Portugal.
Research Degree Ph.D. Field of study: Tissue Engineering Regenerative Medicine

2013-2016: COMSATS Institute of Information and Technology, Abbottabad, Pakistan
Research Degree M. Phil Field of study: Pharmaceutical Sciences 1st Division

2008-2013: COMSATS Institute of Information and Technology, Abbottabad, Pakistan Professional Degree Doctor of Pharmacy 1st Division

RESEARCH INTERESTS

3D/Bioprinting, Microfluidics, Organ/Tissue on chip, Disease Modeling and Drug testing

RECENT SCHOLAR PUBLICATIONS

Engineering the curve of fate: How geometry directs paneth cell localization in intestinal organoids
SM Bakht, JF Mano
Matter 8 (8) , 2025
2025
Contactless 3D acoustic assembly of liquid capsules for bottom-up tissue engineering
MER Luiz, M Carreira, S Nadine, R Tognato, R Parolini, SM Bakht, ...
Biomaterials, 123555 , 2025
2025
Citations: 3
Human Tendon‐on‐Chip: Unveiling the Effect of Core Compartment‐T Cell Spatiotemporal Crosstalk at the Onset of Tendon Inflammation
SM Bakht, A Pardo, M Gomez‐Florit, D Caballero, SC Kundu, RL Reis, ...
Advanced Science 11 (41), 2401170 , 2024
2024
Citations: 19
Guiding stem cell tenogenesis by modulation of growth factor signaling and cell‐scale biophysical cues in bioengineered constructs
SPB Teixeira, A Pardo, SM Bakht, M Gomez‐Florit, RL Reis, ME Gomes, ...
Advanced Functional Materials 34 (29), 2312961 , 2024
2024
Citations: 15
3D writing of multicellular tendon-on-CNC-chip models
RF Monteiro, SM Bakht, M Gomez-Florit, RL Reis, ME Gomes, ...
Orthopaedic Proceedings 106 (SUPP_2), 15-15 , 2024
2024
Citations: 3
3D biomimetic constructs steer stem cell commitment by synergistic modulation of biophysical cues and growth factor signalling
SPB Teixeira, A Pardo, SM Bakht, M Gómez-Florit, RL Reis, ME Gomes, ...
Orthopaedic Proceedings 106 (SUPP_1), 13-13 , 2024
2024
COMBINING MAGNETICALLY ASSISTED AND MATRIX-ASSISTED 3D BIOPRINTING FOR ANISOTROPIC TISSUE ENGINEERING
SM Bakht, A Pardo, RL Reis, RMA Domingues, ME Gomes
Orthopaedic Proceedings 106 (SUPP_2), 59-59 , 2024
2024
MIRNA-LADEN MAGNETIC-RESPONSIVE BIOINK FOR TENDON AND ENTHESIS TISSUE ENGINEERING
CJP Silva, R Dominguez, SM Bakht, A Pardo, V Joris, AI Gonçalves, ...
Orthopaedic Proceedings 106 (SUPP_2), 74-74 , 2024
2024
Citations: 2
Automated Biofabrication of Multicellular Human Tendon Microphysiological Systems Within a Biomimetic Fibrillar Support Platform
RF Monteiro, SM Bakht, MG Florit, RL Reis, ME Gomes, R Domingues
TISSUE ENGINEERING PART A 29 (13-14) , 2023
2023
Bioinspired Hydrogels Promote Tenogenic Stem Cell Commitment by Synergistic Control over Topographical Cues and Growth Factor Signaling
SPB Teixeira, A Pardo, SM Bakht, MG Florit, RL Reis, ME Gomes, ...
TISSUE ENGINEERING PART A 29 (13-14) , 2023
2023
HUMAN 3D TENDON-ON-CHIP MODEL TO INTERROGATE THE MULTICELLULAR CROSSTALK IN TENDINOPATHY
SM Bakht, A Pardo, M Gomez-Florit, RMA Domingues, ME Gomes
TISSUE ENGINEERING PART A 29 (11-12), 788-789 , 2023
2023
MAGNETICALLY-ASSISTED 3D BIOPRINTING OF TISSUE ENGINEERED TENDONS
AP Montero, SM Bakht, M Gomez-Florit, SPB Teixeira, R Domingues, ...
TISSUE ENGINEERING PART A 29 (11-12), 189-190 , 2023
2023
DIRECTING STEM CELL COMMITMENT IN 3D BIOINSPIRED HYDROGELS BY GROWTH FACTOR SEQUESTRATION USING MOLECULARLY IMPRINTED NANOPARTICLES
SP Barbosa Teixeira, A Pardo, SM Bakht, M Gomez-Florit, RL Reis, ...
TISSUE ENGINEERING PART A 29 (11-12), 860-861 , 2023
2023
Writing 3D In Vitro Models of Human Tendon within a Biomimetic Fibrillar Support Platform
RF Monteiro, SM Bakht, M Gomez-Florit, FC Stievani, ALG Alves, RL Reis, ...
ACS Applied Materials & Interfaces 15 (44), 50598-50611 , 2023
2023
Citations: 23
Magnetically‐assisted 3D bioprinting of anisotropic tissue‐mimetic constructs
A Pardo, SM Bakht, M Gomez‐Florit, R Rial, RF Monteiro, SPB Teixeira, ...
Advanced Functional Materials 32 (50), 2208940 , 2022
2022
Citations: 81
TENDON DERIVED EXTRACELLULAR MATRIX HYDROGEL FOR INJECTION AND BIOPRINTING
AL Garcia Alves, FC Stievani, M Gomez-Florit, SM Bakht, ...
TISSUE ENGINEERING PART A 28, S338-S339 , 2022
2022
Tendon derived extracellular matrix hydrogel for injection and bioprinting
ALG Alves, FC Stievani, M Gomez-Florit, SM Bakht, JPH Pfeifer, ...
Mary Ann Liebert, Inc , 2022
2022
3D bioprinting of miniaturized tissues embedded in self‐assembled nanoparticle‐based fibrillar platforms
SM Bakht, M Gomez‐Florit, T Lamers, RL Reis, RMA Domingues, ...
Advanced Functional Materials 31 (46), 2104245 , 2021
2021
Citations: 48
Engineering next-generation bioinks with nanoparticles: moving from reinforcement fillers to multifunctional nanoelements
SM Bakht, A Pardo, M Gómez-Florit, RL Reis, RMA Domingues, ...
Journal of Materials Chemistry B 9 (25), 5025-5038 , 2021
2021
Citations: 48
Natural materials
M Gómez-Florit, RMA Domingues, SM Bakht, BB Mendes, RL Reis, ...
Biomaterials Science, 361-375 , 2020
2020
Citations: 7

MOST CITED SCHOLAR PUBLICATIONS

3D bioprinting for tissue and organ fabrication
YS Zhang, K Yue, J Aleman, K Mollazadeh-Moghaddam, SM Bakht, ...
Annals of biomedical engineering 45 (1), 148-163 , 2017
2017
Citations: 872
Rapid continuous multimaterial extrusion bioprinting
W Liu, YS Zhang, MA Heinrich, F De Ferrari, HL Jang, SM Bakht, ...
Advanced materials 29 (3), 1604630 , 2017
2017
Citations: 550
Elastomeric free-form blood vessels for interconnecting organs on chip systems
W Zhang, YS Zhang, SM Bakht, J Aleman, SR Shin, K Yue, M Sica, ...
Lab on a Chip 16 (9), 1579-1586 , 2016
2016
Citations: 140
Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors
A Hameed, KM Khan, ST Zehra, R Ahmed, Z Shafiq, SM Bakht, M Yaqub, ...
Bioorganic chemistry 61, 51-57 , 2015
2015
Citations: 89
Magnetically‐assisted 3D bioprinting of anisotropic tissue‐mimetic constructs
A Pardo, SM Bakht, M Gomez‐Florit, R Rial, RF Monteiro, SPB Teixeira, ...
Advanced Functional Materials 32 (50), 2208940 , 2022
2022
Citations: 81
Exploration of a library of triazolothiadiazole and triazolothiadiazine compounds as a highly potent and selective family of cholinesterase and monoamine oxidase inhibitors …
I Khan, SM Bakht, A Ibrar, S Abbas, S Hameed, JM White, UA Rana, ...
RSC advances 5 (27), 21249-21267 , 2015
2015
Citations: 55
3D bioprinting of miniaturized tissues embedded in self‐assembled nanoparticle‐based fibrillar platforms
SM Bakht, M Gomez‐Florit, T Lamers, RL Reis, RMA Domingues, ...
Advanced Functional Materials 31 (46), 2104245 , 2021
2021
Citations: 48
Engineering next-generation bioinks with nanoparticles: moving from reinforcement fillers to multifunctional nanoelements
SM Bakht, A Pardo, M Gómez-Florit, RL Reis, RMA Domingues, ...
Journal of Materials Chemistry B 9 (25), 5025-5038 , 2021
2021
Citations: 48
Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, in vitro bioevaluation and molecular docking …
SMA Abid, S Aslam, S Zaib, SM Bakht, M Ahmad, MM Athar, JM Gardiner, ...
Medchemcomm 8 (2), 452-464 , 2017
2017
Citations: 35
Symmetrical aryl linked bis-iminothiazolidinones as new chemical entities for the inhibition of monoamine oxidases: Synthesis, in vitro biological evaluation and molecular …
N Abbas, S Zaib, SM Bakht, A Ibrar, I Khan, S Batool, A Saeed, J Iqbal
Bioorganic Chemistry 70, 17-26 , 2017
2017
Citations: 24
Writing 3D In Vitro Models of Human Tendon within a Biomimetic Fibrillar Support Platform
RF Monteiro, SM Bakht, M Gomez-Florit, FC Stievani, ALG Alves, RL Reis, ...
ACS Applied Materials & Interfaces 15 (44), 50598-50611 , 2023
2023
Citations: 23
Human Tendon‐on‐Chip: Unveiling the Effect of Core Compartment‐T Cell Spatiotemporal Crosstalk at the Onset of Tendon Inflammation
SM Bakht, A Pardo, M Gomez‐Florit, D Caballero, SC Kundu, RL Reis, ...
Advanced Science 11 (41), 2401170 , 2024
2024
Citations: 19
Guiding stem cell tenogenesis by modulation of growth factor signaling and cell‐scale biophysical cues in bioengineered constructs
SPB Teixeira, A Pardo, SM Bakht, M Gomez‐Florit, RL Reis, ME Gomes, ...
Advanced Functional Materials 34 (29), 2312961 , 2024
2024
Citations: 15
Perforated and Endothelialized elastomeric tubes for vascular modeling
M Duchamp, SM Bakht, J Ju, IK Yazdi, W Zhang, YS Zhang
Advanced materials technologies 4 (9), 1800741 , 2019
2019
Citations: 10
Natural materials
M Gómez-Florit, RMA Domingues, SM Bakht, BB Mendes, RL Reis, ...
Biomaterials Science, 361-375 , 2020
2020
Citations: 7
Prescribing Practice of Antibiotics Amongst Children; Physicians’ Behavior and Knowledge
H Ullah, SA Khan, SM Bakht, Y Tehseen, S Karim, A Baseer, G Murtaza
Lat. Am. J. Pharm 31 (9), 1367-9 , 2012
2012
Citations: 4
Contactless 3D acoustic assembly of liquid capsules for bottom-up tissue engineering
MER Luiz, M Carreira, S Nadine, R Tognato, R Parolini, SM Bakht, ...
Biomaterials, 123555 , 2025
2025
Citations: 3
3D writing of multicellular tendon-on-CNC-chip models
RF Monteiro, SM Bakht, M Gomez-Florit, RL Reis, ME Gomes, ...
Orthopaedic Proceedings 106 (SUPP_2), 15-15 , 2024
2024
Citations: 3
MIRNA-LADEN MAGNETIC-RESPONSIVE BIOINK FOR TENDON AND ENTHESIS TISSUE ENGINEERING
CJP Silva, R Dominguez, SM Bakht, A Pardo, V Joris, AI Gonçalves, ...
Orthopaedic Proceedings 106 (SUPP_2), 74-74 , 2024
2024
Citations: 2
Engineering the curve of fate: How geometry directs paneth cell localization in intestinal organoids
SM Bakht, JF Mano
Matter 8 (8) , 2025
2025

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

2020: Natural Materials Manuel Gómez-Florit,Rui M.A. Domingues,Syeda Mahwish Bakht,Bárbara B. Mendes,Rui L. Reis,Manuela E. Gomes
Biomaterials Science 1.3.6 Elsevier 2020 (10.1016/

2019: Perforated and Endothelialized Elastomeric Tubes for Vascular Modeling Margaux Duchamp, Syeda Mahwish Bakht, Jie Ju, Iman K. Yazdi, Weijia Zhang, and Yu Shrike Zhang Advanced Materials Technologies (

2016: Pyrazolobenzothiazine-based carbothioamides as new structural leads for the inhibition of monoamine oxidases: design, synthesis, in-vitro bioevaluation and molecular docking studies. Syed Mobasher Ali Abid, Sana Aslam, Sumera Zaib, Syeda Mahwish Bakht, Matloob Ahmad, Muhammad Makshoof Athar, John M. Gardiner and Jamshed Iqbal. Med. Chem. Commun., 2017,8, 452-464

2016: Symmetrical aryl linked bis-iminothiazolidinones as new chemical entities for the inhibition of monoamine oxidases: Synthesis, in vitro biological evaluation and molecular modelling analysis. Abbas N, Zaib S, Bakht SM, Ibrar A, Khan I, Batool S, Saeed A, Iqbal J. Bioorg Chem. 2016 Nov 9. doi: 10.1016/j..

2016: Rapid Continuous Multimaterial Extrusion Bioprinting. Wanjun Liu, Yu Shrike Zhang, Marcel A. Heinrich, Fabio De Ferrari, Hae Lin Jang, Syeda Mahwish Bakht, Mario Mois´es Alvarez, Jingzhou Yang, Yi-Chen Li, Grissel Trujillo-de Santiago, Amir K. Miri, Kai Zhu, Parastoo Khoshakhlagh, Gyan Prakash,Hao Cheng, Xiaofei Guan, Zhe Zhong, Jie Ju, Geyunjian Zhu, Xiangyu Jin, Su Ryon Shin, Mehmet Remzi Dokmeci, and Ali Khademhosseini. Adv Mater. 2016 Nov 17. doi: 10.1002/

2016: Elastomeric Free-Form Blood Vessels for Interconnecting Organs on Chip Systems. Weijia Zhang, Yu Shrike Zhang, Syeda Mahwish Bakht, Julio Aleman, Su-Ryon Shin, Kan Yue, Marco Sica, João Ribas, Margaux Duchamp, Ramin Banan Sadeghian, Duckjin Kim, Mehmet Remzi Dokmeci Anthony Atala, and Ali Khademhosseini. Lab Chip. 2016 Apr 26;16(9):1579-86. doi: 10.1039/c6lc00001k.

2016:3D Bioprinting for Tissue and Organ Fabrication. Yu Shrike Zhang, Kan Yue, Julio Aleman, Kamyar Mollazadeh-Moghaddam, Syeda Mahwish Bakht, Jingzhou Yang, Weitao Jia, Valeria Dell'Erba, Pribpandao Assawes, Su Ryon Shin, Mehmet Remzi Dokmeci, Rahmi Oklu, Ali Khademhosseini Ann Biomed Eng 2016 Apr 28. Epub 2016 Apr 28.

2015: Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors. Abdul Hameed, Khalid Mohammed Khan, Syeda Tazeen Zehra, Ramasa Ahmed, Zahid Shafiq, Syeda Mahwish Bakht, Muhammad Yaqub, Mazhar Hussain, Antonio de la Vega de León, Norbert Furtmann, Jürgen Bajorath, Hazoor Ahmad Shad, Muhammad Nawaz Tahir, Jamshed Iqbal. Bioorg. Chem Volume 61, 2015, 8 Pages 51–57.

2015: Exploration of a library of triazolothiadiazole and triazolothiadiazine compounds as a highly potent and selective family of cholinesterase and monoamine oxidase inhibitors: Design, synthesis, X-ray diffraction analysis and molecular docking studies. Imtiaz Khan,Syeda Mahwish Bakht, Aliya Ibrar,Saba Abbas,Shahid Hameed,Jonathan M. White,Usman Ali Rana,Sumera Zaib,Mohammad Shahid and Jamshed Iqbal. RSC Adv., 2015, 5, 21249-21267.

INDUSTRY EXPERIENCE

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