Maria Lucia Reale

Verified @gmail.com

Medical Oncologist, Department of Oncology
"Vito Fazzi" Hospital, Lecce

RESEARCH, TEACHING, or OTHER INTERESTS

Oncology, General Neuroscience
49

Scopus Publications

Scopus Publications

  • Amivantamab in advanced non–small cell lung cancer with epidermal growth factor receptor exon 20 insertion mutations: Real-world data from the Italian ATLAS Registry
    Francesco Passiglia, Antonio Passaro, Eleonora Gariazzo, Michele Montrone, Giulia Pasello, Marcello Tiseo, Marco Russano, Fabrizio Citarella, Lucia Anna Muscarella, Daniele Pozzessere, Emilio Bria, Elisa Roca, Giulio Cerea, Alessandro Russo, Salvatore Grisanti, Alessandra Bulotta, Antonello Veccia, Federica Biello, Giuseppe Lo Russo, Sara Pilotto, Carlo Genova, Diego Cortinovis, Gabriele Minuti, Giulia Meoni, Stefania Gori, Maria Lucia Reale, Alberto Pavan, Matteo Ramundo, Francesco Grossi, Hector Soto Parra, Vieri Scotti, Tiziana Vavalà, Claudio Sini, Concetta Sergi, Giacomo Pelizzari, Rita Chiari, Brigida Stanzione, Adolfo Favaretto, Francesco Leone, Anna Cecilia Bettini, Maria Pagano, Luca Tondulli, Luca Toschi, Gaetano Lacidogna, Chiara Bennati, Silvia Catanese, Umberto Malapelle, Diana Giannarelli, Silvia Novello
    Cancer, 2026
    Background The treatment landscape for metastatic non–small cell lung cancer (NSCLC) with EGFR exon 20 insertion ( ex20ins ) is rapidly evolving, with the development of specific targeted therapies. The bispecific antibody amivantamab is the new standard of care for this population but real‐world safety and efficacy data are lacking. Methods This is a multicenter, retrospective, observational study conducted on advanced NSCLC patients harboring EGFRex20ins who were included within the ATLAS Italian real‐world registry between January and December 2024. Clinical‐pathological features, treatment effectiveness, and safety outcomes were retrospectively collected and analyzed. Results A total of 119 advanced NSCLC patients harboring EGFRex20ins mutations were included. Seventy‐six (63.9%) and 24 (20.2%) received first‐line platinum‐based chemotherapy with or without immunotherapy, respectively. Overall 64 of 119 patients received single agent amivantamab in the subsequent lines. Treatment‐related adverse events (TRAEs) of any grade and grade 3–4 were reported in 68.8% and 10.9%, respectively, including skin rash (56%, G3 9.4%), asthenia (9%), peripheral edema (8%), and infusion‐related reactions (9.4%, G3 1.5%). Dose interruptions, reductions, and discontinuations due to TRAEs occurred in 20.3%, 12.5%, and 3.1% patients, respectively. The objective response rate was 37.5%, the DCR was 66.2%, the median progression‐free survival (mPFS) was 9.6 months, and the median overall survival was 16.9 months under amivantamab. Among the 23 patients with brain metastasis, 13% achieved a partial intracranial (ic) response and 43.5% a stable disease. The ic mPFS was 11.6 months. Conclusion This data confirms the efficacy and safety profile of amivantamab observed in the CHRYSALIS trial, showing a meaningful clinical benefit in a heavily pretreated real‐world population.
  • Braf-mutant metastatic non–small-cell lung cancer: Real world data from the Italian biomarker atlas database
    Claudio Sini, Alessandro Russo, Diego Cortinovis, Lucia Anna Muscarella, Marcello Tiseo, Emilio Bria, Salvatore Grisanti, Pierluigi Piovano, Antonello Veccia, Lorenzo Antonuzzo, Fabrizio Citarella, Sara Pilotto, Maria Lucia Reale, Daniele Pignataro, Elisa Roca, Lorenzo Calvetti, Pamela Pizzutilo, Gabriele Minuti, Giacomo Pelizzari, Greta Alì, Anna Bettini, Alberto Pavan, Diego Signorelli, Serena Ricciardi, Giulia Meoni, Concetta Sergi, Carlo Genova, Vieri Scotti, Tiziana Vavalà, Stefania Gori, Giulia Pasello, Paolo Pedrazzoli, Rita Chiari, Alessandro D’Aveni, Roberta Buosi, Luca Toschi, Hector Soto Parra, Lucio Buffoni, Brigida Stanzione, Cinzia Ortega, Cristina Zannori, Diana Giannarelli, Umberto Malapelle, Silvia Novello, Francesco Passiglia, Editta Baldini
    European Journal of Cancer, 2026
    BACKGROUND: BRAF mutations identify a small subgroup of patients (pts) with non-small cell lung cancer (NSCLC). Dabrafenib/trametinib (D/T) combination is associated with high response rates and durable anti-tumor activity in BRAF-V600-mutants. Several open questions still remain unanswered in clinical practice, including the efficacy of treatments based on clinical and molecular characteristics, the activity in patients with brain metastases, the optimal sequence with immunotherapy-based therapies. Here we present outcomes among advanced BRAF-mutant NSCLC patients from the Italian ATLAS registry. METHODS: Patients with metastatic BRAF-mutated NSCLC were included. Clinical-pathological features, treatment effectiveness and safety outcomes were retrospectively collected from the Italian real-world ATLAS registry. RESULTS: A total of 244 BRAF-mutated NSCLC pts were enrolled, including 70 % V600E mutations. The median PFS of first line D/T was 19.8 months (95 % CI: 10.7-29.0), with a 2-year OS rate of 65.4 % and a PFS2 of 6.6 months (95 % CI: 0-14.3). The activity of D/T differs among sex (mPFS was 13.6 mos and 25.3 mos and 2-yr OS rate were 54.9 % and 72.3 % in males and females, respectively) and smoking status (mPFS was 18.4 mos, 25.6 mos and 24 mos in never, former and current smokers, respectively). Concomitant MET amplification was associated with a shorter median PFS (mPFS was 13.6 mos vs. 44.3 mos with and without MET amplification respectively) in pts treated with D/T as 1st line. CONCLUSIONS: These data confirm the efficacy and safety of first line D/T in BRAF V600E-mutated pts in the real-world setting consistently with prior studies, suggesting a differential activity among key clinical-molecular subgroups.
  • Adjuvant atezolizumab in surgically resected NSCLC patients with PD-L1 expression ≥ 50%: real-world data from the Italian ATLAS registry
    Francesco Passiglia, Maria Lucia Reale, Giulia Pasello, Giuseppe Viscardi, Ilaria Attili, Francesca Mazzoni, Domenico Galetta, Chiara Catania, Kallopi Andrikou, Alessandro Russo, Tiziana Vavala, Alessandra Bulotta, Lorenzo Calvetti, Anna Maria Carta, Salvatore Grisanti, Sabrina Mariotti, Giulia La Cava, Alessandra Dodi, Vieri Scotti, Teresa Del Giudice, Gabriele Minuti, Elio Gregory Pizzutillo, Rita Chiari, Carminia Maria Della Corte, Carlo Genova, Giuseppe Lo Russo, Daniele Pignataro, Daniele Pozzessere, Elisa Roca, Luca Toschi, Chiara Bennati, Gloria Borra, Anna Bettini, Adolfo Favaretto, Alain Gelibter, Stefania Gori, Fabrizio Tabbò, Maria Pagano, Alberto Pavan, Lorenzo Belluomini, Luca Tondulli, Concetta Sergi, Brigida Stanzione, Umberto Malapelle, Silvia Novello, Emilio Bria
    Oncologist, 2026
    Background This study describes clinical characteristics, treatment patterns as well as safety outcomes of NSCLC patients harboring PD-L1 ≥ 50% who received adjuvant atezolizumab within the Italian real-world scenario. Methods Patients with surgically resected NSCLC harboring EGFR/ALK wild type disease and PD-L1 TPS ≥ 50%, who received at least one cycle of adjuvant atezolizumab were included. Clinical-pathological and molecular data, safety and efficacy outcomes were collected from the Italian ATLAS real-world registry. Results A total of 132 patients were included across 45 Italian centers between July 2022 and August 2024. Lobectomy was performed in 81.1% of cases, with 8.3% pathological stage IIA, 40.2% stage IIB, 43.9% stage IIIA, and 7.6% stage IIIB, according to the eighth TNM staging edition. The median number of atezolizumab cycles was 12.5 (range: 1-20). Treatment related adverse events (TRAEs) during atezolizumab were reported in 44 patients (33.3%), including 11 (8.3%) who experienced multiple TRAEs. Grade ≥ 3 TRAEs were reported in 21 cases (15.9%), leading to treatment discontinuation in 18 (13.6%). The median time to the first onset of TRAEs was 89 days (range: 3-390 days). 15 patients experienced a disease recurrence, including 6 locoregional-only and 9 distant relapses, with a median time since surgery of 13.3 months. Conclusion This study showed that the safety profile of adjuvant atezolizumab outside of a clinical trial context was comparable to the IMPower-010 study, highlighting the value of the Italian ATLAS registry as source of real-word evidence to optimize the clinical management of NSCLC patients.
  • Bone metastases in NSCLC: Modern paradigms in management and supportive care
    Gabriele Minuti, Giorgia Pasqualini, Alice Avancini, Niccolò Giaj-Levra, Francesca Colonese, Alessandro Di Federico, Alessandra Fozza, Michele Montrone, Emanuela Olmetto, Edoardo Pastorello, Maria Lucia Reale, Silvia Teresa Riva, Elisa Roca, Claudio Sini, Giuseppe Viscardi, Sara Pilotto, Francesco Passiglia
    Cancer Treatment Reviews, 2026
    HighlightsBone metastases occur in up to 60% of NSCLC patients during disease progression Bone-targeted agents reduce SREs and may enhance immunotherapy efficacy Radiotherapy is key for pain control and spinal stability in bone metastases Exercise is safe and may preserve bone health in patients with bone metastases Nutritional support helps preserve muscle mass and improves treatment tolerance Abstract Bone metastases (BoMs) are a frequent complication in advanced non-small-cell lung cancer (NSCLC), affecting approximately one third of patients at diagnosis and 35-60% during the disease course.BoMs increase the risk of skeletal-related events (SREs), which have a detrimental impact on prognosis, performance status, and quality of life (QoL).Management of BoMs in NSCLC requires a multimodal approach.Although systemic anti-cancer therapies remain the cornerstone, the optimal management of BoMs in NSCLC also encompasses bone-targeted agents (BTAs) such as bisphosphonates and denosumab, local treatments including radiotherapy and surgical interventions, and supportive care strategies aimed at preventing SREs, alleviating pain, preserving mobility, and maintaining QoL.This review provides an updated overview of best practices for managing BoMs in NSCLC, covering diagnostic work-up, therapeutic strategies, and the growing role of multidisciplinary care.It emphasizes the importance of supportive interventions, including nutrition and physical activity, to optimize outcomes in the era of targeted and immune-based therapies, alongside comprehensive simultaneous care.
  • Real-world outcomes of second-line carboplatin plus pemetrexed after first-line osimertinib in EGFR-mutant advanced NSCLC: An international multicentre cohort study
    Igor Gomez-Randulfe, Federico Monaca, Ornella Cantale, Maria Lucia Reale, Loredana Mrak, Lodovica Zullo, Sofia Silva Diaz, Marta Zaragoza Bueno, Marya Alejandra Maridueña Moreno, Charlotte Davis, Samantha Cox, Daniel Lee, Riyaz Shah, Tom Geldart, Javier Baena, Jose Carlos Benitez, M.A. Rosario Garcia Campelo, Jordi Remon, David Planchard, Domenico Galetta, Marcello Tiseo, Diego Cortinovis, Giulio Metro, Emilio Bria, Francesco Passiglia, Silvia Novello, Raffaele Califano
    Lung Cancer, 2025
  • Advanced-stage ALK-positive non–small-cell lung cancer (NSCLC) patients: Real-world treatment patterns and outcomes from the Italian biomarker ATLAS database
    Maria Lucia Reale, Daniela Scattolin, Antonio Vitale, Francesco Passiglia, Salvatore Grisanti, Marianna Macerelli, Domenico Galetta, Claudio Sini, Gabriele Minuti, Fabrizio Citarella, Elisa Roca, Francesco Agustoni, Alessandra Dodi, Diego Cortinovis, Lorenzo Belluomini, Serena Ricciardi, Antonello Veccia, Elio Gregory Pizzutilo, Vieri Scotti, Greta Alì, Francesca Mazzoni, Alessandro Russo, Daniele Pignataro, Alessandra Bulotta, Pierluigi Piovano, Concetta Sergi, Anna Bettini, Carlo Genova, Alberto Pavan, Hector José Soto Parra, Cinzia Ortega, Daniele Pozzessere, Tiziana Vavalà, Rita Chiari, Cristina Zannori, Alessandro D’Aveni, Giulia Meoni, Diana Giannarelli, Umberto Malapelle, Silvia Novello, Emilio Bria, Giulia Pasello
    Lung Cancer, 2025
  • Current diagnostic and therapeutical approaches to bone metastases in patients with non-small cell lung cancer: A cross-sectional study
    Alice Avancini, Niccolò Giaj-Levra, Gabriele Minuti, Giorgia Pasqualini, Francesca Colonese, Alessandro Di Federico, Alessandra Fozza, Michele Montrone, Emanuela Olmetto, Edoardo Pastorello, Maria Lucia Reale, Silvia Teresa Riva, Elisa Roca, Claudio Sini, Giuseppe Viscardi, Francesco Passiglia, Sara Pilotto
    Lung Cancer, 2025
    INTRODUCTION: The current study aims to investigate the current practice of bone metastasis management in patients with non-small cell lung cancer. METHODS: An online questionnaire was administered to 92 oncologists. A survey was developed and revised by dedicated experts and was composed of five sections: i) general and work characteristics, ii) diagnostic issues, ii) bone-targeted agents issues, iii) radiotherapy issues, and iv) supportive care issues. Descriptive statistics was applied. RESULTS: The 18F-FDG PET is the preferred evaluation for skeletal assessment for both patients with (62 %) and without (54 %) bone lesions at the CT scan; MRI (63 %) and 18F-FDG PET (61 %) are the most chosen radiographic assessments when a bone oligoprogression is suspected. The number of bone metastatic lesions was the main factor considered when deciding whether to start bone-targeted agents (57 %). In choosing between bone-targeted agents, renal toxicity was the most considered factor (62 %). Over half of the participants did not stop the systemic treatment during stereotactic radiotherapy (68 %) and considered re-irradiation on progressive bone metastases at least 6 months after prior radiotherapy (55 %). Overall, 64 % and 41 % of participants assessed patients' body weight and physical activity, respectively. Oral nutritional supplements or a specific diet were recommended by 34 % and 46 % of clinicians; 40 % of them also advised their patients to increase their physical activity levels, while 54 % were worried that exercise might increase the risk of skeletal-related adverse events. CONCLUSIONS: Lung-cancer dedicated clinicians pay great attention to bone metastases-related diagnostic, bone-targeted agents, and radiotherapy issues, whereas the integration of supportive care approaches seem less standardized.
  • Actionable NSCLC Mutation Identification by Comprehensive Genomic Profiling for Clinical Trial Enrollment: The European Program for the Routine Testing of Patients With Advanced Lung Cancer (EPROPA)
    Francesco Passiglia, Angela Listì, Paolo Bironzo, Alessandra Merlini, Federica Benso, Francesca Napoli, Francesca Alice Barbu, Vanessa Zambelli, Fabrizio Tabbò, Maria Lucia Reale, Claudio Sini, Elisa Roca, Paola Adriana Taveggia, Francesca Simionato, Lucio Buffoni, Laura Mazilu, Vito Barbieri, Daniele Pignataro, Antonio Araujo, Luis Paz-Ares, Enriqueta Felip, Nevena Secen, Alina Comanescu, Kleida Mati Ramizi, Anna Cecilia Bettini, Vieri Scotti, Helena Linardou, Katja Mohorcic, Giulia Meoni, Diana Giannarelli, Marco Volante, Umberto Malapelle, Stefania Vallone, Giorgio Scagliotti, Luisella Righi, Silvia Novello
    Journal of Thoracic Oncology, 2025
  • The evolving landscape of stage III unresectable non-small cell lung cancer “between lights and shadows”
    Marco Donatello Delcuratolo, Veronica Crespi, Giorgio Saba, Andrea Mogavero, Valerio Maria Napoli, Edoardo Garbo, Massimiliano Cani, Antonio Ungaro, Maria Lucia Reale, Alessandra Merlini, Enrica Capelletto, Paolo Bironzo, Mario Levis, Umberto Ricardi, Silvia Novello, Francesco Passiglia
    Cancer Treatment Reviews, 2025
  • MET exon 14 skipping mutations in non-small-cell lung cancer: real-world data from the Italian biomarker ATLAS database
    M.L. Reale, F. Passiglia, F. Cappuzzo, G. Minuti, M. Occhipinti, A. Bulotta, A. Delmonte, C. Sini, D. Galetta, E. Roca, G. Pelizzari, D. Cortinovis, E. Gariazzo, S. Pilotto, F. Citarella, E. Bria, P. Muscolino, D. Pozzessere, A. Carta, D. Pignataro, L. Calvetti, F. Leone, M. Banini, C. Di Micco, E. Baldini, A. Favaretto, U. Malapelle, S. Novello, G. Pasello, M. Tiseo
    ESMO Open, 2024
    BACKGROUND: Mesenchymal-epithelial transition (MET) exon 14 (METex14) skipping mutation is a rare alteration in non-small-cell lung cancer (NSCLC), occurring in about 3%-4% of cases. Here we report disease and patient characteristics, and efficacy and tolerability of MET inhibitors among advanced METex14 NSCLC patients from the Italian real-world registry ATLAS. MATERIALS AND METHODS: Clinical-pathological and molecular data, and treatment efficacy/tolerability outcomes were retrospectively collected from the ATLAS registry. RESULTS: From July 2020 to July 2023 a total of 146 METex14 advanced NSCLC patients were included across 27 Italian centers. Median age was 74 years, and most patients were male (52%), with an Eastern Cooperative Oncology Group performance status < 2 (72%) and adenocarcinoma subtype (83%). One hundred and twenty-five out of 146 (86%) patients received at least one line of systemic anticancer therapy. Fifty-six (38%) were treated with capmatinib and 34 (23%) with tepotinib. 29% and 52% of them received targeted treatment in the first and second line, respectively. In the cohort of patients treated with MET inhibitors, the response rate (RR) was 37% (33% in previously treated patients and 46% in treatment-naïve) with a disease control rate of 62%. With a median follow-up of 10.8 months, progression-free survival was 6.6 months [95% confidence interval (CI) 4.3-8.3 months] and overall survival was 10.7 months (95% CI 7.2-19.3 months). In patients with measurable brain metastases (17 cases), the intracranial RR was 41%. Grade ≥3 treatment-related adverse events (TRAEs) occurred in 12% of patients with grade 3 peripheral edema in 7% of cases. A fatal adverse reaction occurred in one patient due to pneumonitis. TRAEs-related dose reduction and discontinuation were reported in 6% and 8% of cases, respectively. CONCLUSION: Capmatinib and tepotinib represent an effective treatment option in NSCLC patients with METex14. Real-world efficacy outcomes are worse than those reported in prospective clinical trials. Their activity is more pronounced in the treatment-naïve population, suggesting that this is the right setting in the management of patients with METex14.
  • The biomarkers ATLAS: An audit on 1100 non-small cell lung cancer from an Italian knowledge-based database
    Umberto Malapelle, Francesco Passiglia, Francesco Pepe, Pasquale Pisapia, Maria Lucia Reale, Diego Cortinovis, Filippo Fraggetta, Domenico Galetta, Edoardo Garbo, Paolo Graziano, Fabio Pagni, Giulia Pasello, Pierluigi Piovano, Sara Pilotto, Marcello Tiseo, Carlo Genova, Luisella Righi, Giancarlo Troncone, Silvia Novello
    Lung Cancer, 2024
  • Consolidative thoracic radiation therapy for extensive-stage small cell lung cancer in the era of first-line chemoimmunotherapy: preclinical data and a retrospective study in Southern Italy
    Vito Longo, Carminia Maria Della Corte, Alessandro Russo, Francesca Spinnato, Francesca Ambrosio, Riccardo Ronga, Antonella Marchese, Teresa Del Giudice, Concetta Sergi, Francesca Casaluce, Marina Gilli, Michele Montrone, Valerio Gristina, Vincenzo Sforza, Maria Lucia Reale, Raimondo Di Liello, Alberto Servetto, Helga Lipari, Claudio Longhitano, Laura Vizzini, Anna Manzo, Antonella Cristofano, Loretta Paolelli, Annalisa Nardone, Simona De Summa, Antonella Perrone, Carmela Bisceglia, Caterina Derosa, Valerio Nardone, Giuseppe Viscardi, Domenico Galetta, Fabiana Vitiello
    Frontiers in Immunology, 2024
  • Sotorasib in KRASp.G12C mutated advanced NSCLC: Real-world data from the Italian expanded access program
    Francesco Passiglia, Maria Lucia Reale, Giuseppe Lo Russo, Giulia Pasello, Gabriele Minuti, Alessandra Bulotta, Domenico Galetta, Giacomo Pelizzari, Claudio Sini, Emilio Bria, Elisa Roca, Sara Pilotto, Carlo Genova, Giulio Metro, Fabrizio Citarella, Rita Chiari, Diego Cortinovis, Angelo Delmonte, Alessandro Russo, Marcello Tiseo, Giulio Cerea, Annamaria Carta, Vieri Scotti, Tiziana Vavalà, Marta Brambilla, Lucio Buffoni, Roberta Buosi, Chiara Catania, Stefania Gori, Salvatore Grisanti, Francesco Agustoni, Edoardo Garbo, Umberto Malapelle, Silvia Novello
    Lung Cancer, 2024
  • Checkpoint inhibitors in older patients with advanced non-small cell lung cancer
    Maria Lucia Reale, Gianpiero Diego Romano, Loretta Paolelli, Silvana Leo
    Critical Reviews in Oncology Hematology, 2023
  • Analysis of the adequacy of control arms in oncology randomised clinical trials published between 2017 and 2021: a meta-research study
    Alessandro Rossi, Giacomo Aimar, Marco Audisio, Maristella Bungaro, Andrea Caglio, Raimondo Di Liello, Teresa Gamba, Piera Gargiulo, Eleonora Ghisoni, Pasquale Lombardi, Laura Marandino, Annapaola Mariniello, Chiara Paratore, Maria Lucia Reale, Federica Trastu, Valentina Tuninetti, Fabio Turco, Alessandra Fabi, Francesco Perrone, Massimo Di Maio
    European Journal of Cancer, 2023
  • Time trends in health-related quality of life assessment and reporting within publications of oncology randomised phase III trials: a meta-research study
    Laura Marandino, Federica Trastu, Eleonora Ghisoni, Pasquale Lombardi, Annapaola Mariniello, Maria Lucia Reale, Giacomo Aimar, Marco Audisio, Maristella Bungaro, Andrea Caglio, Raimondo Di Liello, Teresa Gamba, Piera Gargiulo, Chiara Paratore, Alessandro Rossi, Valentina Tuninetti, Fabio Turco, Francesco Perrone, Massimo Di Maio
    BMJ Oncology, 2023
  • Subgroup analyses in randomized phase III trials of systemic treatments in patients with advanced solid tumours: a systematic review of trials published between 2017 and 2020
    C. Paratore, C. Zichi, M. Audisio, M. Bungaro, A. Caglio, R. Di Liello, T. Gamba, P. Gargiulo, A. Mariniello, M.L. Reale, F. Perrone, M. Di Maio
    ESMO Open, 2022
  • Comparing T Cell Subsets in Broncho-Alveolar Lavage (BAL) and Peripheral Blood in Patients with Advanced Lung Cancer
    Annapaola Mariniello, Fabrizio Tabbò, Davide Indellicati, Martina Tesauro, Nicole Alessia Rezmives, Maria Lucia Reale, Angela Listì, Enrica Capelletto, Simona Carnio, Valentina Bertaglia, Caterina Mecca, Lorena Consito, Marco De Filippis, Maristella Bungaro, Chiara Paratore, Massimo Di Maio, Francesco Passiglia, Luisella Righi, Dario Sangiolo, Silvia Novello, Massimo Geuna, Paolo Bironzo
    Cells, 2022
  • A systematic review and meta-analysis of trials assessing PD-1/PD-L1 immune checkpoint inhibitors activity in pre-treated advanced stage malignant mesothelioma
    Marco Tagliamento, Paolo Bironzo, Hubert Curcio, Emmanuele De Luca, Daniele Pignataro, Simonetta G. Rapetti, Marco Audisio, Valentina Bertaglia, Chiara Paratore, Maristella Bungaro, Emanuela Olmetto, Elisa Artusio, Maria Lucia Reale, Clizia Zichi, Enrica Capelletto, Simona Carnio, Lucio Buffoni, Francesco Passiglia, Silvia Novello, Giorgio Vittorio Scagliotti, Massimo Di Maio
    Critical Reviews in Oncology Hematology, 2022
  • Molecular Testing and Treatment Strategies in RET-Rearranged NSCLC Patients: Stay on Target to Look Forward
    Maria Lucia Reale, Valentina Bertaglia, Angela Listì, Silvia Novello, Francesco Passiglia
    Journal of Molecular Pathology, 2022
  • Management of Oligoprogression in Patients with Metastatic NSCLC Harboring ALK Rearrangements
    Chiara Pisano, Marco De Filippis, Francesca Jacobs, Silvia Novello, Maria Lucia Reale
    Cancers, 2022
  • Epidermal growth factor receptor exon 20 insertion variants in non-small cell lung cancer patients
    Umberto Malapelle, Sara Pilotto, Maria Lucia Reale, Francesco Passiglia, Pasquale Pisapia, Francesco Pepe, Lorenzo Belluomini, Domenico Galetta, Diego Cortinovis, Marcello Tiseo, Antonio Passaro, Davide Seminati, Fabio Pagni, Hector Soto Parra, Maria Rita Migliorino, Danilo Rocco, Giancarlo Troncone, Silvia Novello
    Critical Reviews in Oncology Hematology, 2022
  • Major breakthroughs in lung cancer adjuvant treatment: Looking beyond the horizon
    Francesco Passiglia, Valentina Bertaglia, Maria Lucia Reale, Marco Donatello Delcuratolo, Fabrizio Tabbò, Emanuela Olmetto, Enrica Capelletto, Paolo Bironzo, Silvia Novello
    Cancer Treatment Reviews, 2021
  • Repositioning PARP inhibitors in the treatment of thoracic malignancies
    Francesco Passiglia, Maria Lucia Reale, Valeria Cetoretta, Elena Parlagreco, Francesca Jacobs, Angela Listì, Luisella Righi, Paolo Bironzo, Silvia Novello, Giorgio Vittorio Scagliotti
    Cancer Treatment Reviews, 2021
  • Immune-checkpoint inhibition in stage III unresectable NSCLC: Challenges and opportunities in the post-PACIFIC era
    Francesco Passiglia, Gianmarco Leone, Emanuela Olmetto, Marco Donatello Delcuratolo, Fabrizio Tabbò, Maria Lucia Reale, Valentina Bertaglia, Lorena Consito, Paolo Bironzo, Enrica Capelletto, Silvia Novello
    Lung Cancer, 2021
  • Predicting immunotherapy outcomes under therapy in patients with advanced NSCLC using dNLR and its early dynamics
    Laura Mezquita, Isabel Preeshagul, Edouard Auclin, Diana Saravia, Lizza Hendriks, Hira Rizvi, Wungki Park, Ernest Nadal, Patricia Martin-Romano, Jose C. Ruffinelli, Santiago Ponce, Clarisse Audigier-Valette, Simona Carnio, Felix Blanc-Durand, Paolo Bironzo, Fabrizio Tabbò, Maria Lucia Reale, Silvia Novello, Matthew D. Hellmann, Peter Sawan, Jeffrey Girshman, Andrew J. Plodkowski, Gerard Zalcman, Margarita Majem, Melinda Charrier, Marie Naigeon, Caroline Rossoni, AnnaPaola Mariniello, Luis Paz-Ares, Anne Marie Dingemans, David Planchard, Nathalie Cozic, Lydie Cassard, Gilberto Lopes, Nathalie Chaput, Kathryn Arbour, Benjamin Besse
    European Journal of Cancer, 2021
  • Early progression in non-small cell lung cancer (Nsclc) with high pd-l1 treated with pembrolizumab in first-line setting: A prognostic scoring system based on clinical features
    Antonio Passaro, Silvia Novello, Diana Giannarelli, Emilio Bria, Domenico Galetta, Alain Gelibter, Maria Lucia Reale, Simona Carnio, Emanuele Vita, Alessio Stefani, Pamela Pizzutilo, Valeria Stati, Ilaria Attili, Filippo de Marinis
    Cancers, 2021
  • Clinical and molecular features of epidermal growth factor receptor (Egfr) mutation positive non‐small‐cell lung cancer (nsclc) patients treated with tyrosine kinase inhibitors (tkis): Predictive and prognostic role of co‐mutations
    Paolo Bironzo, Maria Lucia Reale, Tessa Sperone, Fabrizio Tabbò, Andrea Caglio, Angela Listì, Francesco Passiglia, Massimo Di Maio, Luisella Righi, Federico Bussolino, Giorgio V. Scagliotti, Silvia Novello
    Cancers, 2021
  • Adoption of multiple primary endpoints in phase III trials of systemic treatments in patients with advanced solid tumours. A systematic review
    Clizia Zichi, Chiara Paratore, Piera Gargiulo, Annapaola Mariniello, Maria Lucia Reale, Marco Audisio, Maristella Bungaro, Andrea Caglio, Teresa Gamba, Francesco Perrone, Massimo Di Maio
    European Journal of Cancer, 2021
  • Dealing with NSCLC EGFR mutation testing and treatment: A comprehensive review with an Italian real-world perspective
    Umberto Malapelle, Sara Pilotto, Francesco Passiglia, Francesco Pepe, Pasquale Pisapia, Luisella Righi, Angela Listì, Paolo Bironzo, Lorenzo Belluomini, Fabrizio Tabbò, Maria Lucia Reale, Gianluca Russo, Caterina De Luca, Silvia Novello, Giancarlo Troncone
    Critical Reviews in Oncology Hematology, 2021
  • RAS as a positive predictive biomarker: focus on lung and colorectal cancer patients
    Umberto Malapelle, Francesco Passiglia, Chiara Cremolini, Maria Lucia Reale, Francesco Pepe, Pasquale Pisapia, Antonio Avallone, Diego Cortinovis, Alfonso De Stefano, Matteo Fassan, Gabriella Fontanini, Domenico Galetta, Calogero Lauricella, Angela Listì, Fotios Loupakis, Fabio Pagni, Filippo Pietrantonio, Sara Pilotto, Luisella Righi, Andrea Sartore Bianchi, Hector Soto Parra, Marcello Tiseo, Michela Verzè, Giancarlo Troncone, Silvia Novello
    European Journal of Cancer, 2021
  • Immune-checkpoint inhibitors combinations in metastatic nsclc: New options on the horizon?
    Francesco Passiglia, Maria Lucia Reale, Valeria Cetoretta, Silvia Novello
    Immunotargets and Therapy, 2021
  • Performing oncological procedures during COVID-19 outbreak: a picture from an Italian cancer center
    Maristella Bungaro, Valentina Bertaglia, Marco Audisio, Elena Parlagreco, Chiara Pisano, Valeria Cetoretta, Irene Persano, Francesca Jacobs, Chiara Baratelli, Lorena Consito, Maria Reale, Fabrizio Tabbò, Paolo Bironzo, Giorgio Scagliotti, Silvia Novello
    Exploration of Targeted Anti Tumor Therapy, 2021
  • Italian survey on the clinical management of non-small cell lung cancer patients during the COVID-19 pandemic: A lesson for the second wave
    Valentina Bertaglia, Maria Lucia Reale, Paolo Bironzo, Erica Palesandro, Annapaola Mariniello, Gianmarco Leone, Fabrizio Tabbò, Maristella Bungaro, Marco Audisio, Simonetta Rapetti, Rosario Francesco Di Stefano, Simona Carnio, Elisa Artusio, Enrica Capelletto, Paola Sperone, Francesco Passiglia, Silvia Novello
    Critical Reviews in Oncology Hematology, 2021
  • Resistance to anaplastic lymphoma kinase inhibitors: Knowing the enemy is half the battle won
    Fabrizio Tabbò, Maria Lucia Reale, Paolo Bironzo, Giorgio V. Scagliotti
    Translational Lung Cancer Research, 2020
  • An examination of two dichotomies: Women with lung cancer and living with lung cancer as a chronic disease
    Tiziana Vavalà, Maureen Rigney, Maria Lucia Reale, Silvia Novello, Jennifer C. King
    Respirology, 2020
  • Adjuvant epidermal growth factor receptor tyrosine kinase inhibitors: Are we actually ready?
    Fabrizio Tabbò, Maria Lucia Reale, Silvia Novello
    Translational Lung Cancer Research, 2020
  • SARS-CoV-2 Infection in Cancer Patients: A Picture of an Italian Onco-Covid Unit
    Maria Lucia Reale, Paolo Bironzo, Valentina Bertaglia, Erica Palesandro, Gianmarco Leone, Fabrizio Tabbò, Maristella Bungaro, Marco Audisio, Annapaola Mariniello, Simonetta G. Rapetti, Rosario F. Di Stefano, Elisa Artusio, Enrica Capelletto, Paola Sperone, Adriana Boccuzzi, Marco Calandri, Alberto Perboni, Umberto Malapelle, Francesco Passiglia, Silvia Novello
    Frontiers in Oncology, 2020
  • Quality of life in patients with lung cancer: the way forward
    Maria Lucia Reale, Massimo Di Maio
    Lancet Oncology, 2020
  • 18F-FDG pet parameters and radiomics features analysis in advanced nsclc treated with immunotherapy as predictors of therapy response and survival
    Giulia Polverari, Francesco Ceci, Valentina Bertaglia, Maria Lucia Reale, Osvaldo Rampado, Elena Gallio, Roberto Passera, Virginia Liberini, Paola Scapoli, Vincenzo Arena, Manuela Racca, Andrea Veltri, Silvia Novello, Désirée Deandreis
    Cancers, 2020
  • The KEY for chemo-immunotherapy combination: Taking NOTEs from squamous cell lung cancer
    Maria Lucia Reale, Emmanuele De De Luca, Massimo Di Maio
    Translational Lung Cancer Research, 2020
  • Quality of life assessment and reporting in colorectal cancer: A systematic review of phase III trials published between 2012 and 2018
    Pasquale Lombardi, Laura Marandino, Emmanuele De Luca, Clizia Zichi, Maria Lucia Reale, Daniele Pignataro, Rosario F. Di Stefano, Eleonora Ghisoni, Annapaola Mariniello, Elena Trevisi, Gianmarco Leone, Leonardo Muratori, Anna La Salvia, Cristina Sonetto, Francesco Leone, Massimo Aglietta, Silvia Novello, Giorgio V. Scagliotti, Francesco Perrone, Massimo Di Maio
    Critical Reviews in Oncology Hematology, 2020
  • Be-TeaM: An Italian real-world observational study on second-line therapy for EGFR-mutated NSCLC patients
    Maria Lucia Reale, Rita Chiari, Marcello Tiseo, Fabiana Vitiello, Fausto Barbieri, Diego Cortinovis, Giovanni Luca Ceresoli, Giovanna Finocchiaro, Gianpiero Diego Romano, Pier Luigi Piovano, Alessandro Del Conte, Gloria Borra, Francesco Verderame, Vieri Scotti, Daniela Nonnis, Domenico Galetta, Concetta Sergi, Maria Rita Migliorino, Giuseppe Tonini, Fabiana Cecere, Rossana Berardi, Maria Simona Pino, Olga Martelli, Alain Gelibter, Annamaria Carta, Emanuela Vattemi, Maria Pagano, Alessandro Zullo, Silvia Ferrari, Antonio Rossi, Silvia Novello
    Lung Cancer, 2020
  • Quality of life analysis in lung cancer: A systematic review of phase III trials published between 2012 and 2018
    Maria Lucia Reale, Emmanuele De Luca, Pasquale Lombardi, Laura Marandino, Clizia Zichi, Daniele Pignataro, Eleonora Ghisoni, Rosario F. Di Stefano, Annapaola Mariniello, Elena Trevisi, Gianmarco Leone, Leonardo Muratori, Anna La Salvia, Cristina Sonetto, Paolo Bironzo, Massimo Aglietta, Silvia Novello, Giorgio V. Scagliotti, Francesco Perrone, Massimo Di Maio
    Lung Cancer, 2020
  • Quality-of-Life Assessment and Reporting in Prostate Cancer: Systematic Review of Phase 3 Trials Testing Anticancer Drugs Published Between 2012 and 2018
    Laura Marandino, Emmanuele De Luca, Clizia Zichi, Pasquale Lombardi, Maria Lucia Reale, Daniele Pignataro, Rosario F. Di Stefano, Eleonora Ghisoni, Annapaola Mariniello, Elena Trevisi, Gianmarco Leone, Leonardo Muratori, Anna La Salvia, Cristina Sonetto, Consuelo Buttigliero, Marcello Tucci, Massimo Aglietta, Silvia Novello, Giorgio V. Scagliotti, Francesco Perrone, Massimo Di Maio
    Clinical Genitourinary Cancer, 2019
  • 68Ga-PSMA Uptake in Fibrous Dysplasia
    Maria Lucia Reale, Consuelo Buttigliero, Marcello Tucci, Roberto Giardino, Carlo Poti
    Clinical Nuclear Medicine, 2019
  • Metastatic Renal Medullary Carcinoma Treated With Immune Checkpoint Inhibitor: Case Report and Literature Review
    Rosario F. Di Stefano, Consuelo Buttigliero, Emmanuele De Luca, Maria Lucia Reale, Chiara Pisano, Gianmarco Leone, Clizia Zichi, Federica Massa, Matteo Manfredi, Francesca Vignani, Enrico Bollito, Francesco Porpiglia, Massimo Di Maio, Marcello Tucci
    Clinical Genitourinary Cancer, 2018
  • Deficiencies in health-related quality-of-life assessment and reporting: A systematic review of oncology randomized phase III trials published between 2012 and 2016
    L. Marandino, A. La Salvia, C. Sonetto, E. De Luca, D. Pignataro, C. Zichi, R.F. Di Stefano, E. Ghisoni, P. Lombardi, A. Mariniello, M.L. Reale, E. Trevisi, G. Leone, L. Muratori, M. Marcato, P. Bironzo, S. Novello, M. Aglietta, G.V. Scagliotti, F. Perrone, M. Di Maio
    Annals of Oncology, 2018
  • LATITUDE and other coordinates in quality of life of prostate cancer patients
    Maria Lucia Reale, Consuelo Buttigliero, Marcello Tucci, Rosario F. Di Stefano, Francesca Vignani, Massimo Di Maio
    Translational Cancer Research, 2018