Miguel Angel Martinez Lopez

Verified @gmail.com

Department of Physiology, Facultad de Medicina, Universidad Complutense de Madrid

Miguel Angel Martinez Lopez


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https://researchid.co/miguelangelmartinez

EDUCATION

Máster Universitario en Investigación en Ciencias de la Visión, Facultad de Medicina, Universidad Complutense de Madrid.
Grado en Biología, Facultad de Ciencias Biológicas, Universidad Complutense de Madrid.
4

Scopus Publications

47

Scholar Citations

5

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Citicoline and Coenzyme Q10: Therapeutic Agents for Glial Activation Reduction in Ocular Hypertension
    José A. Matamoros, Sara Rubio-Casado, José A. Fernández-Albarral, Miguel A. Martínez-López, Ana I. Ramírez, Elena Salobrar-García, Eva M. Marco, Victor Paleo-García, Rosa de Hoz, Inés López-Cuenca, Lorena Elvira-Hurtado, Lidia Sánchez-Puebla, José M. Ramírez, Meritxell López-Gallardo, Juan J. Salazar
    Pharmaceuticals, 2025
    Background/Objectives: The loss of retinal ganglion cells (RGCs) is a hallmark of glaucoma, a major cause of blindness. Glial cell activation due to increased intraocular pressure (IOP) significantly contributes to RGC death. Therefore, substances with anti-inflammatory properties could help prevent that process. This study investigated whether combining Citicoline and Coenzyme Q10 (CoQ10) can reduce glial activation in the retina and the rest of the visual pathway, potentially preventing neurodegeneration in a mouse model of unilateral laser-induced ocular hypertension (OHT). Methods: Four groups of mice were used: vehicle (n = 12), CitiQ10 (n = 12), OHT–vehicle (n = 18), and OHT–CitiQ10 (n = 18). The administration of Citicoline and CoQ10 was performed orally once a day, initiated 15 days prior to the laser treatment and maintained post-treatment until sacrifice (3 days for retina or 7 days for the rest of the visual pathway). The retina, dorsolateral geniculate nucleus, superior colliculus, and visual cortex (V1) were immunohistochemically stained and analyzed. Results: In the laser–CitiQ10 group, the Citicoline + CoQ10 compound revealed (1) an IOP decrease at 24 h and 3 days post-laser; and (2) reduced signs of macroglial (decreased GFAP area) and microglial (soma size, arbor area, microglia number, P2RY12 expression) activation in the retina and in the rest of the visual pathway (reduced activated microglial phenotypes and lower GFAP expression). Conclusions: This study shows that oral administration of Citicoline and CoQ10 can reduce glial activation caused by increased IOP in retina and visual pathway in a mouse model of OHT, potentially protecting RGCs from OHT-induced inflammation.
  • Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension
    José A. Matamoros, Sara Rubio-Casado, José A. Fernández-Albarral, Miguel A. Martínez-López, Elena Salobrar-García, Eva M. Marco, Victor Paleo-García, Rosa de Hoz, Inés López-Cuenca, Lorena Elvira-Hurtado, Lidia Sánchez-Puebla, José M. Ramírez, Juan J. Salazar, Meritxell López-Gallardo, Ana I. Ramírez
    Antioxidants, 2025
    Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs), with intraocular pressure (IOP) being its primary risk factor. Despite controlling IOP, the neurodegenerative process often continues. Therefore, substances with neuroprotective, antioxidant, and anti-inflammatory properties could protect against RGC death. This study investigated the neuroprotective effects on RGCs and visual pathway neurons of a compound consisting of citicoline and coenzyme Q10 (CoQ10) in a mouse model of unilateral, laser-induced ocular hypertension (OHT). Four groups of mice were used: vehicle group (n = 6), citicoline + CoQ10 group (n = 6), laser–vehicle group (n = 6), and laser–citicoline + CoQ10 group (n = 6). The citicoline + CoQ10 was administered orally once a day starting 15 days before laser treatment, continuing until sacrifice (7 days post-laser). Retinas, the dorsolateral geniculate nucleus (dLGN), the superior colliculus (SC), and the visual cortex (V1) were analyzed. The citicoline + CoQ10 compound used in the laser–citicoline + CoQ10 group demonstrated (1) an ocular hypotensive effect only at 24 h post-laser; (2) prevention of Brn3a+ RGC death in OHT eyes; and (3) no changes in NeuN+ neurons in the dLGN. This study demonstrates that the oral administration of the citicoline + CoQ10 combination may exert a neuroprotective effect against RGC death in an established rodent model of OHT.
  • Cilastatin as a Potential Anti-Inflammatory and Neuroprotective Treatment in the Management of Glaucoma
    Miguel A. Martínez-López, Sara Rubio-Casado, Diego San Felipe, Beatriz Martín-Sánchez, José A. Fernández-Albarral, Elena Salobrar-García, José A. Matamoros, José M. Ramírez, Rosa de Hoz, Juan J. Salazar, Eva M. Marco, Ana I. Ramírez, Alberto Lázaro, Meritxell López-Gallardo
    International Journal of Molecular Sciences, 2024
    Glaucoma is a neurodegenerative disease that causes blindness. In this study, we aimed to evaluate the protective role of cilastatin (CIL), generally used in the treatment of nephropathologies associated with inflammation, in an experimental mouse model based on unilateral (left) laser-induced ocular hypertension (OHT). Male Swiss mice were administered CIL daily (300 mg/kg, i.p.) two days before OHT surgery until sacrifice 3 or 7 days later. Intraocular Pressure (IOP), as well as retinal ganglion cell (RGC) survival, was registered, and the inflammatory responses of macroglial and microglial cells were studied via immunohistochemical techniques. Results from OHT eyes were compared to normotensive contralateral (CONTRA) and naïve control eyes considering nine retinal areas and all retinal layers. OHT successfully increased IOP values in OHT eyes but not in CONTRA eyes; CIL did not affect IOP values. Surgery induced a higher loss of RGCs in OHT eyes than in CONTRA eyes, while CIL attenuated this loss. Similarly, surgery increased macroglial and microglial activation in OHT eyes and to a lesser extent in CONTRA eyes; CIL prevented both macroglial and microglial activation in OHT and CONTRA eyes. Therefore, CIL arises as a potential effective strategy to reduce OHT-associated damage in the retina of experimental mice.
  • Is saffron able to prevent the dysregulation of retinal cytokines induced by ocular hypertension in mice?
    José A. Fernández-Albarral, Miguel A. Martínez-López, Eva M. Marco, Rosa de Hoz, Beatriz Martín-Sánchez, Diego San Felipe, Elena Salobrar-García, Inés López-Cuenca, María D. Pinazo-Durán, Juan J. Salazar, José M. Ramírez, Meritxell López-Gallardo, Ana I. Ramírez
    Journal of Clinical Medicine, 2021
    Cytokine- and chemokine-mediated signalling is involved in the neuroinflammatory process that leads to retinal ganglion cell (RGC) damage in glaucoma. Substances with anti-inflammatory properties could decrease these cytokines and chemokines and thus prevent RGC death. The authors of this study analysed the anti-inflammatory effect of a hydrophilic saffron extract standardized to 3% crocin content, focusing on the regulation of cytokine and chemokine production, in a mouse model of unilateral laser-induced ocular hypertension (OHT). We demonstrated that following saffron treatment, most of the concentration of proinflammatory cytokines (IL-1β, IFN-γ, TNF-α, and IL-17), anti-inflammatory cytokines (IL-4 and IL-10), Brain-derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and fractalkine were unaffected in response to laser-induced OHT in both the OHT eye and its contralateral eye. Only IL-6 levels were significantly increased in the OHT eye one day after laser induction compared with the control group. These results differed from those observed in animals subjected to unilateral OHT and not treated with saffron, where changes in cytokine levels occurred in both eyes. Therefore, saffron extract regulates the production of proinflammatory cytokines, VEGF, and fractalkine induced by increasing intraocular pressure (IOP), protecting the retina from inflammation. These results indicate that saffron could be beneficial in glaucoma by helping to reduce the inflammatory process.

RECENT SCHOLAR PUBLICATIONS

  • In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension
    JA Matamoros, E Salobrar-García, JJ Salazar, I López-Cuenca, ...
    International Journal of Molecular Sciences 27 (2), 1012 , 2026
    2026
    Citations: 2
  • In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension
    JA Matamoros Felipe, ES García Martín, JJ Salazar Corral, ...
    MDPI , 2026
    2026
  • Aplicación de metodologías de enseñanza-aprendizaje: El aprendizaje basado en proyectos y el aprendizaje basado en problemas desde un enfoque multidisciplinar.
    DA Bravo Vázquez, JI Aguirre de Miguel, F Amaro Torres, ...
    2025
  • THERAPEUTIC POTENTIAL OF THE COMBINATION OF CITICOLINE AND COENZYME Q10 IN MODULATING GLIAL ACTIVATION AND NEUROPROTECTION IN GLAUCOMA MODEL
    JA Matamoros, JA Fernandez-Albarral, E Salobrar-Garcia, ...
    GLIA 73, E302-E303 , 2025
    2025
  • Citicoline and coenzyme Q10: therapeutic agents for glial activation reduction in ocular hypertension
    JA Matamoros, S Rubio-Casado, JA Fernández-Albarral, ...
    Pharmaceuticals 18 (5), 694 , 2025
    2025
    Citations: 7
  • Citicoline and Coenzyme Q10: Therapeutic Agents for Glial Activation Reduction in Ocular Hypertension
    JA Matamoros Felipe, S Rubio Casado, J Fernández Albarral, ...
    MDPI , 2025
    2025
  • Impact of citicoline and coenzyme Q10 (COQUN Combo) on retinal ganglion cell survival in a experimental glaucoma model
    JA Matamoros, JA Fernández‐Albarral, E Salobrar‐Garcia, ...
    Acta Ophthalmologica 103 , 2025
    2025
  • Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension
    JA Matamoros, S Rubio-Casado, JA Fernández-Albarral, ...
    Antioxidants 14 (1), 4 , 2025
    2025
    Citations: 10
  • Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension
    JA Matamoros Felipe, S Rubio-Casado, J Fernández Albarral, ...
    MDPI , 2024
    2024
  • Cilastatin as a protectant against retinal damage in an animal model of malaria
    DS Felipe, R Llorente, B Martin-Sanchez, MA Gonzalez-Nicolas, ...
    ACTA PHYSIOLOGICA 240, 97-97 , 2024
    2024
  • Neuronal and glial alterations associated with treatment with the chemotherapy drug cisplatin: therapeutic approaches
    B Martin-Sanchez, S Rubio-Casado, R Llorente, DS Felipe, ...
    ACTA PHYSIOLOGICA 240, 97-97 , 2024
    2024
  • CoQUN as a potential strategy in the management of glaucoma in the visual pathway
    S Rubio-Casado, JA Matamoros, MA Martinez-Lopez, E Salobrar-Garcia, ...
    ACTA PHYSIOLOGICA 240, 96-97 , 2024
    2024
  • Comprehensive Investigation of Functional and Structural Retinal Alterations in Ocular Albinism: A Study on CD-1 Mice
    E Salobrar-Garcia, JA Matamoros, S Milla-Navarro, ...
    Investigative Ophthalmology & Visual Science 65 (7), 4727-4727 , 2024
    2024
  • Cilastatin as a potential anti-inflammatory and neuroprotective treatment in the management of glaucoma
    MA Martínez-López, S Rubio-Casado, D San Felipe, B Martín-Sánchez, ...
    International Journal of Molecular Sciences 25 (6), 3115 , 2024
    2024
    Citations: 8
  • Impacto del uso de actividades creativas, artísticas, lúdicas y de gamificación en el proceso de aprendizaje y comunicación en estudiantes de fisiología
    A Lázaro Fernández, V Hurtado Carneiro, R Llorente Miguel, ...
    2023
  • Effects of oral saffron on retinal glial cytokine expression in an experimental model of glaucoma
    R de Hoz, JA Fernandez-Albarral, MA Martinez-Lopez, E Salobrar-Garcia, ...
    Wiley , 2023
    2023
  • Modulation of retinal cytokine expression by saffron in an experimental glaucoma model
    JA Fernández‐Albarral, MA Martínez‐López, E Salobrar‐Garcia, ...
    Acta Ophthalmologica 100 , 2022
    2022
  • Creación de una comunidad de aprendizaje para el desarrollo de una estructura de mentorizaje vertical y generación de contenidos digitales para la formación en competencias de …
    R Llorente Miguel, M López Gallardo, EM Marco López, ...
    2022
    Citations: 1
  • Is saffron able to prevent the dysregulation of retinal cytokines induced by ocular hypertension in mice?
    JA Fernández-Albarral, MA Martínez-López, EM Marco, R de Hoz, ...
    Journal of Clinical Medicine 10 (21), 4801 , 2021
    2021
    Citations: 14
  • Política y Democracía
    MA Martínez
    Democracia en el mundo antiguo y en la actualidad, 217-222 , 2013
    2013

MOST CITED SCHOLAR PUBLICATIONS

  • Is saffron able to prevent the dysregulation of retinal cytokines induced by ocular hypertension in mice?
    JA Fernández-Albarral, MA Martínez-López, EM Marco, R de Hoz, ...
    Journal of Clinical Medicine 10 (21), 4801 , 2021
    2021
    Citations: 14
  • Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension
    JA Matamoros, S Rubio-Casado, JA Fernández-Albarral, ...
    Antioxidants 14 (1), 4 , 2025
    2025
    Citations: 10
  • Cilastatin as a potential anti-inflammatory and neuroprotective treatment in the management of glaucoma
    MA Martínez-López, S Rubio-Casado, D San Felipe, B Martín-Sánchez, ...
    International Journal of Molecular Sciences 25 (6), 3115 , 2024
    2024
    Citations: 8
  • Citicoline and coenzyme Q10: therapeutic agents for glial activation reduction in ocular hypertension
    JA Matamoros, S Rubio-Casado, JA Fernández-Albarral, ...
    Pharmaceuticals 18 (5), 694 , 2025
    2025
    Citations: 7
  • El movimiento de okupaciones: una larga e inquietante existencia
    M Martínez
    Revista de Economía Crítica 5, 7-37 , 2010
    2010
    Citations: 5
  • In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension
    JA Matamoros, E Salobrar-García, JJ Salazar, I López-Cuenca, ...
    International Journal of Molecular Sciences 27 (2), 1012 , 2026
    2026
    Citations: 2
  • Creación de una comunidad de aprendizaje para el desarrollo de una estructura de mentorizaje vertical y generación de contenidos digitales para la formación en competencias de …
    R Llorente Miguel, M López Gallardo, EM Marco López, ...
    2022
    Citations: 1
  • In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension
    JA Matamoros Felipe, ES García Martín, JJ Salazar Corral, ...
    MDPI , 2026
    2026
  • Aplicación de metodologías de enseñanza-aprendizaje: El aprendizaje basado en proyectos y el aprendizaje basado en problemas desde un enfoque multidisciplinar.
    DA Bravo Vázquez, JI Aguirre de Miguel, F Amaro Torres, ...
    2025
  • THERAPEUTIC POTENTIAL OF THE COMBINATION OF CITICOLINE AND COENZYME Q10 IN MODULATING GLIAL ACTIVATION AND NEUROPROTECTION IN GLAUCOMA MODEL
    JA Matamoros, JA Fernandez-Albarral, E Salobrar-Garcia, ...
    GLIA 73, E302-E303 , 2025
    2025
  • Citicoline and Coenzyme Q10: Therapeutic Agents for Glial Activation Reduction in Ocular Hypertension
    JA Matamoros Felipe, S Rubio Casado, J Fernández Albarral, ...
    MDPI , 2025
    2025
  • Impact of citicoline and coenzyme Q10 (COQUN Combo) on retinal ganglion cell survival in a experimental glaucoma model
    JA Matamoros, JA Fernández‐Albarral, E Salobrar‐Garcia, ...
    Acta Ophthalmologica 103 , 2025
    2025
  • Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension
    JA Matamoros Felipe, S Rubio-Casado, J Fernández Albarral, ...
    MDPI , 2024
    2024
  • Cilastatin as a protectant against retinal damage in an animal model of malaria
    DS Felipe, R Llorente, B Martin-Sanchez, MA Gonzalez-Nicolas, ...
    ACTA PHYSIOLOGICA 240, 97-97 , 2024
    2024
  • Neuronal and glial alterations associated with treatment with the chemotherapy drug cisplatin: therapeutic approaches
    B Martin-Sanchez, S Rubio-Casado, R Llorente, DS Felipe, ...
    ACTA PHYSIOLOGICA 240, 97-97 , 2024
    2024
  • CoQUN as a potential strategy in the management of glaucoma in the visual pathway
    S Rubio-Casado, JA Matamoros, MA Martinez-Lopez, E Salobrar-Garcia, ...
    ACTA PHYSIOLOGICA 240, 96-97 , 2024
    2024
  • Comprehensive Investigation of Functional and Structural Retinal Alterations in Ocular Albinism: A Study on CD-1 Mice
    E Salobrar-Garcia, JA Matamoros, S Milla-Navarro, ...
    Investigative Ophthalmology & Visual Science 65 (7), 4727-4727 , 2024
    2024
  • Impacto del uso de actividades creativas, artísticas, lúdicas y de gamificación en el proceso de aprendizaje y comunicación en estudiantes de fisiología
    A Lázaro Fernández, V Hurtado Carneiro, R Llorente Miguel, ...
    2023
  • Effects of oral saffron on retinal glial cytokine expression in an experimental model of glaucoma
    R de Hoz, JA Fernandez-Albarral, MA Martinez-Lopez, E Salobrar-Garcia, ...
    Wiley , 2023
    2023
  • Modulation of retinal cytokine expression by saffron in an experimental glaucoma model
    JA Fernández‐Albarral, MA Martínez‐López, E Salobrar‐Garcia, ...
    Acta Ophthalmologica 100 , 2022
    2022

Publications

Fernández-Albarral JA, Martínez-López MA, Marco EM, de Hoz R, Martín-Sánchez B, San Felipe D, Salobrar-García E, López-Cuenca I, Pinazo-Durán MD, Salazar JJ, Ramírez JM, López-Gallardo M, Ramírez AI. Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice? J Clin Med. 2021 Oct 20;10(21):4801. doi: 10.3390/jcm10214801. PMID: 34768320; PMCID: PMC8584889.