MYTHILI T

@ethirajcollege.edu.in

Associate Professor, Department of Plant Biology and Plant Biotechnology
Ethiraj College for Women

MYTHILI T


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https://researchid.co/mythilitg

EDUCATION

M.Sc. M.Phil. Ph.D. Botany

RESEARCH, TEACHING, or OTHER INTERESTS

Plant Science, Agricultural and Biological Sciences, Ecology, Evolution, Behavior and Systematics
2

Scopus Publications

109

Scholar Citations

5

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Bioinformatic study of an antitumor protein, Azurin
    Abiraami Valli S, Mythili T
    Asian Journal of Pharmaceutical and Clinical Research, 2018
    Objective: The main objective of this study is to analyze the structure and function of an antitumor protein, azurin, thereby giving validation to the protein structure and existing physicochemical properties in the anticancer protein which are responsible for the anticancer activity.Methods: Protein sequence analysis was done using Basic Local Alignment Search Tool (BLAST) with ten different randomly selected species of Pseudomonas obtained from GenBank. The physicochemical properties, prediction of secondary structure, identification of motifs and domains, three-dimensional (3-D) structure of the antitumor protein, validation through Ramachandran plot, multiple sequence alignment (MSA), and phylogenetic analysis were studied and functional property was confirmed through in silico docking.Results: The similarity search (BLAST-P analysis) for the primary sequence from GenBank carried out showed 86% similarity to the second sequence, azurin (Pseudomonas nitroreducens). The ProtParam, ExPASy tool server indicated the presence of essential physicochemical properties in azurin. Secondary structure prediction revealed random coil, extended strand, alpha helix, and beta turn. The study on domains indicated the presence of one domain in azurin responsible for the anticancer activity. The 3-D structural analysis revealed azurin as metalloprotein, of length-128, and polymer-1 with α-helices, β-sheets, and β-barrels. The validation carried out through Ramachandran plot showed the presence of two outliers (phi and psi). The biological relationship between the input sequences was studied through MSA and phylogenetic analysis. Further, azurin docked against the target protein (p53 tumor suppressor) showed the maximum binding affinity confirming its functional property of causing apoptosis.Conclusion: All the properties analyzed in the present study revealed that the azurin protein can act as a very good anticancer agent, and through the phylogenetic analysis, it was identified that Pseudomonas nitroreducens was closely related to the test organism Pseudomonas aeruginosa.
  • Phytochemical screening and antimicrobial activity of Sesbania sesban (L.) Merr
    Asian Journal of Pharmaceutical and Clinical Research, 2012

RECENT SCHOLAR PUBLICATIONS

  • Impact of organic manure and mineral nutrient on growth and yield of Spinacia oleracea (Linn.)
    SUG Vaishnavi V V, T Mythili
    Indian Journal of Natural Sciences 14 (80), 61723-61731 , 2023
    2023
  • THERAPEUTIC ANTIDIABETIC BISCUIT – AN EFFECTIVE FUNCTIONAL FOOD
    DTM Dharani sree K
    World Journal of Pharmacy and Pharmaceutical Sciences 12 (7), 1385-1397 , 2023
    2023
    Citations: 1
  • Comparative Study on Growth of Pearl Millet (Pennisetum Glaucum L) Sprouts in Different Types of Water to Treat Anaemia
    MT Bhumika J, Harini R, Yogashree T, Yuvashree D
    Journal of Siddha 7 (1), 32-38 , 2023
    2023
  • Bioinformatic study of an antitumor protein, azurin
    S Valli, T Mythili
    Asian J Pharm Clin Res 11 (6), 169 , 2018
    2018
    Citations: 7
  • Determination of Quercetin by HPTLC method in sesbaniasesban (L.) Merr. stem extract
    T Mythili, R Ravindhran
    Development 10, 10 , 2013
    2013
    Citations: 15
  • Phytochemical screening and antimicrobial activity of Sesbania sesban (L.) Merr
    T Mythili, R Ravindhran
    Asian Journal of Pharmaceutical and Clinical Research 5 (4), 179-182 , 2012
    2012
    Citations: 55
  • www. pelagiaresearchlibrary. com t a Available online
    T Mythili, R Ravindhran
    Asian Journal of Plant Science and Research 2 (6), 659-663 , 2012
    2012
  • Improved phytochemical production using biotic and abiotic elicitors in Marsilea quadrifolia
    R Manjula, T Mythili
    Int J Curr Sci 1, 98-101 , 2012
    2012
    Citations: 25
  • Genetic variability analysis in Bacopa monnieri (L.) Penn.
    TM Y Varalakshmi
    Advanced Biotech 10 (10), 99-100 , 2011
    2011
  • Pharmacognostical and physico-chemical studies of Sesbania sesban (L.) Merr. Stem
    T Mythili, R Ravindhran
    Asian Journal of Plant Science & Research , 2011
    2011
    Citations: 6

MOST CITED SCHOLAR PUBLICATIONS

  • Phytochemical screening and antimicrobial activity of Sesbania sesban (L.) Merr
    T Mythili, R Ravindhran
    Asian Journal of Pharmaceutical and Clinical Research 5 (4), 179-182 , 2012
    2012
    Citations: 55
  • Improved phytochemical production using biotic and abiotic elicitors in Marsilea quadrifolia
    R Manjula, T Mythili
    Int J Curr Sci 1, 98-101 , 2012
    2012
    Citations: 25
  • Determination of Quercetin by HPTLC method in sesbaniasesban (L.) Merr. stem extract
    T Mythili, R Ravindhran
    Development 10, 10 , 2013
    2013
    Citations: 15
  • Bioinformatic study of an antitumor protein, azurin
    S Valli, T Mythili
    Asian J Pharm Clin Res 11 (6), 169 , 2018
    2018
    Citations: 7
  • Pharmacognostical and physico-chemical studies of Sesbania sesban (L.) Merr. Stem
    T Mythili, R Ravindhran
    Asian Journal of Plant Science & Research , 2011
    2011
    Citations: 6
  • THERAPEUTIC ANTIDIABETIC BISCUIT – AN EFFECTIVE FUNCTIONAL FOOD
    DTM Dharani sree K
    World Journal of Pharmacy and Pharmaceutical Sciences 12 (7), 1385-1397 , 2023
    2023
    Citations: 1
  • Impact of organic manure and mineral nutrient on growth and yield of Spinacia oleracea (Linn.)
    SUG Vaishnavi V V, T Mythili
    Indian Journal of Natural Sciences 14 (80), 61723-61731 , 2023
    2023
  • Comparative Study on Growth of Pearl Millet (Pennisetum Glaucum L) Sprouts in Different Types of Water to Treat Anaemia
    MT Bhumika J, Harini R, Yogashree T, Yuvashree D
    Journal of Siddha 7 (1), 32-38 , 2023
    2023
  • www. pelagiaresearchlibrary. com t a Available online
    T Mythili, R Ravindhran
    Asian Journal of Plant Science and Research 2 (6), 659-663 , 2012
    2012
  • Genetic variability analysis in Bacopa monnieri (L.) Penn.
    TM Y Varalakshmi
    Advanced Biotech 10 (10), 99-100 , 2011
    2011