Nasim Habib

I'm Nasim Habib, a 25-year-old citizen of Bangladesh with a B.Sc. degree in Fisheries and Marine Bioscience from
Jashore University of Science and Technology, Bangladesh. During my 22-month tenure as a Coordinator and
Enumerator for two contract-based projects with E.Gen Consultants Ltd, I gained valuable research and project
management skills. I also participated in a research project funded by USAID that focused on the promotion and
adaptation of In-pond Raceway System (IPRS) in the southwestern region of Bangladesh. In addition, I have
published four articles in high-impact journals, and five articles are currently under review in various journals. I
have also obtained an overall 6-band score in IELTS, which is a standardized test for studying abroad. Moreover,
the medium of instruction for my B.Sc. degree was also in English.

EDUCATION

BSc in Fisheries

RESEARCH, TEACHING, or OTHER INTERESTS

Oceanography, Ecology, Evolution, Behavior and Systematics, Molecular Biology, Environmental Science

Scopus Publications

High-throughput virtual screening of marine algae metabolites as high-affinity inhibitors of ISKNV major capsid protein: An analysis of in-silico models and DFT calculation to find novel drug molecules for fighting infectious spleen and kidney necrosis virus (ISKNV)
Sk Injamamul Islam, Sheikh Sunzid Ahmed, Nasim Habib, Md Akib Ferdous, Saloa Sanjida, Moslema Jahan Mou
Heliyon, 2023
Infectious Spleen and Kidney Necrosis Virus (ISKNV) is linked to severe infections that cause significant financial losses in global aquaculture. ISKNV enters the host cell through its major capsid protein (MCP), and the resulting infection can lead to mass mortality of fish. Even though several drugs and vaccines are at various stages of clinical testing, none are currently available. Thus, we sought to assess the potential of seaweed compounds to block viral entrance by inhibiting the MCP. The Seaweed Metabolite Database (1110 compounds) was assessed for potential antiviral activity against ISKNV using high throughput virtual screening. Forty compounds with docking scores of ≥8.0 kcal/mol were screened further. The inhibitory molecules BC012, BC014, BS032, and RC009 were predicted by the docking and MD techniques to bind the MCP protein significantly with binding affinities of −9.2, −9.2, −9.9, and −9.4 kcal/mol, respectively. Also, ADMET characteristics of the compounds indicated drug-likeness. According to this study, marine seaweed compounds may operate as viral entrance inhibitors. For their efficacy to be established, in-vitro and in-vivo testing is required.
Synthesis of Homo-oligomer Models, Functional Characterization, and Annotation of the Virulent HP33 Protein from the Vibrio harveyi Strain of Scale Drop and Muscle Necrosis Disease
Sk Injamamul Islam, Saloa Sanjida, Md. Akib Ferdous, Nasim Habib
Genetics of Aquatic Organisms, 2023
This study used a comprehensive bioinformatic application to discover the functions of the HP33 protein, which is responsible for the scale drop and muscle necrosis disease (SDMND) in fish. The main objective of the study was to the characterization of the HP33 protein and predict the homo-oligomer models to understand the physical effect of the protein for further research. At first, multiple sequence alignment and sub-cellular localization of the HP33 were predicted by the in-silico approach. The result suggests that this putative protein clustered with another hypothetical protein, Vibrio harveyi, and is an unstable, nonpolar, and outer membrane protein. Functional analysis of the protein by Pfam, InterProScan, and SMART tools predicts that the HP has a single functional domain that may signify a cluster of biosynthetic genes. The prediction of the active site, as well as the protein-protein interaction, were also predicted in this study. Furthermore, a protein-ligand docking investigation revealed two potential therapeutic compounds (Ferroheme C, Valine) that can be effective against HP33 pathogenesis. In conclusion, the homo-oligomers model's predictions and the ab-initio docking findings will offer important information for an additional immunological investigation, which may be beneficial in a future study on SDMND prophylaxis.
Ligand-based Virtual Screening, Quantum Mechanics Calculations, and Normal Mode Analysis of Phytochemical Compounds Targeting Toll-Interacting Protein (Tollip) Against Bacterial Diseases
Sk Injamamul Islam, M. Norjit Singh, C. Sonia, Md Akib Ferdous, Nasim Habib, Saloa Sanjida, Md Jamadul Islam, Nahidul Islam, Mohamed H Hamad
Toxicology International, 2023
The Labeo rohita (Rohu) Toll interacting protein (Tollip) is ubiquitously expressed in the kidneys, gills, spleen, liver, and blood. Tollip in L. rohita has higher eukaryotic structural features and is produced in response to bacterial infections. Several bacterial diseases, such as Aeromonas hydrophila and Vibrio spp, have been reported in the internal organs of L. rohita. The consequences of these bacterial infections can be 100% mortality of fish. There are currently no medicines or vaccines available to prevent or treat infections caused by the involvement of this protein. During bacterial infections, it was discovered that Tollip plays an essential function as a negative regulator of the MyD88-dependent TLR signalling pathway. Therefore, the study aimed to evaluate the inhibitory potentiality of the Allium sativum compound against Tollip. A. sativum has been reported to show potential antibacterial activity against numerous microbial pathogens. Still, activity against the Tollip-promoted pathogens has not yet been reported. In silico virtual screen and molecular docking methods were used in this study to calculate the binding affinity of 48 drug compounds of A. sativum against the receptor Tollip. The docking and normal mode analysis methods predict 2 (PubChem CID: 122130381 and CID 12303662) inhibitory compounds that bind strongly with the Tollip with a binding affinity of -9.2 and -8.8 kcal/mol, respectively. The ADMET properties of the compounds also verified the drug resemblance features of the two compounds of A. sativum. Furthermore, to evaluate the efficacy of these two potential inhibitors, more in-vitro testing is required.
Towards characterizing of Enterocytozoon hepatopenaei (EHP) spore wall proteins with feature identification and analogy modeling
Sk Injamamul Islam, Sheikh Sunzid Ahmed, Saloa Sanjida, Moslema Jahan Mou, Sarower Mahfuj, Nasim Habib, Md Akib Ferdous, MD Habibur Rahman, Md Hasan Mahmud Noor
Informatics in Medicine Unlocked, 2023
Enterocytozoon hepatopenaei (EHP) is a parasite that mostly affects shrimp; it is linked to spore-forming and obligatory intracellular microsporidia and causes growth retardation and body length fluctuation, which results in financial consequences for the shrimp industry in Asian nations. However, the introduction of technologies to detect EHP has been complicated by the absence of a thorough knowledge of the properties of spore wall proteins (SWPs) linked to host infection. Thus, characterization, feature identification, 3D modeling of protein sequence, prediction of transmembrane regions, motif analysis, as well as model validation of SWPs can help improve drug delivery in the future. Conservation analysis was performed using ClustalW. InterPro, MEMEsuite, and TMHMM Server v2.0 were used to perform motif analysis, family domain prognosis, and transmembrane region analysis, respectively. Finally, the Alphafold2 server was used for analogy modeling and 3D layout. Different model validation servers were used to validate the protein structural model. Physicochemical features for SWPs were analyzed and found molecular weight around 16.701 KDa-38.314 KDa, theoretical pI 5.25–9.05, instability index 32.04–48.89, aliphatic index 76.49–99.84, grand average of hydropathicity (GRAVY) – 0.059 to −0.892. Each SWP was discovered to be hydrophilic. There was no significant region detected in the conserved region analysis. Both a lower and higher E value were found by the motif analysis. For most of the proteins, there were no transmembrane regions. Finally, analogous 3D models for each protein were created and verified using various bioinformatics tools and software. This investigation could aid in the further research of diseases and the development of drug delivery systems.
CRISPR-Cas Genome Editing Technique for Fish Disease Management: Current Study and Future Perspective
Md. Akib Ferdous, Sk Injamamul Islam, Nasim Habib, Mazen Almehmadi, Mamdouh Allahyani, Ahad Amer Alsaiari, Alaa Shafie
Microorganisms, 2022
Scientists have discovered many ways to treat bacteria, viruses, and parasites in aquaculture; however, there is still an impossibility in finding a permanent solution for all types of diseases. In that case, the CRISPR-Cas genome-editing technique can be the potential solution to preventing diseases for aquaculture sustainability. CRISPR-Cas is cheaper, easier, and more precise than the other existing genome-editing technologies and can be used as a new disease treatment tool to solve the far-reaching challenges in aquaculture. This technique may now be employed in novel ways, such as modifying a single nucleotide base or tagging a location in the DNA with a fluorescent protein. This review paper provides an informative discussion on adopting CRISPR technology in aquaculture disease management. Starting with the basic knowledge of CRISPR technology and phages, this study highlights the development of RNA-guided immunity to combat the Chilodonella protozoan group and nervous necrosis virus (NNV) in marine finfish. Additionally, we highlight the immunological application of CRISPR-Cas against bacterial diseases in channel catfish and the white spot syndrome virus (WSSV) in shrimp. In addition, the review summarizes a synthesis of bioinformatics tools used for CRISPR-Cas sgRNA design, and acceptable solutions are discussed, considering the limitations.

RECENT SCHOLAR PUBLICATIONS

High-throughput virtual screening of marine algae metabolites as high-affinity inhibitors of ISKNV major capsid protein: An analysis of in-silico models and DFT calculation to …
SI Islam, SS Ahmed, N Habib, MA Ferdous, S Sanjida, MJ Mou
Heliyon 9 (6) , 2023
2023
Citations: 17
Ligand-based Virtual Screening, Quantum Mechanics Calculations, and Normal Mode Analysis of Phytochemical Compounds Targeting Toll‐Interacting Protein (Tollip) Against …
MHH Sk Injamamul Islam, M. Norjit Singh, C. Sonia, Md Akib Ferdous, Nasim ...
Toxicology International 30 (2), 139-153 , 2023
2023
Citations: 1
Towards characterizing of Enterocytozoon hepatopenaei (EHP) spore wall proteins with feature identification and analogy modeling
SI Islam, SS Ahmed, S Sanjida, MJ Mou, S Mahfuj, N Habib, MA Ferdous, ...
Informatics in Medicine Unlocked 38, 101215 , 2023
2023
Citations: 2
Synthesis of Homo-oligomer Models, Functional Characterization, and Annotation of the Virulent HP33 Protein from the Vibrio harveyi Strain of Scale Drop and Muscle Necrosis Disease
SI Islam, S Sanjida, MA Ferdous, N Habib
Genetics of Aquatic Organisms 7 (1) , 2022
2022
CRISPR-Cas genome editing technique for fish disease management: current study and future perspective
MA Ferdous, SI Islam, N Habib, M Almehmadi, M Allahyani, AA Alsaiari, ...
Microorganisms 10 (10), 2012 , 2022
2022
Citations: 38
Irish society of gastroenterology: Proceedings of meeting held 26th & 27th november, 1993 at james connolly memorial hospital, Blanchardstown
RWG Watson, HP Redmond, J McCarthy, P Burke, D Bouchier-Hayes, ...
Irish Journal of Medical Science 162 (12), 513-528 , 1993
1993
Irish Society of Gastroenterology—Summer Meeting Held at Educational Centre, Althnagelvin Area Hospital, Londonderry on Friday 5th and Saturday 6th June, 1987
JG Geraghty, PE Burke, E McGovern, KM Shaw, A Tobin, D O’Leary, ...
Irish Journal of Medical Science 157 (6), 207-216 , 1988
1988
Nutritional and organoleptic evaluation of wheat rotis supplemented with soybean flour.
MA Maqbool Ahmad, RA Rohella Albert, A Aurangzeb, NB Nazakat Bibi, ...
1987
Citations: 20
Effect of substitution of sucrose with liquid glucose on the quality of mango squash
M Ahmad, MA Chaudry, I Khan, NS Kai, N Habib
Pakistan J. Sci. Ind. Res 30, 789 , 1987
1987
Citations: 1
Physical characters and chemical and nutrient composition of Pakistani mangoes
M Ahmad, NS Kaif, MA Chaudhry, N Habib
Sarhad Journal of Agriculture (Pakistan) 2 (4) , 1986
1986

MOST CITED SCHOLAR PUBLICATIONS

CRISPR-Cas genome editing technique for fish disease management: current study and future perspective
MA Ferdous, SI Islam, N Habib, M Almehmadi, M Allahyani, AA Alsaiari, ...
Microorganisms 10 (10), 2012 , 2022
2022
Citations: 38
Nutritional and organoleptic evaluation of wheat rotis supplemented with soybean flour.
MA Maqbool Ahmad, RA Rohella Albert, A Aurangzeb, NB Nazakat Bibi, ...
1987
Citations: 20
High-throughput virtual screening of marine algae metabolites as high-affinity inhibitors of ISKNV major capsid protein: An analysis of in-silico models and DFT calculation to …
SI Islam, SS Ahmed, N Habib, MA Ferdous, S Sanjida, MJ Mou
Heliyon 9 (6) , 2023
2023
Citations: 17
Towards characterizing of Enterocytozoon hepatopenaei (EHP) spore wall proteins with feature identification and analogy modeling
SI Islam, SS Ahmed, S Sanjida, MJ Mou, S Mahfuj, N Habib, MA Ferdous, ...
Informatics in Medicine Unlocked 38, 101215 , 2023
2023
Citations: 2
Ligand-based Virtual Screening, Quantum Mechanics Calculations, and Normal Mode Analysis of Phytochemical Compounds Targeting Toll‐Interacting Protein (Tollip) Against …
MHH Sk Injamamul Islam, M. Norjit Singh, C. Sonia, Md Akib Ferdous, Nasim ...
Toxicology International 30 (2), 139-153 , 2023
2023
Citations: 1
Effect of substitution of sucrose with liquid glucose on the quality of mango squash
M Ahmad, MA Chaudry, I Khan, NS Kai, N Habib
Pakistan J. Sci. Ind. Res 30, 789 , 1987
1987
Citations: 1
Synthesis of Homo-oligomer Models, Functional Characterization, and Annotation of the Virulent HP33 Protein from the Vibrio harveyi Strain of Scale Drop and Muscle Necrosis Disease
SI Islam, S Sanjida, MA Ferdous, N Habib
Genetics of Aquatic Organisms 7 (1) , 2022
2022
Irish society of gastroenterology: Proceedings of meeting held 26th & 27th november, 1993 at james connolly memorial hospital, Blanchardstown
RWG Watson, HP Redmond, J McCarthy, P Burke, D Bouchier-Hayes, ...
Irish Journal of Medical Science 162 (12), 513-528 , 1993
1993
Irish Society of Gastroenterology—Summer Meeting Held at Educational Centre, Althnagelvin Area Hospital, Londonderry on Friday 5th and Saturday 6th June, 1987
JG Geraghty, PE Burke, E McGovern, KM Shaw, A Tobin, D O’Leary, ...
Irish Journal of Medical Science 157 (6), 207-216 , 1988
1988
Physical characters and chemical and nutrient composition of Pakistani mangoes
M Ahmad, NS Kaif, MA Chaudhry, N Habib
Sarhad Journal of Agriculture (Pakistan) 2 (4) , 1986
1986