Razieh Sabet

Scopus Publications

Synthesis, QSAR analysis and molecular docking study of a new series of 3-hydroxypyridine-4-one derivatives as anti-tyrosinase agents
Hossein Sadeghpour, Sara Sadeghian, Leila Emami, Mehdi Khoshneviszadeh, Paria Razmi, et al.
BMC Chemistry, 2026
Design, Synthesis, Molecular Docking Studies, Antioxidant Effects, and Enzyme Inhibition of 3-Aryl-4-Hydroxy-6-Methyl-2H-Pyran-2-One Derivatives as Mushroom Tyrosinase Inhibitors
Somaye Karimian, Donya Mazheri, Somaye Pirhadi, Maryam Shahriyari, Mohammadbagher Bahmani, et al.
Chemistryselect, 2025
In this study, thirteen derivatives of 3‐aryl‐4‐hydroxy‐6‐methyl‐2 H ‐pyran‐2‐one ( 3a–3m ) were rationally designed and synthesized as potential tyrosinase inhibitors. All synthesized structures were confirmed by 1 H NMR, 13 C NMR, ESI–MS, IR, and elemental analysis. In the next step, it was found that compounds ( 3i ) and ( 3j ) exhibit the most potent tyrosinase inhibitory activities, with IC 50 values of 1.56 ± 0.21 and 1.82 ± 0.11 µM, respectively, and significantly outperform the reference inhibitor, kojic acid (IC 50 = 9.3 ± 1.27 µM). Antioxidant evaluation using the DPPH assay revealed weak radical scavenging activities (22.97%–36.47%) of all derivatives, suggesting that their inhibitory action is likely unrelated to antioxidant properties. Kinetic studies indicated that compound ( 3i ) acts as a mixed‐type inhibitor with an inhibition constant ( K i ) of 2.2 µM. Molecular docking studies demonstrated favorable binding interactions of compounds ( 3i ) and ( 3j ) within the tyrosinase active site, involving coordination with copper ions and hydrogen bonding with key residues. These findings were further validated by molecular dynamics (MD) simulations, which confirmed the structural stability of the 3i ‐tyrosinase complex over a 100 ns simulation period. Overall, compounds ( 3i ) and ( 3j ) represent promising leads for the development of novel tyrosinase inhibitors for potential use in pharmaceutical, cosmetic, and food industry applications.
l-Aspartic acid-functionalized magnetic nanoparticles: as a new magnetically reusable bifunctional acid–base catalysts for the synthesis of benzo[b]pyran and pyrano[3,2–c] chromene derivatives
Leila Amiri-Zirtol, Hanieh Mostashfi, Razieh Sabet, Zahra Karimi, Reza Ranjbar-Karimi
Scientific Reports, 2025
Antimicrobial evaluation, molecular docking, DFT analysis, and ADME studies of 3-Hydroxypyridin-4-one analogues
Hossein Sadeghpour, Sara Sadeghian, Fateme Zare, Mehdi Jamali, Narjes Moghtaderi Estahbanati, et al.
Results in Chemistry, 2025
New spirooxindole-thiazolidine derivatives as antiseizure agents: Biological evaluation and computational studies
Leila Emami, Leila Moezi, Pegah Mardaneh, Sara Sadeghian, Elaheh Ataollahi, et al.
Results in Chemistry, 2025
In-silico screening of Staphylococcus aureus antibacterial agents based on Isatin scaffold: QSAR, molecular docking, molecular dynamics simulation and DFT analysis
Leila Emami, Sara Sadeghian, Pegah Mardaneh, Fateme Zare, Soghra Khabnadideh, et al.
Molecular Physics, 2025
Pyrazole derivatives as antileishmanial agents: Biological evaluation, molecular docking study, DFT analysis and ADME prediction
Razieh Sabet, Gholamreza Hatam, Leila Emami, Elaheh Ataollahi, Fateme Zare, et al.
Heliyon, 2024
Synthesis, design, biological evaluation, and computational analysis of some novel uracil-azole derivatives as cytotoxic agents
Leila Emami, Fateme Zare, Soghra Khabnadideh, Zahra Rezaei, Zahra Sabahi, et al.
BMC Chemistry, 2024
The design and synthesis of novel cytotoxic agents is still an interesting topic for medicinal chemistry researchers due to the unwanted side effects of anticancer drugs. In this study, a novel series of uracil–azole hybrids were designed and synthesized. The cytotoxic activity, along with computational studies: molecular docking, molecular dynamic simulation, density functional theory, and ADME properties were also, evaluated. The compounds were synthesized by using 3-methyl-6-chlorouracil as the starting material. Cytotoxicity was determined using MTT assay in the breast carcinoma cell line (MCF-7) and Hepatocellular carcinoma cell line (HEPG-2). These derivatives demonstrated powerful inhibitory activity against breast and hepatocellular carcinoma cell lines in comparison to Cisplatin as positive control. Among these compounds, 4j displayed the best selectivity profile and good activity with IC50 values of 16.18 ± 1.02 and 7.56 ± 5.28 µM against MCF-7 and HEPG-2 cell lines respectively. Structure–activity relationships revealed that the variation in the cytotoxic potency of the synthesized compounds was affected by various substitutions of benzyl moiety. The docking output showed that 4j bind well in the active site of EGFR and formed a stable complex with the EGFR protein. DFT was used to investigate the reactivity descriptors of 4a and 4j. The outputs demonstrated that these uracil–azole hybrids can be considered as potential cytotoxic agents.
Synthesis, biological evaluation, molecular docking, MD simulation and DFT analysis of new 3-hydroxypyridine-4-one derivatives as anti-tyrosinase and antioxidant agents
Sara Sadeghian, Fateme Zare, Mehdi Khoshneviszadeh, Arian Fathi Hafshejani, Farhang Salahshour, et al.
Heliyon, 2024
New 3-Hydroxypyridine-4-one Analogues: Their Synthesis, Antimicrobial Evaluation, Molecular Docking, and In Silico ADME Prediction
Sara Sadeghian, Fateme Zare, Lotfollah Saghaie, Afshin Fassihi, Pooria Zare, et al.
Medicinal Chemistry, 2024
Introduction: Drug resistance to existing antimicrobial drugs has become a serious threat to human health, which highlights the need to develop new antimicrobial agents. Methods: In this study, a new set of 3-hydroxypyridine-4-one derivatives (6a-j) was synthesized, and the antimicrobial effects of these derivatives were evaluated against a variety of microorganisms using the microdilution method. The antimicrobial evaluation indicated that compound 6c, with an electron-donating group -OCH3 at the meta position of the phenyl ring, was the most active compound against S. aureus and E. coli species with an MIC value of 32 μg/mL. Compound 6c was more potent than ampicillin as a reference drug. Results: The in vitro antifungal results showed that the studied derivatives had moderate effects (MIC = 128-512 μg/mL) against C. albicans and A. niger species. The molecular modeling studies revealed the possible mechanism and suitable interactions of these derivatives with the target protein. Conclusion: The obtained biological results offer valuable insights into the design of more effective antimicrobial agents.
Design, synthesis, in silico ADME, DFT, molecular dynamics simulation, anti-tyrosinase, and antioxidant activity of some of the 3-hydroxypyridin-4-one hybrids in combination with acylhydrazone derivatives
Razieh Fazel, Bahareh Hassani, Fateme Zare, Habibollah Jokar Darzi, Mehdi Khoshneviszadeh, et al.
Journal of Biomolecular Structure and Dynamics, 2024
Smart Stimuli Responsive Hydrogels; Fascinating platform for Therapeutic Applications
Journal of Mazandaran University of Medical Sciences, 2023
Synthesis, Antimicrobial Evaluation, Molecular Docking, and ADME Studies of Some Novel 3-Hydroxypyridine-4-one Derivatives
Sara Sadeghian, Fateme Zare, Ghazal Goshtasbi, Afshin Fassihi, Lotfollah Saghaie, et al.
Chemistryselect, 2023
Synthesis of 3-hydroxypyridin-4-one derivatives bearing benzyl hydrazide substitutions towards anti-tyrosinase and free radical scavenging activities
Bahareh Hassani, Fateme Zare, Leila Emami, Mehdi Khoshneviszadeh, Razieh Fazel, et al.
Rsc Advances, 2023
Comparison of Protective Effects of Phenolic Acids on Protein Glycation of BSA Supported by in Vitro and Docking Studies
Marzieh Rashedinia, Zeinab Rasti Arbabi, Razieh Sabet, Leila Emami, Alireza Poustforoosh, et al.
Biochemistry Research International, 2023
Aryloxy Alkyl Theophylline Derivatives as Antifungal Agents: Design, Synthesis, Biological Evaluation and Computational Studies
Zeinab Faghih, Leila Emami, Kamiar Zomoridian, Razieh Sabet, Rahele Bargebid, et al.
Chemistryselect, 2022
Fluconazole-Like Compounds as Potential Antifungal Agents: QSAR, Molecular Docking, and Molecular Dynamics Simulation
Farnaz Salehi, Leila Emami, Zahra Rezaei, Soghra Khabnadideh, Behnaz Tajik, et al.
Journal of Chemistry, 2022
Quinazoline analogues as cytotoxic agents; QSAR, docking, and in silico studies
Leila Emami, Razieh Sabet, Soghra Khabnadideh, Zeinab Faghih, Parvin Thayori
Research in Pharmaceutical Sciences, 2021
2-(Chloromethyl)-3-phenylquinazolin-4(3H)-ones as potent anticancer agents; cytotoxicity, molecular docking and in silico studies
Leila Emami, Zeinab Faghih, Soghra Khabnadideh, Zahra Rezaei, Razieh Sabet, et al.
Journal of the Iranian Chemical Society, 2021
An Efficient Method for Synthesis of Some Novel Spirooxindole-4H-Pyran Derivatives
Masoumeh Divar, Kamiar Zomorodian, Razieh Sabet, Maryam Moeini, Soghra Khabnadideh
Polycyclic Aromatic Compounds, 2021
Design, synthesis, in vitro evaluation and molecular docking study of N'-Arylidene imidazo [1,2-a] pyridine -2-carbohydrazide derivatives as novel Tyrosinase inhibitors
Tahereh Damghani, Saba Hadaegh, Mahsima khoshneviszadeh, Somayeh Pirhadi, Razieh Sabet, et al.
Journal of Molecular Structure, 2020
Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents
Soghra Khabnadideh, Zeinab Faghih, Nasrin Rahmannejadi, Razieh Sabet, Kamiar Zomorodian, et al.
Research in Pharmaceutical Sciences, 2019
Novel Catechol Derivatives of Arylimidamides as Antileishmanial Agents
Foroogh Rezaei, Lotfollah Saghaie, Razieh Sabet, Afshin Fassihi, Gholamreza Hatam
Chemistry and Biodiversity, 2018
Iron chelation afforded cardioprotection against H2O 2-induced H9C2 cell injury: Application of novel 3-hydroxy pyridine-4-one derivatives
Razieh Sabet, Mohaddeseh Behjati, Rouhollah Vahabpour, Arash Memarnejadian, Mahboubeh Rostami, et al.
International Journal of Cardiology, 2012
Synthesis, calcium-channel blocking activity, and conformational analysis of some novel 1,4-dihydropyridines: Application of PM3 and DFT computational methods
Afshin Fassihi, Karim Mahnam, Behzad Moeinifard, Maryam Bahmanziari, Hojjat Sadeghi Aliabadi, et al.
Medicinal Chemistry Research, 2012
QSAR study of anthranilic acid sulfonamides as methionine aminopeptidase-2 inhibitors
Afshin Fassihi, Mohsen Shahlaei, Behzad Moeinifard, Razieh Sabet
Monatshefte Fur Chemie, 2012
Computer-aided design of novel antibacterial 3-hydroxypyridine-4-ones: Application of QSAR methods based on the MOLMAP approach
Razieh Sabet, Afshin Fassihi, Bahram Hemmateenejad, Lotfollah Saghaei, Ramin Miri, et al.
Journal of Computer Aided Molecular Design, 2012
Application of different chemometric tools in QSAR study of azolo-adamantanes against influenza A virus
Research in Pharmaceutical Sciences, 2011
QSAR study of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2 using LS-SVM and GRNN based on principal components
Mohsen Shahlaei, Razieh Sabet, Maryam Bahman Ziari, Behzad Moeinifard, Afshin Fassihi, et al.
European Journal of Medicinal Chemistry, 2010
QSAR study of isatin analogues as in vitro anti-cancer agents
Razieh Sabet, Mehrdad Mohammadpour, Amir Sadeghi, Afshin Fassihi
European Journal of Medicinal Chemistry, 2010
Quantitative structure-activity relationship studies on 2-amino-6-arylsulfonylbenzonitriles as human immunodeficiency viruses type 1 reverse transcriptase inhibitors using descriptors obtained from substituents and whole molecular structures
Bahram Hemmateenejad, Razieh Sabet, Afshin Fassihi
Chemical Biology and Drug Design, 2009
QSAR study of PETT derivatives as potent HIV-1 reverse transcriptase inhibitors
Razieh Sabet, Afshin Fassihi, Behzad Moeinifard
Journal of Molecular Graphics and Modelling, 2009
Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides
Afshin Fassihi, Zahra Azadpour, Neda Delbari, Lotfollah Saghaie, Hamid R. Memarian, et al.
European Journal of Medicinal Chemistry, 2009
Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives
Afshin Fassihi, Daryoush Abedi, Lotfollah Saghaie, Razieh Sabet, Hossein Fazeli, et al.
European Journal of Medicinal Chemistry, 2009
QSAR study of antimicrobial 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives using different chemometric tools
Razieh Sabet, Afshin Fassihi
International Journal of Molecular Sciences, 2008
QSAR study of p56 lck protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS
Afshin Fassihi, Razieh Sabet
International Journal of Molecular Sciences, 2008
Composition of the essential oil of lonicera nummularifolia Jaub et Spach
K. Javidnia, R. Miri, R. Sabet, A. Jafari
Journal of Essential Oil Research, 2004

Razieh Sabet

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Scopus Publications