Computational approach for the identification of skeletal muscle-specific AMPK complex (α2β2γ1) activators for type-2 diabetes therapy Srinivasa R. Vulichi, Abhiram Kumar, Ashish Runthala, Shivang Shukla, Partha Sarathi Sahoo, et al. Journal of Applied Pharmaceutical Science, 2026 The present study aims to identify skeletal muscle-specific (α2β2γ1) AMP-activated protein kinase (AMPK) activators by utilizing bioinformatic tools. This study introduces a sensible computational strategy to systematically identify skeletal muscle-specific AMPK activators, thus providing a platform for developing novel therapeutics for Type-2 diabetes mellitus. Owing to the concerning systemic complications and off-target toxicity of the existing anti-diabetic drugs, our preliminary attempt involves structure-based virtual screening of a library of small molecules against the target using a combination of computational tools to reliably pinpoint molecules that could selectively interact with skeletal muscle-specific AMPK complex. The computationally screened library of selective small molecules was retrieved from the PubChem database against the crystal structure of full-length human α2β2γ1 AMPK complex (PDB ID: 6B2E with a resolution of 3.80 Å) from protein databank. The screening comprised a series of approaches, including molecular docking, molecular dynamics simulations, molecular mechanics/generalised born surface area, density functional theory calculations, pharmacokinetics, and toxicity prediction performed using a combination of relevant computational tools. In conclusion, this study has unveiled some interesting in silico hits that seem to have the potential to facilitate the development of a variety of plausible candidate skeletal muscle-specific (α2β2γ1) AMPK activators.
Biodegradable Lipids and Surfactants: Next-Generation Drug Delivery for Cancer Therapeutics Abhiram Kumar, Girija Patel, Kumar Pranav Narayan Applications of Nanomaterials for Oncology, 2026 This chapter explores the emerging role of biodegradable lipids and surfactants as innovative carriers in next-generation drug delivery systems (DDS) for cancer therapeutics. Cancer treatment faces significant challenges, including systemic toxicity, drug resistance, and poor targeting efficiency. Biodegradable lipids and surfactants offer promising solutions due to their biocompatibility, ability to enhance drug solubility, and improved targeted delivery to tumour sites. This chapter discussed the physicochemical properties of these biodegradable materials that facilitate controlled drug release and minimize adverse effects. Additionally, stimuli-responsive biodegradable surfactants that trigger drug release in the tumour microenvironment have been explored and highlighted the potential therapeutic outcomes. Through analysis of recent preclinical and clinical studies, the chapter aims to present a comprehensive overview of how biodegradable lipids and surfactants shape the future of cancer drug delivery, offering more effective, safer, and personalized patient therapies.
Concurrent nanotherapeutics and regulatory updates for the management of amyotrophic lateral sclerosis: a focused review for orphan drug (Tofersen) Abhiram Kumar, Shivang Shukla, Anjali Rai, Priya Pathak, Kumar Pranav Narayan Orphanet Journal of Rare Diseases, 2025 Background Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder affecting nerve cells in the brain and spinal cord. With a global incidence of 1.9 to 6 per 100,000 people, ALS is slightly more common in men and prevalent in individuals over 60. However, this review provides a concise update on the regulatory landscape and therapeutic advancements in managing ALS, focusing on the recent approval of Tofersen, the first gene therapy specifically targeting SOD1 mutation-related ALS. Results It highlights Tofersen unique role as an orphan drug approved by the US FDA, emphasizing its mechanism of action, gene silencing and its impact on reducing neurodegeneration. Additionally, the review synthesizes data from ongoing clinical trials, pharmacovigilance reports, and case studies to comprehensively understand Tofersen’s safety, efficacy and market exclusivity. Beyond this, it explores the emerging potential of nanotherapeutic approaches to ALS treatment, identifying critical research gaps and future directions. Conclusion Integrating regulatory updates, clinical evidence, and innovative therapeutic strategies, the review uniquely contributes to the ALS literature by bridging current treatment realities with potential future therapies, aiming to inform researchers, clinicians, and policymakers on optimizing ALS management. Graphical Abstract
Transforming growth factor-beta (TGF-β) mediated induction of miR-21-5p drives oral squamous cell carcinoma (OSCC) progression through suppression of KLF5 P Karemore, JP Jayaprakash, SV Muralidharan, S Ghosh, KP Narayan, ... The Nucleus, 1-19 , 2026 2026
Folate receptor-mediated delivery of doxorubicin modulates tumor-associated macrophages for effective anti-oral cancer therapy D Bhattacharya, K Sakhare, A Ansari, A Kumar, P Khandelia, R Banerjee, ... The Nucleus, 1-12 , 2026 2026
Emerging role of miR-21 in head and neck squamous cell carcinoma: From molecular functions to therapeutic prospects P Karemore, JP Jayaprakash, KP Narayan, P Khandelia Human Gene, 201559 , 2026 2026
Development and Evaluation of DNA Methyltransferase Inhibitor-Loaded Liposomes as a New Frontier in Pancreatic Ductal Adenocarcinoma Therapy S Katke, S Singh, S Padhi, K Sakhare, KP Narayan, A Chaurasiya Journal of Pharmaceutical Innovation 21 (2), 117 , 2026 2026
Computational Approach for Identification of Skeletal Muscle-Specific AMPK Activators for Type-2 Diabetes Therapy SR Vulichi, A Kumar, A Runthala, S Shukla, PS Sahoo, K Pakeeraiah, ... 2026
Development of DNA Methyltransferase Inhibitor Loaded Surface Engineered Copolymeric Nanoparticles for Pancreatic Ductal Adenocarcinoma Treatment: Optimization … S Katke, K Panchal, S Singh, S Padhi, K Sakhare, KP Narayan, ... BioNanoScience 16 (2), 124 , 2026 2026
Biodegradable Lipids and Surfactants: Next-Generation Drug Delivery for Cancer Therapeutics A Kumar, G Patel, KP Narayan Applications of Nanomaterials for Oncology, 1-34 , 2026 2026
An in situ-forming injectable silk hydrogel with a cocktail of chemotherapeutic drugs simultaneously targeting cancer cells and cancer stem cells J Kumarasekar, A Kumar, J Rajendran, KP Narayan, J Giri Journal of Materials Chemistry B 14 (8), 2612-2629 , 2026 2026
Artificial Intelligence in Detecting and Diagnosing Microbiome-Driven Cancer: An Emerging Paradigm A Kumar, A Rai, S Shukla, C Dhiman, KP Narayan Enhancing Autonomous and Adaptive Systems With AI and IoT, 357-406 , 2026 2026
Nano-formulation technology for simultaneous paclitaxel and andrographolide delivery: pre-formulation insights R Singh, A Kumar, D Srivastava, KP Narayan, M Chaurasia, SJS Flora Essential Chem 2 (1), 2533990 , 2025 2025 Citations: 3
Concurrent nanotherapeutics and regulatory updates for the management of amyotrophic lateral sclerosis: a focused review for orphan drug (Tofersen) A Kumar, S Shukla, A Rai, P Pathak, KP Narayan Orphanet Journal of Rare Diseases 20 (1), 598 , 2025 2025
Development of Folate Receptor (FR-α) Mediated Nano Carrier Sustained Release Formulation for Ameliorating Colorectal Cancer A Kumar, K Narayan MDPI , 2025 2025
Microplastics Are Contaminants of Emerging Concern in Aquatic Environments: An Overview P Rath, LK Bhardwaj, A Kumar, KP Narayan Emerging Contaminants in the Aquatic Environment: Global Overview, 105-127 , 2025 2025
Health and Environmental Hazards E Priyanka, A Kumar, KP Narayan Emerging Contaminants in the Aquatic Environment: Global Overview, 61-85 , 2025 2025
Glucocorticoid receptor-mediated delivery of paclitaxel and anticancer gene p53 for oral cancer therapeutics K Sakhare, D Bhattacharya, C Dhiman, P Erukulla, S Bhattacharya, ... Biomedical Materials 20 (5), 055010 , 2025 2025 Citations: 3
A Concurrent Review on Plant-Derived Biopesticides and Synthetic Pesticides: Their Importance in Plant Protection and Impacts on Human Health. RV Ramchandar, A Kumar, E Priyanka, MR Bharati, LK Bhardwaj, ... Nature Environment & Pollution Technology 24 (3) , 2025 2025 Citations: 5
Regulatory crosstalk between TGF-β signaling and mirnas: a head and neck cancer perspective P Karemore, JP Jayaprakash, KP Narayan, P Khandelia The Nucleus 68 (2), 353-367 , 2025 2025 Citations: 4
Exploring possible hub genes of metabolic syndrome and type 2 diabetes mellitus: a systematic network biology study A Runthala, SR Vulichi, S Kosanam, R Pasupula, K Ramakrishna, ... Scientific Reports 15 (1), 23108 , 2025 2025 Citations: 2
Fabrication of Polymeric Matrix Type Transdermal Patch Containing Glimepiride for Therapeutic Management of Type-2 Diabetes. A Kumar, P Maurya, KP Narayan Indian Journal of Pharmaceutical Education & Research 59 (3) , 2025 2025 Citations: 4
Targeting Cancer Stem Cells in Gynecological Malignancies: Emerging Advanced Therapeutic RSS Kotipalli, M Sharma, NS Kumar, P Khandelia, KP Narayan Breast and Gynecological Cancers-New Perspectives and Applications in Their … , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Genetic relatedness among Trichoderma isolates inhibiting a pathogenic fungi Rhizoctonia solani KP Shalini, Narayan KP, Lata, AS Kotasthane African Journal of Biotechnology 5 (8), 580-584 , 2006 2006 Citations: 81
Dual targeting of folate receptor-expressing glioma tumor-associated macrophages and epithelial cells in the brain using a carbon nanosphere–cationic folate nanoconjugate CK Elechalawar, D Bhattacharya, MT Ahmed, H Gora, K Sridharan, ... Nanoscale Advances 1 (9), 3555-3567 , 2019 2019 Citations: 49
Selective cancer targeting via aberrant behavior of cancer cell-associated glucocorticoid receptor A Mukherjee, KP Narayan, K Pal, JM Kumar, N Rangaraj, SV Kalivendi, ... Molecular Therapy 17 (4), 623-631 , 2009 2009 Citations: 40
Targeting steroid hormone receptors for anti‐cancer therapy—A review on small molecules and nanotherapeutic approaches N Mahadik, D Bhattacharya, A Padmanabhan, K Sakhare, KP Narayan, ... Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 14 (2 … , 2022 2022 Citations: 32
Synthesis and anticancer activity of thiadiazole containing thiourea, benzothiazole and imidazo [2, 1-b][1, 3, 4] thiadiazole scaffolds SP Avvaru, MN Noolvi, UA More, S Chakraborty, A Dash, TM Aminabhavi, ... Medicinal chemistry 17 (7), 750-765 , 2021 2021 Citations: 26
Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management A Kumar, K Sakhare, D Bhattacharya, R Chattopadhyay, P Parikh, ... Frontiers in Nutrition 9, 966152 , 2022 2022 Citations: 21
Effects of alternate nutrient medium on microalgae biomass and lipid production as a bioenergy source for fuel production S Sanghamitra, S Deshmukh, KP Narayan Materials Today: Proceedings 28, 659-664 , 2020 2020 Citations: 21
Decoding the ‘fifth’nucleotide: impact of RNA pseudouridylation on gene expression and human disease A Jalan, PJ Jayasree, P Karemore, KP Narayan, P Khandelia Molecular Biotechnology 66 (7), 1581-1598 , 2024 2024 Citations: 18
Delivery of chemotherapeutic drug targeting folate receptor to oral cancer cells using functionalized carbon nanospheres D Bhattacharya, K Sakhare, C Dhiman, A Ansari, TK Kundu, KP Narayan, ... Biomedical Materials 18 (5), 055012 , 2023 2023 Citations: 17
Bacteriocinogeny: concept, nomenclature, prevalence and application YD Gaur, KP Narayan, S Chauhan, A Ali Indian Journal of Microbiology 44 (1), 1-30 , 2004 2004 Citations: 16
Biodiversity analysis of selected cyanobacteria. KP Narayan, S Tiwari, S Pabbi, DW Dhar Current Science (00113891) 91 (7) , 2006 2006 Citations: 13
Development of a quality by design based hybrid RP-HPLC method for Glimepiride: Bioanalytical and industrial applications A Kumar, C Dhiman, M Kumar, N Kannappan, D Kumar, MK Chourasia, ... Journal of Applied Pharmaceutical Science 15 (4), 102-115 , 2025 2025 Citations: 11
Injectable, in-situ forming, tunable, biocompatible gelatin hydrogels for biomedical applications M Chauhan, P Roopmani, J Rajendran, KP Narayan, J Giri International Journal of Biological Macromolecules 285, 138200 , 2025 2025 Citations: 10
The prospects of nanotherapeutic approaches for targeting tumor-associated macrophages in oral cancer D Bhattacharya, K Sakhare, KP Narayan, R Banerjee Nanomedicine: Nanotechnology, Biology and Medicine 34, 102371 , 2021 2021 Citations: 10
Mineralocorticoid receptor mediated liposomal delivery system for targeted induction of apoptosis in cancer cells P Sharma, R Banerjee, KP Narayan Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (2), 415-421 , 2016 2016 Citations: 10
Recent Advances in Nanotherapeutics and Theranostics for Squamous Cell Carcinoma: A Comprehensive Review N Sharma, A Kumar, S Sambhakar, D Bhatia, S Hussain, M Mursal, ... Current drug delivery , 2025 2025 Citations: 6
Dicationic amphiphiles bearing an amino acid head group with a long-chain hydrophobic tail for in vitro gene delivery applications S Manturthi, KP Narayan, SV Patri RSC advances 12 (51), 33264-33275 , 2022 2022 Citations: 6
A Concurrent Review on Plant-Derived Biopesticides and Synthetic Pesticides: Their Importance in Plant Protection and Impacts on Human Health. RV Ramchandar, A Kumar, E Priyanka, MR Bharati, LK Bhardwaj, ... Nature Environment & Pollution Technology 24 (3) , 2025 2025 Citations: 5
Nanotherapeutics: restoring gut-dysbiosis and inducing cancer apoptosis A Kumar, C Dhiman, KP Narayan, M Kumar, M Sharma Spatially Variable Genes in Cancer: Development, Progression, and Treatment … , 2025 2025 Citations: 5
Regulatory crosstalk between TGF-β signaling and mirnas: a head and neck cancer perspective P Karemore, JP Jayaprakash, KP Narayan, P Khandelia The Nucleus 68 (2), 353-367 , 2025 2025 Citations: 4