Manikkavalli Gurunathan Ragunathan

Dr. M.G. Ragunathan obtained Ph. D Degree in 1996 and his area of specialization is Crustacean Reproduction.
Recipient of several fellowships from reputed Academic societies of the country, recipient of Dr. G.K. Kulkarni gold medal, Environmental Sciences gold medal, Dr. Dutta Munshi gold medal and Dr. K.K. Tyagi gold medal for his contribution in Zoology.
Regional in charge and executive member of Zoological Society of India, Bodh Gaya .
Member of editorial boards of several international journals.
Published 120 research papers in the National and International journals.
Recognized supervisor of University of Madras and guiding students for M. Phil and Ph. D degree programs.
Written several books in Zoology at both School and College level.
Council member of Indian Science Congress Association, Kolkata
Presently the Executive members of Indian Science Congress Association, Kolkata

EDUCATION

PGDESD 2013 Tamilnadu open university Environment
PhD (Zoology) 1995 SirTheagarayaCollege, Chennai – 21
M.Phil (Zoology)1990 Pachaiyappa’s College, Chennai – 30
M.Sc 1989 (Zoology) VoorheesCollege, Vellore – 1
B.Sc 1987 (Zoology) Voorhees College, Vellore– 1

RESEARCH INTERESTS

Crustacean Biology, Entomology, Environmental Science

Scopus Publications

Computational approaches for modeling and structural design of biological systems: A comprehensive review
Ekambaram Gayathiri, Palanisamy Prakash, Priya Kumaravel, Jayanthi Jayaprakash, Manikkavalli Gurunathan Ragunathan, et al.
Progress in Biophysics and Molecular Biology, 2023
Entomophagy practices among the primitive tribes inhabiting the Nilgiris district of Western Ghats, Tamil Nadu, South India
Indian Journal of Traditional Knowledge, 2023
In silico and in vitro approaches to evaluate the bioactivities of Chaetomorpha linum
Ekambaram Gayathiri, Periyasamy Mahalakshmi, Thangaraj Pratheep, Palanisamy Prakash, Kuppusamy Selvam, et al.
South African Journal of Botany, 2022
Application of Fuzzy Matrix in the Analysis of Prevalence of Diabetic Retinopathy in Diabetic Population among Men and Women
T. Subhramaniyan, S. Suruthi, M. S. Paulraj, M. G. Ragunathan, J. Jayanthi
Aip Conference Proceedings, 2022
Plant microbe based remediation approaches in dye removal: A review
Ekambaram Gayathiri, Palanisamy Prakash, Kuppusamy Selvam, Mukesh Kumar Awasthi, Ravindran Gobinath, et al.
Bioengineered, 2022
Increased industrialization demand using synthetic dyes in the newspaper, cosmetics, textiles, food, and leather industries. As a consequence, harmful chemicals from dye industries are released into water reservoirs with numerous structural components of synthetic dyes, which are hazardous to the ecosystem, plants and humans. The discharge of synthetic dye into various aquatic environments has a detrimental effect on the balance and integrity of ecological systems. Moreover, numerous inorganic dyes exhibit tolerance to degradation and repair by natural and conventional processes. So, the present condition requires the development of efficient and effective waste management systems that do not exacerbate environmental stress or endanger other living forms. Numerous biological systems, including microbes and plants, have been studied for their ability to metabolize dyestuffs. To minimize environmental impact, bioremediation uses endophytic bacteria, which are plant beneficial bacteria that dwell within plants and may improve plant development in both normal and stressful environments. Moreover, Phytoremediation is suitable for treating dye contaminants produced from a wide range of sources. This review article proves a comprehensive evaluation of the most frequently utilized plant and microbes as dye removal technologies from dye-containing industrial effluents. Furthermore, this study examines current existing technologies and proposes a more efficient, cost-effective method for dye removal and decolorization on a big scale. This study also aims to focus on advanced degradation techniques combined with biological approaches, well regarded as extremely effective treatments for recalcitrant wastewater, with the greatest industrial potential.
A Study on Finding the Most Prevalent Age Groups of Diabetic Retinopathy among Diabetic Population Using Fuzzy Matrix Theory
T. Subhramaniyan, S. Suruthi, M.S. Paulraj, M. G. Ragunathan, J. Jayanthi
Journal of Physics Conference Series, 2021
In this paper, authors identified the age group of Diabetic population which is affected by Diabetic Retinopathy (DR) using Fuzzy Matrix Theory. It has been shown that there is no significant difference between the men and women age group among Diabetic population developing DR.
In vitro and in silico toxicological properties of natural antioxidant therapeutic agent azima tetracantha. lam
Palanisamy Prakash, Nisha Kumari, Ekambaram Gayathiri, Kuppusamy Selvam, Manikavali Gurunadhan Ragunathan, et al.
Antioxidants, 2021
Plant-derived antioxidants are a large group of natural products with the capacity to reduce radical-scavenging. Due to their potent therapeutic and preventive actions, these compounds receive a lot of attention from scientists, particularly pharmacologists. The pharmacological activities of the Azima tetracantha Lam. (AT) plant, belonging to the Salvadoraceae family, reported here justifies its traditional use in treating several diseases or disorders. This study aims to look at the propensity of certain plant compounds found in natural AT plant extracts that might play a critical role as a secondary metabolite in cervical cancer treatment. There is a shortage of information on the plant’s phytochemical and biological characteristics. Methanol (MeOH) solvent extracts of the dried AT plant were screened phytochemically. Its aqueous extract was tested for antioxidant, antiseptic, anti-inflammatory, and anticancerous properties. Absorption Distribution Metabolism and Excretion (ADME/T), Docking, and HPLC were also performed. In clinical treatment, the plant shown no adverse effects. The antioxidant activity was evaluated and showed the highest concentration at 150 µg/mL (63.50%). MeOH leaf extract of AT exhibited the highest and best inhibitory activity against Staphylococcus aureus (15.3 mm/1000) and displayed a high antiseptic potential. At a 200 µg/mL concentration, MeOH leaves-extract inhibited red blood cells (RBC) hemolysis by 66.56 ± 0.40, compared with 62.33 ± 0.40 from the standard. Albumin’s ability to suppress protein denaturation ranged from 16.75 ± 0.65 to 62.35 ± 0.20 inhibitions in this test, providing even more support for its favorable anti-inflammatory properties. The ADME/T studies were considered for a potential cancer drug molecule, and one of our compounds from MeOH extract fills the ADME and toxicity parameters. The forms of compound 4 showed a strong hydrogen-bonding interaction with the vital amino acids (ASN923, THR410, LEU840TRY927, PHE921, and GLY922). A total of 90% of cell inhibition was observed when HeLa cell lines were treated with 300 µg/mL of compound 4 (7-acetyl-3a1-methyl- 4,14-dioxo-1,2,3a,3a1,4,5,5a,6,8a,9b,10,11,11a-tetradecahydro-2,5a epoxy5,6a (methanooxymethano)phenaleno[1′,9′:5,6,7]indeno[1,7a-b]oxiren-2-yl acetate). The polyphenol compounds demonstrated significant advances in anticancer drug properties, and it could lead to activation of cancer cell apoptosis.
Studies on plant selection framework for soil bioengineering application
E. Gayathiri, R. Gobinath, G.P. Ganapathy, Ashwini Arun Salunkhe, J. Jayanthi, et al.
Computers in Earth and Environmental Sciences Artificial Intelligence and Advanced Technologies in Hazards and Risk Management, 2021
Immunomodulatory activity of Salvinia molesta D.S. Mitchell in fresh water crab Oziotelphusa senex senex bacterially challenged with Pseudomonas aeruginosa
T.G. Nithya, D. Sumalatha, M.G. Ragunathan, J. Jayanthi
Journal of King Saud University Science, 2019
Study of antimicrobial protein from the hemolymph of freshwater crab Oziotelphusa senex senex and its efficacy against the human pathogens
Sumalatha D, Nithya Tg, Jayanthi J, Ragunathan Mg
Asian Journal of Pharmaceutical and Clinical Research, 2018
Objective: The study was done to isolate the antimicrobial protein from the freshwater crab.Methods: Antimicrobial protein was purified by sequential step of ammonium sulfate precipitation, dialysis, ion exchange chromatography, and fast protein liquid chromatography. The apparent molecular mass was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS/MS). Primary structure analysis was done from MASCOT search engine. The antimicrobial activity of the protein was done using well diffusion method against Gram-positive and Gram-negative bacteria.Results: The molecular mass of antimicrobial protein was determined to be 33KDa by SDS-PAGE and MALDI-MS/MS. The antimicrobial protein contains eight peptides which were determined by MASCOT search engine. The protein exhibited antimicrobial activity both for Gram-positive and Gram-negative bacteria.Conclusion: The results could provide information for investigating the antimicrobial protein derived from the hemolymph of the freshwater crab Oziotelphusa senex senex.
Acute toxic effect of sewage effluent on the early life phase of an estuarine crab Scylla serrata
Manickavalli Gurunadhan Ragunathan
Environmental Science and Pollution Research, 2017
Vicissitudes of oxidative stress biomarkers in the estuarine crab Scylla serrata with reference to dry and wet weather conditions in Ennore estuary, Tamil Nadu, India
M.G. Ragunathan
Marine Pollution Bulletin, 2017
Immune protection of Salvinia molesta D.S. mitchell in freshwater crab Oziotelphusa senex senex bacterially challenged with Aeromonas hydrophila
Nithya Tg, Jayanthi J, Ragunathan Mg, Devakumar D
Asian Journal of Pharmaceutical and Clinical Research, 2017
Insilico characterisation of proteins of salvinia molesta d.s.mitchell an aquatic weed and assessment of nanoparticle synthesising ability of closely related plant species
International Journal of Pharma and Bio Sciences, 2016
Antimicrobial potential of hemolymph of a fresh water crab Oziotelphusa senex senex ((Fabricius 1798)
International Journal of Pharmtech Research, 2016
Antioxidant activity, total phenol, flavonoid, alkaloid, tannin, and saponin contents of leaf extracts of Salvinia molesta D. S. Mitchell (1972)
Asian Journal of Pharmaceutical and Clinical Research, 2016
Phytochemical, antibacterial and GC MS analysis of a floating fern salvinia molesta D.S. Mitchell (1972)
International Journal of Pharmtech Research, 2015
Changes in the neurosecretory cells of the brain and thoracic ganglion of male crab, Uca (Celuca) lactea annulipes with respect to seasons
Journal of Environmental Biology, 2001
Biochemical mobilization due to 5-hydroxytryptamine in a freshwater crab, Paratelphusa hydrodromous(Herbst)
Journal of Advanced Zoology, 2000
Changes in the neurosecretory cells in the brain and thoracic ganglion of UCA (celuca) Lactea annulipes due to 5- hydroxytryptamine, octopamlne and dopamine
Journal of Advanced Zoology, 2000
Influence of eyestalk ablation and 5-hydroxytryptamine on the gonadal development of a female crab, Paratelphusa hydrodromous (Herbst)
Current Science, 1999
Effects of biogenic amines on reproduction in a brackish water crab, Uca (Celuca) lactea annulipes
Journal of Environmental Biology, 1999
Concurrent effects of neuroendocrine tissue extracts and tranquilizers on the gonadal indices of a female crab, Paratelphusa hydrodromous (HERBST)
Journal of Advanced Zoology, 1998
Effects of reserpine and chlorpromazine on the phosphatases activity of a female fresh water crab, Paratelphusa hydrodromous (Herbst)
Journal of Environmental Biology, 1998
Impact of two tranquilizers, reserpine and chlorpromazine on certain neurosecretory cells and reproductive organs of eyestalk ablated female crab, Paratelphusa hydrodromous (Herbst)
Indian Journal of Experimental Biology, 1998

RECENT SCHOLAR PUBLICATIONS

A Short Comparative Review of the Biosynthesis of Silver Nanoparticles from Catharanthus roseus for Antibacterial Activity
JR Vaishali, J Jayanthi, MG Ragunathan
UTTAR PRADESH JOURNAL OF ZOOLOGY 46 (24), 179-189 , 2025
2025
Isolation and Characterization of Collagen from Cephalothorax of Penaeus
J Jayanthi, M Jevedha, MG Ragunathan
UTTAR PRADESH JOURNAL OF ZOOLOGY 46 (20), 183-192 , 2025
2025
Quality Retention and Shelf Life Extension in the White Leg Shrimp Litopenaeus Vannamei (Boone, 1931) Using Acalypha indica Leaf Extract
J Jayanthi, MG Ragunathan, M Jayashree, M Jevedha, K Kanakaraj
UTTAR PRADESH JOURNAL OF ZOOLOGY 46 (17), 291-300 , 2025
2025
Riboflavin Enrichment of Oziotelphusa senex senex Meat Via Microbial Biofortification Using Bacillus subtilis
J Jayanthi, K Kanakaraj, MG Ragunathan
UTTAR PRADESH JOURNAL OF ZOOLOGY 46 (15), 185-203 , 2025
2025
Histological Analysis of the Gill and Swim Bladder of Hong Kong Catfish (Clarias fuscus)
K Basu, A YADAV
UTTAR PRADESH JOURNAL OF ZOOLOGY 45 (23), 197-204 , 2024
2024
Shrimp Aquaculture in Inland Saline Waters of Haryana: A Step towards Sustainable Aquafarming
R MG, A Yadav, J Jayanthi, K Basu, S Malakondaiah
UTTAR PRADESH JOURNAL OF ZOOLOGY 45 (17), 265-282 , 2024
2024
Citations: 3
Sustainable biodiversity conservation in tribal area
E Gayathiri, R Gobinath, J Jayanthij, P Prakash, MG Ragunathan
Sustainability of Natural Resources, 24-40 , 2024
2024
Citations: 1
2 Sustainable Biodiversity
P Prakash, MG Ragunathan
Sustainability of Natural Resources: Planning, Development, and Management, 24 , 2024
2024
Computational approaches for modeling and structural design of biological systems: A comprehensive review
E Gayathiri, P Prakash, P Kumaravel, J Jayaprakash, MG Ragunathan, ...
Progress in biophysics and molecular biology 185, 17-32 , 2023
2023
Citations: 84
Entomophagy practices among the primitive tribes inhabiting the Nilgiris district of Western Ghats, Tamil Nadu, South India
V Lokeshkumar, BA Daniel, J Jayanthi, MG Ragunathan
Indian Journal of Traditional Knowledge (IJTK) 22 (1), 195-201 , 2023
2023
Citations: 3
An investigation on the antimicrobial activity of shrimp exoskeleton extracted glycosaminoglycans (GAGs) against Escherichia coli and Staphylococcus aureu
RVJRMG Abhisubesh Vijayakumar, Jayanthi Jayaprakash * , Bharathi Ravikrishan ...
World Journal of Advanced Research and Reviews 17 (02), 570–577 , 2023
2023
Citations: 3
SCREENING AND PRODUCTION OF PROBIOTIC ENZYMES AND BIOMOLECULES FROM GUT MICROFLORA OF SCYLLA SERRATA (FORSKAL, 1775)
JJ M.G. RAGUANATHAN
International Journal of Novel Research and Development 8 (5) , 2023
2023
ANTIBACTERIAL ACTIVITY OF SAND CRAB (EMERITA ASIATICA) HEMOLYMPH AGAINST NILE TILAPIA (OREOCHROMIS NILOTICUS) INFECTED WITH AEROMONAS SALMONICIDA AND EDWARDSIELLA TARDA
JJ M.G. RAGUANATHAN
International Journal of Novel Research and Development 8 (5) , 2023
2023
Enhancement of Biofertilizer with Chitosan Extracted from Shrimp Exoskeleton Waste
RMGJJ Ankesh Yadav, Nabajeet Muhuri
Revisiting the Sustainable goals in applied zoology, 144-154 , 2023
2023
ENTREPRENEURSHIP EDUCATION
JJ M.G. RAGUANATHAN
GURU NANAK JOURNAL OF MULTIDISCIPLINARY RESEARCH 2 (SPECIAL ISSUE) , 2023
2023
Antagonistic Potential Marine Bacteria Against Luminescent Vibriosis Pathogen Vibrio Harveyi Obtained from Shrimp Farm, Marakkanam, Tamil Nadu, India.(2022)
M Sakthivel, J Jayanthi, MG Ragunathan
Int. J. Life Sci. Pharma Res 12 (4), L14-22 , 2023
2023
Citations: 1
DIGITIZATION OF THE DATA ON INDIAN FRESHWATER CRABS: 2 BARYTELPHUSA CUNICULARIS (WESTWOOD & SYKES, 1836)(DECAPODA: GECARCINUCIDAE)
DM Sujipriya, J Jayanthi, KV Jayachandran, MG Ragunathan
Turkish Journal of Physiotherapy and Rehabilitation 32, 3 , 2023
2023
In Vitro and In Silico toxicological properties of natural antioxidant therapeutic agent Azima tetracantha.LAM.
AKNMK Palanisamy Prakash., Nisha Kumari.,ekambaram gayathri., Kuppusamy ...
Antioxidant 10 (1306) , 2023
2023
Citations: 14
Mathematical Predictions of Neuropathic Diabetes from Unit Level Data
P Sankar, T Subhramaniyan, J Jayanthi, MG Ragunathan
2023
PHYSICOCHEMICAL PROPERTIES AND PROFICIENT ACTIVITIES OF CHITIN AND CHITOSAN ISOLATED FROM THE SHELL WASTE OF A NATIVE FRESH WATER CRAB OZIOTELPHUSA SENEX SENEX
D Alwin Rajan, MG Ragunathan, J Jayanthi
2023

MOST CITED SCHOLAR PUBLICATIONS

Computational approaches for modeling and structural design of biological systems: A comprehensive review
E Gayathiri, P Prakash, P Kumaravel, J Jayaprakash, MG Ragunathan, ...
Progress in biophysics and molecular biology 185, 17-32 , 2023
2023
Citations: 84
Plant microbe based remediation approaches in dye removal: a review
E Gayathiri, P Prakash, K Selvam, MK Awasthi, R Gobinath, RR Karri, ...
Bioengineered 13 (3), 7798-7828 , 2022
2022
Citations: 62
Antioxidant activity, total phenol, flavonoid, alkaloid, tannin, and saponin contents of leaf extracts of Salvinia molesta DS Mitchell (1972)
TG Nithya, J Jayanthi, MG Ragunathan
Asian J Pharm Clin Res 9 (1), 185-8 , 2016
2016
Citations: 57
Fabrication of collagen with polyhexamethylene biguanide: A potential scaffold for infected wounds
RMG Sripriya Ramasamy1 | Senthilkumar Muthusamy, Sureshbabu Nagarajan, Asha ...
J Biomed Mater Res., 1–12. , 2021
2021
Citations: 31
Phytochemical, antibacterial and GC MS analysis of a floating fern Salvinia molesta DS Mitchell (1972)
TG Nithya, J Jayanthi, MG Raghunathan
Int. J. PharmTech Res 8, 85-90 , 2015
2015
Citations: 22
Nutritive evaluations of laboratory-reared edible field cricket Coiblemmus compactus Chopard, 1928 (Orthoptera: Gryllidae), for utilising them as an alternate …
V Lokeshkumar, BA Daniel, J Jayanthi, MG Ragunathan
The Journal of Basic and Applied Zoology 83 (1), 26 , 2022
2022
Citations: 17
Vicissitudes of oxidative stress biomarkers in the estuarine crab Scylla serrata with reference to dry and wet weather conditions in Ennore estuary, Tamil Nadu, India
MG Ragunathan
Marine pollution bulletin 116 (1-2), 113-120 , 2017
2017
Citations: 17
In Vitro and In Silico toxicological properties of natural antioxidant therapeutic agent Azima tetracantha.LAM.
AKNMK Palanisamy Prakash., Nisha Kumari.,ekambaram gayathri., Kuppusamy ...
Antioxidant 10 (1306) , 2023
2023
Citations: 14
Antioxidant property of some extracts derived from the mud crab, genus scylla serrata
M Sujeetha, S Sharmila, J Jayanthi, M Ragunathan
International Journal of Phytopharmacology 6 (2), 111-113 , 2015
2015
Citations: 14
Molecular docking based screening dynamics for plant based identified potential compounds of PDE12 inhibitors
S Nirmalraj, E Gayathiri, M Sivamurugan, R Manivasagaperumal, ...
Current Research in Green and Sustainable Chemistry 4, 100122 , 2021
2021
Citations: 13
Quantitative and qualitative analysis of chitin and chitosan from the shell of the mud crab, Scylla serrata(Forskal, 1775)
MG Sujeetha, M., Sharmila, S., Jayanthi, J. and Ragunathan
International Journal of Pharmacy & T 6 (2), 69-72 , 2015
2015
Citations: 12
Changes in the neurosecretory cells of the brain and thoracic ganglion of male crab, Uca (celuca) lactea annulipes with respect to seasons.
S Jadhav, MG Ragunathan, M Deecaraman
Journal of Environmental Biology 22 (4), 311-314 , 2001
2001
Citations: 11
Herbal alternate to Pseudomonas aeruginosa infection in a freshwater crab, Oziotelphusa senex senex
D Devakumar, J Jayanthi, MG Ragunathan
aquaculture 3, 6 , 2013
2013
Citations: 10
A study on physico-chemical characteristics of Otteri Lake and Palar River waters in Vellore town, Tamil Nadu, India.
K Ragunathan,M.G., Mahalingam, S. and Vanitha Devi
J. Aqua. Biol. 15 (1 and 2), 56-58 , 2000
2000
Citations: 9
Studies on plant selection framework for soil bioengineering application
E Gayathiri, R Gobinath, GP Ganapathy, AA Salunkhe, J Jayanthi, ...
Computers in earth and environmental sciences, 299-317 , 2022
2022
Citations: 8
Identification of landslide-prone areas using remote sensing techniques in Sillahalla watershed, Nilgiris District, Tamilnadu, India
J Jayanthi, TN Raj, MS Gandhi
Int J Eng Technol 3 (6), 1947-1952 , 2016
2016
Citations: 8
Influence of eyestalk ablation and 5-hydroxytryptamine on the gonadal development of a female crab, Paratelphusa hydrodromous (Herbst)
MG Ragunathan, A Arivazhagan
Current Science, 583-587 , 1999
1999
Citations: 8
Efficiency of Psidium guajava leaf extract on the nitrogenous wastes in Aeromonas hydrophila infected fresh water crab, Oziotelphusa senex senex, J
D Devakumar, T Kumaran, J Jayanthi, MG Ragunathan
Recent Trends Biosci 2 (1), 47-52 , 2012
2012
Citations: 7
In silico and in vitro approaches to evaluate the bioactivities of Chaetomorpha linum
E Gayathiri, P Mahalakshmi, T Pratheep, P Prakash, K Selvam, ...
South African Journal of Botany 151, 581-590 , 2022
2022
Citations: 6
Plant microbe based remediation approaches in dye removal: A review. Bioengineered 13 (3): 7798–7828
E Gayathiri, P Prakash, K Selvam, MK Awasthi, R Gobinath, RR Karri, ...
2022
Citations: 6