Continuous bed motion versus step-and-shoot acquisition in LAFOV PET/CT: insights from multi-phantom and patient studies P. M. Linder, W. Lan, E. Calderón, I. Rausch, C. la Fougère, et al. Ejnmmi Physics, 2026 Background Continuous bed motion (CBM) allows flexible extension of the scan range compared to conventional step‑and‑shoot (S&S) acquisition but has not yet been evaluated in long axial field‑of‑view (LAFOV) PET/CT. This study systematically assessed the impact of CBM on image quality, noise, and quantitative performance in the Biograph Vision Quadra LAFOV PET/CT using multi‑phantom and patient scans compared to S&S. Methods A uniform tube phantom and a NEMA IEC phantom, positioned centrally and off-centre, were scanned across bed speeds (2.8–50 mm/s), sensitivity modes and scan ranges (106 and 150 cm) to evaluate image uniformity, axial count profiles, noise and contrast recovery coefficients (CRC). Ten oncological patients receiving [ 18 F]PSMA-1007 or [ 18 F]FDG underwent sequential CBM (2.8 mm/s, 378 s) and S&S (300 s) scans. Image noise, net true counts, and liver and lesion SUV values were compared using paired statistics and Bland–Altman analysis, along with PSMA expression scores. Results For comparable count statistics and image noise, CBM required a prolonged acquisition (378 s) to match the S&S (300 s) protocol, resulting in comparable image quality for phantoms and patients. CRC and image uniformity were preserved across all evaluated conditions, even at the FOV’s axial edge (50.5 cm) for 8.4 mm/s (22 mm sphere: CRC 76% S&S vs. 71% CBM). In patient scans, minor differences in axial count profiles, net true counts, and SUV values (SUV mean bias − 0.1 (liver) and − 0.8 (lesions)) did not affect clinical scores. Conclusions The prolonged CBM protocol provides image quality and quantitative performance comparable to S&S in LAFOV PET/CT. While the reconstructed image range remains constrained by CT coverage, the patient scan comparison with 106 cm scan range, together with extended range phantom measurements, indicate that CBM can support scan range extension beyond 106 cm without compromising diagnostic accuracy.
Exploring extended [18F]FDG kinetics in lymphoma with ultra-late LAFOV-PET/CT Matthias Weissinger, Stephan Ursprung, Johann Jacoby, Jonas Vogel, Eduardo Calderón, et al. European Journal of Nuclear Medicine and Molecular Imaging, 2026 Purpose This prospective trial investigated extended [¹⁸F]FDG kinetics in lymphoma to provide in-vivo insights into glucose metabolism with potential relevance for staging and risk stratification. Methods Fifteen consecutive, treatment- naïve lymphoma patients (4 Hodgkin, 11 non-Hodgkin) underwent routine whole-body [ 18 F]FDG-PET/CT at 1 h post injection (p.i., injected activity 3.02 ± 0.34 MBq/kg) followed by additional Long Axial Field-Of-View (LAFOV)-PET/CT scans at 3 h and 6 h p.i. (Biograph Vision Quadra ® , Siemens Healthineers; acquisition 5/15/30 min). Standardised uptake values (SUV) of lymphoma, benign lymph nodes, organs and reference tissues were quantified and multi time-point kinetics were described using Retention Indices (RI) and linear/quadratic trajectory analyses. Image quality was rated by two blinded readers on a 5-point Likert scale. Results Image quality remained diagnostic in all datasets. Median Tumour-to-Background Ratio (TBR) increased significantly from 4.1 (1 h p.i.) to 12.5 (3 h p.i.) and 23.9 (6 h p.i.), p < 0.001. High-grade lymphoma exhibited an almost linear SUV rise, whereas low-grade entities followed a parabolic course, peaking at 3 h p.i. Benign lymph nodes demonstrated constant uptake (1 h: 0.9 ± 0.3, 3 h: 0.8 ± 0.5, 6 h: 0.8 ± 0.4). RIs showed a significant increase in [¹⁸F]FDG uptake over time in lymphoma, compared with a decline in benign lymph nodes (1–3 h p.i.: 19.4% vs. -14.4%, p < 0.001). Conclusion The LAFOV scanner enables high-quality [¹⁸F]FDG PET imaging for up to 6 h p.i., with a six-fold increase of TBR in ultra-late scans 6 h p.i. Extended [¹⁸F]FDG kinetic analysis differentiates high- and low-grade lymphomas from benign lymph nodes and reveals a significant decline in tracer uptake low-grade lymphomas between 3 and 6 h p.i. Trial registration DRKS00027307. Registered 26 November 2021.
Updated Procedure Guideline of the German Society of Nuclear Medicine for Amyloid Brain PET Imaging 30 Henryk Barthel, Matthias Brendel, Nathalie Albert, Henning Boecker, Caroline Bouter, et al. Nuklearmedizin Nuclearmedicine, 2026 Preamble This represents a substantial development of the guideline on the topic first published in 2016. The following notable points have been updated: the sections on background information; the clinical benefit of the method; the resulting differential diagnostic considerations; the outlook for possible future extensions of the indication spectrum; the quantitative analysis of the PET images; the embedding of the method in diagnostic pathways; and the relation to alternative biomarker methods such as amyloid measurement in CSF/blood.
The PET tracer [¹¹C]MODAG-005 targets alpha-synuclein aggregates in the brain Ran Sing Saw, Sabrina Haas, Felix Schmidt, Sergey Ryazanov, Andrei Leonov, et al. Science Translational Medicine, 2026 Synucleinopathies are neurodegenerative diseases characterized by the presence of brain inclusions containing the pathologically aggregated protein α-synuclein. The development of a positron emission tomography tracer to detect aggregates of misfolded α-synuclein could revolutionize early diagnosis, disease monitoring, and the evaluation of therapeutic efficacy. Here, we present the development, preclinical validation, and first-in-human evaluation of [ 11 C]MODAG-005. In vitro binding experiments demonstrated subnanomolar binding affinity to recombinant α-synuclein fibrils and to α-synuclein inclusions in human brain tissue. Specific binding in multiple system atrophy (MSA) brain tissue was detected using autoradiography and microautoradiography and was validated through immunostaining. In vivo, [ 11 C]MODAG-005 showed good brain penetration, rapid clearance from brain tissue, and low metabolite formation in rodents and nonhuman primates. In addition, a pronounced binding and a good signal-to-noise ratio were achieved in an α-synuclein fibril–injected rat model and in an α-synuclein (A30P) transgenic mouse model in correlation to the pathological load. To validate the potential of [ 11 C]MODAG-005 for therapeutic development, we showed target engagement of the drug candidate anle138b in the brain tissues from α-synuclein (A30P) mice and patients with multiple system atrophy as well as in vivo in α-synuclein fibril–injected rats. Last, first-in-human imaging demonstrated [ 11 C]MODAG-005 binding in brain regions affected by α-synuclein pathology in patients with clinically established MSA cerebellar type, MSA cerebellar and parkinsonian type, and Parkinson’s disease.
The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic accuracy compared to histopathology and their impact on patient management Frederik L. Giesel, Stefan A. Koerber, Boris Hadaschik, Selina Kiefer, Sarah Schwarzenboeck, et al. European Journal of Nuclear Medicine and Molecular Imaging, 2026 Purpose Clinically accurate detection of prostate cancer (PCa) metastases is crucial for management of high-risk PCa patients scheduled for radical prostatectomy. We determine the safety and diagnostic accuracy of pre-operative 68 Ga-PSMA-11 PET/CT imaging in newly diagnosed high-risk PCa and assess its impact on patient management. Methods Investigator-initiated prospective multi-center multinational single-arm open-label phase 1/2 imaging trial (EuRadCT 2016–001815-19). Patients with high-risk PCa scheduled for prostatectomy were enrolled at 9 institutions in Germany, Austria, and Switzerland to undergo 68 Ga-PSMA-11 PET/CT for primary staging. The primary objectives were the evaluation of 68 Ga-PSMA-11 PET/CT imaging to detect the primary tumor and lymph node disease and safety assessment. Secondary objectives included detection of distant metastases, correlation of 68 Ga-PSMA-11 uptake with Gleason Score, and determining the impact on clinical management. Impact of pre-operative 68 Ga-PSMA-11 PET/CT imaging on target volume definition for radiation therapy was assessed. Results 173 patients underwent 68 Ga-PSMA-11 PET/CT for primary staging. Histopathologic correlation was available in 139 patients (imaging dataset), with lymph node metastases in 55 patients (39.6%). 20 treatment-emergent AEs unrelated to the test item were reported in 14 of 173 (8.1%) patients and no SAE occurred. On a per-patient basis, sensitivity of 68 Ga-PSMA-11 PET for local disease was 0.971 (95% CI, 0.928–0.992). Sensitivity, specificity, PPV, NPV and accuracy to detect local lymph node disease on a per-patient basis were 0.400 (95% CI 0.271–0.529), 0.988 (95%CI 0.965–1.000), 0.957 (95% CI 0.873–1.000), 0.716 (95% CI 0.633–0.798) and 0.755 (95% CI 0.684–0.827), respectively. Considering the intrinsic PET resolution of 3–5 mm, the exclusion of lesions smaller than 3 or 5 mm on histopathology from the analysis led to increased sensitivity of 56.4% and 69.0%, respectively. Median SUVpeak of local disease was 6.4 (range 1.7–13.6), 8.4 (range 2.3–39.4), 10.7 (range 5.6–23.0), and 13.4 (range 3.8–56.9) for Gleason Score 7a, 7b, 8 and 9, respectively. Based on the results of 68 Ga-PSMA-11 PET/CT, surgical intervention was canceled in 23 patients (13.2%). 68 Ga-PSMA-11 PET/CT resulted in a change of target volume delineation for radiation therapy planning in 29 patients (20.9%). Conclusion In high-risk primary PCa, 68 Ga-PSMA-11 is safe and effective in local staging, resulting in changes in both surgical and radiation management. Moreover, 68 Ga-PSMA-11 uptake is positively correlated with tumor grade and its efficacy is dependent on the size of nodal lesions. 68 Ga-PSMA-11 PET/CT will be highly impactful in the management of newly diagnosed high risk prostate cancer patients. Funding The study was funded by the German Cancer Consortium (DKTK).
Updated Procedure Guideline of the German Society of Nuclear Medicine for Amyloid Brain PET Imaging 3.0 H Barthel, M Brendel, N Albert, H Boecker, C Bouter, J Brumberg, ... Nuklearmedizin-NuclearMedicine 65 (03), 223-235 , 2026 2026
Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association study M Patel, W Feng, NS Mckay, PR Millar, M Liu, C Yang, A Cetin, ... The Lancet Neurology 25 (6), 581-590 , 2026 2026 Citations: 1
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Continuous bed motion versus step-and-shoot acquisition in LAFOV PET/CT: insights from multi-phantom and patient studies PM Linder, W Lan, E Calderón, I Rausch, C la Fougère, FP Schmidt EJNMMI Physics , 2026 2026
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Real-world experience with lutetium (177Lu) vipivotide tetraxetan (177Lu-PSMA-617) in metastatic castration resistant prostate cancer (mCRPC): Results from the first interim … K Herrmann, C la Fougère, T Winkens, A Buck, F Zengerling Nuklearmedizin-NuclearMedicine 65 (02), V77 , 2026 2026
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The German Cancer Consortium (DKTK) multi-center prospective phase 1/2 68Ga-PSMA-11 PET-imaging trial in newly-diagnosed high-risk prostate cancer: Safety and diagnostic … FL Giesel, SA Koerber, B Hadaschik, S Kiefer, S Schwarzenboeck, ... European journal of nuclear medicine and molecular imaging 53 (5), 2994-3006 , 2026 2026
AutoPET challenge on fully automated lesion segmentation in oncologic PET/CT imaging, part 2: domain generalization J Dexl, S Gatidis, M Früh, K Jeblick, A Mittermeier, AT Stüber, ... Journal of Nuclear Medicine 67 (3), 481-488 , 2026 2026 Citations: 5
Exploring extended [ 18 F]FDG kinetics in lymphoma with ultra-late LAFOV-PET/CT M Weissinger, S Ursprung, J Jacoby, J Vogel, E Calderón, B Gückel, ... European Journal of Nuclear Medicine and Molecular Imaging, 1-12 , 2026 2026
Primary Renal Neuroendocrine Tumor: Diagnostic Challenges in a Rare Entity—A Case Report RD Lewetag, K Kluthe, NF Trautwein, UM Lauer, C la Fougère, B Sipos, ... Current Oncology 33 (2), 105 , 2026 2026
Advancing Automated Lesion Segmentation Toward Clinical Integration in Oncologic PET/CT POM Choudja, J Dexl, M Frueh, K Jeblick, A Mittermeier, AT Stueber, ... ONCOLOGY RESEARCH AND TREATMENT 49, 237-237 , 2026 2026
PET-imaging derived prognostic factors for prostate cancer patients with visceral metastases receiving [177Lu] Lu-PSMA radiopharmaceutical therapy (RPT) MS Späth, H Dittmann, R Spallek, E Calderón, J Mück, A Brendlin, ... European Journal of Nuclear Medicine and Molecular Imaging, 1-8 , 2026 2026
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Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study BA Gordon, TM Blazey, Y Su, A Hari-Raj, A Dincer, S Flores, ... The Lancet Neurology 17 (3), 241-250 , 2018 2018 Citations: 740
Joint EANM/EANO/RANO practice guidelines/SNMMI procedure standards for imaging of gliomas using PET with radiolabelled amino acids and [ 18 F]FDG: version … I Law, NL Albert, J Arbizu, R Boellaard, A Drzezga, N Galldiks, ... European journal of nuclear medicine and molecular imaging 46 (3), 540-557 , 2019 2019 Citations: 617
Real versus imagined locomotion: a [18F]-FDG PET-fMRI comparison C La Fougere, A Zwergal, A Rominger, S Förster, G Fesl, M Dieterich, ... Neuroimage 50 (4), 1589-1598 , 2010 2010 Citations: 532
Attention deficit hyperactivity disorder: binding of [ 99m Tc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment S Dresel, J Krause, KH Krause, C LaFougere, K Brinkbäumer, HF Kung, ... European journal of nuclear medicine 27 (10), 1518-1524 , 2000 2000 Citations: 397
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Molecular imaging of gliomas with PET: opportunities and limitations C la Fougere, B Suchorska, P Bartenstein, FW Kreth, JC Tonn Neuro-oncology 13 (8), 806-819 , 2011 2011 Citations: 374
PET and SPECT in epilepsy: a critical review C La Fougère, A Rominger, S Förster, J Geisler, P Bartenstein Epilepsy & Behavior 15 (1), 50-55 , 2009 2009 Citations: 333
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[ 18 F]-fluoro-ethyl- l -tyrosine PET: a valuable diagnostic tool in neuro-oncology, but not all that glitters is glioma M Hutterer, M Nowosielski, D Putzer, NL Jansen, M Seiz, M Schocke, ... Neuro-oncology 15 (3), 341-351 , 2013 2013 Citations: 273
Two decades of SPECT/CT–the coming of age of a technology: an updated review of literature evidence O Israel, O Pellet, L Biassoni, D De Palma, E Estrada-Lobato, ... European journal of nuclear medicine and molecular imaging 46 (10), 1990-2012 , 2019 2019 Citations: 264
The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder KH Krause, SH Dresel, J Krause, C la Fougere, M Ackenheil Neuroscience & Biobehavioral Reviews 27 (7), 605-613 , 2003 2003 Citations: 262
Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases LA Hoffmann, S Jarius, HL Pellkofer, M Schueller, M Krumbholz, F Koenig, ... Journal of Neurology, Neurosurgery & Psychiatry 79 (7), 767-773 , 2008 2008 Citations: 231
Imaging-based target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised, controlled trial U Nestle, T Schimek-Jasch, S Kremp, A Schaefer-Schuler, M Mix, ... The Lancet Oncology 21 (4), 581-592 , 2020 2020 Citations: 230
Imaging and diagnostic advances for intracranial meningiomas RY Huang, WL Bi, B Griffith, TJ Kaufmann, C la Fougère, NO Schmidt, ... Neuro-oncology 21 (Supplement_1), i44-i61 , 2019 2019 Citations: 227
MRI-suspected low-grade glioma: is there a need to perform dynamic FET PET? NL Jansen, V Graute, L Armbruster, B Suchorska, J Lutz, S Eigenbrod, ... European journal of nuclear medicine and molecular imaging 39 (6), 1021-1029 , 2012 2012 Citations: 220
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