Dr. RASHMI SAINI

Verified @gmail.com

ASSISTANT PROFESSOR
GARGI COLLEGE, UNIVERSITY OF DELHI, DELHI

Dr. RASHMI SAINI


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https://researchid.co/rashmisaini
21

Scopus Publications

751

Scholar Citations

13

Scholar h-index

16

Scholar i10-index

Scopus Publications

  • Omega-3-Polyunsaturated Fatty Acids Attenuate Oxidative Stress-Induced DNA Damage
    Neena K. Dhiman, Rashmi Saini
    Omega 3 Fatty Acids Keys to Nutritional Health and Disease, 2025
  • Phyto-Resources of Omega-3 Fatty Acids and Their Role in Immunomodulation
    Neena K. Dhiman, Rashmi Saini
    Omega 3 Fatty Acids Keys to Nutritional Health and Disease, 2025
  • Therapeutic Implications of Omega-3 Fatty Acids in CNS-Neurodegenerative Diseases: Reappraise the Pre-Clinical and Clinical Findings
    Ashish Singh, Pratibha Tripathi, Rashmi Saini, Sarika Singh
    Omega 3 Fatty Acids Keys to Nutritional Health and Disease, 2025
  • Emerging Nanotechnological Applications in Preserving and Improving the Shelf Life of Food
    Rashmi Saini, Neha Paserkar, Anand Varma, Dhaval K. Acharya, Vijay Upadhye, Dinesh Pathak, Ashish Warghane
    Pharmaceutical Nanotechnology, 2025
    The ever-growing demand for safe and nutritious food has activated the scrutinization of innovative approaches to enhance food preservation and extended shelf life. Nanotechnology has progressed by making a significant contribution to the food industry at the nanoscale level and appeared as a promising avenue for these challenges. Various nanomaterials have been employed to preserve and extend the shelf life of a variety of food products. Since most harvested fruits and vegetables have a perishable nature, they cannot be preserved in natural circumstances for a long period. Due to a range of unique qualities, nanotechnology-related shelf life extension technologies can compensate for the limitations of normal preservation procedures. The encapsulation of nutraceuticals increases their stability and bioavailability, resulting in beneficial effects on humans. Nanoparticles are used as carriers of health-promoting and/or functional substances in product formulations. They have shown excellent effectiveness in encapsulating bioactive substances and retaining their qualities to ensure their functioning (antioxidant and antibacterial) in food products. This review focuses on the current developments in nanotechnology and their application for improving shelf life and food preservation techniques. Here we excavated the implementation of different types and forms of nanostructured materials (NSMs), from inorganic metals, metal oxides, and their nanocomposites to nano-organic materials incorporating bioactive chemicals in the food system. This review also focuses on exploring the slow and sustainable release of the bioactive compounds, and nutrients enriching the taste and sensory characteristics of the food. Throughout the paper, we dug deep into the regulatory, food safety, and assessment concerns about nanotechnology. The review provides a deep understanding of the developing landscape of nanotechnological applications, challenges, and future opportunities revolutionizing the preservation and extended shelf life of food products.
  • Application of nanoparticles for management of plant viral pathogen: Current status and future prospects
    Ashish Warghane, Rashmi Saini, Manju Shri, Isha Andankar, Dilip Kumar Ghosh, Balu Ananda Chopade
    Virology, 2024
  • Current Status of Potential Antiviral Drugs Derived from Plant, Marine, and Microbial Sources
    Rashmi Saini, Mohammad I. Ali, Maya Pant, Ashish Warghane
    Anti Infective Agents, 2024
    Natural substances have been the principal source of medications since antiquity. Natural goods are gaining popularity as a source of novel medications. This article investigates a variety of variables like plant, marine, and microbial sources that contribute to the growing interest in natural goods as a source of novel medications. Viruses have remained resistant to treatment and prevention for a longer period than other forms of life. Viral diseases can currently only be treated with a limited number of drugs. Significant research initiatives have been committed to identifying novel antiviral natural compounds to fight viruses that harm people, plants, insects, animals, fungi, and microbes. A recent study of the prevalence and sources of antiviral medications licensed by the Food and Drug Administration (FDA) has focused on natural products. Out of the estimated 250,000 higher plant species, only 5 to 15 percent have been thoroughly evaluated for the existence of bioactive substances in them, and the ability of the other species has hardly been investigated. This review aims to offer an overview of the crucial role played by natural products in the discovery and development of novel antiviral drugs with potent antiviral activity, including phytochemicals such as carbohydrates, coumarins, flavonoids, chromones, alkaloids, lignans, phenols, tannins, proteins, peptides, antiviral plant extracts, other marine, and microbial sources.
  • Dietary Antioxidants and their Potential Role in Human Disease Management
    Neena K. Dhiman, Rashmi Saini, Himaani Mehra, Tanisha Goyal
    Current Nutrition and Food Science, 2023
    Reactive oxygen species (ROS) are usually destroyed by the antioxidant defence systems in our body. ROS in low concentrations may be beneficial or even indispensable for defence against microorganisms and in intracellular signaling, but its higher amounts can trigger negative chain reactions leading to various pathological conditions. A delicate balance between antioxidants and oxidants is maintained in healthy organisms and protection against the harmful effects of ROS is thus provided. The increase in ROS leading to oxidative stress plays a key role in the development of chronic diseases like cancer, diabetes, neurodegenerative, and cardiovascular diseases. Several non-enzymatic and enzymatic antioxidant activities exist as a safeguard against ROS accumulation. Imbalance between the oxidative stress and the antioxidant defence systems causes irreversible changes in cellular components and the normal cell signaling mechanisms are disrupted. The enzymatic and non-enzymatic antioxidant defences include catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), vitamin A, vitamin C (ascorbic acid), vitamin E (α-tocopherol), carotenes, flavonoids, etc. Several human pathologies have been known to be treated by the use of medicinal plants owing to their antioxidant properties. Dietary antioxidants such as vitamins, minerals, carotenes, and flavonoids, with their mechanisms of antioxidant defence are discussed in the review for the effective management of various human diseases.
  • Hypoxia: syndicating triple negative breast cancer against various therapeutic regimens
    Nityanand Srivastava, Salman Sadullah Usmani, Rajasekaran Subbarayan, Rashmi Saini, Pranav Kumar Pandey
    Frontiers in Oncology, 2023
    Triple-negative breast cancer (TNBC) is one of the deadliest subtypes of breast cancer (BC) for its high aggressiveness, heterogeneity, and hypoxic nature. Based on biological and clinical observations the TNBC related mortality is very high worldwide. Emerging studies have clearly demonstrated that hypoxia regulates the critical metabolic, developmental, and survival pathways in TNBC, which include glycolysis and angiogenesis. Alterations to these pathways accelerate the cancer stem cells (CSCs) enrichment and immune escape, which further lead to tumor invasion, migration, and metastasis. Beside this, hypoxia also manipulates the epigenetic plasticity and DNA damage response (DDR) to syndicate TNBC survival and its progression. Hypoxia fundamentally creates the low oxygen condition responsible for the alteration in Hypoxia-Inducible Factor-1alpha (HIF-1α) signaling within the tumor microenvironment, allowing tumors to survive and making them resistant to various therapies. Therefore, there is an urgent need for society to establish target-based therapies that overcome the resistance and limitations of the current treatment plan for TNBC. In this review article, we have thoroughly discussed the plausible significance of HIF-1α as a target in various therapeutic regimens such as chemotherapy, radiotherapy, immunotherapy, anti-angiogenic therapy, adjuvant therapy photodynamic therapy, adoptive cell therapy, combination therapies, antibody drug conjugates and cancer vaccines. Further, we also reviewed here the intrinsic mechanism and existing issues in targeting HIF-1α while improvising the current therapeutic strategies. This review highlights and discusses the future perspectives and the major alternatives to overcome TNBC resistance by targeting hypoxia-induced signaling.
  • The role of nanocomposites against biofilm infections in humans
    Anand Varma, Ashish Warghane, Neena K. Dhiman, Neha Paserkar, Vijay Upadhye, Anupama Modi, Rashmi Saini
    Frontiers in Cellular and Infection Microbiology, 2023
    The use of nanomaterials in several fields of science has undergone a revolution in the last few decades. It has been reported by the National Institutes of Health (NIH) that 65% and 80% of infections are accountable for at least 65% of human bacterial infections. One of their important applications in healthcare is the use of nanoparticles (NPs) to eradicate free-floating bacteria and those that form biofilms. A nanocomposite (NC) is a multiphase stable fabric with one or three dimensions that are much smaller than 100 nm, or systems with nanoscale repeat distances between the unique phases that make up the material. Using NC materials to get rid of germs is a more sophisticated and effective technique to destroy bacterial biofilms. These biofilms are refractory to standard antibiotics, mainly to chronic infections and non-healing wounds. Materials like graphene and chitosan can be utilized to make several forms of NCs, in addition to different metal oxides. The ability of NCs to address the issue of bacterial resistance is its main advantage over antibiotics. This review highlights the synthesis, characterization, and mechanism through which NCs disrupt Gram-positive and Gram-negative bacterial biofilms, and their relative benefits and drawbacks. There is an urgent need to develop materials like NCs with a larger spectrum of action due to the rising prevalence of human bacterial diseases that are multidrug-resistant and form biofilms.
  • Value-addition in citrus processing industry waste through enzyme technology
    Ashish Warghane, Rashmi Saini, Neena K. Dhiman, Khushdil Khan, Meena Koche, Aditya Sharma, R.M. Gade, Prakash Halami, Anunava Das
    Value Addition in Agri Food Industry Waste Through Enzyme Technology, 2023
  • Natural Anti-inflammatory and Anti-allergy Agents: Herbs and Botanical Ingredients
    Neena K. Dhiman, Rashmi Saini
    Anti Inflammatory and Anti Allergy Agents in Medicinal Chemistry, 2022
  • Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: An Insight
    Rashmi Saini, Zaffar Azam, Leena Sapra, Rupesh K. Srivastava
    Reviews of Physiology Biochemistry and Pharmacology, 2021
  • Inducible nitric oxide synthase: An asset to neutrophils
    Rashmi Saini, Sarika Singh
    Journal of Leukocyte Biology, 2019
  • Withania somnifera: Use for skin disease
    Anand A. Zanwar, Sachin L. Badole, Rashmi Saini
    Bioactive Dietary Factors and Plant Extracts in Dermatology, 2013
  • Role of Emblica officinalis in prevention of skin disease
    Anand A. Zanwar, Sachin L. Badole, Rashmi Saini
    Bioactive Dietary Factors and Plant Extracts in Dermatology, 2013
  • Arginine derived nitric Oxide: Key to healthy skin
    Rashmi Saini, Sachin L. Badole, Anand A. Zanwar
    Bioactive Dietary Factors and Plant Extracts in Dermatology, 2013
  • Vitamin C (L -Ascorbic Acid): Antioxidant involved in skin care
    Rashmi Saini, Sachin L. Badole, Anand A. Zanwar
    Bioactive Dietary Factors and Plant Extracts in Dermatology, 2013
  • Erratum: Ultrastructural immunogold localization of nitric oxide synthase isoforms in rat and human eosinophils (Cell and Tissue Research (2010) 340 (381-388) DOI: 10.1007/s00441-010-0947-y)
    Rohit Saluja, Rashmi Saini, Kalyan Mitra, Virendra K. Bajpai, Madhu Dikshit
    Cell and Tissue Research, 2010
  • Ultrastructural immunogold localization of nitric oxide synthase isoforms in rat and human eosinophils
    Rohit Saluja, Rashmi Saini, Kalyan Mitra, Virendra K. Bajpai, Madhu Dikshit
    Cell and Tissue Research, 2010
  • Nitric oxide synthase localization in the rat neutrophils: Immunocytochemical, molecular, and biochemical studies
    R. Saini, S. Patel, R. Saluja, A. A. Sahasrabuddhe, M. P. Singh, S. Habib, V. K. Bajpai, M. Dikshit
    Journal of Leukocyte Biology, 2006
  • Ascorbate-mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: Modulatory effect of nitric oxide
    Prashant Sharma, Santhanam A.V. Raghavan, Rashmi Saini, Madhu Dikshit
    Journal of Leukocyte Biology, 2004

RECENT SCHOLAR PUBLICATIONS

  • Microalgae biorefinery technologies integrated with wastewater remediation for sustainable biofuel and bioproduct applications
    N Bhati, R Saini, G Abishek, KK Jaiswal, AK Jaiswal
    Microalgal Biofuels, 265-299 , 2026
    2026
  • Emerging nanotechnological applications in preserving and improving the shelf life of food
    R Saini, N Paserkar, A Varma, DK Acharya, V Upadhye, D Pathak, ...
    Pharmaceutical Nanotechnology 13 (3), 396-410 , 2025
    2025
    Citations: 13
  • Therapeutic Implications of Omega-3 Fatty Acids in CNS-Neurodegenerative Diseases: Reappraise the Pre-Clinical and Clinical Findings
    A Singh, P Tripathi, R Saini, S Singh
    Omega-3 Fatty Acids: Keys to Nutritional Health and Disease, 213-223 , 2025
    2025
  • Omega-3-Polyunsaturated Fatty Acids Attenuate Oxidative Stress-Induced DNA Damage
    NK Dhiman, R Saini
    Omega-3 Fatty Acids: Keys to Nutritional Health and Disease, 427-432 , 2025
    2025
  • Phyto-Resources of Omega-3 Fatty Acids and Their Role in Immunomodulation
    NK Dhiman, R Saini
    Omega-3 Fatty Acids: Keys to Nutritional Health and Disease, 433-443 , 2025
    2025
    Citations: 1
  • Post-harvest processing and value addition of water chestnut-a review
    AK Gupta, M Singh, S Patel, M Gour, S Nandanwar, R Saini
    Journal of Pharmacognosy and Phytochemistry 14 (2), 39-43 , 2025
    2025
  • Natural antioxidants and their impact on female reproductive health
    NK Dhiman, R Saini
    JOURNAL OF REPRODUCTIVE HEALTHCARE AND MEDICINE Учредители: Scientific … , 2025
    2025
    Citations: 5
  • Application of nanoparticles for management of plant viral pathogen: current status and future prospects
    A Warghane, R Saini, M Shri, I Andankar, DK Ghosh, BA Chopade
    Virology 592, 109998 , 2024
    2024
    Citations: 50
  • Endophytic fungi: symbiotic bioresource for production of plant secondary metabolites
    LS Saini, S Patel, A Gaur, P Warghane, R Saini, A Warghane
    Endophytic fungi: The hidden sustainable jewels for the pharmaceutical and … , 2024
    2024
    Citations: 4
  • COVID 19-The Deadliest Pandemic of the Era
    A Warghane, T Rajguru, S Babar, G Bhardwaj, U Warghane, R Saini, ...
    EURASIAN JOURNAL OF MEDICAL ADVANCES 4 (3), 131-143 , 2024
    2024
  • Current status of potential antiviral drugs derived from plants, marine and microbial sources
    R Saini, IA Mohammad, M Pant, A Warghane
    Anti-Infective Agents , 2024
    2024
    Citations: 11
  • Hypoxia: syndicating triple negative breast cancer against various therapeutic regimens
    N Srivastava, SS Usmani, R Subbarayan, R Saini, PK Pandey
    Frontiers in Oncology 13, 1199105 , 2023
    2023
    Citations: 59
  • Dietary antioxidants and their potential role in human disease management
    R Saini, H Mehra, T Goyal, NK Dhiman
    Current Nutrition & Food Science 19 (3), 262-281 , 2023
    2023
    Citations: 8
  • The role of nanocomposites against biofilm infections in humans
    A Varma, A Warghane, NK Dhiman, N Paserkar, V Upadhye, A Modi, ...
    Frontiers in Cellular and infection Microbiology 13, 1104615 , 2023
    2023
    Citations: 50
  • Value-addition in agri-food industry waste through enzyme technology
    M Kuddus, PW Ramteke
    Elsevier , 2023
    2023
    Citations: 24
  • Replacement of Defective Restorations in Posterior Teeth: An Inlay Case Series
    J Dubey, V Rungta, R Saini, A Dutta, P Agrawal
    2023
  • Value-addition in citrus processing industry waste through enzyme technology
    A Warghane, R Saini, NK Dhiman, K Khan, M Koche, A Sharma, ...
    Value-Addition in Agri-food Industry Waste Through Enzyme Technology, 177-190 , 2023
    2023
    Citations: 4
  • Natural anti-inflammatory and anti-allergy agents: herbs and botanical ingredients
    R Saini, NK Dhiman
    Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistryrrent … , 2022
    2022
    Citations: 26
  • Neuronal nitric oxide synthase (nNOS) in neutrophils: an insight
    R Saini, Z Azam, L Sapra, RK Srivastava
    Reviews of Physiology, Biochemistry and Pharmacology, 49-83 , 2021
    2021
    Citations: 16
  • ADULT SIGMOIDO-RECTAL INTUSSUSCEPTION PRESENTING AS GANGRENOUS BOWEL AND RECTAL PROLAPSE: A RARE PRESENTATION
    R SAINI, U BASU, N KUMAR, DR MITHUN, DS KUMAR
    ACTA SCIENTIFIC GASTROINTESTINAL DISORDERS Учредители: Acta Scientific 3 (5 … , 2020
    2020

MOST CITED SCHOLAR PUBLICATIONS

  • Ascorbate-mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: Modulatory effect of nitric oxide
    P Sharma, SAV Raghavan, R Saini, M Dikshit
    Journal of Leucocyte Biology 75 (6), 1070-1078 , 2004
    2004
    Citations: 116
  • Inducible nitric oxide synthase: An asset to neutrophils
    R Saini, S Singh
    Journal of leukocyte biology 105 (1), 49-61 , 2019
    2019
    Citations: 113
  • Nitric oxide synthase localization in the rat neutrophils: immunocytochemical, molecular, and biochemical studies
    R Saini, S Patel, R Saluja, AA Sahasrabuddhe, MP Singh, S Habib, ...
    Journal of leukocyte biology 79 (3), 519-528 , 2006
    2006
    Citations: 103
  • Hypoxia: syndicating triple negative breast cancer against various therapeutic regimens
    N Srivastava, SS Usmani, R Subbarayan, R Saini, PK Pandey
    Frontiers in Oncology 13, 1199105 , 2023
    2023
    Citations: 59
  • Application of nanoparticles for management of plant viral pathogen: current status and future prospects
    A Warghane, R Saini, M Shri, I Andankar, DK Ghosh, BA Chopade
    Virology 592, 109998 , 2024
    2024
    Citations: 50
  • The role of nanocomposites against biofilm infections in humans
    A Varma, A Warghane, NK Dhiman, N Paserkar, V Upadhye, A Modi, ...
    Frontiers in Cellular and infection Microbiology 13, 1104615 , 2023
    2023
    Citations: 50
  • Herbs and Botanical Ingredients with Benefcial Effects on Blood Sugar Levels in Pre-diabetes
    SS Rashmi Saini
    Herbal Medicine 2 (1), 1-11 , 2016
    2016
    Citations: 41
  • Arginine derived nitric oxide: Key to healthy skin
    R Saini, SL Badole, AA Zanwar
    Bioactive dietary factors and plant extracts in dermatology, 73-82 , 2012
    2012
    Citations: 28
  • Natural anti-inflammatory and anti-allergy agents: herbs and botanical ingredients
    R Saini, NK Dhiman
    Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistryrrent … , 2022
    2022
    Citations: 26
  • Value-addition in agri-food industry waste through enzyme technology
    M Kuddus, PW Ramteke
    Elsevier , 2023
    2023
    Citations: 24
  • Role of active principles of Podophyllum hexandrum in amelioration of radiation mediated lung injuries by reactive oxygen/nitrogen species reduction
    R Saini, S Verma, A Singh, ML Gupta
    CellBio 2 (03), 105-116 , 2013
    2013
    Citations: 21
  • Ultrastructural immunogold localization of nitric oxide synthase isoforms in rat and human eosinophils
    R Saluja, R Saini, K Mitra, VK Bajpai, M Dikshit
    Cell and tissue research 340 (2), 381-388 , 2010
    2010
    Citations: 21
  • Neuronal nitric oxide synthase (nNOS) in neutrophils: an insight
    R Saini, Z Azam, L Sapra, RK Srivastava
    Reviews of Physiology, Biochemistry and Pharmacology, 49-83 , 2021
    2021
    Citations: 16
  • Emerging nanotechnological applications in preserving and improving the shelf life of food
    R Saini, N Paserkar, A Varma, DK Acharya, V Upadhye, D Pathak, ...
    Pharmaceutical Nanotechnology 13 (3), 396-410 , 2025
    2025
    Citations: 13
  • Current status of potential antiviral drugs derived from plants, marine and microbial sources
    R Saini, IA Mohammad, M Pant, A Warghane
    Anti-Infective Agents , 2024
    2024
    Citations: 11
  • Bioactive compounds increase incretins with beneficial effects on diabetes
    R Saini, SL Badole
    Glucose Intake and Utilization in Pre-Diabetes and Diabetes, 349-353 , 2015
    2015
    Citations: 11
  • The protective effect of Podophyllum hexandrum on hepato-pulmonary toxicity in irradiated mice
    S Verma, B Kalita, R Saini, ML Gupta
    Oxid Antioxid Med Sci 3 (1), 51-64 , 2014
    2014
    Citations: 9
  • Dietary antioxidants and their potential role in human disease management
    R Saini, H Mehra, T Goyal, NK Dhiman
    Current Nutrition & Food Science 19 (3), 262-281 , 2023
    2023
    Citations: 8
  • Vitamin C ( l -Ascorbic Acid): Antioxidant Involved in Skin Care
    R Saini, SL Badole, AA Zanwar
    Bioactive Dietary Factors and Plant Extracts in Dermatology, 61-66 , 2012
    2012
    Citations: 6
  • Natural antioxidants and their impact on female reproductive health
    NK Dhiman, R Saini
    JOURNAL OF REPRODUCTIVE HEALTHCARE AND MEDICINE Учредители: Scientific … , 2025
    2025
    Citations: 5