RAVI HARI PHULWARE
@aiimsrishikesh.edu.in
Assistant Professor, Pathology & Laboratory Medicine/ravipaarti@gmail.com
Ravi Hari Phulware/All India Institute of Medical Sciences Rishikesh
Consultant Histopathologist
Cytopathologist
Onco-pathologists
More than 10 years of experience in the field of Pathology
More than 50 PubMed publication in various International and National Journals
EDUCATION
MBBS
MD Pathology
PGDM Executive (NIHFW) Hospital Management
RESEARCH, TEACHING, or OTHER INTERESTS
Pathology and Forensic Medicine, Histology, Oncology, Nephrology
FUTURE PROJECTS
Molecular landscape of Hereditary cancer gene panel in urinary bladder cancer in young adults of Sub Himalayan region of Uttarakhand and Western Uttar Pradesh
There is limited information on an exome scale about the germline molecular alteration leading to urinary bladder cancer in young patients in India. Patients from Uttarakhand and Western Uttar Pradesh are usually from low socioeconomic strata and come with advanced stages of tumor. Hence there is a felt need of doing exome profiling study to pick up the gene mutations in this region. This will add to the understanding of the pathogenesis of disease and will help in making a gene panel for early screening and detection.
Applications Invited
Scopus Publications
Scopus Publications
Erna Ahsan, Saurabh Kumar Gautam, Ashok Singh, Arvind Kumar, and Ravi Hari Phulware
Scientific Scholar
The mainstay of treatment for ovarian cancer is surgery. To prevent under-treatment and overtreatment and to choose the best surgical strategy for patients with ovarian tumors, intraoperative pathological assessment is essential. Frozen sections (FSs) have been historically used for intraoperative evaluation. In 1927, cytology was introduced by Dudgeon and Patrick as a new method of intraoperative pathological examination. Diagnosis can be made in minutes by making smears from the lesion, staining them quickly, and analyzing them under a microscope. Following a comprehensive search of the literature, using pertinent keywords in PubMed, and reviewing the data, it was discovered that intraoperative cytology (IOC) had been reported to have a diagnostic accuracy in ovarian lesions comparable to that of FSs. Few of the studies have confirmed that IOC has several benefits over FSs. There are drawbacks as well, which one should be mindful of. In this review, every aspect that is connected to IOC is covered in detail, along with the potential for raising the standard of IOC to make it more applicable in the present times.
Kartik Saini, Naveen Kumar Kansal, Ravi Hari Phulware, and Riti Bhatia
BMJ
Paediatric Systemic lupus erythematosus (SLE) constitutes 10 to 20% of cases of SLE with more severe disease and higher mortality. We report a case of an adolescent girl with SLE with multisystem involvement who was started on hydroxychloroquine and oral prednisolone. However, due to persistent worsening of skin lesions and falling cell counts, pulsed dexamethasone was initiated which showed improvement in the skin lesions, cell counts, proteinuria and pleural effusion but there was a persistent fall in the haemoglobin. The patient was diagnosed with refractory autoimmune hemolytic anemia (AIHA) and treated with Rituximab which showed marked improvement in AIHA. Therefore, Rituximab can be considered in managing childhood SLE with refractory AIHA.
Monika Maharjan, Zahed Ali Qamer, Bheru Dan Charan, Manu Malhotra, and Ravi Hari Phulware
Springer Science and Business Media LLC
Anshima Singh, Ravi Hari Phulware, Arvind Kumar, Alok Kumar, and Sanjeev Kishore
Ovid Technologies (Wolters Kluwer Health)
Pakesh Baishya, Ravi Hari Phulware, Ashok Singh, Prashant Durgapal, Ankur Mittal, Sanjeev Kishore, and Arvind Kumar
Springer Science and Business Media LLC
Anusha Mruthyunjaya Swamy, Deepak Sundriyal, Mayank Kapoor, Mridul Khanna, Ravi Hari Phulware, Kranthi Kumar Jandrasupalli, Ujjawal Shriwastav, and Amit Sehrawat
Wiley
ABSTRACTIntroductionWith the use of immune checkpoint inhibitors (ICIs) and targeted therapies, the clinical outcomes of metastatic melanoma have drastically improved. The current scenario has reduced the use of chemotherapy as a first‐line treatment. We report an interesting case of a patient with stage IV ano‐rectal canal malignant melanoma with an exceptional response to single‐agent temozolomide.Case ReportWe diagnosed a 55‐year‐old female with stage IV anorectal melanoma, BRAF V600 mutation negative. Owing to her poor performance status (PS) and non‐affordability of immunotherapy, after informed decision‐making, she was started on single agent, temozolomide. She achieved a complete metabolic response and sustained it for 3 years and continues to do so with the first‐line single‐agent temozolomide.ConclusionIn a resource‐limited setting, where access to ICIs and targeted therapies is not feasible, and in patients who fail to tolerate these therapies, oral chemotherapy continues to remain effective and is worth trying in patients with poor PS.
Gajendra Kumar Yadav, Ravi H. Phulware, Ashok Singh, Arvind Kumar, Prashant Durgapal, Nilotpal Chowdhury, Shalinee Rao, Shalini Rajaram, Sanjeev Kishore, and Rajlaxmi Mundhara
S. Karger AG
Introduction: Intraoperative cytology in ovarian tumors involves collecting cell samples from the ovarian sample sent during surgery and quickly examining them for diagnostic information. Frozen section provides rapid diagnosis to guide intraoperative patient management. The indications of frozen section are identification of tissue, evaluation of margins and identification of lymph nodes metastasis. Aim: To evaluate comparative diagnostic utility of squash smear, scrape smear and imprint cytology with frozen section in intraoperative ovarian tumour. Materials and methods: Intraoperative tissue from clinico-radiologically suspected ovarian. tumour for frozen section taken and processed in Department of Pathology and Laboratory Medicine. Squash smear, scrape smear and imprint smear were made. Three stains (Rapid MGG, Rapid Pap and Rapid H & E) with expected TAT of <15 minutes were done. Intraoperative cytological smear (squash, scrape and imprint smear) were correlated with frozen section & Histopathology slide. Final assessment of intraoperative cytological smears for diagnostic accuracy was done using statistical study. Results: Sensitivity, Specificity, and Diagnostic accuracy for frozen and cytology were: Sensitivity of frozen section, squash cytology and scrape cytology was 91.67% in all three, whereas sensitivity of imprint was 87.5%. Specificity of frozen section, imprint cytology, squash cytology and scrape cytology was 96.77%, 93.55%, 90.32% and 90.32% respectively and accuracy was 94.55%, 90.91%, 90.91% and 90.91% respectively. Conclusion: Imprint, squash, and scrape cytology has similar sensitivity and specificity compared to frozen section in identifying the nature of lesion and can be an alternative to frozen section in resource stricken setting.
Palak Nandolia, Khanak Nandolia, Ravi Hari Phulware, and Sonal Saran
Springer Science and Business Media LLC
Palak Nandolia, Khanak Nandolia, Ravi Hari Phulware, and Sonal Saran
Springer Science and Business Media LLC
Shalini Rajaram, Ayush Heda, Latika Chawla, and Ravi Hari Phulware
Springer Science and Business Media LLC
Samikshya Thapa, Gajendra Kumar Yadav, Ramit Kumar Shah, Arvind Kumar, and Ravi Hari Phulware
Springer Science and Business Media LLC
Pragya Singh, Lekshmi R, Sweety Gupta, Ravi Roushan Kumar, Shreyosi Mandal, Mridul Khanna, Satya Sree Balija, Ravi Hari Phulware, and Manoj Gupta
Elsevier BV
Shalini Rajaram, Lakhwinder Singh, Ayush Heda, Latika Chawla, Ravi Hari Phulware, Ashok Singh, and Simardeep Kaur
Elsevier BV
Sonali Mishra, Ravi Hari Phulware, Akash Dhiman, Bibek Keshari, Ashok Singh, and Arvind Kumar
Springer Science and Business Media LLC
Nishi Jha, Ravi Hari Phulware, Arvind Kumar, Ashok Singh, Prashant Durgapal, Nilotpal Chowdhury, Ankur Mittal, and Sanjeev Kishore
Springer Science and Business Media LLC
Palak Nandolia, Khanak Kumar Nandolia, Ravi Hari Phulware, and Sonal Saran
BMJ
Arvind Kumar, Amit Gupta, and Ravi Hari Phulware
Springer Science and Business Media LLC
Akansha Bhatia, Ravi H. Phulware, and Arvind Ahuja
Medknow
Ravi Hari Phulware, Kaashvi Gupta, Gaurav Rajendra Shirsath, and Mohit Dhingra
Editora Cubo
dedifferentiated osteosarcoma. Subsequently, the patient was operated on for the above-knee amputation without any complications. Microscopic examination of the proximal tibial lesion shows a cellular tumor infiltrating bone and soft tissue. Tumor cells exhibited moderate to marked pleomorphism, including vesicular nuclei, prominent nucleoli, and moderate cytoplasm. Lacy-like osteoid material was seen between tumor cells. There were frequent mitoses but no necrosis. The cartilage nests and lobules showed enhanced cellularity, nuclear atypia, and osteoid matrix material revealed histomorphological features of Chondroblastic osteosarcoma. The tumor did not involve all the resection margins. The patient had an uneventful postoperative recovery. The patient was scheduled for regular follow-up to monitor disease progression with imaging studies to detect any local recurrence or metastasis signs
Ravi Hari Phulware, Gayathri K S, Gaurav Rajendra Shirsath, and Amit Gupta
Editora Cubo
undergone a radical prostatectomy two years ago with Gleason grade group 5. Scrotal ultrasound showed a hypoechoic mass involving the right testicle with increased vascularity, suggesting a neoplastic lesion. Hence, the patient was planned for a bilateral orchidectomy. The patient underwent bilateral inguinal orchiectomy without any complications. Macroscopic examination of the right resected testis revealed a solid yellowish-white tumor of 0.5 × 0.5 cm. Histopathological analysis showed that the right testis was infiltrated by metastatic adenocarcinoma. Immunohistochemical examination revealed that tumor cells were diffusely positive for PSA and Alpha ( α )-methylacyl-CoA racemase (AMACR). The patient was diagnosed with right testicular metastasis of Prostatic Carcinoma. The patient had an uneventful postoperative recovery. The patient was scheduled for regular follow-up appointments to monitor disease progression. Serial PSA levels and imaging studies were planned to look for disease status.
Sonali Mishra, Ashok Singh, Arvind Kumar, and Ravi Hari Phulware
Editora Cubo
Samikshya Thapa, Gajendra Kumar Yadav, Ratna Mondal, and Ravi Hari Phulware
Editora Cubo
ABSTRACT Esophageal melanocytosis is a rare entity defined by the proliferation of a melanocytic basal layer of the esophageal squamous lining and deposition of melanin in the esophageal mucosa. Esophageal melanocytosis is considered a benign entity of unknown etiology; however, it has been reported as a melanoma precursor. We report a case of esophageal melanocytosis in a diabetic and hypertensive 67-year-old male with recurrent dizziness and syncope for the past 6 months. Given his complaint of dyspepsia, he underwent an upper gastrointestinal endoscopy, in which an esophageal biopsy revealed the diagnosis of esophageal melanocytosis. The definitive diagnosis of esophageal melanocytosis can only be made by histological analysis. The histologic differential diagnoses include melanocytic nevi and malignant melanoma. Therefore, they need to be ruled out.
Deepali Saxena, Ravi Hari Phulware, Prashant Durgapal, Arvind Kumar, and Amit Kumar Tyagi
Springer Science and Business Media LLC
Sonali Mishra, Ramit K. Shah, Kavya Udyavar, Arvind Kumar, and Ravi H. Phulware
Medknow
Ravi Hari Phulware, Shalini Jain, Akash Dhiman, Arvind Ahuja, and Arvind Kumar
Editora Cubo