Roberto Giovannoni

Scopus Publications

Biomimetic villi-crypt scaffold-on-chip with tunable mechanical properties for intestinal epithelium modeling
Lorenzo Zavagna, Marta R. Casanova, Lara Pierantoni, Mariana R. Carvalho, Joana Silva-Correia, et al.
Materials Today Bio, 2026
Simulated Mars Gravity Impairs Intestinal Epithelial Barrier Integrity via Selective Modulation of Tight Junction Components
Laura Benvenuti, Chiara Bertini, Gemma Marcelli, Chiara Ippolito, Valentina Citi, et al.
Biomolecules, 2026
Future long-duration human space missions will expose astronauts to chronically reduced gravitational loading, a condition associated with oxidative stress and epithelial barrier dysfunction. The intestinal epithelial barrier depends on tight junctions (TJs), yet the impact of partial gravity on TJ composition, assembly, and claudin organization remains poorly defined. Here, we show that differentiated intestinal epithelial monolayers exposed to simulated Mars gravity undergo TJ ultrastructural remodeling, characterized by loss of apical membrane “kissing points” and widening of the paracellular space, accompanied by impaired barrier function. Simulated Mars gravity also induces oxidative stress and accumulation of cytoplasmic and nuclear lipid droplets, consistent with altered membrane and lipid homeostasis. At the molecular level, simulated Mars gravity promotes selective TJ changes, with significant downregulation—but not mislocalization—of barrier-forming claudins CLDN1 and CLDN3 and the scaffolding protein ZO-1, while CLDN2, CLDN4, CLDN7, CLDN12, CLDN23, and OCLN remain unchanged. STAT3 activation, but not ERK or NF-κB signaling, may be associated with these alterations and is consistent with a stress-adaptive remodeling response to oxidative stress under simulated Mars gravity. Overall, these findings identify simulated Mars gravity as a disruptor of intestinal barrier homeostasis and highlight TJ remodeling as a target for countermeasures to preserve gut integrity during deep-space missions.
TGF-β Receptor Inhibitor SB431542 Enhanced the Sensitivity of Gastric Cancer to 5-Fluorouracil: New Combined Targeted Therapy
Sara Bonomo, Roberto Giovannoni, Marialuisa Lavitrano, Massimiliano Cadamuro, Donatella Conconi
International Journal of Molecular Sciences, 2025
Gastric cancer (GC) continues to be a major cause of cancer-related deaths globally, primarily due to resistance to standard treatments like 5-fluorouracil (5FU). The transforming growth factor-β (TGF-β) signaling pathway is recognized as a key contributor to tumor progression and resistance to therapy. This work investigated the therapeutic potential of targeting TGF-β receptor I (TGFBR1) with the selective inhibitor SB431542 to enhance the effect of 5FU in GC. Analysis of public gene expression datasets revealed that increased levels of TGF-β and TGFBR1 are significantly connected with poor prognosis, particularly in high-grade GC. In vitro experiments using AGS and SNU-1 cell lines demonstrated that co-treatment with SB431542 and 5FU significantly reduced cell viability, making GC cells more sensitive to 5FU. This combination treatment led to a significant activation of caspase-dependent apoptosis, indicating an enhanced pro-apoptotic effect. These findings suggest that TGFBR1 inhibition could provide a strategic approach to reduce the dosage of 5FU, thereby minimizing its severe side effects in gastric cancer patients. Furthermore, these results underscore the potential of TGFBR1 as both a prognostic biomarker and a therapeutic target, warranting further investigation in aggressive forms of gastric cancer.
Development of a Mesothelin-Binding Engineered Scaffold Protein as a Theranostic for Pleural Mesothelioma
Roberto Silvestri, Margherita Piccardi, Alessia Laurenza, Filomena Rea, Allison R. Sirois, et al.
Bioconjugate Chemistry, 2025
The potential application of stroma modulation in targeting tumor cells: Focus on pancreatic cancer and breast cancer models
Giuseppina Roscigno, Sacha Jacobs, Belén Toledo, Roberto Borea, Gianluca Russo, et al.
Seminars in Cancer Biology, 2025
Emerging nanocarrier systems for the enhanced delivery of active pharmaceutical ingredients to the intestine
Francesca Re, Sara Pelucchi, Francesco Pettini, Antonella Prantera, Fabiola Troisi, et al.
Nanomedicine, 2025
This review explores the recent advancements in nanodelivery systems designed to improve intestinal delivery, focusing on inflammatory bowel diseases (IBDs) and colorectal cancer (CRC). It outlines the challenges associated with conventional drug therapies, including poor bioavailability, systemic side effects, and nonspecific targeting, which often limit therapeutic outcomes. Nanotechnology-based delivery platforms, such as lipid-based or polymeric nanoparticles, offer promising alternatives due to their ability to enhance drug stability, enable site-specific delivery, and reduce toxicity.It highlights how these nanosystems can be engineered to respond to the unique physiological and biochemical conditions of the inflamed gut, such as pH, enzymes, and reactive oxygen species. It also discusses various strategies to achieve active targeting through ligand-receptor interactions, thereby improving the precision of drug delivery to inflamed tissues.Despite the progress, the review notes that challenges remain in translating these technologies into clinical practice. Regulatory hurdles, manufacturing scalability, long-term safety, and the complexity of disease pathogenesis continue to pose significant obstacles. Overall, nanodelivery systems targeting the intestine represent a transformative approach with the potential to significantly improve IBD and CRC management, though further research and development are essential for clinical implementation.
Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma
Patrizia Tempora, Silvia D’Amico, Paula Gragera, Verena Damiani, Kamila Krol, et al.
Journal of Experimental and Clinical Cancer Research, 2024
Background Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and low neoantigen burden, such as neuroblastoma (NB). Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that trims peptides before loading on MHC class I molecules. Inhibition of ERAP1 results in the generation of new antigens able of inducing potent anti-tumor immune responses. Here, we identify a novel non-toxic combinatorial strategy based on genetic inhibition of ERAP1 and administration of the HDAC inhibitor (HDACi) entinostat that increase the immunogenicity of NB, making it responsive to PD-1 therapy. Methods CRISPR/Cas9-mediated gene editing was used to knockout (KO) the ERAP1 gene in 9464D NB cells derived from spontaneous tumors of TH-MYCN transgenic mice. The expression of MHC class I and PD-L1 was evaluated by flow cytometry (FC). The immunopeptidome of these cells was studied by mass spectrometry. Cocultures of splenocytes derived from 9464D bearing mice and tumor cells allowed the assessment of the effect of ERAP1 inhibition on the secretion of inflammatory cytokines and activation and migration of immune cells towards ERAP1 KO cells by FC. Tumor cell killing was evaluated by Caspase 3/7 assay and flow cytometry analysis. The effect of ERAP1 inhibition on the immune content of tumors was analyzed by FC, immunohistochemistry and multiple immunofluorescence. Results We found that inhibition of ERAP1 makes 9464D cells more susceptible to immune cell-mediated killing by increasing both the recall and activation of CD4+ and CD8+ T cells and NK cells. Treatment with entinostat induces the expression of MHC class I and PD-L1 molecules in 9464D both in vitro and in vivo. This results in pronounced changes in the immunopeptidome induced by ERAP1 inhibition, but also restrains the growth of ERAP1 KO tumors in vivo by remodelling the tumor-infiltrating T-cell compartment. Interestingly, the absence of ERAP1 in combination with entinostat and PD-1 blockade overcomes resistance to PD-1 immunotherapy and increases host survival. Conclusions These findings demonstrate that ERAP1 inhibition combined with HDACi entinostat treatment and PD-1 blockade remodels the immune landscape of a non-immunogenic tumor such as NB, making it responsive to checkpoint immunotherapy.
Impact of thermal processing on polyphenols, carotenoids, glucosinolates, and ascorbic acid in fruit and vegetables and their cardiovascular benefits
Federica Narra, Eugenia Piragine, Giada Benedetti, Costanza Ceccanti, Marta Florio, et al.
Comprehensive Reviews in Food Science and Food Safety, 2024
Bioactive compounds in fruit and vegetables have a positive impact on human health by reducing oxidative stress, inflammation, and the risk of chronic diseases such as cancer, cardiovascular (CV) diseases, and metabolic disorders. However, some fruit and vegetables must be heated before consumption and thermal processes can modify the amount of nutraceuticals, that is, polyphenols, carotenoids, glucosinolates, and ascorbic acid, that can increase or decrease in relation to different factors such as type of processing, temperature, and time but also the plant part (e.g., flower, leaf, tuber, and root) utilized as food. Another important aspect is related to the bioaccessibility and bioavailability of nutraceuticals. Indeed, the key stage of nutraceutical bioefficiency is oral bioavailability, which involves the release of nutraceuticals from fruit and vegetables in gastrointestinal fluids, the solubilization of nutraceuticals and their interaction with other components of gastrointestinal fluids, the absorption of nutraceuticals by the epithelial layer, and the chemical and biochemical transformations into epithelial cells. Several studies have shown that thermal processing can enhance the absorption of nutraceuticals from fruit and vegetable. Once absorbed, they reach the blood vessels and promote multiple biological effects (e.g., antioxidant, anti‐inflammatory, antihypertensive, vasoprotective, and cardioprotective). In this review, we described the impact of different thermal processes (such as boiling, steaming and superheated steaming, blanching, and microwaving) on the retention/degradation of bioactive compounds and their health‐promoting effects after the intake. We then summarized the impact of heating on the absorption of nutraceuticals and the biological effects promoted by natural compounds in the CV system to provide a comprehensive overview of the potential impact of thermal processing on the CV benefits of fruit and vegetables.
Electrospun Fiber-Based Tubular Structures as 3D Scaffolds to Generate In Vitro Models for Small Intestine
Lorenzo Zavagna, Eligio F. Canelli, Bahareh Azimi, Fabiola Troisi, Lorenzo Scarpelli, et al.
Macromolecular Materials and Engineering, 2024
Recently, in vitro models emerge as valuable tools in biomedical research by enabling the investigation of complex physiological processes in a controlled environment, replicating some traits of interest of the biological tissues. This study focuses on the development of tubular polymeric scaffolds, made of electrospun fibers, aimed to generate three‐dimensional (3D) in vitro intestinal models resembling the lumen of the gut. Polycaprolactone (PCL) and polyacrylonitrile (PAN) are used to produce tightly arranged ultrafine fiber meshes via electrospinning in the form of continuous tubular structures, mimicking the basement membrane on which the epithelial barrier is formed. Morphological, physical, mechanical, and piezoelectric properties of the PCL and PAN tubular scaffolds are investigated. They are cultured with Caco‐2 cells using different biological coatings (i.e., collagen, gelatin, and fibrin) and their capability of promoting a compact epithelial layer is assessed. PCL and PAN scaffolds show 42% and 50% porosity, respectively, with pore diameters and size suitable to impede cell penetration, thus promoting an intestinal epithelial barrier formation. Even if both polymeric structures allow Caco‐2 cell adhesion, PAN fiber meshes best suit many requirements needed by this model, including highest mechanical strength upon expansion, porosity and piezoelectric properties, along with the lowest pore size.
Correction to: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation (Oncogene, (2016), 35, 33, (4368-4378), 10.1038/onc.2015.504)
E. Grassilli, F. Pisano, A. Cialdella, S. Bonomo, C. Missaglia, et al.
Oncogene, 2024
De Novo Genome Assembly at Chromosome-Scale of Hermetia illucens (Diptera Stratiomyidae) via PacBio and Omni-C Proximity Ligation Technology
Simone Costagli, Linda Abenaim, Giulia Rosini, Barbara Conti, Roberto Giovannoni
Insects, 2024
Strategies for single base gene editing in an immortalized human cell line by CRISPR/Cas9 technology
Alda Corrado, Romina Aceto, Simona Miglietta, Roberto Silvestri, Irene Dell’Anno, et al.
3 Biotech, 2024
Endothelial Effects of Simultaneous Expression of Human HO-1, E5NT, and ENTPD1 in a Mouse
Paulina Mierzejewska, Noemi Di Marzo, Magdalena A. Zabielska-Kaczorowska, Iga Walczak, Ewa M. Slominska, et al.
Pharmaceuticals, 2023
Current Therapeutical Approaches Targeting Lipid Metabolism in NAFLD
Manuela Vitulo, Elisa Gnodi, Giulia Rosini, Raffaella Meneveri, Roberto Giovannoni, et al.
International Journal of Molecular Sciences, 2023
Radiation dose-escalation and dose-fractionation modulate the immune microenvironment, cancer stem cells and vasculature in experimental high-grade gliomas
Matteo RIVA, Roxanne WOUTERS, David NITTNER, Jolien CEUSTERS, Edmond STERPIN, et al.
Journal of Neurosurgical Sciences, 2023
DNAM-1 chimeric receptor-engineered NK cells: a new frontier for CAR-NK cell-based immunotherapy
Loredana Cifaldi, Ombretta Melaiu, Roberto Giovannoni, Monica Benvenuto, Chiara Focaccetti, et al.
Frontiers in Immunology, 2023
Tumor Microenvironment and Immune Escape in the Time Course of Glioblastoma
Assunta Virtuoso, Ciro De Luca, Giovanni Cirillo, Matteo Riva, Gabriele Romano, et al.
Molecular Neurobiology, 2022
CoCl2-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors
Barbara Kutryb-Zajac, Ada Kawecka, Alicja Braczko, Marika Franczak, Ewa M. Slominska, et al.
Biomedicines, 2022
News on immune checkpoint inhibitors as immunotherapy strategies in adult and pediatric solid tumors
Ombretta Melaiu, Valeria Lucarini, Roberto Giovannoni, Doriana Fruci, Federica Gemignani
Seminars in Cancer Biology, 2022
Inhibition of plasminogen/plasmin system retrieves endogenous nerve growth factor and adaptive spinal synaptic plasticity following peripheral nerve injury
Assunta Virtuoso, Anna Maria Colangelo, Sohaib Ali Korai, Sara Izzo, Antonio Todisco, et al.
Neurochemistry International, 2021
Pro64His (rs4644) Polymorphism within Galectin-3 Is a Risk Factor of Differentiated Thyroid Carcinoma and Affects the Transcriptome of Thyrocytes Engineered via CRISPR/Cas9 System
Alda Corrado, Romina Aceto, Roberto Silvestri, Irene Dell'Anno, Benedetta Ricci, et al.
Thyroid, 2021
p65BTK Is a Novel Biomarker and Therapeutic Target in Solid Tumors
Emanuela Grassilli, Maria Grazia Cerrito, Sara Bonomo, Roberto Giovannoni, Donatella Conconi, et al.
Frontiers in Cell and Developmental Biology, 2021
Erratum: The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently (Biology Open (2019) 8 (bio038554) DOI: 10.1242/bio.038554)
Barbara Torsello, Sofia De Marco, Silvia Bombelli, Elisa Chisci, Valeria Cassina, et al.
Biology Open, 2021
The glioblastoma microenvironment: Morphology, metabolism, and molecular signature of glial dynamics to discover metabolic rewiring sequence
Assunta Virtuoso, Roberto Giovannoni, Ciro De Luca, Francesca Gargano, Michele Cerasuolo, et al.
International Journal of Molecular Sciences, 2021
Radiotherapy, Temozolomide, and Antiprogrammed Cell Death Protein 1 Treatments Modulate the Immune Microenvironment in Experimental High-Grade Glioma
Matteo Riva, Roxanne Wouters, Edmond Sterpin, Roberto Giovannoni, Louis Boon, et al.
Neurosurgery, 2021
Rhabdomyosarcoma Cells Produce Their Own Extracellular Matrix With Minimal Involvement of Cancer-Associated Fibroblasts: A Preliminary Study
Stefania D’Agostino, Lucia Tombolan, Mattia Saggioro, Chiara Frasson, Elena Rampazzo, et al.
Frontiers in Oncology, 2021
BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers
Marialuisa Lavitrano, Leonarda Ianzano, Sara Bonomo, Annamaria Cialdella, Maria Grazia Cerrito, et al.
Journal of Pathology, 2020
Sperm-Mediated Genetic Modifications
Marialuisa Lavitrano, Laura Farina, Maria Grazia Cerrito, Roberto Giovannoni
Methods in Molecular Biology, 2020
HDL therapy today: from atherosclerosis, to stent compatibility to heart failure
C.R. Sirtori, M. Ruscica, L. Calabresi, G. Chiesa, R. Giovannoni, et al.
Annals of Medicine, 2019
P65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma
Federica Giordano, Valentina Vaira, Diego Cortinovis, Sara Bonomo, Joyce Goedmakers, et al.
Journal of Experimental and Clinical Cancer Research, 2019
CHRNA2 and nocturnal frontal lobe epilepsy: Identification and characterization of a novel loss of function mutation
Chiara Villa, Giulia Colombo, Simone Meneghini, Cecilia Gotti, Milena Moretti, et al.
Frontiers in Molecular Neuroscience, 2019
Specific expression of a new bruton tyrosine kinase isoform (P65BTK) in the glioblastoma gemistocytic histotype
Luca Sala, Giovanni Cirillo, Gabriele Riva, Gabriele Romano, Carlo Giussani, et al.
Frontiers in Molecular Neuroscience, 2019
The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently
Barbara Torsello, Sofia De Marco, Silvia Bombelli, Elisa Chisci, Valeria Cassina, et al.
Biology Open, 2019
CT-2A neurospheres-derived high-grade glioma in mice: A new model to address tumor stem cells and immunosuppression
Matteo Riva, Roxanne Wouters, Akila Weerasekera, Sarah Belderbos, David Nittner, et al.
Biology Open, 2019
APOA-1Milano muteins, orally delivered via genetically modified rice, show anti-atherogenic and anti-inflammatory properties in vitro and in Apoe −/− atherosclerotic mice
Gabriele Romano, Serena Reggi, Barbara Kutryb-Zajac, Amanda Facoetti, Elisa Chisci, et al.
International Journal of Cardiology, 2018
The role of hydrogen peroxide in redox-dependent signaling: Homeostatic and pathological responses in mammalian cells
Noemi Di Marzo, Elisa Chisci, Roberto Giovannoni
Cells, 2018
Metronomic combination of Vinorelbine and 5-Fluorouracil inhibit triple-negative breast cancer cells results from the proof of- concept VICTOR-0 study
Maria Grazia Cerrito, Marco De Giorgi, Davide Pelizzoni, Sara Maria Bonomo, Nunzio Digiacomo, et al.
Oncotarget, 2018
CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells
Michela Lupia, Francesca Angiolini, Giovanni Bertalot, Stefano Freddi, Kris F. Sachsenmeier, et al.
Stem Cell Reports, 2018
A novel KCNJ2 mutation identified in an autistic proband affects the single channel properties of Kir2.1
Anna Binda, Ilaria Rivolta, Chiara Villa, Elisa Chisci, Massimiliano Beghi, et al.
Frontiers in Cellular Neuroscience, 2018
Simultaneous overexpression of human E5NT and ENTPD1 protects porcine endothelial cells against H2O2-induced oxidative stress and cytotoxicity in vitro
Elisa Chisci, Marco De Giorgi, Elisa Zanfrini, Angela Testasecca, Elena Brambilla, et al.
Free Radical Biology and Medicine, 2017
Resveratrol impairs glioma stem cells proliferation and motility by modulating the wnt signaling pathway
Chiara Cilibrasi, Gabriele Riva, Gabriele Romano, Massimiliano Cadamuro, Riccardo Bazzoni, et al.
Plos One, 2017
Thyrospheres from B-CPAP cell line with BRAF and TERT promoter mutations have different functional and molecular features than parental cells
Paola Caria, Rita Pillai, Tinuccia Dettori, Daniela Virginia Frau, Patrizia Zavattari, et al.
Journal of Cancer, 2017
Unexpected frequency of genomic alterations in histologically normal colonic tissue from colon cancer patients
Donatella Conconi, Serena Redaelli, Giorgio Bovo, Biagio Eugenio Leone, Emanuela Filippi, et al.
Tumor Biology, 2016
A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation
E Grassilli, F Pisano, A Cialdella, S Bonomo, C Missaglia, et al.
Oncogene, 2016
Platinum-Based Drugs and DNA Interactions Studied by Single-Molecule and Bulk Measurements
Domenico Salerno, Giovanni L. Beretta, Giuliano Zanchetta, Simone Brioschi, Matteo Cristofalo, et al.
Biophysical Journal, 2016
The TGF-β pathway is activated by 5-fluorouracil treatment in drug resistant colorectal carcinoma cells
Gabriele Romano, Ludovica Santi, Maria Rosaria Bianco, Maria Rita Giuffrè, Mariateresa Pettinato, et al.
Oncotarget, 2016
Circulating tumor cells and cholangiocarcinoma
Roberto Giovannoni, Augusto Villanueva
Hepatology, 2016
Simultaneous overexpression of functional human HO-1, E5NT and ENTPD1 protects murine fibroblasts against TNF-α-induced injury in vitro
Alessandro Cinti, Marco De Giorgi, Elisa Chisci, Claudia Arena, Gloria Galimberti, et al.
Plos One, 2015
Co-expression of functional human Heme Oxygenase 1, Ecto-5'-Nucleotidase and ecto-nucleoside triphosphate diphosphohydrolase-1 by "self-cleaving" 2A peptide system
Marco De Giorgi, Alessandro Cinti, Iwona Pelikant-Malecka, Elisa Chisci, Marialuisa Lavitrano, et al.
Plasmid, 2015
SCN4A mutation as modifying factor of Myotonic Dystrophy Type 2 phenotype
E. Bugiardini, I. Rivolta, A. Binda, A. Soriano Caminero, F. Cirillo, et al.
Neuromuscular Disorders, 2015
A functional biological network centered on XRCC3: A new possible marker of chemoradiotherapy resistance in rectal cancer patients
Marco Agostini, Andrea Zangrando, Chiara Pastrello, Edoardo D'Angelo, Gabriele Romano, et al.
Cancer Biology and Therapy, 2015
GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis
Emanuela Grassilli, Leonarda Ianzano, Sara Bonomo, Carola Missaglia, Maria Grazia Cerrito, et al.
Plos One, 2014
Functional analysis of expression of human ecto-nucleoside triphosphate diphosphohydrolase-1 and/or ecto-5′-nucleotidase in pig endothelial cells
M. De Giorgi, I. Pelikant-Malecka, A. Sielicka, E. M. Slominska, R. Giovannoni, et al.
Nucleosides Nucleotides and Nucleic Acids, 2014
Diet induced mild hypercholesterolemia in pigs: Local and systemic inflammation, effects on vascular injury - Rescue by high-dose statin treatment
Marco Busnelli, Stefano Manzini, Alberto Froio, Alessia Vargiolu, Maria Grazia Cerrito, et al.
Plos One, 2013
Biliverdin Protects against Liver Ischemia Reperfusion Injury in Swine
Barbara Andria, Adele Bracco, Chiara Attanasio, Sigismondo Castaldo, Maria Grazia Cerrito, et al.
Plos One, 2013
Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy
Emanuela Grassilli, Robert Narloch, Elena Federzoni, Leonarda Ianzano, Fabio Pisano, et al.
Clinical Cancer Research, 2013
Magnetic tweezers measurements of the nanomechanical stability of DNA against denaturation at various conditions of pH and ionic strength
A. Tempestini, V. Cassina, D. Brogioli, R. Ziano, S. Erba, et al.
Nucleic Acids Research, 2013
Methods for sperm-mediated gene transfer
Methods in Molecular Biology, 2013
Prevalence of plasmid-mediated quinolone resistance genes in uropathogenic Escherichia coli isolated in a teaching hospital of Northern Italy
Rosario Musumeci, Marco Rausa, Roberto Giovannoni, Anna Cialdella, Simone Bramati, et al.
Microbial Drug Resistance, 2012
Importance of nitric oxide synthase in the anchoring structures of Neobenedenia girellae - an important fish parasite
Forcella Matilde, Fusi Paola, Villa Anna, Tedeschi Gabriella, Giovannoni Roberto, et al.
Biochemical Systematics and Ecology, 2011
Heme oxygenase-1 inhibition prevents intimal hyperplasia enhancing nitric oxide-dependent apoptosis of vascular smooth muscle cells
Maria Grazia Cerrito, Alessandra Scagliarini, Alberto Froio, Angela Liloia, Marco Busnelli, et al.
Biological and Pharmaceutical Bulletin, 2011
AAV-mediated photoreceptor transduction of the pig cone-enriched retina
C Mussolino, M della Corte, S Rossi, F Viola, U Di Vicino, et al.
Gene Therapy, 2011
In vitro production of multigene transgenic blastocysts via sperm-mediated gene transfer allows rapid screening of constructs to be used in xenotransplantation experiments
A. Vargiolu, S. Manzini, M. de Cecco, M.L. Bacci, M. Forni, et al.
Transplantation Proceedings, 2010
Head glands of monogenoidea: Morphology, functionality, and potentialities in industrial production of surgery bioadhesives
Paolo Galli, Giovanni Strona, Roberto Giovannoni, Marialuisa Lavitrano
Journal of Parasitology, 2009
Sperm-mediated gene transfer-treated spermatozoa maintain good quality parameters and in vitro fertilization ability in swine
M.L. Bacci, A. Zannoni, M. De Cecco, P. Fantinati, C. Bernardini, et al.
Theriogenology, 2009
Pathogenetic role of hypercholesterolemia in a novel preclinical model of vascular injury in pigs
Marco Busnelli, Alberto Froio, Maria Laura Bacci, Massimo Giunti, Maria Grazia Cerrito, et al.
Atherosclerosis, 2009
Reactive astrocytosis and glial glutamate transporter clustering are early changes in a spinocerebellar ataxia type 1 transgenic mouse model
Roberto Giovannoni, Nicola Maggio, Maria Rosaria Bianco, Carlo Cavaliere, Giovanni Cirillo, et al.
Neuron Glia Biology, 2007
Reduction of hyperacute rejection and protection of metabolism and function in hearts of human decay accelerating factor (hDAF)-expressing pigs
R SMOLENSKI, M FORNI, M MACCHERINI, M BACCI, E SLOMINSKA, et al.
Cardiovascular Research, 2007
Genetically modified pigs produced with a nonviral episomal vector
Stefano Manzini, Alessia Vargiolu, Isa M Stehle, Maria Laura Bacci, Maria Grazia Cerrito, et al.
Proceedings of the National Academy of Sciences of the United States of America, 2006
Sperm-mediated gene transfer
Marialuisa Lavitrano, Marco Busnelli, Maria Grazia Cerrito, Roberto Giovannoni, Stefano Manzini, et al.
Reproduction Fertility and Development, 2006
Multi-transgenic pigs expressing three fluorescent proteins produced with high efficiency by sperm mediated gene transfer
Nicole L. Webster, Monica Forni, Maria Laura Bacci, Roberto Giovannoni, Riccardo Razzini, et al.
Molecular Reproduction and Development, 2005
Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs
Marialuisa Lavitrano, Ryszard T. Smolenski, Antonino Musumeci, Massimo Maccherini, Ewa Slominska, et al.
FASEB Journal, 2004
Dual Control of Neurogenesis by PC3 through Cell Cycle Inhibition and Induction of Math1
Daniela Canzoniere, Stefano Farioli-Vecchioli, Filippo Conti, Maria Teresa Ciotti, Ada Maria Tata, et al.
Journal of Neuroscience, 2004
Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation
Marialuisa Lavitrano, Maria Laura Bacci, Monica Forni, Davide Lazzereschi, Carla Di Stefano, et al.
Proceedings of the National Academy of Sciences of the United States of America, 2002

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