Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine
54
Scopus Publications
Scopus Publications
The quantitative haemodynamic effect of levosimendan, dobutamine, and milrinone in heart failure patients: a meta-analysis Vincenzo Nuzzi, Cristina Madaudo, Paolo Manca, Antonio Cannata, Giuseppe Raffa, Massimiliano Mulè, Stefano Cannata, Eluisa La Franca, Calogera Pisano, Manlio Cipriani, Roberto Lorusso Esc Heart Failure, 2026 Introduction Inotropic therapy is a cornerstone of medical treatment for patients with low-output heart failure (HF). We aimed to investigate the quantitative effect of specific inotropic drugs on invasive haemodynamics. Methods This meta-analysis assessed the haemodynamic effects of dobutamine, levosimendan, and milrinone in patients with low-output HF. Only studies using invasive haemodynamic assessment were included. The primary outcome was the quantitative change in variables such as cardiac index, pulmonary artery wedge pressure, mean pulmonary artery pressure, mean arterial pressure (MAP), pulmonary and systemic vascular resistance (before and after administration of each drug. Quality was assessed using the National Institutes of Health Quality Assessment Tool (NIH-QAT). A sensitivity analysis compared the effect on acute versus chronic HF populations. Results Twenty-six studies (n = 1888 patients) were included in the analyses. Based on the NIH-QAT checklist, 11 studies were at low risk of bias, 14 at moderate risk, and 1 at high risk. Meta-analysis showed that all the study drugs improved the haemodynamic variables assessed, without significant differences amongst them, except for MAP (P = .0486). Dobutamine and levosimendan caused a non-significant increase in MAP, while milrinone showed a trend towards a reduction in MAP [−3.46 (−7.27 to +0.35)]. The heterogeneity across studies was high. In the sensitivity analysis, dobutamine improved CI more than levosimendan in patients with chronic HF. Conclusion The use of inotropes improves haemodynamic status in patients with low-output HF, with no consistent superiority of one agent over the others. These findings support the current clinical practice of agent selection based on individual patient characteristics. Head-to-head trials in well-phenotyped HF populations are warranted to guide personalized inotrope use.
Pharmacological decongestion: From loop diuretics to sequential nephron blockade Giornale Italiano Di Cardiologia, 2026
Inotropic therapy in outpatients with worsening or advanced heart failure: Literary evidence and comparison of Italian management models Paolo Manca, Maria Vittoria Matassini, Piero Gentile, Emilia D’Elia, Concetta Di Nora, Luca Fazzini, Luca Baldetti, Riccardo M. Inciardi, Renata De Maria, Samuela Carigi, Vincenzo Nuzzi, Manlio Cipriani, Luisa De Gennaro, Matteo Bianco, Maria Denitza Tinti, Vittorio Palmieri, Vittoria Rizzello, Sara Doimo, Simone Cappannelli, Marco Marini, Andrea Garascia, Gabriella Masciocco, Michele Senni, Mauro Driussi, Silvia Ajello, Anna Mara Scandroglio, Marco Metra, Marco Corda, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva, Mauro Gori Giornale Italiano Di Cardiologia, 2026 La terapia con farmaci inotropi domiciliari rappresenta una strategia terapeutica nei pazienti con insufficienza cardiaca (IC) avanzata, sia come ponte verso trattamenti salvavita come il trapianto cardiaco o i dispositivi di assistenza ventricolare, sia a scopo palliativo nei pazienti non eleggibili a queste opzioni terapeutiche. In questa rassegna riportiamo il ruolo del supporto inotropo infusionale domiciliare, in particolare con dobutamina, dopamina, milrinone e levosimendan, attraverso una sintesi della letteratura disponibile e la presentazione di modelli gestionali adottati in alcuni centri italiani. Le esperienze riportate suggeriscono un possibile miglioramento della qualità di vita, una riduzione delle ospedalizzazioni e una maggiore stabilità clinica nei pazienti con IC avanzata. Tali modelli possono costituire esempi concreti per l’organizzazione di percorsi assistenziali in un ambito clinico tuttora poco definito dalle linee guida.
First quinquennium completed: highlights from EHJ Open 2025 Magnus Bäck, Maciej Banach, Frieder Braunschweig, Salvatore De Rosa, Frank A Flachskampf, Thomas Kahan, Daniel F J Ketelhuth, Patrizio Lancellotti, Susanna C Larsson, Linda Mellbin, Gianluigi Savarese, Annette Schophuus Jensen, Karolina Szummer, Denis Wahl, European Heart Journal Open Section Editors, Ana Almeida, Marie-Luce Bochaton-Piallat, Mats Börjesson, Ronny Buechel, Emmanouil Charitakis, Arrigo Cicero, Domenico D'Amario, Christian de Chillou, Jérémy Fauconnier, Nicolas Girerd, Anders Gottsäter, Joerg Herrmann, Christian Jung, Stefan Koudstaal, Seth Martin, Edit Nagy, John Pernow, Davide Stolfo, Giuseppe Vergaro, Michal Zembala, Andre Zimerman, Harry Björkbacka, Haran Burri, Kevin Damman, Marat Fudim, Bruna Gigante, Patrick Lacolley, Gustavs Latkovskis, Sven-Christian Pawelzik, Veronique Regnault, Leyla Elif Sade Akdogan, Michael Shapiro, Marcus Ståhlberg, Arik Wolak, Mani A Vannan, Erika Aagaard, Assia Aajal, Mohamed Abdelhamid, Ryo Abe, Abdelmomen Abouborda, Elisabetta Abruzzese, Maurizio Acampa, Gareth Ackland, Dimitris Afendoulis, Siddharth Agarwal, Arian Aghilinejad, Malik Takreem Ahmad, Adam Ahmed, Alberto Aimo, Ibrahim Akin, Hyeon-Ju Ali, Baravan Al-Kassou, Till Althoff, Gökhan Alıcı, Matthew Ambrosio, Rafael Amorim Belo Nunes, Niels H Andersen, Daniel Andersson, Giuseppe Ando', Alessia Argiro, Matthew K Armstrong, Amir Askarinejad, Morten Bækgaard Thomsen, Christian Bär, Hooman Bakhshi, Tosho Balabanski, Anna Baritussio, Ozcan Basaran, Cristina Basso, Akash Batta, Guillaume Baudry, Anıl Başkurt, Hans Christian Beck, Benedikt Beer, Maria Giulia Bellicini, Karim Benali, Alexander E Berezin, Justine Bergeon, Jutta Bergler-Klein, Marco Bernardi, Matteo Bertini, Francesco Bianco, Maro Biffi, Giuseppe Biondi-Zoccai, Konstantinos Bitos, Ana Blasco, Aleš Blinc, Franck Boccara, Marton Boga, Laurent Bonello, Maria Bonsignore, Rasmus Borgquist, Josip Andelo Borovac, Alicja Bortkiewicz, Ilze Bot, John Bourke, Luisa Branco, Helge Brandberg, Axel Brandes, Ole Breithardt, Michele Brignole, Olof Broberg, Jasper Brugts, Natale Brunetti, Sergio Buccheri, Benjamin Buckley, Rebecca Burton, Gianluca Campo, Nicole Carabetta, Luis Miguel Cardoso Dos Santos, Thierry Carrel, Edina Cenko, Alberto Cereda, Dick C Chan, Shih-Ann Chen, Qingui Chen, Yun-Yu Chen, Romain Chopart, Arrigo Cicero, Giuseppe Ciconte, Thomas R Cimato, Pascal Clephas, Sean Coffey, Stefano Coiro, Bernardo Cortese, Giorgio Costantino, J J Coughian, Elaine Coutinho, Harry Crijns, Otilia Cristea, Michal Czapla, Mohamed Dafaalla, Ioana Cristina Daha, Anna Damlin, Richard Davis, Marzia De Bortoli, Victor de Ledinghen, Peter De leeuw, Annamaria Del Franco, Gabriele Dell'Era, Omar Dewidar, Tarvinder Dhanjal, Michele Di Mauro, Luigi Di Serafino, Borislav Dinov, Erwan Donal, Teodora Donisan, Nikola Drca, Daniel J Drucker, David Duncker, Angela Durante, Dragos Duse, Brett Dyer, Maciej Dyrbuś, Mathieu Echivard, Betty Eipper, Sheref Elseidy, Francesco Fanelli, Alessandro Filippeschi, Thomas Fink, Matthias Fischer, Joseph Flynn, Luigi Formisano, Hidehira Fukaya, Shinya Furukawa, Mattias Götberg, Mattia Galli, Cosme García-García, Rodrigue Garcia, Xavier Garcia-Moll, Mario Gaudino, Davide Genovese, Francesco Gentile, Bijan Ghaleh-Marzban, Daniele Giacoppo, Anton Gisterå, Jens P Goetze, Ana Gomes, Tommaso Gori, Shinya Goto, Felice Gragnano, Trisha Grevengoed, Chrysanthos Grigoratos, Eduard Guasch, Philippe Guerci, Norbert Guettler, Nicole Habel, Payam Haftbaradaran Esfahani, Camilla Hage, Nazha Hamdani, Dorela Haxhiademi, Holger Hein, Kevin Heist, Rayyan Hemetsberger, Johan Heritz, Jussi Hernesniemi, Gerd Heusch, Jochen Lukas Hilgendorf, Yoshitaka Hirooka, Joanna Hlebowicz, Katarzyna Holcman, Fortunato Iacovelli, Ignatios Ikonomidis, Yoshitaka Iwanaga, Jin Iwasawa, Allan Jaffe, Akhil Jain, Vikash Jaiswal, Martin Jansson, Ana Jelaković, Anders Jeppsson, Aravdeep Jhand, Juhani Junttila, Juliane Jurga, Wayne Kaesemeyer, Koray Kalenderoglu, Hannah Kentenich, Thorsten Kessler, Alexander Kharlamov, Alexander Kirsch, Umut Kocabaş, Stavros Konstantinides, Yuval Konstantino, Yosua Darmadi Kosen, Irina Kotlar, Mila Kovacevic, Andrew D Krahn, Piotr Kulakowski, Toshiki Kuno, Jacob Lønborg, Renzo Laborante, Stephan Lange, Alf Inge Larsen, Carl Lavie, Thierry Le Tourneau, Seung-Yul Lee, Matthew M Y Lee, Orly Leiva, Isabella Leo, Carolin Lerchenmüller, Finn Olav Levy, Chee Woon Lim, Johan Ulrik Lind, Bertil Lindahl, Helena Lindberg, Felix Lindberg, Gregory Lip, Ioan Liuba, Mark Luedde, Pia Lundman, Julian Müller, Cristina Madaudo, Pasquale Maffia, Michele Magnocavallo, Johannes Mair, Maan Malahfji, Guy Malkinson, Paolo Manca, Antonio Mangieri, Muhammad Talha Maniya, Masab Mansoor, Stephane Manzo-Silberman, Benjamin Marchandot, Michele Marchetta, Eloi Marijon, Steven M Markowitz, Ahmad Masri, Finlay A McAlister, David Messika-Zeitoun, Lars Michel, Desai Milind Y, Emilia Monteiro, Carlos Arturo Morillo, Marco Moscarelli, Sara Moscatelli, Francisco Moscoso Costa, Shunsuke Murata, Daud Mutahar, Jan Naar, Umbreen Nadeem, Sotirios Nedios, Jens Cosedis Nielsen, Muhammad Nizam, Alleh Nogueira, Vincenzo Nuzzi, Fredrik Nyström, Marish Oerlemans, Taishi Okuno, Brian Olshansky, Muhammed Bahadır Omar, Elmir Omerovic, Elena Osto, Marina M Ostojic, Yihui Ou, Cécile Oury, Helmut Pürerfellner, Paolo Palatini, Nicolai Palstrøm, Francesco Paneni, Giuseppe Panuccio, Michael Papadakis, Andriana Papaioannou, Carlo Pappone, Elizabeth Paratz, Manan Pareek, Maria Concetta Pastore, Astrid Paul Nordin, Rita Pavasini, Natalia Pavon, Pauline Pearcy, Pierpaolo Pellicorri, Jonas Persson, Marcelo Petri, Gregory Piazza, Francois Picard, Marco Piccininni, Gianluigi Pironti, Arman Postadzhiyan, Alonzo Prata, Francesco Prati, Riccardo Proietti, Joao Ramos, Tripti Rastogi Gupta, Manuel Rattka, Elina Rautio, Dimitris Richter, Benoit Robaye, Vincenzo Rochira, Alfredo Rodriguez, Jolien Roos-Hesselink, Lars Rydén, Manel Sabaté, Jolanda Sabatino, Pierre Sabouret, Christian Salbach, John Sanderson, Pasquale Santangeli, Raul D Santos, Gaetano Santulli, Serkan Saygi, Paolo Sciarrone, Shantanu Sengupta, Murat Sezer, Erdinc Sezgin, Bahira Shahim, Arman Shahriar, Chetan Shenoy, Mikio Shiba, Stephanie Sibley, Anwar Siddiqui, Antti Siika, Moa Simonssonn, Judith Sluimer, Alina Maria Smaranda, Erik Ekker Solberg, Philipp Sommer, Jonas Spaak, Torkel Steen, Lee Sterling, Robert Storey, Antonio Strangio, Gaspard Suc, Tadafumi Sugimoto, Atsushi Sugiura, Alexander Sullivan, Praveena Sunkara, Richard Sutton, Saeko Takahashi, Ju Tan, Neville Tan, Hongwei Tan, Susumu Tao, Jean-Claude Tardif, Julie Tarp, Rene Tavernier, Rod Taylor, Andrew Teh, Dominic Theuns, Holger Thiele, Ulf Thilén, Roland Tilz, Ana Teresa Timoteo, Tomasz Tokarek, José María Tolosana, Daniela Tomasoni, Peter Toth, Karin Tran-Lundmark, Gal Tsaban, Grigorios Tsigkas, Chukwuemeka Umeh, Mileen van de Kar, ErikVan Iterson, Richard S Vander Heide, Bart Velders, Gruschen R Veldtman, Kevin Vernooy, Alessandro Villaschi, Ada Visentini, F L J Visseren, Konstantinos Vlachos, Arnold von Eckardstein, Håkan Wallén, Anne Wang Gottlieb, Michael A Weber, Martin Wilkins, Roger Winkle, Jonas Wixner, Christopher Woods, Xinzhou Xie, Masahiro Yamamoto, In-Ho Yang, Di Yang, Derek M Yellon, Zhichao Zhou, Li Ziang, Andreas Zietzer European Heart Journal Open, 2026
Intra-annular self-expanding or balloon-expandable TAVI in small annuli: the NAVULTRA registry Stefano Cannata, Ibrahim Sultan, Nicolas M. Van Mieghem, Arturo Giordano, Ole De Backer, Jonathan Byrne, Didier Tchétché, Sergio Buccheri, Luis Nombela-Franco, Rui Campante Teles, Marco Barbanti, Emanuele Barbato, Ignacio Amat Santos, Daniel J. Blackman, Francesco Maisano, Roberto Lorusso, Ketty La Spina, Antonella Millin, Dustin E. Kliner, Mark van den Dorpel, Elena Acerbi, Davorka Lulic, Hossam Fayed, Chiara De Biase, Jorge Francisco Chavez Solsol, Joao Brito, Giuliano Costa, Matteo Casenghi, Clara Fernandez Cordon, Amanda Sherwen, Nicola Buzzatti, Salvatore Pasta, Marco Turrisi, Paolo Manca, Vincenzo Nuzzi, Corrado Tamburino, Francesco Bedogni, Caterina Gandolfo, Azeem Latib Eurointervention, 2026 BACKGROUND: Comparative data between self-expanding Navitor (NAV) and balloon-expandable SAPIEN 3 Ultra (ULTRA) transcatheter heart valves (THVs) in patients with small aortic annuli are lacking. AIMS: This study sought to evaluate outcomes of transcatheter aortic valve implantation (TAVI) using the intra-annular NAV and the ULTRA THVs in severe aortic stenosis patients with small annuli. METHODS: undergoing TAVI with either NAV or ULTRA from the NAVULTRA registry were included. Propensity-matched analysis was performed for adjustment. Primary endpoints included 1-year mortality, a composite endpoint (all-cause mortality, disabling stroke, or heart failure hospitalisation), and 30-day device-oriented outcomes (severe prosthesis-patient mismatch, moderate or greater paravalvular leak [PVL], mean gradient ≥20 mmHg). RESULTS: Among 1,617 patients, 524 propensity score-matched pairs were analysed. At 1 year, all-cause mortality was 8.8% with NAV versus 9.0% with ULTRA (adjusted p=0.585), and the composite endpoint occurred in 11.3% versus 11.8%, respectively (adjusted p=0.149). The device-oriented endpoint favoured NAV compared to ULTRA (6.0% vs 29.3%; adjusted p<0.01), with a lower residual transvalvular gradient (7.3 mmHg vs 12.7 mmHg; adjusted p<0.01), and reduced incidence of any prosthesis-patient mismatch (odds ratio 0.27, 95% confidence interval: 0.18-0.43; adjusted p<0.01). However, NAV was associated with higher rates of mild paravalvular leak (NAV 33.5% vs ULTRA 23.2%; adjusted p<0.05) and permanent pacemaker implantation (PPI; NAV 20.1% vs 11.9% ULTRA; adjusted p<0.01). CONCLUSIONS: In patients with small aortic annuli, TAVI with both NAV and ULTRA provided comparable 1-year clinical outcomes, but NAV showed better haemodynamic performance at the cost of higher rates of mild PVL and PPI.
Initiation, titration, and safety of vericiguat for treatment of heart failure in United States clinical practice Stephen J. Greene, Alexander Michel, Coralie Lecomte, Paolo Manca, Katsiaryna Holl, Michele Senni American Heart Journal Plus Cardiology Research and Practice, 2026 Study objective: To evaluate the following among new users of vericiguat: up-titration patterns, factors associated with up-titration, occurrence of hypotension/syncope, predictors of hypotension/syncope. Design: Retrospective cohort study (linked claims and electronic health record data). Setting: US clinical practice. Participants: 1361 new users of vericiguat. Interventions: N/A. Main outcome measures: Vericiguat starting dose, up-titration patterns and predictors, occurrence and predictors of hypotension/syncope, over a 3-month follow-up period. Results: < 0.0001). A > 2.5 mg/day vericiguat starting dose was not associated with the occurrence of hypotension/syncope (vs. 2.5 mg/day); adj. HR 0.82, 95% C.I. (0.58, 1.16). Conclusion: Vericiguat users initiated on the 5 mg/day dose were considerably more likely to reach the target dose of 10 mg/day vs. those started on the recommended 2.5 mg/day dose, without excess risk of hypotension or syncope.
Effects of calcium channel blockers on GDMT prescription and outcomes according to ejection fraction: IN-HF real world data Mauro Gori, Luca Fazzini, Jennifer Meessen, Raul Limonta, Samuela Carigi, Matteo Bianco, Luisa De Gennaro, Concetta Di Nora, Paolo Manca, Maria Vittoria Matassini, Vittoria Rizzello, Denitza Tinti, Aldo Pietro Maggioni, Francesco Orso, Marco Gorini, Renata De Maria, Mauro Gori, Vittorio Palmieri, Luisa De Gennaro, Concetta Di Nora, Paolo Manca, Maria Vittoria Matassini, Matteo Bianco, Maria Denitza Tinti, Vittoria Rizzello, Renata De Maria, Aldo Pietro Maggioni, Francesco Orso, Marco Gorini, Donata Lucci, Lucio Gonzini, Ilaria Cangioli, Vittorio Palmieri, Alessandro Battagliese, Maria Rosaria Catalano, Anna Rita Felici, Marina Floresta, Giuseppe Leonardi, Alessandro Navazio, Giovanni Pulignano, Maria Cristina Orlando, Gaetano Senatore, Elisa Pelissero, Filippo Rabajoli, Laura Montagna, Maria Giulia Perrelli, Iris Parrini, Chiara Calcagnile, Patrizia Noussan, Vincenzo Duino, Alice Ravera, Lorenzo Caprini, Claudio Cuccia, Roberto Grassini, Claudio Pedrinazzi, Matteo Pernigo, Corinna Antonia Inserra, Maurizio D'Urbano, Emanuela Zanelli, Simonetta Scalvini, Stefano Maggiolini, Alice Sacco, Fabrizio Giovanni Oliva, Ada Francesca Giglio, Maria Frigerio, Giuliana Germana Mombelli, Antonia Alberti, Ornella Agostoni, Antonio Mafrici, Giuseppe Galati, Laura Salvini, Giampaolo Guazzotti, Egidio Traversi, Antonella Vincenzi, Andrea Mortara, Pietro Delfino, Laura Scelsi, Luigi Maria Oltrona Visconti, Maria De Salvo, Giovanni Forni, Anna Frisinghelli, Daniela Pini, Bernhard Reimers, Daniele Nassiacos, Sabina Meloni, Andrea Cafro, Daniela Belloli, Paolo Carlo Sganzerla, Fabrizio Morandi, Patrizia Quorso, Carla Paolini, Claudio Bilato, Gabriele Vianello, Francesca De Cian, Albino Zanocco, Salvatore Saccà, Giulia Maria Frigo, Maurizio Anselmi, Sara Giacomelli, Elvira Loiudice, Daniela Pavan, Marco Merlo, Gianfranco Sinagra, Giulia Russo, Andrea Di Lenarda, Daniela Miani, Alessandro Proclemer, Marco Canepa, Francesco Chiarella, Francesco Mainardi, Paolo Rubartelli, Silvia Costa, Pamela Gallo, Gianni Casella, Eugenio Roberto Cosentino, Claudio Borghi, Paola Prestinenzi, Stefano Urbinati, Chiara Mariani, Stefano Cappelli, Michela Bartolotti, Marco Marconi, Alessandro Fucili, Roberto Ferrari, Elisa Gardini, Marcello Galvani, Alessandro Navazio, Elisa Guerri, Vera Zanasi, Pierangelo Del Corso, Giancarlo Piovaccari, Flavio Bologna, Giancarlo Piovaccari, Francesca Menozzi, Franco Cosmi, Flavio Venturi, Attilio Del Rosso, Francesco Grossi, Massimo Milli, Calogero Minneci, Alessandra Pratesi, Andrea Ungar, Luigia Garritano, Roberta Poletti, Marina Parigi, Giovanni Scopelliti, Antonio D'Arpino, Franco Antonio Pagliaro, Serafina Valente, Giuliana Bardelli, Rosita Panciarola, Donatella Severini, Adriano Murrone, Erberto Carluccio, Giuseppe Ambrosio, Lucia Filippucci, Cristina Martino, Ilaria Battistoni, Gian Piero Perna, Francesco Travaglini, Ettore Savini, Domenico Gabrielli, Loreta Prosseda, Natale Di Belardino, Paolo Midi, Anna Rita Felici, Myriam Lo Presti, Massimo Mancone, Giovanni Pulignano, Massimo Uguccioni, Fiammetta Albi, Vittoria Rizzello, Alessandro Battagliese, Nicoletta Pagnoni, Angela Beatrice Scardovi, Stefania Angela Di Fusco, Furio Colivicchi, Claudia Tota, Simone Refice, Teymour Nejat, Laura Lalla Piccioni, Cosimo Napoletano, Vittorio Palmieri, Luigi Tedesco, Lucia Lardo, Carmela Lirato, Francesco Piemonte, Maria Angela Losi, Domenico Bonaduce, Alberto Gigantino, Giuseppe Padula, Giovanni Cicia, Margherita Liotino, Alessandra De Castro, Natale Daniele Brunetti, Francesco Sturniolo, Cettina Ruperto, Maria Teresa Giannone, Maria Brunilde Zisa, Salvatore Felis, Mariarosaria Catalano, Francesco Amico, Simona Giubilato, Giuseppe Leonardi, Gerlando Montana, Giuseppina Maura Francese, Michele Massimo Gulizia, Donatella Armata, Tommaso Alberto Cipolla, Salvatore Arcidiacono, Vincenzo Crisci, Francesca Napoli, Antonino Saitta, Agata Maria Floresta, Calogero Falletta, Giuseppe Iabichella, Antonino Nicosia, Marco Corda, Valeria Orrù European Journal of Internal Medicine, 2026
Hypokinetic nondilated cardiomyopathy: clinical characteristics, prognosis, and therapy response compared to dilated cardiomyopathy Paolo Manca, Samuela Carigi, Luca Fazzini, Vittoria Rizzello, Maria Denitza Tinti, Luisa De Gennaro, Matteo Bianco, Maria Vittoria Matassini, Vittorio Palmieri, Concetta Di Nora, Marco Gorini, Francesco Orso, Alessandro Battagliese, Anna Rita Felici, Mariarosaria Catalano, Marina Floresta, Giuseppe Leonardi, Renata De Maria, Mauro Gori Journal of Cardiovascular Medicine, 2026 Aims Hypokinetic nondilated cardiomyopathy (HNDC) is defined by left ventricular dysfunction without significant dilatation. The distinct features and prognosis of HNDC compared to classical dilated cardiomyopathy (DCM) are partially unexplored. We investigated the differences between HNDC and DCM cohorts from the multicentric Italian IN-HF registry. Methods All patients with a diagnosis of DCM enrolled in the registry between 2008 and 2023 were considered. HNDC was defined by a left ventricular end-diastolic diameter of less than 34 mm/m 2 in men and less than 31 mm/m 2 in women, or a left ventricular end-diastolic volume of 70 ml/m 2 or less in men and less than 60 ml/m 2 in women. The primary outcome was a composite of all-cause death and heart failure hospitalizations (HFHs). Results Of 1748 patients, 568 (32.5%) met the criteria for HNDC. HNDC patients were more likely to be male, with a higher prevalence of obesity and atrial fibrillation. HNDC also showed less advanced disease (less advanced New York Association class, higher left ventricular ejection fraction, lower prevalence of moderate-severe mitral regurgitation, and less atrial dilatation). After a median follow-up of 13 months, the primary outcome occurred less frequently in HNDC compared with DCM [12.5 vs. 17.1%; hazard ratio 0.762, 95% confidence interval (95% CI) 0.581–0.999; P = 0.049]. However, the adjusted prognosis was similar between groups (hazard ratio 1.031, 95% CI 0.771–1.380; P = 0.834). Beta-blockers emerged as the most protective drug for HNDC (hazard ratio 0.462, 95% CI 0.258–0.826; P = 0.009). Conclusion HNDC appears as a distinct form of DCM with milder clinical presentation. However, the absence of LV dilation did not independently influence prognosis. Beta-blockers may offer the most consistent benefit in HNDC.
Interleukin-6 in Cardiogenic Shock Luca Fazzini, Michele Golino, Francesco Moroni, Matteo Castrichini, Gregorio Tersalvi, Paolo Manca, Antonio Abbate Current Cardiology Reports, 2025
MAD or MADness? Francesco Fulvio Faletra, Giuseppe Sgarito, Francesca Parisi, Eluisa La Franca, Massimiliano Mulè, Alessandra Carvelli, Giovanni Di Stefano, Rita Laura Borrello, Vincenzo Nuzzi, Paolo Manca, Manlio Cipriani Cardiovascular Ultrasound, 2025
Risk Stratification Tools in Acute Heart Failure and Their Roles in Personalized Follow-Up Vittoria Rizzello, Samuela Carigi, Renata De Maria, Maria Denitza Tinti, Raul Limonta, Francesco Orso, Matteo Bianco, Luisa De Gennaro, Maria Vittoria Matassini, Paolo Manca, Concetta Di Nora, Alessandro Navazio, Giovanna Geraci, Furio Colivicchi, Claudio Bilato, Federico Nardi, Massimo Grimaldi, Fabrizio Oliva Journal of Clinical Medicine, 2025
Finerenone: Extending MRAs Prognostic Benefit to the Recently Hospitalized and More Symptomatic Patient with HFpEF Maria Denitza Tinti, Luisa De Gennaro, Raul Limonta, Renata De Maria, Samuela Carigi, Matteo Bianco, Concetta Di Nora, Paolo Manca, Maria Vittoria Matassini, Vittoria Rizzello, Emilia D’Elia, Manuela Benvenuto, Marco Cittar, Geza Halasz, Massimo Iacoviello, Domenico Gabrielli, Furio Colivicchi, Claudio Bilato, Federico Nardi, Massimo Grimaldi, Fabrizio Oliva Journal of Clinical Medicine, 2025
SGLT2-is in Acute Heart Failure Matteo Bianco, Concetta Di Nora, Renata De Maria, Amir Hassan Mousavi, Samuela Carigi, Luisa De Gennaro, Paolo Manca, Maria Vittoria Matassini, Vittoria Rizzello, Maria Denitza Tinti, Giovanna Geraci, Attilio Iacovoni, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva Journal of Clinical Medicine, 2025
Home Inotropes in Advanced Heart Failure: A Practical Review Paolo Manca, Maria Vittoria Matassini, Luca Fazzini, Matteo Bianco, Concetta Di Nora, Vittoria Rizzello, Samuela Carigi, Luisa De Gennaro, Maria Denitza Tinti, Renata De Maria, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva, Mauro Gori Journal of Clinical Medicine, 2025
Kidney protection: Role of sodium-glucose co-transporter 2 inhibitors and finerenone Manuela Benvenuto, Emilia D’Elia, Marco Cittar, Ilaria Battistoni, Gianluigi Tagliamonte, Daniele Masarone, Geza Halasz, Raul Limonta, Maria Denitza Tinti, Luisa De Gennaro, Renata De Maria, Samuela Carigi, Matteo Bianco, Concetta Di Nora, Paolo Manca, Maria Vittoria Matassini, Vittoria Rizzello, Vittorio Palmieri, Claudio Bilato, Giovanna Geraci, Mauro Gori, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva, Massimo Iacoviello, a nome dell’Area Cardiorenale e Metabolica ANMCO e dell’Area Giornale Italiano Di Cardiologia, 2025
Transcatheter Aortic Valve Replacement With Intra-Annular Self-Expanding or Balloon-Expandable Valves: The Multicenter International NAVULTRA Registry Stefano Cannata, Ibrahim Sultan, Nicolas Van Mieghem, Arturo Giordano, Ole De Backer, Johnathan Byrne, Didier Tchetche, Sergio Buccheri, Luis Nombela-Franco, Rui Campante Teles, Marco Barbanti, Emanuele Barbato, Ignacio Amat Santos, Daniel J. Blackman, Francesco Maisano, Roberto Lorusso, Ketty La Spina, Antonella Millin, Dustin E. Kliner, Mark van den Dorpel, Elena Acerbi, Davorka Lulic, Kaivalya Divekar, Vincenzo Cesario, Jorge Francisco Chavez Solsol, Joao Brito, Giuliano Costa, Matteo Casenghi, Clara Fernandez Cordon, Amanda Sherwen, Nicola Buzzatti, Salvatore Pasta, Marco Turrisi, Michele Minacori, Paolo Manca, Vincenzo Nuzzi, Corrado Tamburino, Francesco Bedogni, Caterina Gandolfo, Azeem Latib Jacc Cardiovascular Interventions, 2025
ISMETT experience with long-term left ventricular assist devices Vincenzo Nuzzi, Sergio Sciacca, Alessandro Lucchino, Paolo Manca, Giovanna Panarello, Matteo Rossetti, Alessandra Fontana, Simona Leone, Maria Scarlata, Eleonora Bonicolini, Massimiliano Mulè, Giuseppe Raffa, Marco Morsolini, Francesca Parisi, Stefano Cannata, Caterina Gandolfo, Gaetano Burgio, Francesco Musumeci, Francesco F. Faletra, Antonio Arcadipane, Michele Pilato, Manlio G. Cipriani Giornale Italiano Di Cardiologia, 2025
Diagnosis and treatment of iron deficiency in heart failure Federico Fortuni, Giuseppe Ciliberti, Mauro Gori, Pietro Scicchitano, Michele Magnesa, Antonella Spinelli, Enrica Vitale, Concetta Di Nora, Luca Franchin, Stefano Cornara, Paolo Manca, Stefano Cangemi, Samuela Carigi, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva Giornale Italiano Di Cardiologia, 2025
Follow-up of patients with acute and chronic heart failure: Risk stratification to diversify the pathway Samuela Carigi, Vittoria Rizzello, Renata De Maria, Raul Limonta, Francesco Orso, Matteo Bianco, Luisa De Gennaro, Maria Vittoria Matassini, Paolo Manca, Concetta Di Nora, Maria Denitza Tinti, Vittorio Palmieri, Alessandro Navazio, Giovanna Geraci, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva, Mauro Gori Giornale Italiano Di Cardiologia, 2025
Role of inflammation in heart failure with preserved ejection fraction: From nephro-metabolic interactions to future therapeutic implications Emilia D’Elia, Manuela Benvenuto, Ilaria Battistoni, Marco Cittar, Gianluigi Tagliamonte, Daniele Masarone, Geza Halasz, Raul Limonta, Luisa De Gennaro, Renata De Maria, Samuela Carigi, Matteo Bianco, Concetta Di Nora, Paolo Manca, Maria Vittoria Matassini, Vittoria Rizzello, Vittorio Palmieri, Claudio Bilato, Giovanna Geraci, Mauro Gori, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva, Massimo Iacoviello, a nome dell’Area Scompenso Cardiaco e dell’Area Cardiorenale Giornale Italiano Di Cardiologia, 2025
Worsening heart failure: Definition, management and treatment Maria Vittoria Matassini, Paolo Manca, Raul Limonta, Marco Marini, Francesco Orso, Samuela Carigi, Luisa De Gennaro, Maria Denitza Tinti, Matteo Bianco, Vittoria Rizzello, Vittorio Palmieri, Renata De Maria, Attilio Iacovoni, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva, Mauro Gori, Concetta Di Nora Giornale Italiano Di Cardiologia, 2025
Biomarkers for Congestion in Heart Failure: State-of-the-art and Future Directions Antonio Luca Maria Parlati, Cristina Madaudo, Vincenzo Nuzzi, Paolo Manca, Piero Gentile, Daniela Di Lisi, Antonio Jordán-Ríos, Aamir Shamsi, Mattia Manzoni, Matthew Sadler, Cosmo Godino, Egle Corrado, Stefania Paolillo, Giuseppina Novo, Antonino Tuttolomondo, Alfredo Ruggero Galassi, Pasquale Perrone Filardi, Daniel Bromage, Antonio Cannata Cardiac Failure Review, 2025
Mineralocorticoid receptor antagonists in heart failure with mildly reduced or preserved ejection fraction: From TOPCAT to FINEARTS-HF Maria Denitza Tinti, Luisa De Gennaro, Emilia D’Elia, Manuela Benvenuto, Marco Cittar, Raul Limonta, Renata De Maria, Samuela Carigi, Matteo Bianco, Concetta Di Nora, Paolo Manca, Maria Vittoria Matassini, Vittoria Rizzello, Vittorio Palmieri, Ilaria Battistoni, Gianluigi Tagliamonte, Daniele Masarone, Geza Halasz, Attilio Iacovoni, Massimo Iacoviello, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva, Mauro Gori, a nome dell’Area Scompenso Cardiaco e dell’Area Cardiorenale Giornale Italiano Di Cardiologia, 2025
The IN-HF Registry: The history and the scientific production for the Italian cardiology community Vittoria Rizzello, Maria Denitza Tinti, Mauro Gori, Marco Marini, Vittorio Palmieri, Luisa De Gennaro, Paolo Manca, Maria Vittoria Matassini, Concetta Di Nora, Matteo Bianco, Samuela Carigi, Piero Gentile, Giuseppe Leonardi, Francesco Orso, Marco Gorini, Lucio Gonzini, Donata Lucci, Aldo Pietro Maggioni, Renata De Maria, Luigi Tavazzi, a cura dell’Area Scompenso Cardiaco ANMCO e a nome dei Ricer Giornale Italiano Di Cardiologia, 2024
Diuretic dose trajectories in dilated cardiomyopathy: prognostic implications Vincenzo Nuzzi, Antonio Cannatà, Pierpaolo Pellicori, Paolo Manca, Davide Stolfo, Caterina Gregorio, Giulia Barbati, Daniel I. Bromage, Theresa McDonagh, John G. F. Cleland, Marco Merlo, Gianfranco Sinagra Clinical Research in Cardiology, 2023
Left Atrial Reverse Remodeling in Dilated Cardiomyopathy Vincenzo Nuzzi, Anne Raafs, Paolo Manca, Michiel T.H.M. Henkens, Caterina Gregorio, Andrea Boscutti, Job Verdonschot, Mark Hazebroek, Christian Knackstedt, Marco Merlo, Davide Stolfo, Gianfranco Sinagra, Stephane R.B. Heymans Journal of the American Society of Echocardiography, 2023
Cardiovascular Damage in COVID-19: What We Know Two Years Later Vincenzo Nuzzi, Eva Del Mestre, Alessia Degrassi, Daniel I. Bromage, Paolo Manca, Susan Piper, Jessica Artico, Piero Gentile, Paul A. Scott, Mario Chiatto, Marco Merlo, Nilesh Pareek, Mauro Giacca, Gianfranco Sinagra, Theresa A. McDonagh, Antonio Cannata Current Cardiology Reports, 2022
Association of Titin Variations with Late-Onset Dilated Cardiomyopathy Antonio Cannatà, Marco Merlo, Matteo Dal Ferro, Giulia Barbati, Paolo Manca, Alessia Paldino, Sharon Graw, Marta Gigli, Davide Stolfo, Renee Johnson, Darius Roy, Kevin Tharratt, Daniel I. Bromage, Jean Jirikowic, Antonio Abbate, Allison Goodwin, Krishnasree Rao, Amr Marawan, Gerry Carr-White, Leema Robert, Victoria Parikh, Euan Ashley, Theresa McDonagh, Neal K. Lakdawala, Diane Fatkin, Matthew R. G. Taylor, Luisa Mestroni, Gianfranco Sinagra JAMA Cardiology, 2022
Echocardiographic evaluation of centenarians in Trieste Antonio Cannatà, Piero Gentile, Alessia Paldino, Vincenzo Nuzzi, Luca Camparini, Giulio Ciucci, Paolo Manca, Jessica Artico, Matteo Dal Ferro, Gabriella Marcon, Mauro Tettamanti, Marco Merlo, Gianfranco Sinagra, Francesco S. Loffredo Journal of Cardiovascular Medicine, 2020
