Prof. M. Vijjulatha
Email id: vijjulatha@, vijjulathamanga@,
vijjulatha manga - Google Scholar
- Born on 15th September 1970
- Schooling St. Poius X girls high School Ramnagar Hyderabad -1985
- Intermediate Stanley Junior College, Abids Hyderabad - 1987
- B.Sc. University college for women, Koti - 1990
- M.Sc (1992) and Ph.D (1998) in Chemistry from University of Hyderabad as Junior Research Fellow and Senior Research Fellow (CSIR, New Delhi, India)
- Assistant Professor in Department of Chemistry, Nizam collage since December 1999 till December 2008.
- Associate Professor in Department of Chemistry, Nizam collage since December 2008 till December 2013.
- Professor in Department of Chemistry, University college of Science, Osmania University Since December 2013 till date.
- Dean Development and UGC Affairs Osmania University, from 23rd October 2020 to 4th July 2021.
- Director Central facilities for research and Development (CFRD), from May 2021 to 21st Jul
EDUCATION
• Schooling – LKG – X at St. Pious X girl’s high school, Ramnagar, Hyderabad, till 1985
• Intermediate- Stanley Junior & Degree College, Hyderabad. 1985-87
• B.Sc., -Botany, Zoology, Chemistry. Osmania University, 1987-90.
• M.Sc., - Chemistry: University of Hyderabad, – 1992.
• M. Sc., Project work was done in Organic Chemistry (Carbohydrates/ Sugars), under the supervision of Prof. M. Nagarajan, Dean School of Chemistry, University of Hyderabad, Hyderabad.
• Qualified “CSIR-UGC National Entrance Test” conducted by Council of Scientific and Industrial Research (CSIR), held in the year 1992.
• Worked for Ph.D. in Chemistry on the project entitled “Synthesis, Structure and Reactivity of some Cyclic Phosphorus Compounds” under the Supervision of Dr. K. C. Kumaraswamy, Reader, School of Chemistry, University of Hyderabad. Submitted thesis in the month of December 1998.
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Organic Chemistry, Cancer Research, Structural Biology
Design, Synthesis, and Biological Evaluation of a New Imidazole–Pyrazole–Triazole Hybrid: Antidiabetic, and Molecular Docking Studies Nagesh Patnam, Kishan Chevula, Mangalapally Srikanth, Tota Jagadish, Nalaparaju Nagaraju, et al. Chemistryselect, 2026 A novel series of imidazole–pyrazole ‐ 1,2,3‐triazole hybrids ( 7a–b and 8c–j ) were synthesized and evaluated for their in vitro antidiabetic potential through inhibition of the aldose reductase (AR) enzyme. Sorbinil was used as the standard reference inhibitor (IC 50 = 2.01 ± 0.31 µM). Several hybrids exhibited superior inhibitory activity, particularly the fluoro‐substituted analogue 7a , the methoxy derivative 7b , and the methyl analogue 8c , with IC 50 values of 1.20 ± 0.39, 1.88 ± 0.19, and 1.93 ± 0.23 µM, respectively. The trimethoxy analogue 8h also demonstrated potent activity (IC 50 = 2.19 ± 0.36 µM), comparable to Sorbinil . Molecular docking studies were performed using the AR crystal structure (PDB ID: 1PWM), and the docking protocol was validated by re‐docking the co‐crystallized ligand Fidarestat (RMSD = 1.18 Å). All synthesized hybrids showed stronger binding affinities (–13.8—16.3 kcal/mol) compared to Sorbinil (–11.2 kcal/mol). Notably, compound 8c displayed the highest docking score (–16.3 kcal/mol) and formed key stabilizing interactions, including π–π stacking with Trp219 and π‐cation interactions with Leu301 and Ser302. The favorable binding energies and interaction profiles strongly correlate with the observed in vitro activities, highlighting these hybrids as promising AR inhibitors for antidiabetic drug development.
Exploring Indole-1,3,4-Thiadiazole Schiff Base Derivatives as Anticancer Agents: Design, Synthesis, In Vitro and In Silico Evaluation Umadevi Etikyala, Rajkumar Reddyrajula, Udaya kumar Dalimba, Premalatha Kokku, Vijjulatha Manga Chemmedchem, 2025 Cancer remains a major global health challenge, with resistance to existing therapeutic regimens underscoring the development of novel agents with improved efficacy and reduced toxicity. The indole and 1,3,4‐thiadiazole scaffolds are distinguished for their broad‐spectrum bioactivities, including anticancer properties. In this study, the synthesis and biological evaluation of a new series of indole‐1,3,4‐thiadiazole Schiff bases ( U1‐U31 ) designed to enhance anticancer efficacy is explored. In vitro evaluation demonstrates potent and selective cytotoxicity of several compounds, particularly U19 and U24 , against multiple cancer cell lines, with minimal toxicity to normal cells. Molecular docking and density functional theory studies demonstrate that these hybrid compounds effectively occupy the ATP‐binding sites of Pi3K and Akt proteins, exhibiting notable binding interactions comparable to the respective standard inhibitors. In addition, molecular dynamics simulation is performed to understand the conformational changes of the protein–ligand complex. Overall, the findings indicate that these novel indole‐1,3,4‐thiadiazole derivatives have selective inhibitory potency, making them promising leads for further anticancer drug development.
Design Synthesis of 1,2,3-Triazoles Based Thiazolidine-2,4-dione Derivatives Anticancer, Antimicrobial, and Molecular Docking Studies Kishan Chevula, Prasad Chennamsetti, Nalaparaju Nagaraju, Nagesh Patnam, Saikrishna Balabadra, et al. Chemistry and Biodiversity, 2025 Herein, we report the design and synthesis of new thiazolidine‐2,4‐dione derivatives as anticancer and antimicrobial agents using both conventional and microwave irradiation methods. The compound structures were characterized using different spectral analyses, for example, infrared, proton nuclear magnetic resonance ( 1 H NMR), carbon‐13 NMR ( 13 C NMR), mass spectroscopy, and elemental analyses. Among all the synthesized scaffolds, compounds 6a and 6 h exhibit significant activity against the MCF‐7 cell line with a half‐maximal inhibitory concentration value of 12.11 ± 2.9 and 15.82 ± 10.1 µM, respectively. In addition to that, compound 6k showed potent antibacterial activity, and compound 6l showed good antifungal activity. Furthermore, molecular docking studies were conducted to explore the interactions between the synthesized compounds and the Topoisomerase II enzyme. Higher yields, less reaction time, minimal purification, and a simple procedure are the advantages of this method.
3D-QSAR studies on substituted purines as HIV-1 TAR inhibitors, a non-trivial target of HIV-1 Research Journal of Pharmaceutical Biological and Chemical Sciences, 2016
Greener Synthesis of Indole-Derived Polycyclic Scaffolds: Sustainable Strategies and Challenges K Jahan, S Ahmed, AP Sakla, N Neshat, S Aaghaz, V Manga, A Kamal Journal of Molecular Structure, 146622 , 2026 2026
Design, synthesis and antiproliferative properties of 7-azaindole linked imidazole–1, 2, 3-triazole hybrids and computational screening MK Vanga, V Thumma, R Bhukya, SK Manthena, SS Ambadipudi, ... Bioorganic & Medicinal Chemistry Letters, 130683 , 2026 2026
Development of potential CDK9 inhibitors through pharmacophore-based virtual screening, 3D-QSAR, molecular docking, MD simulation, and in vitro anticancer evaluation R Reddyrajula, U Etikyala, P Dinesha, PV Sampat, SS Hegde, ... Scientific Reports , 2026 2026
Development of Potential CDK9 Inhibitors through Pharmacophore-Based Virtual Screening, 3D-QSAR, Molecular Docking, MD Simulation, and In Vitro Anticancer Evaluation RR Rajula, U Etikyala, SS Hedge, MUR Mohammed, CSKV Gowri, ... 2026
Design, Synthesis, and Biological Evaluation of a New Imidazole–Pyrazole–Triazole Hybrid: Antidiabetic, and Molecular Docking Studies N Patnam, K Chevula, M Srikanth, T Jagadish, N Nagaraju, SR Sagurthi, ... ChemistrySelect 11 (10), e05698 , 2026 2026
Exploring Indole‐1, 3, 4‐Thiadiazole Schiff Base Derivatives as Anticancer Agents: Design, Synthesis, In Vitro and In Silico Evaluation U Etikyala, R Reddyrajula, U Kumar Dalimba, P Kokku, V Manga ChemMedChem 20 (22), e202500231 , 2025 2025 Citations: 2
Design Synthesis of 1, 2, 3‐Triazoles Based Thiazolidine‐2, 4‐dione Derivatives Anticancer, Antimicrobial, and Molecular Docking Studies K Chevula, P Chennamsetti, N Nagaraju, N Patnam, S Balabadra, ... Chemistry & Biodiversity 22 (11), e01142 , 2025 2025 Citations: 4
Synthesis of novel 1, 3, 4-thiadiazole linked 1, 2, 3-triazole hybrids: As a potent anticancer agents and their molecular docking studies. V Manga, S Sirasani Journal of Chemistry Letters, e224264 , 2025 2025 Citations: 1
An in silico approach to identify novel and potential Akt1 (protein kinase B-alpha) inhibitors as anticancer drugs U Etikyala, R Reddyrajula, T Vani, V Kuchana, U Dalimba, V Manga Molecular Diversity 29 (2), 1009-1032 , 2025 2025 Citations: 6
Exploration of novel quinoline derivatives: Anticancer potential revealed through design, synthesis and biological evaluation J Chevula, S Balabadra, R Munnaluri, V Manga Journal of Chemical Sciences 137 (2), 25 , 2025 2025 Citations: 1
Ionic liquid promoted facile one-pot synthesis of phenothiazine-thiazolidin-4-ones as potent antitubercular agents via mycobacterial ATP synthase inhibition R Reddyrajula, U Etikyala, HC Mahapathra, RA Udaybhan, V Manga, ... Journal of Molecular Structure 1323, 140696 , 2025 2025 Citations: 4
Synthesis, anticancer evaluation and in-silico molecular docking studies of Benzimidazole-containing 1, 2, 3-Triazoles V Manga, B Aleti, N Patnam, K Chevula, P Chennamsetti, P Edigi Journal of Chemistry Letters 6 (2), 108-120 , 2025 2025 Citations: 10
Ensemble Pharmacophore Meets Molecular Docking: A Novel Screening Approach for the Identification of β-Tubulin Inhibitors. V Kuchana, V Kashetti, U Etikyala, SKR Peddi, S Sivan, V Manga 2025
Morpholine catalyzed synthesis of novel 4H-chromene linked pyrazole-1, 2, 3-triazole hybrids, screening for anticancer and antimicrobial effects K Chevula, N Patnam, P Chennamsetti, V Thumma, V Kuchana, V Manga ARKIVOC , 2025 2025
Computational Analysis of HSP90 Isoforms Identifies Differential Sensitivity Towards Specific Inhibitors. S Ravula, SC Mullaguri, SK Sivan, S Akula, V Manga, RK Kancha Current Trends in Biotechnology & Pharmacy 19 (1) , 2025 2025
Rings and cages containing phosphorus, arsenic and antimony-new chemistry MA Said, M Vijjulatha, KCK Swamy Journal of Chemical Sciences 137 , 2025 2025
Antioxidant and Antimicrobial Activities of 4 H ‐Chromene Based Indole‐Pyrimidine Hybrids: Synthesis and Molecular Docking Studies MK Vanga, R Bhukya, V Thumma, V Tamalapakula, LS Boddu, V Manga Chemistry & Biodiversity 21 (12), e202401583 , 2024 2024 Citations: 19
Design, synthesis, and screening for anticancer and antimicrobial activities of new dihydropyridine‐anchored pyrazole and 1, 2, 3‐triazole hybrids K Chevula, N Patnam, P Chennamsetti, V Kashetti, V Thumma, ... ChemistrySelect 9 (42), e202404451 , 2024 2024 Citations: 11
Design, Synthesis, Anticancer Evaluation and Molecular Docking Study of Novel 4 H ‐Chromene‐7‐Azaindole‐1,2,3‐Triazole Hybrids V Kashetti, M Krishna Vanga, K Chevula, V Kuchana, V Manga ChemistrySelect 9 (38), e202403149 , 2024 2024 Citations: 4
N-Acyl phenothiazines as mycobacterial ATP synthase inhibitors: Rational design, synthesis and in vitro evaluation against drug sensitive, RR and MDR-TB R Reddyrajula, S Perveen, A Negi, U Etikyala, V Manga, R Sharma, ... Bioorganic Chemistry 151, 107702 , 2024 2024 Citations: 3
MOST CITED SCHOLAR PUBLICATIONS
Microwave-assisted synthesis, biological evaluation and molecular docking studies of new coumarin-based 1, 2, 3-triazoles R Dharavath, N Nagaraju, MR Reddy, D Ashok, M Sarasija, M Vijjulatha, ... RSC advances 10 (20), 11615-11623 , 2020 2020 Citations: 97
Synthesis, docking and evaluation of antioxidant and antimicrobial activities of novel 1, 2, 4-triazolo [3, 4-b][1, 3, 4] thiadiazol-6-yl) selenopheno [2, 3-d] pyrimidines Y Kotaiah, K Nagaraju, N Harikrishna, CV Rao, L Yamini, M Vijjulatha European Journal of Medicinal Chemistry 75, 195-202 , 2014 2014 Citations: 91
Microwave irradiated one pot, three component synthesis of a new series of hybrid coumarin based thiazoles: Antibacterial evaluation and molecular docking studies S Mamidala, SR Peddi, RK Aravilli, PC Jilloju, V Manga, RR Vedula Journal of Molecular Structure 1225, 129114 , 2021 2021 Citations: 72
Dimers of coumarin-1, 2, 3-triazole hybrids bearing alkyl spacer: Design, microwave-assisted synthesis, molecular docking and evaluation as antimycobacterial and antimicrobial … D Ashok, S Gundu, VK Aamate, MG Devulapally, R Bathini, V Manga Journal of Molecular Structure 1157, 312-321 , 2018 2018 Citations: 65
Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents K Bacharaju, SR Jambula, S Sivan, S JyostnaTangeda, V Manga Bioorganic & medicinal chemistry letters 22 (9), 3274-3277 , 2012 2012 Citations: 61
Synthesis and evaluation of naphthyl bearing 1, 2, 3-triazole analogs as antiplasmodial agents, cytotoxicity and docking studies S Balabadra, MK Kotni, V Manga, AD Allanki, R Prasad, PS Sijwali Bioorganic & medicinal chemistry 25 (1), 221-232 , 2017 2017 Citations: 56
Molecular docking and 3D-QSAR studies on inhibitors of DNA damage signaling enzyme human PARP-1 S Fatima, R Bathini, SK Sivan, V Manga Journal of Receptors and Signal Transduction 32 (4), 214-224 , 2012 2012 Citations: 54
Molecular docking and 3D-QSAR studies on triazolinone and pyridazinone, non-nucleoside inhibitor of HIV-1 reverse transcriptase SK Sivan, V Manga Journal of molecular modeling 16 (6), 1169-1178 , 2010 2010 Citations: 42
Molecular docking, MM/GBSA and 3D-QSAR studies on EGFR inhibitors R Bathini, SK Sivan, S Fatima, V Manga Journal of Chemical sciences 128 (7), 1163-1173 , 2016 2016 Citations: 41
Synthesis, antitubercular, antimicrobial activities and molecular docking study of quinoline bearing dihydropyrimidines NC Desai, GM Kotadiya, KA Jadeja, KN Shah, AH Malani, V Manga, ... Bioorganic Chemistry 115, 105173 , 2021 2021 Citations: 40
Molecular dynamics and MM/GBSA-integrated protocol probing the correlation between biological activities and binding free energies of HIV-1 TAR RNA inhibitors SR Peddi, SK Sivan, V Manga Journal of Biomolecular Structure and Dynamics 36 (2), 486-503 , 2018 2018 Citations: 39
Synthesis, reactivity and structures of spirocyclic products derived from octachlorocyclotetraphosphazene: comparison with spirocyclic cyclotriphosphazenes and linear phosphazenes S Kumaraswamy, M Vijjulatha, C Muthiah, KCK Swamy, U Engelhardt Journal of the Chemical Society, Dalton Transactions, 891-900 , 1999 1999 Citations: 36
Design, synthesis and docking studies of novel 1, 2-dihydro-4-hydroxy-2-oxoquinoline-3-carboxamide derivatives as a potential anti-proliferative agents S Banu, R Bollu, R Bantu, L Nagarapu, S Polepalli, N Jain, R Vangala, ... European Journal of Medicinal Chemistry 125, 400-410 , 2017 2017 Citations: 33
Molecular docking, 3D QSAR and dynamics simulation studies of imidazo-pyrrolopyridines as janus kinase 1 (JAK 1) inhibitors R Itteboina, S Ballu, SK Sivan, V Manga Computational Biology and Chemistry 64, 33-46 , 2016 2016 Citations: 32
Quinazolinones–Phenylquinoxaline hybrids with unsaturation/saturation linkers as novel anti-proliferative agents JD Palem, GR Alugubelli, R Bantu, L Nagarapu, S Polepalli, SN Jain, ... Bioorganic & Medicinal Chemistry Letters 26 (13), 3014-3018 , 2016 2016 Citations: 31
Synthesis and structures of new bicyclic 1, 3-Di-t-butyl-1, 3, 2-λ3, 4-λ3-diazadiphosphetidines containing ten-and eleven-membered rings M Vijjulatha, S Kumaraswamy, KCK Swamy, U Engelhardt Polyhedron 18 (19), 2557-2562 , 1999 1999 Citations: 31
Synthesis, biological evaluation and molecular docking of spirofurochromanone derivatives as anti-inflammatory and antioxidant agents D Ashok, EVL Madhuri, M Sarasija, SS Kanth, M Vijjulatha, MD Alaparthi, ... RSC advances 7 (41), 25710-25724 , 2017 2017 Citations: 30
Design, synthesis, molecular-docking and antimycobacterial evaluation of some novel 1, 2, 3-triazolyl xanthenones GL Goud, S Ramesh, D Ashok, VP Reddy, P Yogeeswari, D Sriram, ... MedChemComm 8 (3), 559-570 , 2017 2017 Citations: 30
Synthesis, anti-microbial activity, cytotoxicity of some novel substituted (5-(3-(1 H -benzo[d]imidazol-2-yl)-4-hydroxybenzyl)benzofuran-2-yl)(phenyl)methanone … B Shankar, P Jalapathi, B Saikrishna, S Perugu, V Manga Chemistry Central Journal 12 (1), 1 , 2018 2018 Citations: 29
Discovery of 1, 2, 3-triazole incorporated indole-piperazines as potent antitubercular agents: Design, synthesis, in vitro biological evaluation, molecular docking and ADME studies R Reddyrajula, U Etikyala, V Manga, U kumar Dalimba Bioorganic & Medicinal Chemistry 98, 117562 , 2024 2024 Citations: 28
