Harnessing biomaterials to overcome challenges in cancer immunotherapy Vivek Pazhamalai, Meenupriya Venkatesan, Jayasri Rajkumar, S. S. Meenambiga, S. Ivo Romauld, K. Rajakumari, V. Gowthami Innovations and Applications of Advanced Biomaterials in Healthcare and Engineering, 2025 The intrinsic immune system activity awakens and trains the patient's immune system to destroy tumor cells. Immunotherapy has become a standard method for treating cancer since it is a more potent and secure option than conventional therapies like surgery, radiotherapy, and chemotherapy. Chimeric antigen receptor-modified T cells, immune checkpoint blockades, and cancer vaccines are the three primary forms of cancer immunotherapy that have been developed recently. Chemotherapy, radiation therapy, and surgery continue to be the mainstays of cancer treatment despite decades of advancements. Lung cancer, melanoma, advanced bladder, kidney, and other advanced tumors have all been successfully treated with immunotherapy. Immunotherapy is used to cure illnesses by regulating an overactive or underactive immune system. Biomaterials efficiency will be increased with the help of immune system engineering and targeted drug delivery. Chapter highlights the recent advancement in tailored biomaterials for cancer immunotherapy.
Green Synthesis of Nickel Oxide Nanoparticles using Vitex negundo Leaf for Antibacterial and Anti-inflammatory Activities A Hajeera Aseen, P Jyolsna, Gowthami V, M Anbarasu, P Vivek Indian Journal of Biochemistry and Biophysics, 2025 This study addresses the crucial need for an environmentally sustainable method by synthesizing Nickel Oxide nanoparticles (NiO NPs) by using Vitex negundo(VN) leaf extract as a natural stabilizing and reducing agent. As the demand for green nanoparticle synthesis continues to increase and innovative approaches are essential to reduce reliance on harmful chemicals and high energy consumption. The synthesis of NiO NPs process was carried out at room temperature, followed by annealing at 500°C and 700°C to enhance the nanoparticles' properties respectively. X-ray diffraction (XRD) analysis revealed improved crystallinity at higher temperatures, with crystalline sizes of 20.91 nm at 500°C and 32.61 nm at 700°C. These findings underscore the potential of using plant extracts of green synthesis, offering a sustainable pathway for producing high-quality nanoparticles and contributing to the advancement of eco-friendly nanotechnology. The UV-Vis spectrum showed an energy band gap of 3.38 eV. SEM analysis revealed spherical particles with some agglomeration, while EDX confirmed the elemental composition. FTIR analysis identified functional groups in the sample annealed at 500°C. Antibacterial testing using the agar well diffusion method demonstrated activity against B. subtilis, S. aureus, E. coli, and P. aeruginosa. Additionally, the nanoparticles exhibited significant anti-inflammatory activity, highlighting their potential for biomedical applications.
Bio-synthesised nanoparticles employment for eliminating metals from wastewater via implementation of a three level Box-Behnken technique P. Jyolsna, V. Gowthami, A. Hajeera Aseen Applied Water Science, 2025 The objective of the present study is to optimise the removal of metals such as aluminium, zinc, and copper from industrial wastewater using green-synthesised nanoadsorbents. To achieve this, the Box–Behnken experimental design and response surface methodology will be employed. We used inductively coupled plasma mass spectrometry to analyse the metals present in the wastewater. A three-factor, three-stage Box–Behnken design was used to maximise the removal of these metals from aqueous solution. This involved response surface modelling and quadratic programming based on 17 different experimental data from a batch study. The study focused on three independent variables: pH, contact time, and adsorbent amount. The nanoadsorbents were prepared using a combination of Citrus X sinensis peel and Musa Cavendish peel extract, which served as the reducing agents, to produce a combined peel extract-silver nanoparticle product. Field emission scanning electron microscopy imaging and UV–visible spectroscopic analysis unequivocally demonstrated the presence of nanoparticles, with a surface plasmon resonance at 438 nm. The optimal values of the selected variables were determined by solving the quadratic regression model and analysing the contour plots of the reaction surface. At the experimental conditions of pH = 5, contact time = 92.5 min, and adsorbent dosage = 0.1 g/L, the recovery efficiency of Al, Cu, and Zn was significantly reduced. The optimised parameters were successfully applied to wastewater collected, and the degradation of detected metal ions was tested. The experiment demonstrated an effective reduction in these metals.
Green synthesis of NiO/ZnO nanocomposite using Vitex negundo leaf extract for antibacterial and anti-inflammatory activities A. Hajeera Aseen, V Gowthami, P Jyolsna Journal of Integrated Science and Technology, 2025 The eco-friendly synthesis of Nickel Oxide/Zinc Oxide (NiO/ZnO) nanocomposite nanoparticles (NPs) using Vitex negundo leaf extract offers a sustainable and green approach to developing nanomaterials for biomedical applications. Three different molar ratios were synthesized: F1 (equal proportion of NiO and ZnO), F2 (high zinc, low nickel), and F3 (high nickel, low zinc). XRD analysis confirmed excellent crystallinity, with ZnO particle sizes of 14.35 nm (F1), 15.91 nm (F2), and 22.97 nm (F3), while NiO sizes ranged from 14.11 nm to 15.75 nm. UV-Vis spectroscopy revealed bandgap energies of 2.7 eV (F1), 2.75 eV (F2), and 2.55 eV (F3), highlighting compositional effects. SEM analysis demonstrated sheets morphology with minimal agglomeration, and EDX confirmed elemental composition. The F1 ratio exhibited superior antibacterial performance, showing a 1.5 mm inhibition zone against Staphylococcus aureus and Pseudomonas aeruginosa. Anti-inflammatory studies revealed concentration-dependent inhibition, with F1 achieving the highest inhibition (46.2% at 500 µg), though lower than diclofenac (70.3%). This study highlights the successful synthesis of NiO/ZnO nanocomposites, particularly F1, with significant antibacterial and anti-inflammatory potential, emphasizing the role of eco-friendly methods in advancing biomedical research.
A detailed investigation of the catalytic abilities and adsorption curves of Banana peel with nanodendrite Silver nanoparticles for wastewater purification P Jyolsna, V Gowthami Journal of Integrated Science and Technology, 2024 In this investigation, banana peel extract (Musa cavendish) (BPE) was used to produce silver nanoparticles. The paper presents a green method for the synthesis of silver nanoparticles from bananas. In this all-natural synthesis, biodegradable silver nanoparticles were produced using BPE as a reducing agent. The addition of the aqueous banana peel extract to the silver nitrate solution caused a change in the colour of the reaction medium from pale yellow to brown, indicating the reduction of silver ions to silver nanoparticles. The SPR band increases with increasing concentration. Further analysis of the AgNPs was carried out using XRD, FTIR and SEM techniques. XRD was used to determine the crystalline nature and purity of the silver nanoparticles produced. The functional molecules responsible for the reduction and stabilisation of silver nanoparticles produced by banana peel extract were identified by FTIR analysis. The Langmuir adsorption isotherm showed that the adsorption takes place in a monolayer. The photocatalytic activity of the synthesised silver nanoparticles was tested by degrading methylene blue using the dried nanoparticles. It was found that the silver nanoparticles synthesised using green methods were effective in degrading the pollutant at different exposure times.
Structural and optical properties of nebulized nickel oxide thin films V. Gowthami, M. Meenakshi, N. Anandhan, Chinnappanadar Sanjeeviraja Advanced Materials Research, 2014 Nickel oxide has been widely used as material for antiferromagnetic, electrochromic display and functional layer for chemical sensors. Nickel oxide thin films of various molarities were deposited using a simple nebulizer technique and the substrate temperature was fixed at 350C. The effect of the molarity of precursor solution on structural and optical properties was studied using X-ray diffraction (XRD) and UV-Vis-NIR spectrometer techniques respectively. The band gap of the material was confirmed by photoluminescence spectrometer. It is found that increase in the molarity of 10ml volume of the sprayed solution leads to the increasing in film thickness. X-ray diffraction studies indicated cubic structure and the crystallites are preferentially oriented along (1 1 1) plane. It is also found that as the concentration of the solution increases the transmittance decreases, consequently the band-gap energy wanes from 4.0 eV to 3.2 eV.
Preparation of Cu-doped nickel oxide thin films and their properties V. Gowthami, M. Meenakshi, N. Anandhan, C. Sanjeeviraja Aip Conference Proceedings, 2014 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation V. Gowthami, M. Meenakshi, N. Anandhan, C. Sanjeeviraja; Preparation of Cu-doped nickel oxide thin films and their properties. AIP Conference Proceedings 24 April 2014; 1591 (1): 884–886. https://doi.org/10.1063/1.4872790 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Effect of RF power on the structuraland optical characterization of (WO3)0.90(V2O5)0.10 thin films International Journal of Chemtech Research, 2014
Optical dispersion characterization of NiO thin films prepared by nebulized spray technique International Journal of Chemtech Research, 2014
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Green Synthesis of NiO/CuO Nanocomposites with a Snow Flake-Like Shape Morphology, Biological and Photocatalytic Activities Utilizing Vitex Negundo Leaf Extract D Sridevi, S Jegadheeshwari, M Kesavan, P Jyolsna, M Parthasarathy, ... 2025
Green Synthesis of Nickel Oxide Nanoparticles using Vitex negundo Leaf for Antibacterial and Anti-inflammatory Activities AH Aseen, P Jyolsna, M Anbarasu, P Vivek Indian Journal of Biochemistry and Biophysics (IJBB) 62 (4), 363-371 , 2025 2025 Citations: 4
Bio-synthesised nanoparticles employment for eliminating metals from wastewater via implementation of a three level Box-Behnken technique P Jyolsna, V Gowthami, A Hajeera Aseen Applied Water Science 15 (2), 37 , 2025 2025 Citations: 1
Green synthesis of NiO/ZnO nanocomposite using Vitex negundo leaf extract for antibacterial and anti-inflammatory activities AH Aseen, V Gowthami, P Jyolsna Journal of Integrated Science and Technology 13 (3), 1056-1056 , 2025 2025 Citations: 2
Adsorption performance with field emission scanning electron microscopy of fruit peel induced Silver Nanoparticles in C16H18ClN3S for waste water treatment P Jyolsna, V Gowthami, A Hajeera Aseen MethodsX 13, 102951 , 2024 2024 Citations: 3
Hierarchical NiCo2O4 needle-like heterostructure arrays anchored on WO3 as high-performance asymmetric supercapacitors for energy storage applications A Siveswari, V Gowthami Chemical Physics Impact 9, 100666 , 2024 2024 Citations: 18
Green synthesis of nanoparticles and its biological applications-A review A Hajeera Aseen, P Jyolsna, V Gowthami Journal of Eco-friendly Agriculture 19 (2), 232-239 , 2024 2024
Detailed investigation of the catalytic abilities and adsorption curves of banana Peel with nanodendrite silver nanoparticles for wastewater purification P Jyolsna, V Gowthami J. Integr. Sci. Technol 12 , 2024 2024 Citations: 4
Optical and Electrochromic Properties of Pure and Cu-Doped NiO Thin Films V Gowthami, M Meenakshi, C Sanjeeviraja New Frontiers in Physical Science Research Vol. 1 1, 92-96 , 2022 2022
Influence of dopant concentration on the electrochromic properties of tungsten oxide thin films M Meenakshi, V Gowthami, P Perumal, R Sivakumar, C Sanjeeviraja Electrochimica Acta 174, 302-314 , 2015 2015 Citations: 79
Preparation of rod shaped nickel oxide thin films by a novel and cost effective nebulizer technique V Gowthami, M Meenakshi, P Perumal, R Sivakuma, C Sanjeeviraja Materials science in semiconductor processing 27, 1042-1049 , 2014 2014 Citations: 31
Structural and optical studies on nickel oxide thin film prepared by nebulizer spray technique V Gowthami, P Perumal, R Sivakumar, C Sanjeeviraja Physica B: Condensed Matter 452, 1-6 , 2014 2014 Citations: 78
Effect of concentration on structural and optical properties of thin films prepared by RF magnetron sputtering M Meenakshi, V Gowthami, P Perumal, C Sanjeeviraja AIP Conference Proceedings 1620 (1), 307-314 , 2014 2014 Citations: 4
Structural and Optical properties of nebulized Nickel Oxide thin films V Gowthami, M Meenakshi, N Anandhan, C Sanjeeviraja Advanced Materials Research 938, 103-107 , 2014 2014 Citations: 2
Preparation of Cu-doped nickel oxide thin films and their properties V Gowthami, M Meenakshi, N Anandhan, C Sanjeeviraja AIP Conference Proceedings 1591 (1), 884-886 , 2014 2014 Citations: 6
Effect of RF power on the structuraland optical characterization of (WO3) 0.90 (V2O5) 0.10 thin films M Meenakshi, V Gowthami, P Perumal, C Sanjeeviraja Int. J. ChemTech. Res 6 (13), 5412-5418 , 2014 2014 Citations: 4
Optical dispersion characterization of NiO thin films prepared by nebulized spray technique V Gowthami, M Meenakshi, P Perumal, R Sivakumar, C Sanjeeviraja Int. J. ChemTech Res 6 (13), 5196-5202 , 2014 2014 Citations: 35
Structural and optical behavior of (WO {sub 3}){sub 0.90}(V {sub 2} O {sub 5}){sub 0.10} thin films M Meenakshi, V Gowthami, N Anandhan, C Sanjeeviraja 2013
Structural and optical behavior of (WO3) 0.90 (V2O5) 0.10 thin films M Meenakshi, V Gowthami, N Anandhan, C Sanjeeviraja Proceedings of the international conference on thin films and applications … , 2013 2013
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Influence of dopant concentration on the electrochromic properties of tungsten oxide thin films M Meenakshi, V Gowthami, P Perumal, R Sivakumar, C Sanjeeviraja Electrochimica Acta 174, 302-314 , 2015 2015.0 Citations: 79
Structural and optical studies on nickel oxide thin film prepared by nebulizer spray technique V Gowthami, P Perumal, R Sivakumar, C Sanjeeviraja Physica B: Condensed Matter 452, 1-6 , 2014 2014.0 Citations: 78
Optical dispersion characterization of NiO thin films prepared by nebulized spray technique V Gowthami, M Meenakshi, P Perumal, R Sivakumar, C Sanjeeviraja Int. J. ChemTech Res 6 (13), 5196-5202 , 2014 2014.0 Citations: 35
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Hierarchical NiCo2O4 needle-like heterostructure arrays anchored on WO3 as high-performance asymmetric supercapacitors for energy storage applications A Siveswari, V Gowthami Chemical Physics Impact 9, 100666 , 2024 2024.0 Citations: 18
Preparation of Cu-doped nickel oxide thin films and their properties V Gowthami, M Meenakshi, N Anandhan, C Sanjeeviraja AIP Conference Proceedings 1591 (1), 884-886 , 2014 2014.0 Citations: 6
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Detailed investigation of the catalytic abilities and adsorption curves of banana Peel with nanodendrite silver nanoparticles for wastewater purification P Jyolsna, V Gowthami J. Integr. Sci. Technol 12 , 2024 2024.0 Citations: 4
Effect of concentration on structural and optical properties of thin films prepared by RF magnetron sputtering M Meenakshi, V Gowthami, P Perumal, C Sanjeeviraja AIP Conference Proceedings 1620 (1), 307-314 , 2014 2014.0 Citations: 4
Effect of RF power on the structuraland optical characterization of (WO3) 0.90 (V2O5) 0.10 thin films M Meenakshi, V Gowthami, P Perumal, C Sanjeeviraja Int. J. ChemTech. Res 6 (13), 5412-5418 , 2014 2014.0 Citations: 4
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Adsorption performance with field emission scanning electron microscopy of fruit peel induced Silver Nanoparticles in C16H18ClN3S for waste water treatment P Jyolsna, V Gowthami, A Hajeera Aseen MethodsX 13, 102951 , 2024 2024.0 Citations: 3
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Green Synthesis of NiO/CuO Nanocomposites with a Snow Flake-Like Shape Morphology, Biological and Photocatalytic Activities Utilizing Vitex Negundo Leaf Extract D Sridevi, S Jegadheeshwari, M Kesavan, P Jyolsna, M Parthasarathy, ... 2025.0
Green synthesis of nanoparticles and its biological applications-A review A Hajeera Aseen, P Jyolsna, V Gowthami Journal of Eco-friendly Agriculture 19 (2), 232-239 , 2024 2024.0
Optical and Electrochromic Properties of Pure and Cu-Doped NiO Thin Films V Gowthami, M Meenakshi, C Sanjeeviraja New Frontiers in Physical Science Research Vol. 1 1, 92-96 , 2022 2022.0
Structural and optical behavior of (WO {sub 3}){sub 0.90}(V {sub 2} O {sub 5}){sub 0.10} thin films M Meenakshi, V Gowthami, N Anandhan, C Sanjeeviraja 2013.0
