Dr. Sachin Kamlakar Jagdale

@mmcop.edu.in

Assistant Professor - Department of Pharmaceutics
Marathwada Mitra Mandal's College of Pharmacy, Thergaon Pune



              

https://researchid.co/sachin10pharmacy

EDUCATION

M Pharm., Ph D

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Biomaterials, Physical and Theoretical Chemistry, Pharmacy

11

Scopus Publications

Scopus Publications

  • Development and Validation of Stability Indicating RP-HPLC Method for the Estimation of Glycopyrrolate and Neostigmine in Bulk and Injection
    Babita Agarwal, Sachin Jagdale, Prasad Kadam, Pramod Sakpal, Santaji Nalawade, Shivraj Maske, and Pooja Dale
    Oxford University Press (OUP)
    Abstract A stability indicating RP-HPLC method is suggested for determination of Glycopyrrolate-Neostigmine (GLY/NEO) in bulk drugs and injection formulation. GLY/NEO were eluted from a Chromolith High Resolution RP-18e (100 mm×4.6 mm) with buffer solution (pH 3.0) as mobile phase A and a mixture of HPLC grade acetonitrile and water mixture (90:10) as mobile phase B. The gradient was optimized with a flowrate of 0.5 mL/min and wavelength of 222 nm. A complete analytical method validation was effectively carried out as per ICH Q2 (R1) guidelines. Recovery studies were performed at 50–150% level of working concentrations, and results were in the range of 99–101%. The linearity was detected in the range of LOQ to 200% of the specification limits i.e., 0.5% each for NEO and GLY, 0.01% for NEO Impurity B and 1.0% for rest of the impurities with respect to the test concentration of the respective components. For stability study, various stress conditions such as acid, base, oxidation and thermal as per ICH guidelines were studied. The high recovery and low relative standard deviation confirm the suitability of proposed method that can be employed for the routine analysis in bulk and pharmaceutical formulation.

  • Chitosan as excellent bio-macromolecule with myriad of anti-activities in biomedical applications – A review
    Sachin Jagdale, Babita Agarwal, Abhishek Dixit, and Saurabh Gaware
    Elsevier BV


  • Forced Degradation Study of Sofosbuvir: Identification of Degradation Products by LC-ESI-MS
    Babita Agarwal, Sachin Jagdale, and Santosh Gandhi
    Manuscript Technomedia LLP

  • Experimental measurement–correlation of solubility and dissolution thermodynamics study of itraconazole in pure monosolvents at various temperatures
    Sachin K. Jagdale and Rajesh B. Nawale
    Informa UK Limited
    Abstract The information about the solubility and thermodynamic properties of solution is important for pharmaceutically important processes, formulation development, and further theoretical studies. In the present study, the solid–liquid equilibrium (solubility) for itraconazole (ITC) was determined experimentally in 14 monosolvents at temperatures between 293.15 K and 318.15 K under pressure of 0.1 MPa. The mole fraction solubilities were found to increase with increasing temperatures and followed inverse trend with the polarity of selected solvents. Besides, KAT-LSER analysis was performed to study the effect of solvent. The results revealed that the solute–solvent interaction (43.94%) was much higher than that of solvent–solvent interaction (16.59%). Thermodynamic based models like van’t Hoff equation, modified Apelblat equation, Buchowski–Ksiazaczak equation, and polynomial empirical equation were applied to fit and correlate the experimental solubilities. Overall relative average deviation and overall root-mean square deviation ( ) were observed to be minimum with the empirical polynomial equation and attained the values of 0.0033 and 0.0047, respectively. Furthermore, theoretical ideal solubilities, activity coefficients, and thermodynamic properties of dissolution including molar enthalpy, molar entropy, molar Gibbs free energy, and excess enthalpy were estimated. Ideal solubilities were projected considerably higher than experimental solubilities at each studied temperature. Thermodynamic properties of dissolution indicated that the dissolution was not a spontaneous process; observed to be endothermic ( and enthalpy driven Such solid–liquid equilibrium data of ITC will be of immense help in process and formulation development in pharmaceutical sciences.


  • Bird's eye view on aquasome: Formulation and application
    Sachin Jagdale and Simran Karekar
    Elsevier BV

  • Extended hildebrand solubility approach: Prediction and correlation of the solubility of itraconazole in triacetin: Water mixtures at 298.15°k
    Sachin JAGDALE and Rajesh B NAWALE
    Galenos Yayinevi
    Objectives: The aim of the study is to explore the suitability of an empirical approach for the extended Hildebrand solubility approach (EHSA) to predict and correlate the solubility of the crystalline drug itraconazole (ITRA) in triacetin: water mixtures. Materials and Methods: The physicochemical properties of ITRA like fusion enthalpy, solubility parameter, and ideal mole fraction solubility were estimated. The solubilities of ITRA in mixed solvent blends comprising triacetin: water were determined at 298.15°K. Theoretical solubilities were back calculated using a polynomial regression equation of the interaction energy parameter W as a function of the solubility parameter (δ1) of the solvent mixture. Similarly, the solubilities were predicted by direct method based on the use of logarithmic experimental solubilities (logX2) against the solubility parameter (δ1) of the solvent mixture. The predictive capabilities of both EHSA and the direct method were compared using mean percent deviations. Results: The solubility of ITRA was increased in all the triacetin: water blends and was highest in the blend in which the solubility parameter of ITRA equaled that of the solvent mixture. The prediction capacities of the direct method (mean % deviation was -1.89%) were better than those of EHSA (mean % deviation was 9.76%) in the fifth order polynomial. Conclusion: The results indicated that the solubility of any crystalline solute can be adequately predicted and correlated with the mere knowledge of physicochemical properties and EHSA. The information could be of help in process and formulation development.

  • Solubilization and determination of solution thermodynamic properties of itraconazole in different solvents at different temperatures
    Sachin K. Jagdale and Rajesh B. Nawale
    Informa UK Limited
    Abstract The solubility of itraconazole (ITRA) in thirteen pure solvents including water, dimethyl sulphoxide, acetonitrile, methanol, 1,4-butanediol, ethanol, isopropyl alcohol, n-butanol, octanol, ethyl acetate, toluene, benzene, 1,4-dioxane were estimated at the temperatures ranging from 293.15 K to 318.15 K under atmospheric pressure (0.1 MPa). The results reflected that the solubility of ITRA was a function of temperature and was increased with a rise in temperature in each solvent. Moreover, the solubility in polar solvents was less and found to be increased in non-polar solvents. Furthermore, the results of solubilization were correlated by the Van’t Hoff equation, the modified Apelblat equation, the Buchowski − Ksiazaczak λh equation, and the polynomial empirical equation. The polynomial empirical equation proved to be more accurate and suitable for the correlation of solubilities of ITRA in studied solvents at various temperatures. Besides, theoretical ideal solubilities, activity coefficients, and thermodynamic properties of the solution process including standard molar enthalpy, entropy, Gibbs free energy, and excess enthalpy were calculated from the experimental solubility data. These thermodynamic parameters indicated that the solubilization process was not spontaneous, endothermic, and enthalpy driven. Such thermodynamic based solubility data of ITRA will be of immense help in solubilization, synthesis, process development, preformualtion, and dosage form development in pharmaceuticals.

  • Enhancement of dissolution of fenofibrate using complexation with hydroxy propyl β-cyclodextrin
    Sachin K. JAGDALE, Mohammad H. DEHGHAN, and Nilesh S. PAUL
    Galenos Yayinevi
    Objectives: The aim of the present study was to enhance the dissolution rate of fenofibrate using complexation with hydroxy propyl β-cyclodextrin (HPβCD). Materials and Methods: The phase solubility behavior of fenofibrate was studied in various concentrations of (HPβCD) aq. solution at 37°C. The solubility of fenofibrate increased with an increase in the amount of HPβCD aq. solution. Gibbs free energy (ΔG°)tr values were all negative. Complexes of fenofibrate with HPβCD were prepared in 1:1 ratio by kneading and coprecipitation. These complexes were evaluated by dissolution studies, fourier transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC) studies. Results: The complexation of fenofibrate with HPβCD exhibited an enhanced dissolution rate. The mean dissolution time of fenofibrate decreased significantly upon complexation. FTIR studies showed the formation of intermolecular hydrogen bonding between fenofibrate and HPβCD. DSC studies indicated a loss in crystalline state of fenofibrate in complexes. Conclusion: Complexation with HPβCD can be used as a useful tool for the enhancement of dissolution of fenofibrate.

  • Development, characterization and optimization of mucoadhesive tablet for buccal delivery of domperidone
    Jagdale Sachin, Panbude Aishwarya, and Navasare Priya
    Bentham Science Publishers Ltd.
    Background and Objective: Upon oral administration domeperidone is rapidly absorbed, but subjected to the first pass effect which lowers systemic bioavailability to 15%. Mucoadhesive tablet can remain attached to buccal mucosa and becomes capable of bypassing hepatic first-pass metabolism to improve absorption directly into systemic circulation. The present research work was carried with an aim to develop, evaluate and optimize mucoadhesive tablet containing domperidone (DOME) for buccal delivery using different bio-adhesive polymeric combinations. </P><P> Methods: The buccal tablets were formulated by wet granulation method using isopropyl alcohol. The preliminary formulations were prepared using combinations of HPMC K4, HPMC K15, HPMC K100, HPMC E5 as mucoadhesive polymers. 32 full factorial design was applied to determine the effect of independent variables like concentration of mucoadhesive polymers (HPMC K15 and HPMC K100) over dependent variables like mucoadhesive properties (swelling index, bioadhesive strength and in vitro drug release). The prepared mucoadhesive tablets were evaluated for their tablet properties and mucoadhesive properties. The interactions between drug and polymers were studied by Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). </P><P> Results: All formulations of factorial design showed satisfactory physicochemical, mechanical and bioadhesive characteristics. The formulation F9 exhibited maximum cumulative drug release, mucoadhesive strength and swelling index. Conclusion: The developed buccal tablet of domperidone might prove alternative to bypass the hepatic first pass metabolism and to avoid degradation which in turn may result in reducing the frequency of administration. Thus, mucoadhesive tablet of domeperidone may become viable alternative overcoming the side effects; achieving greater therapeutic effectiveness and improving the patient compliance.