Adrian Tibor Press

Scopus Publications

Sodium thiosulfate attenuates liver injury in a rat model of sepsis by modulating ferroptosis and oxidative stress
Andrei Otto Mitre, Ioana Baldea, Gabriela Adriana Filip, Raluca Maria Pop, Maria Adriana Neag, et al.
Scientific Reports, 2026
Extrahepatic Gene Editing In Vivo Using Organic Solvent-Free Lipid Nanoparticles
Michael Streiber, Na Liu, Laurianne Simon, Franziska Adermann, Vivien Bachmann, et al.
Small, 2026
Targeted therapy, which modifies genes and their expression, holds great promise for treating a variety of diseases, including cancer, inborn errors of metabolism, and acute and chronic inflammatory and infectious conditions. However, it also presents challenges related to RNA delivery, immune responses, side effects of delivery vectors, and the need for individualized formulations. To overcome these limitations, the choice of lipids and formulation processes might be re‐evaluated, with a focus on eliminating critical components, such as poly(ethylene glycol) (PEG) and ethanol. Thus, a purely water‐based formulation for lipid nanoparticles was developed, offering a material‐efficient, time‐saving process with high reproducibility. Initially, a stealth lipid containing poly(2‐methyl‐2‐oxazoline) (PMeOx) was used, and the formulation was later expanded to include approved lipids. These nanoparticles not only efficiently transfect primary human immune cells but also effectively deliver multiple nucleotides in CRISPR‐Cas9 applications. Moreover, an in vivo comparison revealed that the nanoparticles exhibited preferential transfection in extrahepatic tissues. This distinguishes them from conventional cholesterol‐rich lipid nanoparticles, which primarily target the liver regardless of the application route.
From Ostrich to Mouse to Human: Translation of the Functional Liver PET Tracer [68Ga]Ga-TEoS-DAZA
Journal of Nuclear Medicine, 2026
Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness
Anna Kleyman, Walter Pisciotta, Charlotte Gaupp, Waqas Khaliq, Daniel Hofmaenner, et al.
Critical Care, 2025
Background Sepsis-induced cardiomyopathy (SIM) is characterized by myocardial dysfunction, diminished catecholamine responsiveness and worse outcomes. Hypocholesterolemia is also a well-recognized prognosticator of poor outcomes in sepsis. In vitro physiology/pharmacology studies indicate that low cholesterol levels within the cardiomyocyte membrane regulate ß-adrenergic receptor activity. We therefore hypothesized that cardiomyocyte membrane cholesterol levels are reduced in sepsis and this contributes to SIM. Methods Cardiovascular biomarkers and plasma lipid profiles measured sequentially (6, 24 and 72 h) in a fluid-resuscitated rat model of fecal peritonitis were compared against those measured in 27 septic patients on Days 1–3 of ICU admission. In separate studies, rat hearts were excised at the same time points for measurement of cardiomyocyte membrane cholesterol and downstream adrenergic signaling. In a final study, the impact of a 15-hour infusion of cholesterol, either given as HDL-cholesterol or liposomal cholesterol, commencing at 6 h post-sepsis induction, on dobutamine responsiveness and cardiomyocyte membrane cholesterol levels was assessed. Results The magnitude of fall in stroke volume, rise in heart rate, plasma troponin and BNP, and fall in plasma HDL-cholesterol on ICU Day 1 in septic patients and at 6 h in the rat model all prognosticated for poor outcomes. In parallel, cardiomyocyte membrane cholesterol fell in the rats, more so in poor prognosis animals, with a blunted inotropic response to dobutamine, indicative of SIM. Cholesterol administration restored cardiomyocyte membrane cholesterol, dobutamine responsiveness and adrenergic signaling. Conclusions In a long-term rat model of sepsis, that parallels changes seen in septic patients, cardiomyocyte membrane cholesterol fell with associated decreases in catecholamine responsiveness. These features could be restored by cholesterol infusion, suggesting potential utility as a therapeutic.
Hepatobiliary PET with [68Ga]Ga-BP-IDA – preclinical evaluation and its translational potential for liver function monitoring
Julia Greiser, Robert Drescher, Marta Pomraenke, Mitali Sonawane, Olga Perkas, et al.
Ejnmmi Research, 2025
Background The aim of this study was to investigate the preclinical biodistribution and molecular pathway of [68Ga]Ga-BP-IDA and to evaluate its clinical suitability for quantitative monitoring of liver function during transarterial radioembolization (TARE) therapy of a hepatocellular carcinoma (HCC). Results [68Ga]Ga-BP-IDA undergoes hepatobiliary clearance, with uptake into hepatocytes via OATP1B1 and OATP1B3. [68Ga]Ga-BP-IDA exhibits demetallation in vivo but is nevertheless suitable for clinical application due to its rapid uptake into functional liver tissue. In a clinical case [68Ga]Ga-BP-IDA PET/CT allowed for differentiation of functional liver mass from cancerous tissue and enabled monitoring the effect on liver and tumor volume as well as on residual liver function after TARE therapy. Following TARE treatment, a reduction of the hepatic uptake rate was observed in both non-cancerous liver lobes, but was more pronounced in the right lobe, indicating a correlation to the higher non-targeted radiation dose from the TARE treatment in this lobe. [68Ga]Ga-BP-IDA PET/CT thus revealed additional information on liver function impairment which was not represented by CT-based volumetry alone. Conclusion [68Ga]Ga-BP-IDA PET/CT is a suitable tool for planning and monitoring TARE therapy of primary liver tumors and may complement the limits of volumetry-based methods with functional information about the liver.
Hyperactivity of the non-canonical inflammasome in SPG11 and SPG48
Muhammad Awais Afzal, Mohamed Ghait, Adeela Hussain, Anke Siegmund, Lorena Tuchscherr, et al.
Ebiomedicine, 2025
LILRA5 Functions to Induce ROS Production on Innate Immune Cells
Zuyi Fu, Matevž Rumpret, Irina Kube‐Golovin, Mykola Lyndin, Vera Solntceva, et al.
European Journal of Immunology, 2025
Activating immune receptors provides mechanisms for phagocytes to elicit important effector functions that promote the killing of microbes. Leukocyte immunoglobulin‐like receptor A5 (LILRA5), an orphan immune receptor expressed by human phagocytes and co‐localising with FcRγ, remains poorly characterised. To address this, we developed a highly specific anti‐LILRA5 monoclonal antibody that has agonistic properties. We show LILRA5 expression on naïve monocytes and neutrophils, and that ligation of LILRA5 stimulates ROS production. While increased LILRA5 transcripts have been associated with sepsis, we also observed increased levels in patients with systemic infection but without sepsis complications. Ex vivo bacterial infection of whole blood did not alter surface LILRA5 expression, but LPS stimulation changed expression levels, indicating that surface LILRA5 expression is dynamic and likely regulated post‐transcriptionally, changing responses to different stimuli or over time. Soluble (s)LILRA5 was enhanced in sera from sepsis patients and in supernatants of monocytes that were LPS‐stimulated, indicating that shedding of LILRA5 from cell surfaces or that expression of sLILRA5 isoforms provides a mechanism to regulate surface LILRA5 expression levels. Finally, we show that altered surface LILRA5 expression influences LILRA5‐induced ROS production capacity. Thus, LILRA5 is a dynamically regulated activating receptor expressed on phagocytes that stimulates ROS production.
Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models
Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, et al.
Pharmacological Research, 2025
Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis
Ritvik Mathur, Sara Elsafy, Adrian T. Press, Julian Brück, Mathias Hornef, et al.
ACS Nano, 2024
Sepsis is characterized by a dysregulated immune response and is very difficult to treat. In the cecal ligation and puncture (CLP) mouse model, we show that nanomedicines can effectively alleviate systemic and local septic events by targeting neutrophils. Specifically, by decorating the surface of clinical-stage dexamethasone liposomes with cyclic arginine-glycine-aspartic acid (cRGD) peptides, we promote their engagement with neutrophils in the systemic circulation, leading to their prominent accumulation at primary and secondary sepsis sites. cRGD-targeted dexamethasone liposomes potently reduce immature circulating neutrophils and neutrophil extracellular traps in intestinal sepsis induction sites and the liver. Additionally, they mitigate inflammatory cytokines systemically and locally while preserving systemic IL-10 levels, contributing to lower IFN-γ/IL-10 ratios as compared to control liposomes and free dexamethasone. Our strategy addresses sepsis at the cellular level, illustrating the use of neutrophils both as a therapeutic target and as a chariot for drug delivery.
Nanoscale chemical characterization of secondary protein structure of F-Actin using mid-infrared photoinduced force microscopy (PiF-IR)
Jesvin Joseph, Lukas Spantzel, Maryam Ali, Dijo Moonnukandathil Joseph, Sebastian Unger, et al.
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2024
Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model
Na Liu, Mitali Sonawane, Oliver Sommerfeld, Carl-Magnus Svensson, Marc Thilo Figge, et al.
Frontiers in Immunology, 2024
Impaired flux of bile acids from the liver to the gut reveals microbiome-immune interactions associated with liver damage
Howell Leung, Ling Xiong, Yueqiong Ni, Anne Busch, Michael Bauer, et al.
Npj Biofilms and Microbiomes, 2023
Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs
Hyeonsoo Bae, Marko Rodewald, Tobias Meyer-Zedler, Thomas W. Bocklitz, Gregor Matz, et al.
Scientific Reports, 2023
Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease
Friederike Dellbrügge, Lena D. Jesse, Anna Medyukhina, Na Liu, Sophie Neugebauer, et al.
Heliyon, 2023
Raman Spectroscopy Profiling of Splenic T-Cells in Sepsis and Endotoxemia in Mice
Ibukun Elizabeth Osadare, Ling Xiong, Ignacio Rubio, Ute Neugebauer, Adrian T. Press, et al.
International Journal of Molecular Sciences, 2023
Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury
Adrian T. Press, Luisa Ungelenk, Anna Medyukhina, Samantha A. Pennington, Sandor Nietzsche, et al.
Free Radical Biology and Medicine, 2023
RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis
Jessica Hoff, Ling Xiong, Tobias Kammann, Sophie Neugebauer, Julia M. Micheel, et al.
Cell Death and Disease, 2023
Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells
WanLing Foo, Zoltán Cseresnyés, Carsten Rössel, Yingfeng Teng, Anuradha Ramoji, et al.
Biomaterials, 2023
Dysregulated Immune Response and Organ Dysfunction: Liver
Adrian T. Press, Michael Bauer
Lessons from the Icu, 2023
The immunological function of CXCR2 in the liver during sepsis
Na Liu, Michael Bauer, Adrian T. Press
Journal of Inflammation United Kingdom, 2022
The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation
Dustin Beyer, Jessica Hoff, Oliver Sommerfeld, Alexander Zipprich, Nikolaus Gaßler, et al.
Molecular Medicine, 2022
Author Correction: Cargo–carrier interactions significantly contribute to micellar conformation and biodistribution (NPG Asia Materials, (2017), 9, 10, (e444), 10.1038/am.2017.161)
Adrian T. Press, Anuradha Ramoji, Moritz vd Lühe, Alexandra C. Rinkenauer, Jessica Hoff, et al.
Npg Asia Materials, 2022
Automated multicolor mesoscopic imaging for the 3-dimensional reconstruction of fluorescent biomarker distribution in large tissue specimens
Wanling Foo, Alexander Wiede, Sebastian Bierwirth, Rainer Heintzmann, Adrian T. Press, et al.
Biomedical Optics Express, 2022
Etiology–histomorphology–entity correlation in liver pathology: a narrative review
Nikolaus Gassler, Adrian Press, Falk Rauchfuß, Bernhard Theis, Elke Kaemmerer
Ame Medical Journal, 2022
Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data
Bianca Hoffmann, Ruman Gerst, Zoltán Cseresnyés, WanLing Foo, Oliver Sommerfeld, et al.
Photoacoustics, 2022
Poly(2-oxazoline) Homopolymers and Diblock Copolymers Containing Retinoate ω‑End Groups
Leanne M. Stafast, Christine Weber, Maren T. Kuchenbrod, Stephanie Hoeppener, Mira Behnke, et al.
ACS Applied Polymer Materials, 2022
The Many Roles of Cholesterol in Sepsis A Review
Daniel A. Hofmaenner, Anna Kleyman, Adrian Press, Michael Bauer, Mervyn Singer
American Journal of Respiratory and Critical Care Medicine, 2022
Automated multicolour mesoscopic imaging for the 3-dimensional reconstruction of fluorescent biomarker distribution in large tissue specimens
Optics Infobase Conference Papers, 2022
Intracellularly released cholesterol from polymer-based delivery systems alters cellular responses to pneumolysin and promotes cell survival
Tobias Kammann, Jessica Hoff, Ilknur Yildirim, Blerina Shkodra, Tina Müller, et al.
Metabolites, 2021
Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis
Yunxia Ma, Miljana Nenkov, Yuan Chen, Adrian T Press, Elke Kaemmerer, et al.
World Journal of Hepatology, 2021
Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis
Adrian T Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, et al.
EMBO Molecular Medicine, 2021
Biochemical analysis of leukocytes after in vitro and in vivo activation with bacterial and fungal pathogens using raman spectroscopy
Aikaterini Pistiki, Anuradha Ramoji, Oleg Ryabchykov, Daniel Thomas-Rüddel, Adrian T. Press, et al.
International Journal of Molecular Sciences, 2021
Controlled release of the α-tocopherol-derived metabolite α-13′-carboxychromanol from bacterial nanocellulose wound cover improves wound healing
Jessica Hoff, Berit Karl, Jana Gerstmeier, Uwe Beekmann, Lisa Schmölz, et al.
Nanomaterials, 2021
Stealth Effect of Short Polyoxazolines in Graft Copolymers: Minor Changes of Backbone End Group Determine Liver Cell-Type Specificity
Irina Muljajew, Sophie Huschke, Anuradha Ramoji, Zoltán Cseresnyés, Stephanie Hoeppener, et al.
ACS Nano, 2021
In vivo coherent anti-Stokes Raman scattering microscopy reveals vitamin A distribution in the liver
Marko Rodewald, Hyeonsoo Bae, Sophie Huschke, Tobias Meyer‐Zedler, Michael Schmitt, et al.
Journal of Biophotonics, 2021
Characterization of a library of vitamin A-functionalized polymethacrylate-based nanoparticles for siRNA delivery
Paul Klemm, Sophie Huschke, Marko Rodewald, Nadia Ehteshamzad, Mira Behnke, et al.
Polymer Chemistry, 2021
Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis
Oliver Sommerfeld, Anna Medyukhina, Sophie Neugebauer, Mohamed Ghait, Svenja Ulferts, et al.
Molecular Therapy, 2021
Formulation of liver-specific PLGA-dy-635 nanoparticles loaded with the protein kinase C inhibitor bisindolylmaleimide i
Blerina Shkodra, Adrian T. Press, Antje Vollrath, Ivo Nischang, Stephanie Schubert, et al.
Pharmaceutics, 2020
Polymethine Dye-Functionalized Nanoparticles for Targeting CML Stem Cells
Philipp Ernst, Adrian T. Press, Mike Fischer, Vivien Günther, Christine Gräfe, et al.
Molecular Therapy Oncolytics, 2020
Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice
Barbara Schaarschmidt, Sebastian Vlaic, Anna Medyukhina, Sophie Neugebauer, Sandor Nietzsche, et al.
Theranostics, 2018
Fast simultaneous assessment of renal and liver function using polymethine dyes in animal models of chronic and acute organ injury
A. T. Press, M. J. Butans, T. P. Haider, C. Weber, S. Neugebauer, et al.
Scientific Reports, 2017
Uptake of Retinoic Acid-Modified PMMA Nanoparticles in LX-2 and Liver Tissue by Raman Imaging and Intravital Microscopy
Turgay Yildirim, Christian Matthäus, Adrian T. Press, Stephanie Schubert, Michael Bauer, et al.
Macromolecular Bioscience, 2017
Cargo–carrier interactions significantly contribute to micellar conformation and biodistribution
Adrian T Press, Anuradha Ramoji, Moritz vd Lühe, Alexandra C Rinkenauer, Jessica Hoff, et al.
Npg Asia Materials, 2017
Short-term treatment with taurolidine is associated with liver injury
René Fahrner, Anika Möller, Adrian T. Press, Andreas Kortgen, Michael Kiehntopf, et al.
BMC Pharmacology Toxicology, 2017
A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo
Adrian T. Press, Luisa Ungelenk, Alexandra C. Rinkenauer, Marko Gröger, Frank Lehmann, et al.
Journal of Biophotonics, 2016
Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo
Alexandra C. Rinkenauer, Adrian T. Press, Martin Raasch, Christian Pietsch, Simon Schweizer, et al.
Journal of Controlled Release, 2015
Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles
Adrian T. Press, Anja Traeger, Christian Pietsch, Alexander Mosig, Michael Wagner, et al.
Nature Communications, 2014
The liver in sepsis: Patterns of response and injury
Michael Bauer, Adrian T. Press, Michael Trauner
Current Opinion in Critical Care, 2013

RECENT SCHOLAR PUBLICATIONS

Extrahepatic Gene Editing In Vivo Using Organic Solvent‐Free Lipid Nanoparticles
M Streiber, N Liu, L Simon, F Adermann, V Bachmann, L Gath, ...
Small 22 (27), e11489 , 2026
2026
Citations: 1
68GA-TRACERS FOR IMAGING OF THE HEPATOBILIARY FUNCTION
J Greiser, R Drescher, A Werner, C Kühnel, T Ross, FM Bengel, A Press, ...
EANM Innovation 2, 100097 , 2026
2026
From Ostrich to Mouse to Human: Translation of the Functional Liver PET Tracer [68Ga] Ga-TEoS-DAZA
J Greiser, R Drescher, M Sonawane, C Kuehnel, S Wiegand, O Perkas, ...
Journal of Nuclear Medicine , 2026
2026
Citations: 1
Sodium thiosulfate attenuates liver injury in a rat model of sepsis by modulating ferroptosis and oxidative stress
AO Mitre, I Baldea, GA Filip, RM Pop, MA Neag, B Mitre, A Negoescu, ...
Scientific Reports , 2025
2025
Hyperactivity of the non-canonical inflammasome in SPG11 and SPG48
MA Afzal, M Ghait, A Hussain, A Siegmund, L Tuchscherr, P Babic, ...
Ebiomedicine 121 , 2025
2025
Citations: 1
Hepatobiliary PET with [ 68 Ga]Ga-BP-IDA – preclinical evaluation and its translational potential for liver function monitoring
J Greiser, R Drescher, M Pomraenke, M Sonawane, O Perkas, C Kuehnel, ...
EJNMMI research 15 (1), 128 , 2025
2025
LILRA5 Functions to Induce ROS Production on Innate Immune Cells
Z Fu, M Rumpret, I Kube‐Golovin, M Lyndin, V Solntceva, Y Zhao, ...
European Journal of Immunology 55 (10), e70079 , 2025
2025
Citations: 2
Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness
A Kleyman, W Pisciotta, C Gaupp, W Khaliq, D Hofmaenner, D Brealey, ...
Critical Care 29 (1), 399 , 2025
2025
Citations: 3
PKCalpha-PlIOSPHATASE FEEDBACK LOOPS IN SEPSIS-ASSOCIATED LIVER FAILURE: MOLECULAR INSIGHTS
A Gomeniuk, L Xiong, CM Svensson, MT Figge, M Bauer, AT Press
SHOCK 64 (3 S), S11-S11 , 2025
2025
PKCalpha-PHOSPHATASE FEEDBACK LOOPS IN HEPATOCYTES: A THERAPEUTIC LINK TO SEPSIS-ASSOCIATED LIVER FAILURE
L Xiong, A Gomeniuk, N Liu, M Bauer, AT Press
SHOCK 64 (3 S), S41-S41 , 2025
2025
COMPETITIVE CXCR2 ANTAGONISM RESTORES NEUTROPHIL'S ABILITY TO CONTROL THE HOST RESPONSE TO INFECTION IN SURVIVAL AND SEVERITY STRATIFIED POLYMICROBIAL MOUSE SEPSIS
N Liu, J Halbauer, M Bauer, AT Press
SHOCK 64 (3 S), S19-S20 , 2025
2025
Die Rolle von Cholesterol bei systemischen Infektionen von Neugeborenen–eine prospektive Studie am Universitätsklinikum Jena
D Beyer, O Sommerfeld, H Proquitté, AT Press
Zeitschrift für Geburtshilfe und Neonatologie 229 (03), KV-018 , 2025
2025
Sterol therapy
M Singer, A Kleyman, A Press, M Bauer
US Patent App. 18/688,602 , 2025
2025
Leukocyte immunoglobulin-like receptor A5 functions to induce ROS production on innate immune cells
Z Fu, M Rumpret, I Kube-Golovin, M Lyndin, V Solntceva, Y Zhao, ...
bioRxiv, 2025.03. 16.643524 , 2025
2025
Bildgebung der Leber-(dys)-funktion mit hepatobiliären Gallium-68-Tracern
J Greiser, R Drescher, T Winkens, C Kühnel, M Pomraenke, A Press, ...
Nuklearmedizin-NuclearMedicine 64 (01), L04 , 2025
2025
Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models
L Xiong, D Beyer, N Liu, T Lehmann, S Neugebauer, S Schaeuble, ...
Pharmacological Research 212, 107581 , 2025
2025
Citations: 4
Prognostic value of admission H3. 1 nucleosome levels in sepsis-associated acute kidney injury: a secondary analysis of the SISPCT randomised clinical trial
C Neumann, F Bloos, TTW Hla, T Bygott, H Bogatsch, M Kiehntopf, ...
medRxiv, 2025.01. 28.25321238 , 2025
2025
Citations: 1
Solvent-Free Lipid Nanoparticle Formulation Enables In Vivo Gene Editing Predominantly in Extrahepatic Tissues
M Streiber, N Liu, L Simon, F Adermann, V Bachmann, S Hoeppener, ...
Available at SSRN 5200072 , 2024
2024
Neutrophil hitchhiking enhances liposomal dexamethasone therapy of sepsis
R Mathur, S Elsafy, AT Press, J Brück, M Hornef, L Martin, T Schürholz, ...
ACS nano 18 (42), 28866-28880 , 2024
2024
Citations: 26
Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model
N Liu, M Sonawane, O Sommerfeld, CM Svensson, MT Figge, R Bauer, ...
Frontiers in Immunology 15, 1432307 , 2024
2024
Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

The many roles of cholesterol in sepsis: a review
DA Hofmaenner, A Kleyman, A Press, M Bauer, M Singer
American journal of respiratory and critical care medicine 205 (4), 388-396 , 2022
2022
Citations: 149
The liver in sepsis: patterns of response and injury
M Bauer, AT Press, M Trauner
Current opinion in critical care 19 (2), 123-127 , 2013
2013
Citations: 127
The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation
D Beyer, J Hoff, O Sommerfeld, A Zipprich, N Gaßler, AT Press
Molecular Medicine 28 (1), 84 , 2022
2022
Citations: 119
Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles
AT Press, A Traeger, C Pietsch, A Mosig, M Wagner, MG Clemens, ...
Nature communications 5 (1), 5565 , 2014
2014
Citations: 72
Targeting complement C5a receptor 1 for the treatment of immunosuppression in sepsis
O Sommerfeld, A Medyukhina, S Neugebauer, M Ghait, S Ulferts, A Lupp, ...
Molecular Therapy 29 (1), 338-346 , 2021
2021
Citations: 52
Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo
AC Rinkenauer, AT Press, M Raasch, C Pietsch, S Schweizer, ...
Journal of Controlled Release 216, 158-168 , 2015
2015
Citations: 51
Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis
Y Ma, M Nenkov, Y Chen, AT Press, E Kaemmerer, N Gassler
World Journal of Hepatology 13 (11), 1512 , 2021
2021
Citations: 46
Impaired flux of bile acids from the liver to the gut reveals microbiome-immune interactions associated with liver damage
H Leung, L Xiong, Y Ni, A Busch, M Bauer, AT Press, G Panagiotou
npj Biofilms and Microbiomes 9 (1), 35 , 2023
2023
Citations: 40
Controlled release of the α-tocopherol-derived metabolite α-13′-carboxychromanol from bacterial nanocellulose wound cover improves wound healing
J Hoff, B Karl, J Gerstmeier, U Beekmann, L Schmölz, F Börner, D Kralisch, ...
Nanomaterials 11 (8), 1939 , 2021
2021
Citations: 35
Stealth effect of short polyoxazolines in graft copolymers: Minor changes of backbone end group determine liver cell-type specificity
I Muljajew, S Huschke, A Ramoji, Z Cseresnyés, S Hoeppener, I Nischang, ...
ACS nano 15 (7), 12298-12313 , 2021
2021
Citations: 35
Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis
AT Press, P Babic, B Hoffmann, T Müller, W Foo, W Hauswald, J Benecke, ...
EMBO molecular medicine 13 (10), EMMM202114436 , 2021
2021
Citations: 34
Cargo–carrier interactions significantly contribute to micellar conformation and biodistribution
AT Press, A Ramoji, AC Rinkenauer, J Hoff, M Butans, C Rössel, ...
NPG Asia Materials 9 (10), e444-e444 , 2017
2017
Citations: 34
Biochemical analysis of leukocytes after in vitro and in vivo activation with bacterial and fungal pathogens using Raman spectroscopy
A Pistiki, A Ramoji, O Ryabchykov, D Thomas-Rüddel, AT Press, ...
International journal of molecular sciences 22 (19), 10481 , 2021
2021
Citations: 27
Neutrophil hitchhiking enhances liposomal dexamethasone therapy of sepsis
R Mathur, S Elsafy, AT Press, J Brück, M Hornef, L Martin, T Schürholz, ...
ACS nano 18 (42), 28866-28880 , 2024
2024
Citations: 26
RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis
J Hoff, L Xiong, T Kammann, S Neugebauer, JM Micheel, N Gaßler, ...
Cell death & disease 14 (4), 275 , 2023
2023
Citations: 23
Feasibility studies of multimodal nonlinear endoscopy using multicore fiber bundles for remote scanning from tissue sections to bulk organs
H Bae, M Rodewald, T Meyer-Zedler, TW Bocklitz, G Matz, ...
Scientific reports 13 (1), 13779 , 2023
2023
Citations: 18
Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury
AT Press, L Ungelenk, A Medyukhina, SA Pennington, S Nietzsche, ...
Free Radical Biology and Medicine 204, 151-160 , 2023
2023
Citations: 18
Short-term treatment with taurolidine is associated with liver injury
R Fahrner, A Möller, AT Press, A Kortgen, M Kiehntopf, F Rauchfuss, ...
BMC Pharmacology and Toxicology 18 (1), 61 , 2017
2017
Citations: 18
The immunological function of CXCR2 in the liver during sepsis
N Liu, M Bauer, AT Press
Journal of Inflammation 19 (1), 23 , 2022
2022
Citations: 17
Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice
B Schaarschmidt, S Vlaic, A Medyukhina, S Neugebauer, S Nietzsche, ...
Theranostics 8 (14), 3766 , 2018
2018
Citations: 17

Adrian Tibor Press

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RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS