Dr.T.Vadivel
@aagasc.edu.in
Arignar Anna Government Arts and Science College karaikal
Scopus Publications
Scopus Publications
K. Amirthaganesan, T. Vadivel, M. Dhamodaran, and V.L. Chandraboss
Elsevier BV
T. Vadivel, M. Dhamodaran, S. Kulathooran, S. Kavitha, K. Amirthaganesan, S. Chandrasekaran, S. Ilayaraja, and S. Senguttuvan
Elsevier BV
Rhodium(III) complexes such as [Rh(Chi4Hy3mb)(H2O)2]Cl2, [Rh(Chi2Hymb)(H2O)2]Cl2, and [Rh(Chi2Hy3mb)(H2O)2]Cl2 were synthesized by metal chelation/complexation with chitosan Schiff base ligands. Stable Schiff base ligands were prepared by chemical modification of chitosan with aromatic aldehydes such as vanillin, salicylaldehyde and orthovanillin. These chitosan based Schiff base ligands were performed as bidentate ligands through azomethine nitrogen atom and methoxy/hydroxy oxygen atom. These bidentate ligands were favoured to the formation of stable coordination complex with metal ions. The series of Rhodium(III) complexes were characterized by Elemental analysis, FT-IR, UV-Vis spectroscopy, P-XRD and Thermo-gravimetric analysis (TGA). The electrochemical property of Rhodium(III) complexes were analyzed by cyclic voltametry.
A. Lakshmi Narayanan, M. Dhamodaran, J. Samu Solomon, B. Karthikeyan, and R. Govindhan
Elsevier BV
Sensing ability of caffeine interaction with Phe-Phe annotates (PNTs), is presented (Govindhan et al., 2017; Karthikeyan et al., 2014; Tavagnacco et al., 2013; Kennedy et al., 2011; Wang et al., 2017) [1–5] in this data set. Investigation of synthesized caffeine carrying peptide nanotubes are carried out by FT-Raman spectral analysis and high resolution transmission electron microscopy (HR-TEM). Particle size of the caffeine loaded PNTs is < 40 nm. The FT-Raman spectrum signals are enhanced in the region of 400–1700 cm−1. These data are ideal tool for the applications like biosensing and drug delivery research (DDS).
Mohammad Ramezani and Jamal Shamsara
Bentham Science Publishers Ltd.
AIM AND OBJECTIVE
MMP-13 belongs to a large family of proteases called matrix metalloproteinases (MMPs) that degrades type II collagen, the main structural protein of articular cartilage. The main pathologic role of MMP-13 over expression is to contribute to the development of osteoarthritis.
METHODS
To find new inhibitors with possible selectivity for MMP-13 a structure based virtual screening was employed. The inhibitory activities of 11 inhibitors among 19 purchased compounds were approved by enzyme inhibition assay.
RESULTS
Our results demonstrated that the CADD (computer aided drug design) could be successfully applied to find new MMP-13 inhibitors using a receptor structure (PDB code: 3O2X) which had been demonstrated a good performance in a cross-docking study.
CONCLUSION
We discovered inhibitors with new scaffolds for inhibition of MMP-13 and some selectivity features such as proper S1' occupancy and interactions with S1' pocket that could be subjected to a future lead optimization study.
T. Vadivel and M. Dhamodaran
Elsevier BV
Chitosan can be modified chemically by condensation reaction of deacetylated chitosan with aldehyde in homogeneous phase. This condensation is carried by primary amine (NH2) with aldehyde (CHO) to form corresponding schiff base. The chitosan biopolymer schiff base derivatives are synthesized with substituted aldehydes namely 4-hydroxy-3-methoxy benzaldehyde, 2-hydroxy benzaldehyde, and 2-hydroxy-3-methoxy benzaldehyde, becomes a complexing agent or ligand. The Ruthenium(III) complexes were obtained by complexation of Ruthenium with schiff base ligands and this product exhibits as an excellent solubility and more biocompatibility. The novel series of schiff base Ruthenium(III) complexes are characterized by Elemental analysis, FT-IR spectroscopy, and Thermo-gravimetric analysis (TGA). The synthesized complexes have been subjected to antibacterial study. The antibacterial results indicated that the antibacterial activity of the complexes were more effective against Gram positive and Gram negative pathogenic bacteria. These findings are giving suitable support for developing new antibacterial agent and expand our scope for applications.
Kulathooran Singaram, Dhamodaran Marimuthu, Selvakumar Baskaran, and Sureshkumar Chinaga
Wiley
A facile synthesis of new 4,6-dichloropyridine derivatives 5(a–f), 6(a–c), and 7(a–c) were synthesized using both conventional heating and solvent-free microwave irradiation techniques. The results revealed that the latter method is superior to the conventional heating method. The easy work-up of the products, rapid reaction, and mild conditions are noticeable features of this protocol. Structural elucidation of the synthesized compounds was made on the basis of various spectroscopic methods. The synthesized compounds were evaluated for their in vitro antimicrobial activity (minimum inhibitory concentration; MIC) against various microbial strains using the agar well-diffusion method. Among the compounds, 5c showed best antimicrobial activity against most of the employed strains, especially against Staphylococcus aureus, Escherichia coli, Rhizopus arrhizus, and Candida albicans. Compounds 5a, 6a, 6c, 7a, and 7c showed significant antioxidant activity when compared to the other compounds. In addition to this, theoretical docking studies were performed for the highly potent compounds 5a, 6a, 6c, 7a, and 7c against three different drug targets belonging to the oxidoreductase family, and the results were found to be highly satisfactory.
S Kulathooran, T Vadivel, M Dhamodaran, and B Selvakumar
Oriental Scientific Publishing Company
A series of some new 1-thiocarbamoyl-3-(2,5-dimethylfuran-3-yl)-5-(fluoro/trifluoromethylphenyl) -2-pyrazolines 4a-f have been synthesized by treating with various fluoro/trifluoromethyl substituted chalcones, thiosemicarbazide and potassium carbonate using conventional heating and solventfree microwave irradiation techniques. The easy work-up of the products, rapid reaction and mild conditions are noticeable features of this protocol. Synthesized compounds have been screened for their in vitro antimicrobial activity against six microbial strains. Among them, 1-Thiocarbamoyl3-(2,5-dimethylfuran-3-yl)-5-(3-fluorophenyl)-2-pyrazoline 4b showed maximum zone of inhibition against all the tested microorganisms. Structural elucidation of the synthesized compounds were determined on the basis of various spectroscopic methods.
Kulathooran Singaram, Dhamodaran Marimuthu, Selvakumar Baskaran, and Venkataraman Ramaswamy
National Library of Serbia
Three series of heteroaromatic analogs (twenty seven compounds) with monoketone linkers have been synthesized and evaluated for their antimicrobial activity against six microbial strains. Among them, 3,5-dibenzylidene-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)piperidin-4-one 5e showed best antifungal activity against Aspergillus niger and Aspergillus fumigatus. Structural elucidation of the synthesized compounds was determined on the basis of various spectroscopic methods.
Kulathooran Singaram and Dhamodaran Marimuthu
Informa UK Limited
ABSTRACT A practical and convenient method for the synthesis of oxabicyclo[3.3.1]nonenes has been developed using InCl3 (20 mol%) under mild conditions from aldehydes and R-(+)-limonene. Corresponding oxabicyclic compounds were obtained in high yields via (3,5)-oxonium-ene reaction. This protocol tolerates a wide range of substituents and functional groups. Mild reaction conditions, shorter time, and convenient workup makes this methodology practical. GRAPHICAL ABSTRACT