Miriam del Carmen Carrasco Portugal

@gob.mx

Researcher in Medical Sciences D
Clinical and Experimental Pharmacology Laboratory

Miriam del Carmen Carrasco Portugal


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https://researchid.co/miriam_carrasco
Born in Culiacán, Sinaloa; resident of Mexico City since 1995. Researcher in Medical Sciences at SSA since 1997.
First job at INP, Pharmacology Laboratory (1997- 2007).
Since 2007 researcher in Medical Sciences D of INER, Laboratory of Clinical and Experimental Pharmacology.
58 publications in research journals and 2 book chapters. 31 theses directed (4 doctoral, 16 master's and 11 bachelor's).
Currently, I am the Head of the Institutional Center of Pharmacovigilance of INER and creator of the same, recognized by COFEPRIS since September 2014 and therefore I am also the one who has made the Organization and Procedures Manuals of the area and who coordinates the activities of Pharmacovigilance in INER. Member of the Committee of Pharmacy and Therapeutics of INER (COFAT) since 2011 and part of the group that created this committee.
Associated to: American College of Clinical Pharmacology and the Latin American Society of pharmacogenomics and personalized medicine.

EDUCATION

PhD in Medical Research, ESM, IPN.
Master's Degree in Pharmacy (Biopharmacy), Faculty of Chemistry, UNAM.
Bachelor's Degree in Pharmaceutical Chemistry and Biology, Faculty of Chemistry, UAS.

RESEARCH, TEACHING, or OTHER INTERESTS

General Pharmacology, Toxicology and Pharmaceutics, Pharmacology (medical), Pharmaceutical Science, Pharmacy

FUTURE PROJECTS

Pharmacokinetic differences in drug metabolism by CYP450.

To establish the cytochrome P450 enzymes that produce pharmacokinetic variations in metabolism in Mexicans.


Applications Invited
To determine the pharmacogenetic differences between Mexicans and other races.
570

Scholar Citations

13

Scholar h-index

19

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Pharmacokinetics of the potassium-competitive acid blocker tegoprazan administered by the oral route in healthy Mexicans
    FJFM 19. Miriam del Carmen Carrasco-Portugal, Gisselle Vanessa González ...
    International Journal of Clinical Pharmacology and Therapeutics 64 (03), 164-168 , 2026
    2026
  • Anti-inflammatory effect of free and microencapsulated extract of Lippia graveolens Kunth in a carrageenan-induced paw edema model and an ovalbumin-induced asthma model in mice
    MJ Bernal-Millán, JE Roa-Coria, FJ Flores-Murrieta, JC Huerta-Cruz, ...
    Journal of Ethnopharmacology 348, 119905 , 2025
    2025
    Citations: 4
  • Development of a novel co-amorphous curcumin and L-arginine (1: 2): Structural characterization, biological activity and pharmacokinetics
    JA Mancillas-Quiroz, MC Carrasco-Portugal, K Mondragón-Vásquez, ...
    Pharmaceutics 17 (1), 11 , 2024
    2024
    Citations: 8
  • Green Extracts and UPLC-TQS-MS/MS Profiling of Flavonoids from Mexican Oregano ( Lippia graveolens ) Using Natural Deep Eutectic Solvents/Ultrasound …
    MJ Bernal-Millán, MC Carrasco-Portugal, JB Heredia, ...
    Plants 12 (8), 1692 , 2023
    2023
    Citations: 17
  • Effect of the melanocortin 4-receptor Ile269Asn mutation on weight loss response to dietary, phentermine and bariatric surgery interventions
    IG Salazar-Valencia, H Villamil-Ramírez, F Barajas-Olmos, ...
    Genes 13 (12), 2267 , 2022
    2022
    Citations: 13
  • Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature …
    P León-Mimila, H Villamil-Ramírez, LR Macías-Kauffer, ...
    Arteriosclerosis, Thrombosis, and Vascular Biology 41 (9), 2494-2508 , 2021
    2021
    Citations: 23
  • Genome wide association study identifies a functional SIDT2 variant associated with HDL-C levels and premature coronary artery disease
    P León-Mimila, H Villamil-Ramírez, LR Macias-Kauffer, ...
    Arteriosclerosis, thrombosis, and vascular biology 41 (9), 2494 , 2021
    2021
    Citations: 1
  • Three-and six-month efficacy and safety of phentermine in a Mexican obese population
    M Márquez-Cruz, A Kammar-García, JC Huerta-Cruz, ...
    International Journal of Clinical Pharmacology and Therapeutics 59 (8), 539 , 2021
    2021
    Citations: 15
  • A Simple Method for Determination of Losartan in Human Plasma By HPLC With Fluorescence Detection and its Application in a Pharmacokinetic Study
    JC AGUILAR-CARRASCO, FJ FLORES-MURRIETA, ...
    Latin American Journal of Pharmacy 40, 2153-2158 , 2021
    2021
  • Pharmacokinetic evaluation of two pirfenidone formulations in patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis
    LM Barranco-Garduño, I Buendía-Roldan, JJ Rodriguez, ...
    Heliyon 6 (10) , 2020
    2020
    Citations: 16
  • A functional variant of the SIDT2 gene involved in cholesterol transport is associated with HDL-C levels and premature coronary artery disease
    P León-Mimila, H Villamil-Ramírez, LR Macias-Kauffer, ...
    medRxiv, 2020.09. 19.20197673 , 2020
    2020
    Citations: 2
  • ALTERNATIVAS FARMACÉUTICAS:¿ PUEDEN SER INTERCAMBIABLES?
    MDC CARRASCO-PORTUGAL, F FLORES-MURRIETA
    LATIN AMERICAN JOURNAL OF CLINICAL SCIENCES AND MEDICAL TECHNOLOGY … , 2020
    2020
  • Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease
    LR Macias-Kauffer, H Villamil-Ramírez, P León-Mimila, ...
    International Journal of Cardiology 279, 168-173 , 2019
    2019
    Citations: 28
  • Relationship between pharmacokinetics and the antihyperalgesic and anti-inflammatory effects of meloxicam in the rat
    FJ Flores-Murrieta, MC Carrasco-Portugal, J Rodriguez-Silverio, ...
    Proceedings for Annual Meeting of The Japanese Pharmacological Society … , 2018
    2018
  • Evidence of interethnic differences in the pharmacokinetics of a marker of cyp1a2 activity
    MC Carrasco-Portugal, FJ Flores-Murrieta
    Proceedings for Annual Meeting of The Japanese Pharmacological Society … , 2018
    2018
  • Oseltamivir pharmacokinetics in Mexican obese and non‐obese healthy subjects and patients. Evidence for an absence of interethnic variability
    G Castañeda‐Hernández, A Martínez‐Talavera, LM Barranco‐Garduño, ...
    British Journal of Clinical Pharmacology 82 (3), 890 , 2016
    2016
    Citations: 2
  • Determination of Ketoconazole in Micro-Samples of Human Plasma by HPLC with Fluorescence Detection. Application in a Pharmacokinetic Study.
    JC Aguilar-Carrasco, MC Carrasco-Portugal, FJ Flores-Murrieta, ...
    LATIN AMERICAN JOURNAL OF PHARMACY 35 (10), 2254-2260 , 2016
    2016
    Citations: 1
  • Evaluation of the possible pharmacokinetic interaction between amlodipine, losartan and hydrochlorothiazide in Mexican healthy volunteers
    N Santos-Caballero, LM Barranco-Garduño, JC Aguilar-Carrasco, ...
    International Journal of Pharmacology 12 (2), 101-107 , 2016
    2016
    Citations: 2
  • Evaluation of the Influence of Hyoscine Butylbromide on the Oral Bioavailability of Lansoprazole in Healthy Adult Volunteers
    N Santos-Caballero, LM Barranco-Garduño, JC Aguilar-Carrasco, ...
    2016
  • Evaluation of Side Effects of Sertraline in Healthy Volunteers Enrolled in a Bioequivalence Study: Poster# 049
    MD Carrasco-Portugal, FJ Flores-Murrieta
    Clinical Pharmacology in Drug Development 4, 1-60 , 2015
    2015

MOST CITED SCHOLAR PUBLICATIONS

  • B-vitamin mixture improves the analgesic effect of diclofenac in patients with osteoarthritis: a double blind study
    MC Magaña-Villa, HI Rocha-González, CF del Valle-Laisequilla, ...
    Drug research 63 (06), 289-292 , 2013
    2013
    Citations: 84
  • Effects of a cyclooxygenase-2 preferential inhibitor in young healthy dogs exposed to air pollution: a pilot study
    L Calderón-Garcidueñas, A Mora-Tiscareño, G Gomez-Garza, ...
    Toxicologic pathology 37 (5), 644-660 , 2009
    2009
    Citations: 38
  • Effects of gender and phase of the menstrual cycle on the kinetics of ranitidine in healthy volunteers
    JF Pérez, HJ Olguín, CF Pérez, GP Guillé, AG Pérez, AC Vieyra, AT López, ...
    Chronobiology international 20 (3), 499-508 , 2003
    2003
    Citations: 38
  • Rapid and sensitive determination of levofloxacin in microsamples of human plasma by high‐performance liquid chromatography and its application in a pharmacokinetic study
    JC Aguilar‐Carrasco, J Hernández‐Pineda, JM Jiménez‐Andrade, ...
    Biomedical Chromatography 29 (3), 341-345 , 2015
    2015
    Citations: 32
  • Gender differences in the pharmacokinetics of oral drugs
    M del Carmen Carrasco-Portugal, FJ Flores-Murrieta
    Pharmacology & Pharmacy 2 (1), 31 , 2011
    2011
    Citations: 31
  • Gender differences in the oral pharmacokinetics of fluconazole
    MC Carrasco-Portugal, FJ Flores-Murrieta
    Clinical drug investigation 27 (12), 851-855 , 2007
    2007
    Citations: 31
  • Evaluation of gender in the oral pharmacokinetics of clindamycin in humans
    MC Carrasco‐Portugal, M Luján, FJ Flores‐Murrieta
    Biopharmaceutics & Drug Disposition 29 (7), 427-430 , 2008
    2008
    Citations: 30
  • Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease
    LR Macias-Kauffer, H Villamil-Ramírez, P León-Mimila, ...
    International Journal of Cardiology 279, 168-173 , 2019
    2019
    Citations: 28
  • Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature …
    P León-Mimila, H Villamil-Ramírez, LR Macías-Kauffer, ...
    Arteriosclerosis, Thrombosis, and Vascular Biology 41 (9), 2494-2508 , 2021
    2021
    Citations: 23
  • Green Extracts and UPLC-TQS-MS/MS Profiling of Flavonoids from Mexican Oregano ( Lippia graveolens ) Using Natural Deep Eutectic Solvents/Ultrasound …
    MJ Bernal-Millán, MC Carrasco-Portugal, JB Heredia, ...
    Plants 12 (8), 1692 , 2023
    2023
    Citations: 17
  • Pharmacokinetic evaluation of two pirfenidone formulations in patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis
    LM Barranco-Garduño, I Buendía-Roldan, JJ Rodriguez, ...
    Heliyon 6 (10) , 2020
    2020
    Citations: 16
  • Three-and six-month efficacy and safety of phentermine in a Mexican obese population
    M Márquez-Cruz, A Kammar-García, JC Huerta-Cruz, ...
    International Journal of Clinical Pharmacology and Therapeutics 59 (8), 539 , 2021
    2021
    Citations: 15
  • A simple method for determination of nimesulide in rat blood samples by high-performance liquid chromatography
    MC Carrasco-Portugal, V Granados-Soto, GA Camacho-Vieyra, ...
    Taylor & Francis Group 23 (14), 2237-2244 , 2000
    2000
    Citations: 15
  • Effect of the melanocortin 4-receptor Ile269Asn mutation on weight loss response to dietary, phentermine and bariatric surgery interventions
    IG Salazar-Valencia, H Villamil-Ramírez, F Barajas-Olmos, ...
    Genes 13 (12), 2267 , 2022
    2022
    Citations: 13
  • Bioavailability of an extemporaneous suspension of propafenone made from tablets
    HJ Olguín, CF Pérez, JF Pérez, BR Mendiola, MC Portugal, JB Chávez
    Biopharmaceutics & drug disposition 27 (5), 241-245 , 2006
    2006
    Citations: 13
  • La farmacocinética poblacional y su importancia en la terapéutica.
    LM Barranco Garduño, JC Neri Salvador, HL Molina, ...
    Medicina Interna de México 27 (4) , 2011
    2011
    Citations: 12
  • Neuro-protective effects of carbamazepine on sleep patterns and head and body shakes in kainic acid-treated rats
    A Alfaro-Rodríguez, R González-Piña, E Arch-Tirado, ...
    Chemico-biological interactions 180 (3), 376-382 , 2009
    2009
    Citations: 11
  • Pharmacokinetics of lidocaine and its metabolite as a hepatic function marker in dogs
    BE Pérez-Guillé, F Villegas-Alvarez, A Toledo-López, MA Jiménez-Bravo, ...
    Proc West Pharmacol Soc 54, 62-65 , 2011
    2011
    Citations: 10
  • Further evidence for interethnic differences in the oral pharmacokinetics of meloxicam
    MC Carrasco-Portugal, JC Aguilar-Carrasco, M Luján, G Reyes-García, ...
    Clinical drug investigation 25 (5), 307-313 , 2005
    2005
    Citations: 10
  • Bioequivalence of two oral formulations of glyburide (glibenclamide).
    FJ Flores-Murrieta, G Reyes-García, R Medina-Santillán, JE Herrera
    Proceedings of the Western Pharmacology Society 50, 64-66 , 2007
    2007
    Citations: 9

Industry, Institute, or Organisation Collaboration

Cambridge University, Medix Laboratories, Senosiain Laboratories, Pfizer, Instituto Nacional de Pediatria, Instituto Politécnico Nacional, Universidad del Estado de Hidalgo, Universidad de Chihuahua, Universidad Autónoma de Sinaloa, CINVESTAV, Centro de Investigación en Alimentación y Desarrollo.

INDUSTRY EXPERIENCE

Development of natural products with pharmacological activities (in-vitro and preclinical studies).
Phase research studies.
Pharmacovigilance specialist.
Research studies for the improvement of therapeutics.
Bioequivalence expert.

STARTUP

National Institute of Health (Instituto Nacional de Salud)
It is a school institution where research and care are carried out.

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

PROJECT FINANCED IN 2024: “Population pharmacokinetics and clinical monitoring of chemotherapeutic agents in cancer patients for individualization of pharmacotherapeutics”. Registered in the call for FPIS projects of the SSA. I am the Principal INER research projects on obesity and sleep, rational use of amphotericin, voriconazole and population pharmacokinetics of meropenem. Other projects focused on improving therapeutics, in collaboration with other institutions such as INMEGEN, Universidad Autónoma de Chihuahua, Universidad de Hidalgo, Centro de Investigación en Alimentación y PROJECT protocol in collaboration with the University of Cambridge during the COVID-19 FINANCED BY CONACYT (2014, 2015)Support No.: 222046 PROINOVA Applied Clinical Research on the Determinant Factors that Modify the Response to Anti-obesity Treatment in Mexican Population - High Scientific and Social that participated: Productos Medix, INER, INMEGEN. CONACYT-Funded Project 18: B25-15 (2015) Development and pharmacokinetic characterization of a new octreotide formulation in rats, as part of a broader initiative on nanotechnological biopolymers and sustained-release on injectable peptide-based suspensions, chemically complexed for improved physicochemical stability in a spray-dried nanobiopolymeric matrix, aimed at treating oncological,gastric, and hormone-dependent No.: 221934