ENGKU HUSNA BINTI ENGKU ISMAIL

@usm.my

LECTURER, DEPARTMENT OF OBSTETRICS & GYNAECOLOGY, SCHOOL OF MEDICAL SCIENCES
UNIVERSITI SAINS MALAYSIA

ENGKU HUSNA BINTI ENGKU ISMAIL


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https://researchid.co/engkuhusna
Current position:
Lecturer, Obstetrician & Gynaecologist, Universiti Sains Malaysia,
Kubang Kerian, Kelantan

Nationality: Malaysian

Sex: Female

Address:
Department of Obstetrics & Gynaecology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia

E-mail: enhusna@ drengkuhusna@

EDUCATION

Year Degree/Qualification Discipline University/Institute
2011 Doctor of Medicine (MD) Medicine & Surgery Universiti Malaysia Sabah
2019 Master of Medicine (MMED) Obstetrics & Gynaecology Universiti Sains Malaysia

RESEARCH INTERESTS

OBSTETRICS & GYNAECOLOGY, FETOMATERNAL MEDICINE, HIGH-RISK PREGNANCY, LABOUR ROOM MANAGEMENT

FUTURE PROJECTS

NUCHAL CORD AND ITS IMPLICATION: HOSPITAL USM EXPERIENCE

Nuchal cord occurs when the umbilical cord becomes wrapped around the fetal neck 360 degrees. Nuchal cord occur in about 10–29% of fetuses, and the incidence increases with advancing gestation age. Most are not associated with perinatal morbidity and mortality. Still, a few studies have shown that nuchal cord can affect the outcome of delivery with possible long-term effects on the infants. Nuchal cord more likely to cause problems when the cord is tightly wrapped around the neck, with results of a tight nuchal cord conceptually similar to strangulation. Umbilical cord compression due to tight nuchal cord may cause obstruction of blood flow in thin-walled umbilical vein, while infant’s blood continues to be pumped out of the baby through the thicker-walled umbilical arteries causing hypovolemia, acidosis and anaemia. Some of these infants have physical features secondary to tight nuchal cords that are distinct from those seen with birth asphyxia. The purpose of this article is to review the pathophysiology of tight nuchal cord and explore gaps in knowledge and research areas.


Applications Invited
9

Scopus Publications

89

Scholar Citations

4

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Endometrial cancer in a young nulliparous woman: a case report
    Herfiana Mohd Rapi, Azlina Ishak, Juliawati Muhammad, Engku Ismail Engku-Husna
    Korean Journal of Family Medicine, 2026
    Prolonged or irregular menstrual bleeding is common in women, particularly in the early years after menarche. Over time, menstrual cycles often become regular; however, persistently irregular menstruation warrants further investigation. Serious conditions, such as endometrial cancer, which is often linked to prolonged unopposed estrogen exposure, can be prevented with timely detection. We report a case involving a 27-year-old obese, nulliparous woman with a history of prolonged irregular menstrual bleeding since menarche. She had not undergone regular health checkups and had never been properly evaluated until multiple admissions for severe anemia prompted further investigation, which confirmed the diagnosis of endometrial carcinoma. Delays in seeking care for abnormal menstrual bleeding resulted in serious outcomes. Endometrial carcinoma may significantly reduce future fertility potential. Therefore, primary healthcare providers play a pivotal role in educating and raising public awareness about this frequently under-recognized issue, as timely investigation for early recognition is paramount.
  • A dark umbilical nodule in a postmenopausal woman: What is your diagnosis?
    Nur Hidayah Mohd Fauzi, Nik Ahmad Zuky Nik Lah, S. Hamzah, W Fadhlina W Adnan, Adibah Ibrahim, et al.
    Malaysian Family Physician, 2025
    Sister Mary Joseph's nodule is a rare but significant clinical sign that often indicates advanced intraabdominal malignancy. It presents as a palpable umbilical nodule and may be the first indication of an occult primary cancer. In this article, we discuss the case of a 58-year-old postmenopausal woman who presented to a primary care clinic with a darkened umbilical lesion and progressive abdominal symptoms. She wps ultimately diagnosed with metastatic endometrial carcinoma. This uncommon presentation highlights the importance of a comprehensive approach to umbilical lesions in the primary care setting. Recognising this subtle sign in primary care can lead to expedited investigations and timely intervention.
  • Severe Uterine Hemorrhage Resulting from Uterine Arteriovenous Malformation: A catastrophic scenario
    Thai Journal of Obstetrics and Gynaecology, 2024
  • May-Hegglin Anomaly: A Rare Cause of Thrombocytopenia and Potentially Overlooked
    Marne Abdullah, Shafini Mohamed Yusoff, Engku Ismail Engku-Husna, Salfarina Iberahim, Zefarina Zulkafli, et al.
    Malaysian Journal of Medicine and Health Sciences, 2024
    May-Hegglin Anomaly is a rare congenital platelet disorder with macrothrombocytopenia and leucocytes inclusions. We report a 25-year-old primigravida Malay woman with asymptomatic severe thrombocytopenia and strong family history of thrombocytopenia. Blood film showed the presence of many giant platelets with inclusion bodies in the neutrophils. Initially, she was treated as immune-mediated thrombocytopenia. However, the platelet count was not responding to corticosteroid therapy. This case report highlighted the rare cause of thrombocytopenia due to congenital cause in a young Malay ethnic primigravida woman who was asymptomatic for bleeding manifestation. This case also emphasized the importance of detailed family history and a proper evaluation of peripheral blood smear as a key for establishing the diagnosis as well as multidisciplinary approaches in treating the patient. Hence, this rare cause of thrombocytopenia would not be overlooked.
  • A Study of Micro-shock Hazard in EMIS-Based pH Sensor During Fetal Acidosis Assessment
    Siti Fatimah Abdul Halim, Zulkarnay Zakaria, Engku Ismail Engku-Husna, Ahmad Nasrul Norali, Jaysuman Pusppanathan, Anas Mohd Noor, Mohd Hafiz Fazalul Rahiman, Siti Zarina Mohd Muji, Ruzairi Abdul Rahim, Aiman Abdulrahman Ahmed
    Lecture Notes in Mechanical Engineering, 2024
  • Uterine Epithelioid Leiomyosarcoma Arising Within Leiomyoma in A Postmenopausal Woman: A Case Report
    Engku Husna Engku Ismail, Noorul Balqis Che Ibrahim, Mohd Hafizuddin Husin, Sharifah Emilia Tuan Sharif
    Malaysian Journal of Medicine and Health Sciences, 2023
    Uterine leiomyosarcoma is a malignant smooth muscle tumour of the uterus. It is rare and accounting for less than 2% of cases in malignant gynaepathology. To date, only a few reported cases of leiomyosarcoma arising from leiomyoma documented in the literature. We shared an uncommon occurrence of leiomyosarcoma arising from leiomyoma. Presented herein is a case of a ‘rare epithelioid subtype’ of leiomyosarcoma arising from a leiomyoma in a postmenopausal woman. We highlighted the importance of recognizing the possibilities of this event to allow for a timely diagnosis of leiomyosarcoma and to provide insights on management of patients presented with clinically presumed fibroid.
  • Probiotic Improves Skin Oxidation, Elasticity, and Structural Properties in Aging Rats
    Boon-Kiat Lee, Pei Xu, Uma-Mageswary Mageswaran, Woo-Sik Jeong, Engku Ismail Engku-Husna, Kadir Muhammad-Nashriq, Svetoslav Dimitrov Todorov, Guoxia Liu, Yong-Ha Park, Siti Nurma Hanim Hadie, Min-Tze Liong
    Preventive Nutrition and Food Science, 2023
    Skin aging, which affects all living organisms, is associated with oxidative stress. Probiotics exhibit antioxidant properties by producing reactive metabolites that counter oxidative stress. We hypothesized that Limosilactobacillus fermentum USM 4189 (LF 4189) has antioxidative properties and may prevent skin aging. In the present study, we used a D-galactose senescence-induced rat model to evaluate the potential antioxidative capability of LF 4189. The results indicated that rats administered LF 4189 exhibited increased plasma antioxidative activity (P=0.004), lipid peroxidation capacity (P=0.007), and skin elasticity compared with untreated aged rats (P=0.005). LF 4189 prevented telomere length shortening (P<0.05), indicating the potential to prevent senescence. A higher apoptotic activity was observed in old rats compared with young rats, whereas LF 4189 reduced the expression of four antioxidative enzyme genes that function as radical scavengers (all P<0.05), suggesting that the LF 4189 group had a reduced need to scavenge free radicals. Our findings indicate the potential of probiotics, such as LF 4189, as an anti-aging dietary intervention with antioxidant potential to improve skin health.
  • A Review on Magnetic Induction Spectroscopy Potential for Fetal Acidosis Examination
    Siti Fatimah Abdul Halim, Zulkarnay Zakaria, Jaysuman Pusppanathan, Anas Mohd Noor, Ahmad Nasrul Norali, Mohd Hafiz Fazalul Rahiman, Siti Zarina Mohd Muji, Ruzairi Abdul Rahim, Engku Ismail Engku-Husna, Muhamad Khairul Ali Hassan, Muhammad Juhairi Aziz Safar, Ahmad Faizal Salleh, Mohd Hanafi Mat Som
    Sensors, 2022
    Fetal acidosis is one of the main concerns during labor. Currently, fetal blood sampling (FBS) has become the most accurate measurement of acidosis detection. However, it is invasive and does not provide a real time measurement due to laboratory procedures. Delays in diagnosis of acidosis have caused serious injury to the fetus, especially for the brain and the heart. This paper reviews the new technique in diagnosis of acidosis non-invasively. Magnetic Induction Spectroscopy (MIS) has been proposed to be a new device for acidosis detection in recent years. This paper explains the basic principle of MIS and outlines the design specifications and design considerations for a MIS pH probe. It is expected that readers will gain a basic understanding of the development of a MIS pH probe from this review.
  • Müllerian duct anomalies with term pregnancy: a case report
    Engku Ismail Engku-Husna, Nik Lah Nik-Ahmad-Zuky, Kadir Muhammad-Nashriq
    Journal of Medical Case Reports, 2020
    Background Müllerian duct anomaly is a rare condition. Many cases remain unidentified, especially if asymptomatic. Thus, it is difficult to determine the actual incidence. Müllerian duct anomaly is associated with a wide range of gynecological and obstetric complications, namely infertility, endometriosis, urinary tract anomalies, and preterm delivery. Furthermore, congenital anomalies in pregnant mothers have a high risk of being genetically transmitted to their offspring. Case presentation We report a case of a patient with unsuspected müllerian duct anomaly in a term pregnancy. A 33-year-old Malay woman with previously uninvestigated involuntary primary infertility for 4 years presented with acute right pyelonephritis in labor at 38 weeks of gestation. She has had multiple congenital anomalies since birth and had undergone numerous surgeries during childhood. Her range of congenital defects included hydrocephalus, for which she was put on a ventriculoperitoneal shunt; imperforated anus; and tracheoesophageal fistula with a history of multiples surgeries. In addition, she had a shorter right lower limb length with limping gait. Her physical examination revealed a transverse scar at the right hypochondrium and multiple scars at the posterior thoracic region, levels T10–T12. Abdominal palpation revealed a term size uterus that was deviated to the left, with a singleton fetus in a nonengaged cephalic presentation. The cervical os was closed, but stricture bands were present on the vagina from the upper third until the fornices posteriorly. She also had multiple rectal prolapses and strictures over the rectum due to previous anorectoplasty. An emergency cesarean delivery was performed in view of the history of anorectoplasty, vaginal stricture, and infertility. Intraoperative findings showed a left unicornuate uterus with a communicating right rudimentary horn. Conclusion Most cases of müllerian duct anomaly remain undiagnosed due to the lack of clinical suspicion and the absence of pathognomonic clinical and radiological characteristics. Because it is associated with a wide range of gynecological and obstetric complications, it is vital for healthcare providers to be aware of its existence and the role of antenatal radiological investigations in its diagnosis. The presence of multiple congenital abnormalities and a history of infertility in a pregnant woman should warrant the exclusion of müllerian duct anomalies from the beginning. Early detection of müllerian duct anomalies can facilitate an appropriate delivery plan and improve the general obstetric outcome.

RECENT SCHOLAR PUBLICATIONS

  • Development and Validation of Menstrual Disorder of Adolescent (MenDA) Questionnaire in the Malay Language
    NB Mansor, MZ Erinna, NR Afendi, NMZN Mahmood, NAHC Hashim, ...
    IIUM Medical Journal Malaysia 24 (04) , 2025
    2025.0
  • Impact of the Probiotic on the Modulation of Vaginal Bacterial and Fungal Microbiota in HPV‐Positive Women
    P Xu, M Uma Mageswary, AA Nisaa, SD Balasubramaniam, SB Samsudin, ...
    Molecular Nutrition & Food Research 69 (18), e70142 , 2025
    2025.0
  • Roles of probiotics against HPV through the gut‐vaginal axis
    P Xu, UM Mageswaran, AA Nisaa, SD Balasubramaniam, D Rajendran, ...
    International Journal of Gynecology & Obstetrics 169 (1), 1-8 , 2025
    2025.0
    Citations: 12
  • Probiotic enhanced immunity and mental wellbeing of generally healthy women: a randomised, placebo-controlled and double-blind study
    AA Nisaa, U Mageswary, X Pei, MN Kadir, CE Oon, D Rajendran, JJ Tan, ...
    Beneficial microbes 1 (aop), 1-18 , 2025
    2025.0
    Citations: 4
  • Impact of fetal spine alignment according to maternal lateralization during early labor on maternal comfort and birth outcomes: A prospective cohort study in Kelantan, Malaysia
    NA Rahman, EM Zon, EHE Ismail, NAN Abdullah, WMZW Mohammad, ...
    European Journal of Midwifery 8, 10.18332/ejm/191737 , 2024
    2024.0
    Citations: 3
  • Large placental chorioangioma with maternal and perinatal morbidity
    WFW Adnan, EHE Ismail, AS Azmi, AAM Zin, AM Elisabeth
    European Journal of Obstetrics & Gynecology and Reproductive Biology 300 … , 2024
    2024.0
    Citations: 2
  • Oxidative stress biomarkers in pregnancy: a systematic review
    A Ibrahim, MI Khoo, EHE Ismail, NHN Hussain, AAM Zin, L Noordin, ...
    Reproductive Biology and Endocrinology 22 (1), 93 , 2024
    2024.0
    Citations: 58
  • Comparison between hCG and GnRH agonist for ovulation trigger in GnRH antagonist in-vitro fertilization cycles in a tertiary hospital in Malaysia: an observational study
    NA Aziz, A Ibrahim, R Ramli, N Yaacob, SNA Rahman, EHE Ismail, ...
    JBRA Assisted Reproduction 28 (1), 21 , 2024
    2024.0
    Citations: 4
  • Managing a Pseudo-Mobitz Type II Atrioventricular (AV) Block Intrapartum: A Case Report
    MK Othman, MZ Konok, EHE Ismail, Z Yusof, WYHW Isa, EHE ISMAIL, ...
    Cureus 15 (12) , 2023
    2023.0
    Citations: 2
  • Validation study of AR Gynae endotrainer-a new mobile laparoscopic simulator
    AA Omar, MM O&G1, EM Zon, MP Ismail, M Mahdi, MM O&G3, A Ibrahim, ...
    Med J Malaysia 78 (6), 711 , 2023
    2023.0
  • Effect of Different Fetal Spine Positions During Early Labour on Maternal Comfort and Birth Outcomes
    NA Rahman, EM Zon, EHE Ismail, NAN Abdullah, WMZW Mohammad, ...
    2023.0
  • Pericentric Inversion of Chromosome 9 in Twins With Cyclopia: A Rare Entity
    NAZN Lah, F Taib, EM Zon, EHE Ismail, AA Annuar, EHE ISMAIL
    Cureus 15 (2) , 2023
    2023.0
  • 46, XY Female Presenting With Dysgerminoma, Gonadoblastoma And Serous Cystadenoma With Androgen Receptor Mutation: A Swyer Syndrome Coexisting With Androgen Insensitivity Syndrome
    MR Hamid, EHE Ismail, NRNM Afendi, NBC Ibrahim, AA Annuar
    Journal of Angiotherapy 6 (3), 729-729 , 2022
    2022.0
  • A 10-year review of methotrexate treatment for ectopic pregnancy in a Malaysian tertiary referral hospital
    AA Omar, LK Leng, AN Apana, A Ibrahim, RA Rahim, NM Yaacob, ...
    Cureus 14 (10) , 2022
    2022.0
    Citations: 4
  • Understanding the behavior of a low-grade serous carcinoma
    LS Joo, EHE Ismail, MP Ismail, NMZN Mahmood, WFW Adnan, HP Sung

MOST CITED SCHOLAR PUBLICATIONS

  • Oxidative stress biomarkers in pregnancy: a systematic review
    A Ibrahim, MI Khoo, EHE Ismail, NHN Hussain, AAM Zin, L Noordin, ...
    Reproductive Biology and Endocrinology 22 (1), 93 , 2024
    2024.0
    Citations: 58
  • Roles of probiotics against HPV through the gut‐vaginal axis
    P Xu, UM Mageswaran, AA Nisaa, SD Balasubramaniam, D Rajendran, ...
    International Journal of Gynecology & Obstetrics 169 (1), 1-8 , 2025
    2025.0
    Citations: 12
  • Probiotic enhanced immunity and mental wellbeing of generally healthy women: a randomised, placebo-controlled and double-blind study
    AA Nisaa, U Mageswary, X Pei, MN Kadir, CE Oon, D Rajendran, JJ Tan, ...
    Beneficial microbes 1 (aop), 1-18 , 2025
    2025.0
    Citations: 4
  • Comparison between hCG and GnRH agonist for ovulation trigger in GnRH antagonist in-vitro fertilization cycles in a tertiary hospital in Malaysia: an observational study
    NA Aziz, A Ibrahim, R Ramli, N Yaacob, SNA Rahman, EHE Ismail, ...
    JBRA Assisted Reproduction 28 (1), 21 , 2024
    2024.0
    Citations: 4
  • A 10-year review of methotrexate treatment for ectopic pregnancy in a Malaysian tertiary referral hospital
    AA Omar, LK Leng, AN Apana, A Ibrahim, RA Rahim, NM Yaacob, ...
    Cureus 14 (10) , 2022
    2022.0
    Citations: 4
  • Impact of fetal spine alignment according to maternal lateralization during early labor on maternal comfort and birth outcomes: A prospective cohort study in Kelantan, Malaysia
    NA Rahman, EM Zon, EHE Ismail, NAN Abdullah, WMZW Mohammad, ...
    European Journal of Midwifery 8, 10.18332/ejm/191737 , 2024
    2024.0
    Citations: 3
  • Large placental chorioangioma with maternal and perinatal morbidity
    WFW Adnan, EHE Ismail, AS Azmi, AAM Zin, AM Elisabeth
    European Journal of Obstetrics & Gynecology and Reproductive Biology 300 … , 2024
    2024.0
    Citations: 2
  • Managing a Pseudo-Mobitz Type II Atrioventricular (AV) Block Intrapartum: A Case Report
    MK Othman, MZ Konok, EHE Ismail, Z Yusof, WYHW Isa, EHE ISMAIL, ...
    Cureus 15 (12) , 2023
    2023.0
    Citations: 2
  • Development and Validation of Menstrual Disorder of Adolescent (MenDA) Questionnaire in the Malay Language
    NB Mansor, MZ Erinna, NR Afendi, NMZN Mahmood, NAHC Hashim, ...
    IIUM Medical Journal Malaysia 24 (04) , 2025
    2025.0
  • Impact of the Probiotic on the Modulation of Vaginal Bacterial and Fungal Microbiota in HPV‐Positive Women
    P Xu, M Uma Mageswary, AA Nisaa, SD Balasubramaniam, SB Samsudin, ...
    Molecular Nutrition & Food Research 69 (18), e70142 , 2025
    2025.0
  • Validation study of AR Gynae endotrainer-a new mobile laparoscopic simulator
    AA Omar, MM O&G1, EM Zon, MP Ismail, M Mahdi, MM O&G3, A Ibrahim, ...
    Med J Malaysia 78 (6), 711 , 2023
    2023.0
  • Effect of Different Fetal Spine Positions During Early Labour on Maternal Comfort and Birth Outcomes
    NA Rahman, EM Zon, EHE Ismail, NAN Abdullah, WMZW Mohammad, ...
    2023.0
  • Pericentric Inversion of Chromosome 9 in Twins With Cyclopia: A Rare Entity
    NAZN Lah, F Taib, EM Zon, EHE Ismail, AA Annuar, EHE ISMAIL
    Cureus 15 (2) , 2023
    2023.0
  • 46, XY Female Presenting With Dysgerminoma, Gonadoblastoma And Serous Cystadenoma With Androgen Receptor Mutation: A Swyer Syndrome Coexisting With Androgen Insensitivity Syndrome
    MR Hamid, EHE Ismail, NRNM Afendi, NBC Ibrahim, AA Annuar
    Journal of Angiotherapy 6 (3), 729-729 , 2022
    2022.0
  • Understanding the behavior of a low-grade serous carcinoma
    LS Joo, EHE Ismail, MP Ismail, NMZN Mahmood, WFW Adnan, HP Sung

Publications

1. Engku Husna Engku Ismail, Ahmad Amir Ismail. A Retrospective Study of Obstetric Anal Sphincter Injury at Hospital USM: 10 Years Review (2007-2016). Med J Malaysia Vol 74 Aug 2019. Supplement p28-28.

2. Joo LS, Ismail EHE, Ismail MP, Mahmood NMZN, Adnan WFW, Sung HP. Understanding the Behaviour of a Low-Grade Serous Carcinoma. Edorium J Gynecol Obstet 2019;5:100023G06LJ2019.