Resurfacing the Threat of Asymptomatic Syphilis: A Retrospective Analysis of Clinico-epidemiological Trends of Syphilis at a Tertiary Care Centre in Eastern Uttar Pradesh Swale Iftikhar, Anil K. Gupta, Rajkumar, Durga P. Dubey, Divyanshu Srivastava Indian Dermatology Online Journal, 2026 Background: Syphilis is a bacterial infection caused by Treponema pallidum . In recent years, there has been a rising trend of syphilis noted worldwide, including in India. The aim of this study was to analyze the changing epidemiological patterns, demographic attributes, high-risk behavior, clinical presentations, and stages of syphilis among patients attending the sexually transmitted infections (STI) clinic at a tertiary healthcare facility in eastern Uttar Pradesh over the last 7 years. Patients and Methods: We conducted a retrospective study spanning 7 years (2017–2023) at a tertiary care center. Demographics and clinical data of all confirmed cases were recorded and analyzed. Results: Over 7 years, 8,325 patients who attended the STI clinic were included in this study. Among STI clinic attendees, 2.78% tested positive for syphilis, confirmed by either a positive venereal disease research laboratory (VDRL) test along with a positive Treponema pallidum hemagglutination assay (TPHA) test or by TPHA positivity alone, with males representing the majority at 87%. The mean age of patients was 34.80 ± 8.01 years, with most patients falling into the 25–34 years age group. The prevalence of syphilis among STI clinic attendees showed a rising trend from 1.55% in 2017 to 4.05% in 2023, which was statistically significant. High-risk behaviors such as multiple sexual partners (62%) and contact with commercial sex workers (35%) were frequently reported. In our study, 73% of patients were diagnosed in the late latent stage of syphilis, whereas 13% were in the secondary stage, 9% in the early latent phase, and 5% in the primary stage. Additionally, concurrent STIs were observed in 24% of syphilis-positive patients, with genital warts being the most common. Limitations: The retrospective nature of the study, and this being a single-center study, are the major limitations of this study. Conclusion: This study shows that syphilis is becoming more common. Risky behaviors, such as engaging in sex with multiple partners or with sex workers, were identified as major contributing factors. There is a need for enhanced educational campaigns on safe sex practices.
Beyond the surface: A closer look at hirsutism Journal of Pakistan Association of Dermatologists, 2024
PRP and Its Benefit as an Adjunctive Therapy with Subcision and Microneedling in Atrophic Scars: A Comparative Study Aditi Vashisht, Arvind Krishna, Robin Chugh, Abhinav David, Divyanshu Srivastava Journal of Cutaneous and Aesthetic Surgery, 2024 Context: Scarring is a biological process of wound repair which leads to a difference in the normal structure and function of the skin and manifests as a depressed or raised area. Treatment of scars is challenging. A number of therapeutic approaches like surgical techniques and non-surgical techniques are performed to improve scarring. Aims and Objectives: The aim of this study was to compare the outcome of subcision followed by microneedling versus subcision followed by microneedling and topical platelet-rich plasma (PRP) in atrophic scars. Materials and Methods: A comparative prospective study was conducted at a tertiary care hospital in North India to compare the efficacy of subcision followed by microneedling versus subcision followed by microneedling and topical PRP. A total of 40 cases were taken and were randomly divided into two groups, A and B of 20 patients in each group. Topical PRP was applied as an additional therapy in Group B in the same sitting. Minimum three sittings were done in each patient at an interval of 4 weeks and results were assessed after 1 month of the third session. The statistical software used is Microsoft Excel and SPSS software program, version 24.0 for analysis of data and Microsoft Word to generate graphs and tables. Results: Improvement in scar grading was more in Group B as compared to Group A with statistically significant difference (P = 0.032). There was an improvement in scar grading from grade 4 scar to grade 2 in 15% and 30% patients of Groups A and B, respectively, with improvement in skin texture and pigmentation more in Group B. Conclusion: PRP proved to add to the improvement of grade of atrophic scars when combined with subcision and microneedling.
A Comparative Study of the Efficacy of Methotrexate versus Methotrexate with Apremilast in Moderate to Severe Chronic Plaque Psoriasis Divyanshu Srivastava, Arvind Krishna, Abhinav David Indian Journal of Dermatology, 2023 Background: Psoriasis is an inflammatory systemic disease with a chronic relapsing course. Methotrexate, a dihydrofolate reductase inhibitor, and Apremilast, an oral phosphodiesterase type 4 inhibitor, are currently the mainstay drugs in the treatment of psoriasis. Aims and Objectives: To compare the efficacy of Methotrexate with a combination of Methotrexate and Apremilast in treating chronic plaque psoriasis. Materials and Methods: The present study was a prospective comparative study conducted among 40 patients, aged above 18 years, with clinically diagnosed psoriasis attending Dermatology OPD of a tertiary care hospital in North India. The study utilised a pre-structured proforma to record a detailed demographic profile and clinical examination related to chronic plaque psoriasis. The patients were divided into two groups of 20 each. Group A was treated with oral Methotrexate, while Group B was treated with oral Apremilast and Methotrexate, and they were evaluated every 4 weeks for 12 weeks. Necessary investigations were done wherever indicated. Results: The male-to-female ratio was 1.35, and the majority (55.0%) of patients belonged to the age group of 31-50 years. 27.5% of patients had comorbidities like diabetes, hypertension, etc., The mean PASI score of group A at the first, second and third follow-ups was higher than that of group B. The reduction in mean PASI score was statistically significant in group B at successive follow-ups, with a percentage improvement of 89.4% at the end of 12 weeks. Conclusions: When comparing monotherapy with methotrexate and multidrug therapy with Methotrexate and Apremilast, multidrug therapy had better efficacy.
Confluent and Reticulated Papillomatosis Resembling Pityriasis Versicolor and Acanthosis Nigricans: Case Report Abhinav David, Divyanshu Srivastava Jmir Dermatology, 2023 Confluent and reticulated papillomatosis (CARP) is a rare disorder mostly seen in young adults. It is characterized by persistent dull-brown, centrally confluent, peripherally reticulate macules and papules, which coalesce to form patches and plaques on the upper trunk and neck. It is commonly confused with pityriasis versicolor and acanthosis nigricans (AN). We report the case of a 15-year-old male with multiple pigmented confluent and reticulated patches and plaques on the neck, trunk, and chin for 3 years, which was successfully treated with oral minocycline, resulting in complete resolution of lesions within 2 weeks. The morphology of CARP resembles that of various other dermatological conditions such as AN and pityriasis versicolor, and, as a result, it is frequently misdiagnosed and mistreated, leading to social embarrassment for the patient. Therefore, it is prudent for dermatologists to carry out comprehensive clinical and histopathological assessments to facilitate prompt diagnosis and management of this condition.
RECENT SCHOLAR PUBLICATIONS
Chronic Perianal Ulcer in an Immunocompetent Child: An Unusual Presentation of Cutaneous Tuberculosis S Iftikhar, P Mishra, D Agarwal, AK Gupta, D Srivastava Dermatology Practical & Conceptual 16 (1), 5991-5991 , 2026 2026
Asteatotic eczema D Srivastava, NC Sathe, Y Persaud StatPearls [Internet] , 2026 2026 Citations: 25
Resurfacing the Threat of Asymptomatic Syphilis: A Retrospective Analysis of Clinico-epidemiological Trends of Syphilis at a Tertiary Care Centre in Eastern Uttar Pradesh S Iftikhar, AK Gupta, DP Dubey, D Srivastava Indian Dermatology Online Journal 17 (1), 33-39 , 2026 2026
Beyond the surface: A closer look at hirsutism Y Saaqib, S Saaqib, D Srivastava, N Shahzadi, A Shahzad, NA Azfar Journal of Pakistan Association of Dermatologists 34 (4 Suppl.), S95-S104 , 2024 2024 Citations: 2
PRP and its benefit as an adjunctive therapy with subcision and microneedling in atrophic scars: a comparative study A Vashisht, A Krishna, R Chugh, A David, D Srivastava Journal of Cutaneous and Aesthetic Surgery 17 (2), 137-145 , 2024 2024 Citations: 7
A Comparative Study of the Efficacy of Methotrexate versus Methotrexate with Apremilast in Moderate to Severe Chronic Plaque Psoriasis D Srivastava, A Krishna, A David Indian Journal of Dermatology 68 (4), 393-398 , 2023 2023 Citations: 2
Confluent and reticulated papillomatosis resembling Pityriasis Versicolor and acanthosis Nigricans: case report A David, D Srivastava JMIR dermatology 6, e41245 , 2023 2023 Citations: 2
A case report of aceclofenac induced drug induced hypersensitivity syndrome D Srivastava, A Krishna, R Chugh, A David Int J Res Dermatol 8, 128-31 , 2022 2022 Citations: 1
A case report of asymptomatic cutaneous larva migrans A David, D Srivastava Int J Res Dermatol 7 (5), 734-737 , 2021 2021 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Asteatotic eczema D Srivastava, NC Sathe, Y Persaud StatPearls [Internet] , 2026 2026 Citations: 25
PRP and its benefit as an adjunctive therapy with subcision and microneedling in atrophic scars: a comparative study A Vashisht, A Krishna, R Chugh, A David, D Srivastava Journal of Cutaneous and Aesthetic Surgery 17 (2), 137-145 , 2024 2024 Citations: 7
Beyond the surface: A closer look at hirsutism Y Saaqib, S Saaqib, D Srivastava, N Shahzadi, A Shahzad, NA Azfar Journal of Pakistan Association of Dermatologists 34 (4 Suppl.), S95-S104 , 2024 2024 Citations: 2
A Comparative Study of the Efficacy of Methotrexate versus Methotrexate with Apremilast in Moderate to Severe Chronic Plaque Psoriasis D Srivastava, A Krishna, A David Indian Journal of Dermatology 68 (4), 393-398 , 2023 2023 Citations: 2
Confluent and reticulated papillomatosis resembling Pityriasis Versicolor and acanthosis Nigricans: case report A David, D Srivastava JMIR dermatology 6, e41245 , 2023 2023 Citations: 2
A case report of asymptomatic cutaneous larva migrans A David, D Srivastava Int J Res Dermatol 7 (5), 734-737 , 2021 2021 Citations: 2
A case report of aceclofenac induced drug induced hypersensitivity syndrome D Srivastava, A Krishna, R Chugh, A David Int J Res Dermatol 8, 128-31 , 2022 2022 Citations: 1
Chronic Perianal Ulcer in an Immunocompetent Child: An Unusual Presentation of Cutaneous Tuberculosis S Iftikhar, P Mishra, D Agarwal, AK Gupta, D Srivastava Dermatology Practical & Conceptual 16 (1), 5991-5991 , 2026 2026
Resurfacing the Threat of Asymptomatic Syphilis: A Retrospective Analysis of Clinico-epidemiological Trends of Syphilis at a Tertiary Care Centre in Eastern Uttar Pradesh S Iftikhar, AK Gupta, DP Dubey, D Srivastava Indian Dermatology Online Journal 17 (1), 33-39 , 2026 2026